Articles tagged with Clinical Trials
The consortium will conduct Phase 1-4 vaccine and treatment trials, including human challenge trials. The leadership group will prioritize candidate vaccines, diagnostics, and therapeutics to test in clinical trials.
A retrospective study found that women with government insurance had lower survival rates, increased risk of dying, and were more likely to stop treatment early in breast cancer clinical trials. The study also did not find a significant association between neighborhood socioeconomic status and trial outcomes.
The NRG Oncology/NSABP B-42 trial found that extending letrozole therapy for five additional years improved disease-free survival in postmenopausal women with HR+ breast cancer. The study showed a 26% decrease in the risk of breast-cancer-free interval events and a 29% reduction in distant recurrence rates.
A study found that more than 25% of lung cancer patients are prescribed medications with potential cardiac risk, and almost 10% take multiple such medications. The researchers argue that these criteria may be excessive and could be too strict, excluding patients who don't pose a cardiac risk.
A new study found that Huntington's disease patients are at risk of therapeutic misconception due to a lack of understanding about clinical trial risks and benefits. Investigators recommend improving patient-doctor communication to address this issue.
The E1912 follow-up analysis shows that ibrutinib-based therapy lived longer and with sustained benefit in previously untreated CLL patients. The majority of patients were well-tolerated, with only 14% stopping due to side effects.
A clinical trial is underway to study the efficacy of umbilical cord-derived mesenchymal stem cells as a potential therapeutic for new onset type 1 diabetes. The trial, funded by the NIH, aims to determine if systemic administration of these cells can reduce disease progression and preserve insulin secretion.
The NRG Oncology clinical trial found that accelerated partial-breast irradiation (APBI) did not meet the criteria for equivalence to whole-breast irradiation (WBI) in controlling ipsilateral breast tumor recurrence. APBI did show a 1% difference in 10-year cumulative incidence of IBTR compared to WBI.
The Defitech Foundation has teamed up with EPFL, CHUV and UNIL to develop innovative therapies for paraplegic and quadriplegic patients. Researchers will trial personalized treatments that use electrical stimulation to restore motor function.
A new study by Murdoch Childrens Research Institute found that children with food allergies are seen 10 months sooner and experience fewer allergic reactions when treated by a paediatrician in their own community. This community-based approach delivered similar quality of allergy care to specialist hospital-based clinics.
A large study found that a single dose of radiotherapy is as effective as five doses in controlling pain and alleviating symptoms for end-of-life cancer patients with spinal canal compression. The study, published in JAMA, showed similar patient outcomes between one-dose and multi-fraction radiotherapy regimens.
The TB TRIAGE+ project aims to improve early access to diagnosis and treatment for tuberculosis patients in remote areas by assessing novel active case finding strategies. A large-scale cluster-randomized clinical trial will test automated chest x-ray analysis and blood marker triage tests, aiming to reduce diagnostic costs.
A meta-analysis of 44 clinical trials found that patient-reported outcomes are significantly associated with overall survival, confirming their importance as prognostic factors. This study aims to improve patient care by providing clinicians with valuable insights into cancer patients' needs and concerns.
A secondary analysis of the NRG Oncology clinical trial shows that neurocognitive function (NCF) declines in half of patients with high-risk, low-grade gliomas up to a year after receiving temozolomide-based chemoradiotherapy. However, quality of life (QOL) remains stable or improves in these patients, according to the study.
Researchers at ETH Zurich have created a protective membrane made of cellulose that significantly reduces fibrotic tissue formation around cardiac pacemaker implants. The membrane's unique surface structure impedes protein deposition and cell adhesion, leading to reduced tissue growth and improved surgical outcomes.
The Ivy Brain Tumor Center is collaborating with SonALAsense to develop and test sonodynamic therapy, a promising new treatment for recurrent glioblastoma. The Phase 0/2 clinical trial will assess the safety and efficacy of this non-invasive therapy in patients with glioblastoma.
The Phase 2 randomized clinical trial confirmed the safety and well-tolerability of a single transplantation of autologous bone-marrow derived MSC-NTF cells (NurOwn) in participants with ALS. Key efficacy findings included stabilization of ALS disease progression, improvement in ALSFRS-R slope, and changes in CSF neurotrophic factors a...
In a randomized clinical trial, adults with moderate to severe migraines took either ubrogepant or a placebo. After two hours, participants reported a significant reduction in pain and associated symptoms. The study provides encouraging results for the treatment of migraine pain.
A randomized clinical trial compared maternal blood loss with immediate and delayed umbilical cord clamping, finding no significant difference. The study included 113 women who had a scheduled cesarean delivery at term, with results suggesting that delaying cord clamping may not impact maternal bleeding.
A randomized clinical trial found that providing HIV self-tests increased HIV testing and diagnosis among men who have sex with men. The study also improved rates of viral suppression and reduced stigma around HIV testing.
Researchers at MIT have developed a way to encapsulate iron and vitamin A in a biocompatible polymer, which can be easily added to staple foods. The technology has the potential to help billions of people suffering from micronutrient deficiencies, particularly children who are more susceptible to diseases like measles.
A team of scientists has created a new microparticle-based platform that can preserve and deliver micronutrients such as iron. The particles address issues with preservation, which have hindered treatment of micronutrient deficiencies in developing countries.
A massive collaborative research incubator will develop trials for Alzheimer's disease interventions, funded by the National Institute on Aging. Regenstrief researchers will lead a two-year junior career development program to train researchers in embedded pragmatic clinical trials.
BIOCAD announces plans to introduce netakimab and progolimab, two original monoclonal antibody-based drugs, to the European market. The company has already received permission to conduct clinical trials in Europe for these innovative treatments.
A randomized clinical trial evaluated mailed HPV self-sampling test kits versus standard care reminders for detecting and treating cervical precancers. The study found that the self-sampling kit increased detection rates without a significant impact on treatment outcomes.
The RNI is conducting a clinical trial using deep brain stimulation to treat patients with treatment-resistant opioid use disorder. The trial aims to investigate the mechanism of addiction in the brain and potentially provide a new tool to help those severely impacted by opioid use disorder.
A new clinical trial at Marshall University is investigating the use of biologic augmentation in ACL reconstruction surgery. The study aims to assess improvements in pain, failure rates and clinical outcomes using a minimally invasive technique combining bone marrow concentrate, autograft bone and demineralized bone matrix.
The Zeriscope system enables veterans to virtually take their doctor with them during prolonged exposure therapy, providing real-time feedback on physical and psychological information. This innovation aims to improve treatment outcomes and reduce dropout rates for veterans with PTSD.
A clinical trial will investigate the use of S-adenosylmethionine (SAMe) to improve liver function and mortality in patients with alcoholic cirrhosis. The study, led by IU School of Medicine researcher Suthat Liangpunsakul, aims to provide new avenues for treating this condition.
The PROLONG trial found that weekly injections of 17-alpha-hydroxyprogesterone caproate do not reduce recurrent preterm birth or neonatal morbidity. In contrast, a previous study showed a 34% reduction in recurrent preterm birth with this medication. The differing results may be attributed to differences in the populations studied.
A team of researchers at Medical University of South Carolina enhances an existing informatics tool to better identify Emergency Department cases of nonfatal opioid overdose. The enhanced tool uses natural language processing to analyze clinical notes and provide real-time information on opioid addiction, enabling more intelligent clin...
A new clinical trial funded by the National Eye Institute found that vision therapy for convergence insufficiency does not improve reading test scores in children. While in-office vision therapy can improve visual function, it fails to lead to better reading fluency and comprehension.
A clinical trial is recruiting volunteers aged 18-50 to be deliberately infected with influenza virus under controlled conditions. The study aims to assess the impact of pre-existing antibodies on flu symptoms, fever and muscle aches. Volunteers will undergo follow-up clinic visits for up to 90 days after challenge.
A randomized clinical trial in Australia compared the effectiveness of SSRIs like fluoxetine with placebos for reducing obsessive-compulsive behaviors in children and adolescents with ASD. The study found lower scores for fluoxetine, but interpretation is limited by high dropout rates and baseline differences between groups.
A study of over 14,000 participants found associations between specific cigarette characteristics and lung cancer outcomes. Researchers analyzed data from a lung screening trial to investigate the impact of cigarette filter status, tar level, and menthol flavor on lung cancer outcomes.
Researchers at UCLA Jonsson Comprehensive Cancer Center are launching a pioneering chimeric antigen receptor (CAR) T cell immunotherapy trial targeting CD19 and CD20 proteins on B-cell lymphoma and leukemia. The goal is to minimize resistance and increase life expectancy for patients diagnosed with these cancers.
The Bob Woodruff Foundation has awarded Boston University a grant to expand the Strength at Home program, which prevents and treats intimate partner violence in veteran populations. The program has been shown to be effective in addressing trauma-related violence and utilizing a trauma-informed approach.
A randomized clinical trial found that varenicline was well-tolerated but did not significantly improve abstinence rates among adolescents and young adults. However, secondary findings suggest that varenicline helped smokers achieve earlier and better self-reported abstinence during treatment and follow-up.
A study of 845 CF patients found that lumacaftor-ivacaftor improves lung function, body weight, and reduces intravenous antibiotic treatment needs. However, nearly one in five patients discontinued treatment due to adverse events, highlighting the need for cautious interpretation.
A new study published in The Lancet Digital Health found that a digital clinical trial using the MyHeart Counts app increased physical activity by 10% in participants. The trial, which enrolled over 1,000 participants and ran for 18 months, showed that even simple prompts from a smartphone app can encourage people to exercise more.
A new clinical trial investigates the effectiveness of whole-body cooling in comatose patients after a cardiac arrest, with a focus on optimal cooling duration. The study aims to improve neurological recovery rates and full recovery in cardiac arrest survivors.
A pioneering study published in The Lancet Neurology presents a four-limb robotic system controlled by brain signals that enabled a tetraplegic man to move his arms and walk. The system, operated by recording and decoding brain signals, showed promising early results but requires further improvements before clinical application.
A new study published in JAMA found that treating septic patients with intravenous vitamin C infusions significantly reduced mortality and improved recovery times. The trial showed a 30% reduction in mortality at day 28 compared to the placebo group, and patients spent three fewer days in the ICU.
A study by HVTN 105 demonstrated that DNA (DNA-HIV-PT123) and protein (AIDSVAX B/E) combination vaccine regimens induced high magnitude and long-lasting binding antibody responses. The findings showed more rapid potentially protective immune responses when the vaccine regimens were co-administered.
Emerging norms in engaged translational genomics research raise substantial ethical concerns. Simplified Spanish-language consent materials require cultural congruence, while participant benefits in HIV prevention research highlight potential direct and indirect benefits for stigmatized populations.
A major meta-analysis found daily omega-3 supplementation reduced risks of heart attack and CVD events by 8%, with higher doses providing greater risk reduction. The study included over 120,000 adults in 13 randomized trials worldwide.
The NIH has initiated a collaborative influenza vaccine research network to develop more durable and broadly protective vaccines. The CIVICs program will support the development of universal influenza vaccines with longer-lasting protection against a wider variety of influenza viruses.
A new blood test can identify complex DNA mutations in lung cancer patients, replacing invasive biopsies. The test has shown promise in detecting ALK genetic mutations, which respond well to targeted therapy.
A new trial shows that adding a PARP inhibitor to bevacizumab improves ovarian cancer patients' chances of responding to chemotherapy. The study found median progression-free survival of 22.1 months in the olaparib arm, compared to 16.6 months in the placebo group.
A new trial found that men with prostate cancer who receive radiotherapy after surgery have no difference in disease recurrence compared to those who do not. The study suggests that observation should be the standard approach and radiotherapy only used if the cancer comes back.
Researchers at the University of Strathclyde are working on a system to measure blood chemistry levels in premature and sick babies through their skin, which could replace invasive blood tests. The technology aims to collect glucose and lactate levels using a wireless patch sensor that can be placed on the baby's stomach.
ECOG-ACRIN announces late-breaking TAILORx data on chemotherapy regimens for early-stage breast cancer. The data, published concurrently in JAMA Oncology, focuses on patients with a score of 26-100 on the 21-tumor gene recurrence score assay.
The AIDS and Cancer Specimen Resource (ACSR) has been renewed for 5 years with a $22 million grant from the National Institutes of Health. The ACSR provides annotated HIV malignancy specimens to qualified researchers, supporting research into HIV-associated cancers.
Researchers found deep brain stimulation to be safe and effective in reducing the severity of tinnitus in patients with no other confounding comorbidity. The procedure showed significant clinical improvement in three out of five patients, with improvements in Tinnitus Functional Index scores and Tinnitus Handicap Inventory scores.
A novel gene therapy treatment has shown promising results in patients with glycogen storage disease, allowing them to discontinue their reliance on cornstarch and experience normal blood glucose levels. Patients have reported significant improvements in energy, muscle strength, and overall quality of life.
Researchers found that surgical intervention for sleep apnea in children does not significantly improve behavior, cognitive performance, or symptoms of attention deficit hyperactivity disorders. The study suggests alternative explanations for improved outcomes, shedding new light on a widely performed pediatric surgical procedure.
A randomized clinical trial of 6,000 patients with type 2 diabetes compared the cardiovascular outcomes of linagliptin and glimepiride. The results suggest that linagliptin may be associated with reduced cardiovascular risk.
A new study by University of Washington researchers found that fluoride varnish has modest anti-cavity effects in preschoolers, with a 12% decline in new cavities. The study calls for cost-effectiveness analyses to determine its value in dental services.
The iStride Device, a patented therapeutic shoe, helps stroke patients relearn how to walk by strengthening the affected leg. Clinical trials show improved gait symmetry and functional walking in six participants, with four achieving double limb support.
Researchers developed a new ultra-hypofractionated stereotactic body radiotherapy (SBRT) technique that safely delivers curative treatment for some prostate cancer patients in just one or two weeks. The study found similar levels of side effects and less overall toxicity compared to the current standard of care.