Articles tagged with Clinical Trials
A clinical trial found that electrical stimulation improved symptoms in 53% of women with constipation, with lasting benefits for at least 3 months. The treatment was well-tolerated and offered a promising alternative to laxative medications.
A new study by Mayo Clinic researchers found that catheter ablation reduced the risk of death or hospitalization due to worsening heart failure in patients with both conditions. The study analyzed data from over 289,000 patients and showed an 18% reduction in risk for those who received ablation.
Researchers have achieved a groundbreaking milestone in treating inherited blindness by using CRISPR gene editing within the human body. The BRILLIANCE clinical trial aims to repair mutations causing Leber congenital amaurosis type 10, a rare form of blindness. This permanent approach avoids passing on genetic changes to offspring.
A randomized clinical trial in 60 urban workplaces in China found that a wellness program with hypertension management component significantly improved blood pressure control among employees. The program reduced systolic blood pressure by 3.5 mmHg and diastolic blood pressure by 2.5 mmHg compared to usual care.
Researchers identified key features and events over four phases of recovery in mice with surgically narrowed arteries, creating signposts for understanding PAD and developing treatments. By using multiple imaging methods, the study aims to facilitate more optimal approaches to treatment and improve diagnosis.
Most clinical trial participants are not informed about the results of studies they participated in, despite wanting this information. Researchers want to share findings but lack effective communication skills to reach lay public. The study highlights the need for better training on communicating research results to study participants.
Research shows that cancer clinical trials inadequately report treatment efficacy and adverse effects specific to older adults. A new study has developed templates to address this issue, providing a framework for more accurate assessment of senior cancer patients.
The Ohio State University Wexner Medical Center has successfully used a new atrial fibrillation device, achieving 100% pulmonary vein isolation without nerve injuries or serious side effects. The PFA technology uses pulsed electric fields to interrupt pathways and triggers in the heart, potentially becoming the standard tool for resolv...
A phase 2b clinical trial of gefapixant, a new treatment for unexplained chronic cough, has shown promising results. The study found that patients who received the medication experienced a significant reduction in cough frequency, with the lowest dose of 50mg showing the most pronounced effect.
The NIH has begun a randomized, controlled clinical trial to evaluate the safety and efficacy of remdesivir in hospitalized adults with COVID-19. The study aims to assess whether remdesivir can improve clinical outcomes for patients with severe respiratory illness.
A follow-up study of the Wingspan stent suggests it is safe and effective for reducing recurrent stroke risk, with a long-term one-year rate of 8.5% compared to 20% in another trial. The study follows 152 patients treated with the stent according to FDA guidelines.
A University of Houston researcher is increasing health literacy among Hispanics/Latinos to address the significant disparities in Alzheimer's disease development and treatment. The largest ethnic minority group in the US, H/Ls are 50% more likely to develop AD, yet they comprise less than 1% of clinical trials.
The NRG-CC001 trial found that lowering radiotherapy dose to hippocampal stem cells reduces cognitive toxicity and neurologic symptoms in patients with brain metastases. Patients who received whole-brain radiotherapy with hippocampal avoidance reported improved cognitive function, reduced fatigue, and fewer cognitive symptoms.
A meta-analysis of five controlled trials including 471 patients found that vitamin C administration shortened ventilation time by 25% on average, with the effect dependent on the severity of illness. Vitamin C has been shown to have various biochemical effects, including influencing cardiovascular and energy metabolism.
A randomized clinical trial evaluated subconcussive head impacts in soccer players, finding those who received heading shots performed worse on eye movement tests compared to a control group. The study suggests that such impacts may cause short-term effects on neuro-eye function.
A novel injectable drug, NOV004, is being developed by Novosteo Inc. to heal broken bones faster and strengthen weak bones. The treatment concentrates at the fracture site while reducing exposure to the rest of the body, potentially reducing mortality rates among older adults.
A randomized controlled trial found that T'ai Chi was feasible and acceptable for improving chronic low back pain in adults over 65. High attendance rates and perceived benefits were observed among participants, suggesting a potential treatment option for this population.
A randomized clinical trial found that outpatient palliative care was associated with better patient and caregiver outcomes for patients with Parkinson disease. The study included 210 patients and 175 caregivers and examined the effects of palliative care on quality of life, mood, and sleep.
The CD19 CAR NK-cell therapy achieved a 73% response rate in patients with relapsed or refractory non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL), with no major toxicities reported. The treatment was administered in an outpatient setting, and responses were evident within one month following infusion.
A new study finds that rosiglitazone increases the risk of heart failure and cardiovascular events by 33% compared to controls. The research highlights the importance of access to raw clinical trial data for accurate drug safety assessments.
A new device can automatically manage glucose levels and deliver needed insulin quickly, eliminating the need for constant blood sugar checks and insulin injections. The adhesive patch, about the size of a quarter, has been successfully tested on mice and pigs, showing promise as a potential diabetes treatment.
Recent clinical trials of Prolonged Exposure Therapy and Cognitive Processing Therapy show limited effectiveness in treating active duty military personnel and veterans with PTSD. The studies suggest that emotionally demanding therapies may not be beneficial for all patients, and more personalized treatment approaches are needed to acc...
A phase I clinical trial has confirmed the safety and effectiveness of a monoclonal antibody in neutralizing henipaviruses, which have pandemic potential. The antibody, m102.4, was found to be well-tolerated in healthy volunteers, with no serious adverse events reported.
A new study shows that a single dose of the Army-developed Zika vaccine can induce potent cross-neutralizing antibody responses against both Zika and dengue viruses. Researchers found that these antibodies, called MZ4, protected against both viruses in a mouse model of infection.
Researchers have established new guidelines for analyzing patient-reported outcomes (PROs) in cancer clinical trials, aiming to provide more consistent and comparable Quality of Life (QoL) results. The adoption of these standards will ensure that trial results are more reliable and beneficial for patients.
A gene therapy trial conducted in US and UK patients with X-linked Chronic Septic Granulomatosis, a rare genetic disease causing severe infections, has shown success. Six of nine patients are free of treatment complications, offering hope for sustainable treatment.
A study by Johns Hopkins Bloomberg School of Public Health found that people on high fiber diets are 40% more likely to experience bloating if they consume protein-rich diets. The researchers suggest that substituting high-quality carb calories for protein calories may reduce bloating and make these diets more tolerable.
Researchers found daratumumab to be safe and successful in treating patients with relapsed AL amyloidosis, a condition characterized by organ failure. The treatment was well-tolerated and effective when used with appropriate pre- and post-infusion medications.
A Phase 1 clinical trial tests the safety and effectiveness of mAb CIS43LS in preventing malaria infection. Volunteers will receive a single dose of the antibody and then be exposed to malaria-carrying mosquitoes to assess protection.
SU2C's new health equity initiative aims to reduce racial and ethnic disparities in cancer research, addressing socio-economic, cultural, trust barriers that prevent minority participation. The organization requires grant proposals to include diverse patient recruitment and retention plans.
Researchers found significant physical and emotional benefits a decade after prenatal surgery for myelomeningocele, including better walking ability and bladder control. School-age children who received corrective surgery in the womb demonstrated improved gross and fine motor skills and a lower need for shunts and surgeries.
A guided self-help approach was safe and effective in reducing psychological distress and improving functioning among female South Sudanese refugee women living in Uganda. The intervention resulted in meaningful improvements in symptoms of depression, PTSD, and explosive anger, with benefits seen across different trauma histories and l...
A new analysis of HPV vaccine clinical trials raises doubts about their effectiveness, citing methodological problems and limited trial populations. The study found that the trials were not designed to detect cervical cancer, which takes decades to develop, and that vaccination may only prevent low-grade abnormal cell changes.
Researchers found that only 0.1% of cancer patients were enrolled in clinical trials as their first course of therapy after diagnosis. White males with private health insurance and metastatic cancers are more likely to enroll, but the low enrollment rate is still troubling due to the potential for increased life expectancy.
A randomized clinical trial evaluated the absorption of six sunscreen active ingredients in four formulations, with all ingredients surpassing FDA thresholds for potentially waiving additional safety studies. The study highlights the need for further research on sunscreen ingredient exposure and its effects.
A study found that fewer than half of US clinical trials comply with the law on reporting results, with non-industry sponsored trials most likely to breach. Trials with industry sponsors are more likely to report results on time, but progress has stalled since July 2018.
The PEPTIC trial compared two strategies for preventing stress ulcers in ICU patients requiring mechanical ventilation. The study found no significant difference in in-hospital death rates between proton pump inhibitors and histamine-2 receptor blockers.
A randomized clinical trial of 200 patients with septic shock found that combining vitamin C, hydrocortisone, and thiamine did not significantly improve survival rates over seven days compared to hydrocortisone alone. The study's findings were released in conjunction with the Critical Care Reviews Meeting 2020.
A collaborative clinical trial has led to changes in the treatment of leukemia driven by the Philadelphia chromosome, a high-risk subtype associated with poor outcomes. Dasatinib was found to provide greater benefit than the standard of care, resulting in improved event-free survival rates.
A study of families in Singapore found that parents defer discussing their psychological pain with spouses to avoid emotional distress. Researchers developed a therapeutic app called Narrative e-Writing Intervention (NeW-I) to support caregivers.
The MND-SMART trial is a comprehensive clinical study that seeks to find treatments for motor neurone disease (MND), a progressive condition affecting the nervous system. The trial will involve over 1,500 participants and test multiple treatments against a shared placebo group.
A randomized clinical trial found that a telephone-based program encouraging increased vegetable consumption did not decrease the risk of prostate cancer progression over two years. The study suggested that the intervention may have been underpowered to identify a clinically important difference in cancer progression.
A recent investigation by Science found that companies, universities, and institutions are often non-compliant with the requirement to report clinical trial results in a federal database. More than 55% of trials violated this law, yet regulatory agencies have failed to enforce penalties or actions against violators.
A recent clinical trial found that nerve stimulation via TENS significantly improved movement-related pain and fatigue in women with fibromyalgia. The treatment, given along with standard treatments, offers a non-invasive self-management option for chronic pain management.
Women who were overweight at the start of their pregnancy benefit from attending commercial weight management groups post-pregnancy, losing around 3kgs by 12 months. The researchers argue that a larger clinical trial is needed to determine the definitive health and cost-effectiveness benefits of such programs.
Researchers have successfully tested a new immunotherapy approach that targets brain plaque and tau protein aggregates linked to Alzheimer's disease. The treatment, developed using a combination of vaccines, shows promise for preventing dementia in humans within two years.
The consortium will conduct Phase 1-4 vaccine and treatment trials, including human challenge trials. The leadership group will prioritize candidate vaccines, diagnostics, and therapeutics to test in clinical trials.
A retrospective study found that women with government insurance had lower survival rates, increased risk of dying, and were more likely to stop treatment early in breast cancer clinical trials. The study also did not find a significant association between neighborhood socioeconomic status and trial outcomes.
The NRG Oncology/NSABP B-42 trial found that extending letrozole therapy for five additional years improved disease-free survival in postmenopausal women with HR+ breast cancer. The study showed a 26% decrease in the risk of breast-cancer-free interval events and a 29% reduction in distant recurrence rates.
A study found that more than 25% of lung cancer patients are prescribed medications with potential cardiac risk, and almost 10% take multiple such medications. The researchers argue that these criteria may be excessive and could be too strict, excluding patients who don't pose a cardiac risk.
A new study found that Huntington's disease patients are at risk of therapeutic misconception due to a lack of understanding about clinical trial risks and benefits. Investigators recommend improving patient-doctor communication to address this issue.
The E1912 follow-up analysis shows that ibrutinib-based therapy lived longer and with sustained benefit in previously untreated CLL patients. The majority of patients were well-tolerated, with only 14% stopping due to side effects.
A clinical trial is underway to study the efficacy of umbilical cord-derived mesenchymal stem cells as a potential therapeutic for new onset type 1 diabetes. The trial, funded by the NIH, aims to determine if systemic administration of these cells can reduce disease progression and preserve insulin secretion.
The NRG Oncology clinical trial found that accelerated partial-breast irradiation (APBI) did not meet the criteria for equivalence to whole-breast irradiation (WBI) in controlling ipsilateral breast tumor recurrence. APBI did show a 1% difference in 10-year cumulative incidence of IBTR compared to WBI.
The Defitech Foundation has teamed up with EPFL, CHUV and UNIL to develop innovative therapies for paraplegic and quadriplegic patients. Researchers will trial personalized treatments that use electrical stimulation to restore motor function.
A new study by Murdoch Childrens Research Institute found that children with food allergies are seen 10 months sooner and experience fewer allergic reactions when treated by a paediatrician in their own community. This community-based approach delivered similar quality of allergy care to specialist hospital-based clinics.
A large study found that a single dose of radiotherapy is as effective as five doses in controlling pain and alleviating symptoms for end-of-life cancer patients with spinal canal compression. The study, published in JAMA, showed similar patient outcomes between one-dose and multi-fraction radiotherapy regimens.
The TB TRIAGE+ project aims to improve early access to diagnosis and treatment for tuberculosis patients in remote areas by assessing novel active case finding strategies. A large-scale cluster-randomized clinical trial will test automated chest x-ray analysis and blood marker triage tests, aiming to reduce diagnostic costs.
A meta-analysis of 44 clinical trials found that patient-reported outcomes are significantly associated with overall survival, confirming their importance as prognostic factors. This study aims to improve patient care by providing clinicians with valuable insights into cancer patients' needs and concerns.
A secondary analysis of the NRG Oncology clinical trial shows that neurocognitive function (NCF) declines in half of patients with high-risk, low-grade gliomas up to a year after receiving temozolomide-based chemoradiotherapy. However, quality of life (QOL) remains stable or improves in these patients, according to the study.