Articles tagged with Clinical Trials
A randomized clinical trial found that combining behavioral and physical therapy before and after midurethral sling surgery improved symptoms of mixed urinary incontinence. However, the small difference may not be clinically significant due to a lack of established thresholds for minimal clinically important differences.
A randomized clinical trial compared the effectiveness of two surgical methods: vaginal mesh hysteropexy and hysterectomy with ligament suspension. The study included 175 postmenopausal women and found that vaginal mesh hysteropexy was better at preventing prolapse symptoms, but further research is needed for definitive results.
A substudy of the NRG Oncology clinical trial found that women rated post-lumpectomy partial breast irradiation as equivalent to whole breast irradiation in terms of cosmetic outcomes and satisfaction. The results suggest that PBI may be a viable option for patients seeking to minimize radiation time commitment and healthcare costs.
The NRG-HN002 trial found that reduced-dose intensity-modulated radiotherapy (IMRT) with cisplatin achieved acceptable progression-free survival (PFS) rates and swallowing-related quality of life for p16-positive oropharyngeal cancer patients. Patients who received IMRT and cisplatin reported higher acute toxicities, but similar late t...
A secondary analysis of NRG-RTOG 9601 showed that pre-SRT PSA was a prognostic and predictive biomarker in determining the benefit of adding anti-androgen therapy to early SRT. Patients with PSAs <0.6 ng/mL experienced an increase in other-cause mortality and higher-grade cardiac events.
The Georgia Cancer Center at Augusta University has received a six-year $6 million grant from the NCI to improve access to clinical trials for minority and rural populations. The grant will be used to recruit patients to conduct multi-site cancer clinical trials and care delivery studies in their communities.
A new Cochrane review consolidates the results of 50 trials involving over 84,000 participants, showing little to no effect of deworming on haemoglobin, cognition, school performance, and mortality. The review suggests that donors and countries should reassess policies for mass treatment.
A systematic review and meta-analysis found that the FDA approved drugs and devices based on nonrandomized clinical trials (10%), with estimated treatment effects higher for these approvals. The study's findings suggest that no clear threshold of treatment effect exists, which may lead to more frequent RCTs in the future.
A survey of European patients with lung cancer revealed that many were unaware of or had never heard of clinical trials. Despite positive experiences by over 50%, respondents identified difficulties in accessing trials, including language barriers, limited information, and disparities across Europe.
Patients taking nivolumab experience a significant five-fold increase in overall survival, with five-year rates of 13.4% compared to docetaxel's 2.6%. Long-term benefits and improved progression-free survival have been observed with nivolumab treatment.
The Impower131 Trial found that atezolizumab + chemotherapy improved overall survival by 3.9 months compared to chemotherapy alone, particularly among patients with high PD-L1 expression. Treatment-related side effects were common but manageable in both arms.
Researchers at Brown University and Hebrew SeniorLife will create a collaborative research incubator to support trials aimed at improving care for people living with dementia. The grant will fund up to 40 pilot projects that test non-drug, care-based interventions.
A third family welcomes a baby after participating in a landmark uterus transplant clinical trial at Baylor University Medical Center. The successful birth is the largest program in the world, having performed a total of 20 uterus transplants.
A European lung cancer screening model outperformed a US model in detecting cancers, with 99% of cancers found using the European method compared to 77%. The study found that the model detected more cancers among high-risk patients and had a higher accuracy rate.
A pilot study under the Lung Cancer Master Protocol (Lung-MAP) found that most cancer patients lack a clear understanding of their genomic test results. The study revealed serious knowledge gaps about the potential uses of gene sequencing results, with only 86% correctly knowing their test results would select their treatment regimen.
A blood test has been shown to detect lung cancer earlier, identifying 32% of cases with a high specificity of 90%. This could lead to reduced late-stage presentations and improved survival rates for patients.
Durvalumab plus chemotherapy significantly improved overall survival in patients with extensive-stage small cell lung cancer, with a median survival of 13 months compared to 10.3 months for the control group. The study found that 33.9% of patients receiving durvalumab were alive at 18 months.
The bioMILD trial demonstrated that a blood microRNA assay, combined with low-dose CT screening, is safe and effective in enhancing lung cancer prevention. Preliminary analysis showed a significantly higher lung cancer incidence and overall mortality in subjects with positive LDCT and/or miRNA at baseline.
Researchers at Penn Medicine and Deloitte Consulting LLP used behavioral insights, gaming elements, and social incentives to improve workplace physical activity. The study found that adding competition led to significant increases in physical activity, while other groups saw only temporary improvements.
The bioMILD trial demonstrated that combining low-dose CT screening with a microRNA blood test reduces lung cancer mortality and incidence in high-risk individuals. The study found that participants with positive LDCT and/or miRNA at baseline had a significantly higher lung cancer incidence and overall mortality.
The MYSTIC trial found that patients with STK11 or KEAP1 gene mutations in metastatic non-small cell lung cancer experienced poorer overall survival compared to those without these mutations. Additionally, patients with ARID1A mutations in the durvalumab + tremelimumab arm had longer median overall survival rates.
The MYSTIC trial found that patients with STK11 or KEAP1 mutations had poorer outcomes to anti-PD-L1 and anti-CTLA-4 immunotherapies compared to those without these mutations. ARID1A mutations were associated with improved survival in the durvalumab + tremelimumab arm.
Researchers have found that deep transcranial magnetic stimulation can improve symptoms of obsessive-compulsive disorder (OCD) by targeting specific brain areas. After six weeks of daily treatment, 38% of patients showed a significant reduction in symptom severity, with 45.2% responding after a month.
A 2009 trial showed inducing labor at the end of pregnancy reduced high-risk situations, benefiting both mothers and babies. In a follow-up analysis in Ultrasound in Obstetrics & Gynecology, this finding was corroborated, supporting the optimal management strategy for hypertensive disease.
LSU Health New Orleans has been awarded a $13.6 million grant to expand its clinical trials network, providing cancer care and access to over 50% of newly diagnosed patients in the region. The new network will also increase minority patient participation in clinical trials.
A 12-week clinical trial found BioCell Collagen increased skin collagen content by 12% and improved signs of aging in women. The study showed significant reductions in facial lines and wrinkles, crow's feet width, and improved skin elasticity compared to placebo.
Research studies by SWOG Cancer Research Network reveal that low-income cancer patients and those without insurance may not receive the same treatment benefits as their counterparts. Socioeconomic deprivation is found to be a significant factor in cancer outcomes, even after adjusting for race and insurance status.
The University of Minnesota Medical School has been awarded a $945K grant to advance its cell-based therapy for Duchenne muscular dystrophy. Researchers aim to replace diseased muscle tissue with healthy muscle cells using human induced pluripotent stem cells.
The PARAGON-HF trial found that sacubitril-valsartan reduced hospitalizations for heart failure in lower ejection fraction patients, but not overall; women and those with ejection fractions 45-57% showed benefits.
Researchers at King's College London found that early planned delivery for women with preterm pre-eclampsia reduces maternal complications and severe hypertension. The study also showed lower costs compared to the current method of care in the UK.
A new clinical trial from Penn Medicine found that administering arginine vasopressin to trauma patients with severe bleeding can significantly reduce the need for blood products, a promising way to save lives. The study, published in JAMA Surgery, showed that patients treated with AVP required less than half the usual volume of blood ...
A cancer therapy invented at Rice University has shown promising results in clinical trials, destroying tumors without debilitating side effects. Thirteen of the first 15 prostate cancer patients treated with AuroLase Therapy showed no detectable signs of cancer a year after treatment.
Researchers found that high-intensity stepping with variable tasks improved dynamic balance and balance confidence in stroke survivors. High-intensity training resulted in significant clinical gains for 57% to 80% of participants, compared to 9% to 31% following low-intensity exercises.
A systematic review of over 58,000 participants found that consuming more long-chain omega-3 fats from fish oils had no impact on diabetes diagnosis or glucose metabolism. However, high doses may worsen glucose metabolism in some individuals.
The FDA approved a new minimally invasive open-heart surgery approach for low-surgical-risk patients with aortic stenosis. Baylor Scott & White has performed over 3,600 TAVRs and is a top-five provider nationally. This marks a significant shift towards catheter-based treatment options.
A randomized clinical trial found that interventions targeting parents in primary care pediatric settings can improve communications between parents and teens about sexual health and alcohol use. The study showed an increased frequency of parent-teen communications about these topics in intervention groups compared to the control group.
A clinical trial found that an oral activator, veledimex, controlled the transcription of human interleukin-12, reducing toxicity while preserving anti-tumor effects. Patients with recurrent glioblastoma had improved overall survival rates, with some experiencing up to 17.8 months of survival.
Landos Biopharma has completed a $60 million Series B financing round to support global Phase 2 clinical trials of its lead product BT-11 for ulcerative colitis and Crohn's disease. The funding will also advance additional pipeline candidates, addressing an unmet clinical need for new therapies in inflammatory bowel disease.
A study found that providing current medical research to patients and visitors in waiting rooms increases interest by 30 percent. The trial, conducted in North Queensland, Australia, showed that age and gender also play a role in public interest.
A Phase 1 clinical trial enrolls healthy adults to evaluate the safety and immune response of two licensed influenza vaccines administered with novel adjuvants. The trial aims to improve seasonal flu vaccine effectiveness, which varies from year to year.
A clinical trial published in Appetite found that transcranial direct current stimulation (tDCS) can reduce or increase appetite depending on a patient's genetic profile. The study used a current of 2 milliamperes and 17 thirty-minute sessions over a month, with participants monitored for six months.
A randomized clinical trial compared a technology-enhanced community health nursing intervention to standard care for female adolescents and young adults with pelvic inflammatory disease. The study found that the tech-enhanced intervention may offer improved medication adherence and treatment outcomes.
A review of clinical trials published in top psychology and psychiatry journals found that more than half of the abstracts contained 'spin' - exaggerating the clinical significance of a particular treatment without statistics to back it up. This practice raises concerns about its impact on doctors' treatment decisions.
Researchers at MIT developed a machine-learning model that can predict cognitive decline in patients with Alzheimer's disease up to two years in the future. This could help clinicians select candidate drugs and participant cohorts for clinical trials more effectively, ultimately leading to faster discovery of effective treatments.
A novel RSV vaccine candidate, DS-Cav1, has shown early promise in a Phase 1 clinical trial, prompting large increases in RSV-neutralizing antibodies. The vaccine induced a sevenfold increase in neutralizing antibody levels after a single dose of 50 μg and a 12-fold surge with a dose of 150 μg.
A new vaccine candidate, DS-Cav1, has shown promising results in a Phase 1 human clinical trial, eliciting large increases in RSV-neutralizing antibodies that were sustained for several months. The vaccine's structure-based design approach aims to overcome the challenges of traditional methods in creating an RSV vaccine.
A $21 million national study will test three evidence-based treatments for chronic low back pain in a 20-site trial. The Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response (SCEPTER) trial aims to find the best approach to manage chronic low back pain, with implications for the general population.
A new wearable device has been shown to detect eye flicker with high accuracy, helping diagnose the most common causes of dizziness. Researchers collected 9,000 hours of data from 17 participants, proving the technology's reliability and safety.
A new Phase III clinical trial will assess the efficacy and safety of thrombectomy procedure in patients with larger ischemic strokes. The trial aims to determine if thrombectomy is safe and effective for this population, which has limited treatment options.
Researchers investigated acupuncture as an added treatment to reduce frequency of angina attacks in patients with chronic stable angina. The study, conducted in China, involved approximately 400 adults and showed promising results for acupuncture as a complementary therapy.
This systematic review and meta-analysis found parent-based interventions associated with improved condom use and parent-child sexual communication in adolescents. The findings were generally modest, but there was a significant association across studies.
A Phase 0 clinical trial shows ribociclib effectively targets glioblastoma cells and breaks the blood-brain barrier, offering a new treatment hope. The study identifies a potential mechanism of drug resistance, paving the way for a combined-drug regimen to overcome resistance.
A comprehensive systematic review and meta-analysis of testosterone treatment for women found significant improvements in sexual desire, function, and pleasure. Non-oral formulations appear to have fewer side effects compared to oral testosterone, with benefits including reduced concerns and distress about sex.
A new imaging diagnosis device called a Compton camera enables simultaneous PET and SPECT scans, reducing time and radiation exposure. Researchers detected and imaged radioactive tracers with improved accuracy, paving the way for new forms of medical analysis.
Researchers are investigating how to make talk therapy treatment more accessible to all women, particularly those with mild to severe symptoms. The study aims to determine the effectiveness of non-specialist delivered interventions, such as nurses trained to deliver behavioral activation therapy, in improving mental health outcomes.
Researchers at Cincinnati Children's Hospital Medical Center designed an AI-powered system to streamline clinical trial recruitment. The Automated Clinical Trial Eligibility Screener (ACTES) reduces patient screening time by 34 percent and improves enrollment by 11.1 percent compared to manual screening.
A new study published in PLOS Medicine found that a Mediterranean-style diet during pregnancy may reduce weight gain and the risk of gestational diabetes, but has no overall impact on adverse maternal and offspring outcomes. The diet's high intake of nuts, olive oil, fruits, and vegetables was associated with these benefits.
A recent Nordic collaboration study found no significant difference in functional outcomes between operative and non-operative treatment in patients over 60 with displaced proximal humerus fractures. Non-operative treatment using a collar and cuff sling and physiotherapy was as effective as surgery in improving patient recovery.
A new study suggests that partial knee replacements (PKR) are as effective as total knee replacements (TKR), with a lower cost. Over five years, PKR has similar or slightly better clinical outcomes than TKR, while offering substantial economic benefits.
A recent review explores how artificial intelligence can improve the success of clinical trials. AI-based models can help with trial design, patient recruitment, and monitoring adherence, potentially boosting success rates by up to 30%.