Articles tagged with Clinical Trials
A secondary analysis of a randomized clinical trial found no significant benefit of intensive lipid treatment with simvastatin and ezetimibe compared to simvastatin alone in older patients after acute coronary syndrome. The study suggests that age may be an important factor in determining the effectiveness of lipid-lowering therapies.
A clinical trial at Flinders University and Royal Adelaide Hospital included 27 adults with a history of allergic reactions to European honeybee stings. The vaccine used an adjuvant developed in Australia to neutralize bee venom, showing promising results and confirming safety.
The Keck School of Medicine of USC has received a $4.5 million NIH grant to recruit underrepresented patients in cardiac surgery clinical trials. The grant aims to translate clinical research findings into clinical practice, addressing the No. 1 cause of mortality in the US.
A randomized clinical trial involving 1,685 ICU patients in Brazil found no significant difference in delirium reduction between flexible and standard visitation policies. The study's limitations include its focus on a single country.
Researchers found that a 12% calorie reduction over two years improved cholesterol, blood pressure, blood sugar levels and reduced biomarkers of chronic inflammation. Participants who maintained a 25% calorie reduction showed significant weight loss, primarily fat, and reductions in metabolic risk markers.
A Yale-developed scorecard has been found to promote better clinical trial data sharing among pharmaceutical companies, with 33% of companies meeting standards after being given the opportunity to improve their practices. The scorecard assesses companies' data-sharing practices and provides a ranking system to encourage transparency.
Eteplirsen shows supportive results in delaying respiratory decline in DMD patients, with slower rates of decline observed in both ambulatory and non-ambulatory patients. This may have notable positive implications on quality of life and potentially delayed mortality.
A new clinical trial will test the effects of the anti-obesity drug setmelanotide on participants with Bardet-Biedl syndrome or Alström syndrome, two rare genetic disorders that include obesity as a symptom. The trial aims to assess the drug's ability to lead to significant weight loss in these individuals.
A new international consensus document provides guidelines for the conduct of magnetic resonance imaging studies after a myocardial infarction. The main outcome measure recommended is absolute infarct size, with scanning timing between 3 and 7 days post-infarction.
A new study published in Contemporary Clinical Trials found that treadmill exercise reduced period pain by 6% after four weeks and 22% after seven months. Women who participated in the supervised aerobic training regime also reported improved quality of life and daily functioning, but not increased sleep quality.
A significant decrease in depression cases was observed after CPAP treatment for sleep apnea in patients with cardiovascular disease. The study found that CPAP treatment had a broader benefit of preventing depression, independent of improved sleepiness.
A new study published in Brain suggests that neurotechnology-based therapies, such as brain-machine interfaces and robotics, can lead to largest treatment effects when tailored to individual patient needs. Personalized combination of these therapies may allow patients to continue their recovery beyond what is possible today.
A QUT study found that sharing medical 'selfies' improves confidence and satisfaction among patients, while also enhancing the relationship between doctors and patients. Parents who took photos of their children's surgical wounds after laparoscopic appendectomy reported feeling reassured and valued by the service.
A study published in the American Journal of Gastroenterology found that high sodium intake increases bloating among individuals, particularly those on high-fiber diets. Reducing sodium intake may be an effective way to reduce bloating and maintain a healthy, high-fiber diet.
A new study found that walking interventions can lead to sustained increases in physical activity and a reduced risk of cardiovascular events and fractures. The research followed participants with pedometer-based walking interventions for up to four years, demonstrating the long-term health benefits of increased walking activity.
A restrictive approach to blood cell transfusions in heart surgery patients resulted in fewer transfusions without increasing the risk of acute kidney injury. The study found that reducing transfusions could prevent adverse effects and conserve the blood supply, while minimizing negative impacts on kidney health.
A clinical trial for a new sickle cell disease treatment, IMR-687, has shown early promise with an increase in F-cells and a reduction in pain, improving biomarkers of the disease.
A nationwide clinical trial found that topical application of ruxolitinib was effective in repigmenting the skin of over 50% of participants with facial vitiligo. The treatment has an excellent safety profile and may lead to better results when combined with phototherapy and sunlight exposure.
Researchers identify barriers to trial accrual, including complexity in staying aware of available trials, identifying eligible patients, and enrolling them. The study suggests addressing these challenges through changes in trial-specific reimbursement and incentives for administrative costs.
The NRG-GOG 0258 trial showed that carboplatin and paclitaxel chemotherapy alone resulted in comparable recurrence-free survival rates compared to combined modality treatment. The study found a reduced incidence of vaginal, pelvic, and para-aortic lymph node recurrences but increased distant recurrences with combined modality treatment.
Common conditions like cartilage defects over 55 or under 18 are often excluded from clinical trials due to concerns about optimal results and complications. Researchers highlight promising therapies for these populations, including scaffolding for cartilage growth and 3D-printed tissues for larger defects.
A new approach is needed for clinical trials in dialysis patients to address high morbidity and mortality. Innovative RCT designs, such as pragmatic clinical trials and adaptive platform designs, can improve the success of testing interventions in ESRD.
Chronic kidney disease (CKD) is associated with increased cardiovascular risk due to high LDL-C levels. PCSK9 inhibitors like evolocumab and alirocumab have shown promise in reducing cardiovascular events, but more research is needed to prove their efficacy and safety in CKD patients.
The topline Phase 3 results of ULTOMIRIS (ravulizumab) show efficacy and safety in treating aHUS. The therapy has shown promise in reducing inflammation and blood clotting, with the potential to treat patients with progressive organ damage.
Researchers at Marshall University found that tart cherry consumption reduced mean pain levels by 34.7% compared to a placebo group, with no impact on the effectiveness of aromatase inhibitor treatments for non-metastatic breast cancer patients.
A new study found that saline fluids commonly used to treat critically ill children with sepsis may trigger acid blood and lead to organ failure. The research team recommends using alternative buffered solutions that contain less chloride to prevent these adverse effects.
The National Institutes of Health will fund clinical trials to assess genomic medicine interventions for managing diseases such as high blood pressure, depression, and chronic pain. The trials aim to improve treatment outcomes by tailoring drug prescriptions based on patients' genetic makeup.
A 12-month home exercise program reduced fall rates by 36% in high-risk seniors with a history of falls and mobility impairments. The study found improved cognitive function as a secondary benefit, reducing risk of injury and loss of independence for older adults.
A Phase II clinical trial conducted at MD Anderson Cancer Center revealed an 84.6% overall response rate and 38.5% complete response rate when combination targeted therapy was given prior to chemotherapy for newly diagnosed patients with a specific type of diffuse large B-cell lymphoma. The findings suggest that patients who respond to...
A pilot study found that video consultations can help patients with long-term health problems and working individuals, saving time and travel. However, doctors emphasize the importance of in-person visits for delivering bad news or discussing serious issues.
The Phase 1 clinical trial shows median survival of GBM patients was 3.5-fold the expected survival based on published modeling studies, with very few side effects among patients. The gene therapy uses O-benzylguanine and temozolomide with repair enzyme MGMT.
The NRG GOG 0261 clinical trial shows that paclitaxel plus carboplatin is not inferior to paclitaxel plus ifosfamide in treating women with stage I-IV, recurrent carcinosarcoma of the uterus or ovary. The treatment improved overall survival and progression-free survival outcomes.
The combination immunotherapy of nivolumab and ipilimumab met the primary endpoint of the NEOSTAR trial with a 33% overall major pathologic response rate in early-stage lung cancer patients. The treatment was also shown to be effective in reducing tumor viability, with six out of 21 patients achieving a complete pathological response.
The NRG-LU001 trial showed that metformin was well-tolerated by patients with locally advanced non-small cell lung cancer, but did not improve progression-free survival or overall survival rates. The study found better-than-expected PFS and OS rates in both treatment arms.
Cancer patients with HIV and viral hepatitis can also reap benefits of immunotherapy, study suggests. These patients respond as well to immune checkpoint inhibitors as those tested in clinical trials.
A virtual clinical trial using real-world data found entrectinib to be more effective than crizotinib in treating ROS1+ lung cancer. Patients on entrectinib stayed on treatment longer and had a 44% increased chance of cancer recurrence compared to those on crizotinib.
A new study by Brigham and Women's Hospital found that older women who took 4,400 steps per day had significantly lower mortality rates compared to those taking 2,700 steps per day. Risk of death continued to decrease with more steps taken, leveling off at around 7,500 steps per day.
A large-scale analysis of over 3,000 patients with early oesophagus and stomach cancer found that female patients are more likely to survive longer than male patients, but experience more severe gastrointestinal side effects during chemotherapy. Researchers hope the findings can help tailor treatment approaches for individual patients.
A new study conducted by Vanderbilt University found that bioimpedance spectroscopy (BIS) is more effective than traditional tape measures in assessing the risk of developing lymphedema after breast cancer surgery. The technology reduces rates of progression by approximately 10%, a clinically meaningful improvement.
A new study found that a mobile phone app designed for physically inactive women increased their daily physical activity and helped them sustain it over nine months. The app, combined with an activity tracker and personal counseling, provided motivational messages and interactive feedback, leading to short- and long-term fitness benefits.
A new minimally invasive treatment option has been shown to dramatically lower rates of low-density lipoprotein (LDL) cholesterol in patients following a heart attack. The procedure, called LDL-apheresis, decreases LDL levels by 50-80 percent in two to three hours.
The BRAVO-3 clinical trial found ProGlide VCD to be associated with lower rates of vascular complications and shorter hospitalizations after TAVR. The study showed ProGlide offered fewer complications compared to ProStar XL, with lower rates of acute kidney injury.
A pilot study led by Dr. Stephanie McGrath found that 89% of dogs who received CBD had a reduction in seizure frequency. The research suggests a correlation between CBD concentration and seizure reduction, leading to potential alternative treatments for canine epilepsy.
A multi-center clinical trial found that performing an additional surgical procedure called lateral extra-articular tenodesis (LET) can improve patient outcomes in young athletes. The study showed a 65% relative risk reduction for graft failure, suggesting patients under 25 may benefit from considering the LET procedure
A new study found that limiting extended-duration shifts improved sleep duration among pediatric resident physicians, with weekly sleep duration increasing nearly four hours overall. The study enrolled 302 resident physicians and used a clustered-randomized crossover clinical trial to compare two work schedules.
Researchers used big data to identify four distinct subtypes of sepsis, each with unique clinical characteristics and treatment needs. These findings could lead to the development of precision medicine approaches for sepsis treatment, potentially improving patient outcomes.
The Case Comprehensive Cancer Center has been selected as a Lead Academic Participating Site by the National Cancer Institute for a six-year grant worth $8.9 million. This renewal grant enables the center to provide patients with additional access to clinical trials through the National Clinical Trials Network.
A La Trobe University study has found significant levels of fatigue and poor brain function can persist after concussion, with implications for diagnosis and treatment of persistent post-concussion syndrome (PCS). The study used innovative brain technology to assess brain functioning in a way that has never been done before.
A trial remedy for racial disparities in early-stage lung and breast cancer treatment has shown nearly eliminating existing gaps. The intervention consisted of a real-time warning system, race-specific feedback, health equity training, and nurse navigators to reengage patients.
Researchers compared two cardiac resynchronization therapies in a pilot study, finding comparable rates of response between His bundle pacing and biventricular pacing. The study suggests that His bundle pacing may be a viable alternative for treating heart failure patients with electrical disturbances.
New trials suggest whole body MRI can diagnose cancer stage more quickly and accurately than standard imaging for colorectal and non-small cell lung cancers. This reduces treatment decision time from an average of 13 days to 8 days, while costs are lowered by nearly a quarter in some cases.
A phase I/II clinical trial of an enzyme-based treatment found reduced signs of disease and discomfort in participants with severe dry eye disease. The treatment, DNase, was shown to be safe and effective in improving corneal health and reducing symptoms.
A study led by Vanderbilt University Medical Center's Sheila Ridner found bioimpedance spectroscopy to be more accurate than a tape measure in identifying women at risk of developing lymphedema. The technology reduced rates of progression by approximately 10%, a clinically meaningful improvement.
A clinical trial found that all four tested sunscreen active ingredients (avobenzone, oxybenzone, octocrylene, and ecamsule) were detected in blood samples at levels exceeding the FDA's recommended toxicology threshold. The study's limitations include lack of exposure to heat, sunlight, or humidity, which may impact absorption rates.
A rare but potentially fatal infection of the genitals has been identified as a side effect of SGLT2 inhibitors, requiring immediate attention and surgical intervention. Awareness of this association can inform prescriber-patient discussions about appropriate diabetes therapy.
A clinical trial found that transcatheter aortic valve replacement (TAVR) is equivalent or potentially preferable to surgical aortic valve replacement (SAVR) for low-risk surgical patients. TAVR showed strong post-procedure benefits, including reduced re-hospitalizations and improved quality of life metrics at 30 days.
A new surgical technique using ultrasonic energy to seal pulmonary artery branches has been shown to reduce post-operative bleeding, complications, and pain in patients with lung cancer. The study's results have the potential to make this less invasive procedure more widely available, leading to faster recovery times for thousands of C...
A multi-site international trial has shown promise in reducing the incidence of thoracotomy conversion for VATS/robotic anatomical lung resection. The use of an ultrasonic vessel-sealing device resulted in fewer bleeding complications and a faster recovery time, with no postoperative bleeding from divided PA branches.
Researchers found that omitting chemotherapy in HER2 positive metastatic breast cancer can significantly shorten progression-free survival but not overall survival. The PERNETTA trial suggests that targeted therapy alone may be safe for patients with low-to-intermediate tumour burden.
Researchers found that radiotherapy after chemotherapy improved survival in patients with large tumours, with a 7-10% survival benefit at three and five years. This trial suggests that radiotherapy should be considered for these patients to balance cure rates with toxic side effects.