Articles tagged with Clinical Trials
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A randomized clinical trial investigates the safety and efficacy of two chloroquine diphosphate dosages in patients with severe COVID-19. The study suggests that high-dose chloroquine diphosphate may be effective in treating SARS-CoV-2 infection.
A nationwide trial tests video counseling to help cancer patients quit smoking, addressing a significant public health concern. The study aims to provide evidence for tobacco treatment as standard care in community hospitals and clinics.
The Asia-Pacific region has launched expedited review processes for COVID-19 treatment and vaccine trials, with South Korea offering approval in under 9 days. Novotech is a leading contract research organization (CRO) in the region, supporting vital research with its fast-track services.
A recent trial of a MERS coronavirus vaccine candidate has shown promising results, with the vaccine inducing antibody and T cell responses in nearly all trial subjects. The findings have implications for the development of a vaccine against SARS-CoV-2, with plans to conduct further trials.
A randomized clinical trial found that patients who used smartphone-compatible devices and received video care visits had better blood pressure control after a heart attack. The study suggests that these interventions can help improve patient adherence to guideline-based therapy following a heart attack.
Novotech Research reveals that the top 10 biotech sites in Australia are open for clinical trial activity. The country's favorable environment is supporting clinical research during the global COVID-19 crisis, with many sites modifying their practices to ensure continuity of operations.
A new clinical trial aims to find effective alternative solutions for critically ill COVID-19 patients, reducing the need for treatment with a ventilator and improving patient outcomes. The RECOVERY-RS Respiratory Support trial will compare standard care with non-invasive treatments using masks or high-flow oxygen.
Gimsilumab, targeting granulocyte macrophage-colony stimulating factor (GM-CSF), may help reduce lung hyper-inflammation in COVID-19 patients with ARDS. A multi-site clinical trial enrolls up to 270 patients to assess mortality and duration of mechanical ventilation.
A novel clinical trial using the REMAP-CAP platform aims to rapidly test multiple treatment approaches for COVID-19. The UPMC-REMAP-COVID19 trial will integrate with electronic health records, allowing doctors to prescribe treatments quickly and efficiently.
Researchers at the University of Montreal are using convalescent plasma to develop a passive immunization program for COVID-19 treatment. The program, which involves transfusing plasma from recovered patients, has shown promise in reducing mortality rates in severe viral pneumonias.
A large randomized clinical trial investigated whether anti-viral drugs used to treat HIV would relieve the symptoms of COVID-19, showing promise for further study. The trial found patients who received lopinavir-ritonavir improved faster and experienced shorter times to clinical improvement, with acceptable safety levels.
A clinical trial is underway to assess the potential treatment of COVID-19-related respiratory failure using the anti-clotting drug tPA. The trial aims to evaluate whether tPA can reduce deaths among patients with severe lung injury, alleviating an expected shortage of ventilators for critically ill patients.
Researchers at Texas A&M University discovered that a majority of fungi associated with cotton can reduce galling caused by the Southern root knot nematode. The study found highly repeatable reductions in gall formation across independent trials, suggesting these fungi may have previously unappreciated positive effects on plant health.
Researchers at UIC are studying the effectiveness of sarilumab and remdesivir as potential COVID-19 treatments in hospitalized patients. The trials aim to determine whether these drugs can provide evidence-based therapeutic options for this highly contagious virus.
The Duke Clinical Research Institute is leading a $50 million study to evaluate hydroxychloroquine as a preventive drug for COVID-19 in healthcare workers. The study, called HERO, aims to assess the impact of the novel coronavirus on healthcare workers' health and examine whether hydroxychloroquine can prevent infections.
A PCORI-funded registry will engage healthcare workers, while a randomized clinical trial will examine HCQ's effectiveness in preventing COVID-19 infections and limiting virus spread. The study aims to provide insights quickly to those who need it most.
A new study funded by PCORI aims to evaluate the effectiveness of hydroxychloroquine in preventing COVID-19 infections in healthcare workers. The study will use the PCORnet network to quickly and efficiently conduct the research, providing insights that can inform prevention strategies for this high-risk population.
Using radial artery instead of saphenous vein reduces death, heart attack and repeat revascularization procedures by 23-38%. Women benefit most from this approach. Further confirmation needed through larger randomized trial.
A medical mystery was solved when a severely ill patient was tested and diagnosed with COVID-19, leading to changes in CDC guidelines. The case highlights the importance of testing and demonstrates that even without clear risk factors or exposure, patients can still be infected.
The SCTR Institute, a Clinical and Translational Award (CTSA) hub, has been awarded $24 million to advance translational research in South Carolina. The institute will partner with various institutions to develop bioinformatics tools, enhance clinical trial recruitment, and improve health outcomes.
In a two-year follow-up, patients undergoing TAVR showed comparable death, stroke, and rehospitalization rates compared to those who underwent open-heart valve replacement surgery, according to the PARTNER 3 trial. However, TAVR had higher rates of valve thrombosis, highlighting the need for further research on the procedure's durability.
In a broad patient population, TAVR showed non-inferiority to open-heart surgery at one year. However, TAVR patients had higher rates of vascular complications and aortic regurgitation.
A new study found that mobile health devices and photoplethysmography technology can reduce stroke risk, rehospitalisation rates, and mortality in patients with atrial fibrillation. The integrated care approach showed significant benefits in managing AF-related adverse events.
A review article published in Antimicrobial Agents and Chemotherapy highlights the potential of remdesivir as a treatment for COVID-19. The antiviral has shown effectiveness against a range of coronaviruses, including SARS-CoV-2, with prophylactic treatment preventing clinical disease and viral replication.
Researchers found that the abundance of Lactobacillus iners was associated with clearance of high-risk HPV infections, while Gardnerella bacteria were linked to progression to precancer. Monitoring Gardnerella and microbial diversity could help identify women at risk for pre-cancer.
Vivli has launched a portal for sharing data from completed COVID-19 trials, waiving member and user fees. The move aims to advance knowledge around the pandemic by making data transparently available to all researchers.
Lundbeck contributes clinical trial data from over 2,500 patients to CPAD consortium's integrated database. C-Path and Lundbeck aim to expedite the development of new therapies for Alzheimer's disease through public-private partnerships.
A global review found that fear about testing new treatments and possible side effects is the most common reason for not participating in clinical research. Trust in doctors and clinical staff, as well as a desire to help others, motivated patients to get involved.
The National Institute of Allergy and Infectious Diseases has begun a Phase 1 clinical trial for an investigational COVID-19 vaccine in the Seattle area. The trial is evaluating different doses of the mRNA-1273 vaccine for safety and immune response in healthy adult volunteers.
A randomized clinical trial found that gabapentin, commonly used for nerve pain, was effective in reducing symptoms of alcohol use disorder. The study suggests that this medication may be beneficial for millions of Americans struggling with problem drinking and a history of withdrawal symptoms.
Research reveals bias and stereotyping among healthcare professionals when recruiting patients for cancer clinical trials. The study highlights language barriers, misconceptions, and negative perceptions of minority participants as challenges. Experts call for culturally tailored approaches to address biases in clinical trial recruitment.
A clinical trial found that electrical stimulation improved symptoms in 53% of women with constipation, with lasting benefits for at least 3 months. The treatment was well-tolerated and offered a promising alternative to laxative medications.
A new study by Mayo Clinic researchers found that catheter ablation reduced the risk of death or hospitalization due to worsening heart failure in patients with both conditions. The study analyzed data from over 289,000 patients and showed an 18% reduction in risk for those who received ablation.
Researchers have achieved a groundbreaking milestone in treating inherited blindness by using CRISPR gene editing within the human body. The BRILLIANCE clinical trial aims to repair mutations causing Leber congenital amaurosis type 10, a rare form of blindness. This permanent approach avoids passing on genetic changes to offspring.
A randomized clinical trial in 60 urban workplaces in China found that a wellness program with hypertension management component significantly improved blood pressure control among employees. The program reduced systolic blood pressure by 3.5 mmHg and diastolic blood pressure by 2.5 mmHg compared to usual care.
Researchers identified key features and events over four phases of recovery in mice with surgically narrowed arteries, creating signposts for understanding PAD and developing treatments. By using multiple imaging methods, the study aims to facilitate more optimal approaches to treatment and improve diagnosis.
Most clinical trial participants are not informed about the results of studies they participated in, despite wanting this information. Researchers want to share findings but lack effective communication skills to reach lay public. The study highlights the need for better training on communicating research results to study participants.
Research shows that cancer clinical trials inadequately report treatment efficacy and adverse effects specific to older adults. A new study has developed templates to address this issue, providing a framework for more accurate assessment of senior cancer patients.
The Ohio State University Wexner Medical Center has successfully used a new atrial fibrillation device, achieving 100% pulmonary vein isolation without nerve injuries or serious side effects. The PFA technology uses pulsed electric fields to interrupt pathways and triggers in the heart, potentially becoming the standard tool for resolv...
A phase 2b clinical trial of gefapixant, a new treatment for unexplained chronic cough, has shown promising results. The study found that patients who received the medication experienced a significant reduction in cough frequency, with the lowest dose of 50mg showing the most pronounced effect.
The NIH has begun a randomized, controlled clinical trial to evaluate the safety and efficacy of remdesivir in hospitalized adults with COVID-19. The study aims to assess whether remdesivir can improve clinical outcomes for patients with severe respiratory illness.
A follow-up study of the Wingspan stent suggests it is safe and effective for reducing recurrent stroke risk, with a long-term one-year rate of 8.5% compared to 20% in another trial. The study follows 152 patients treated with the stent according to FDA guidelines.
A University of Houston researcher is increasing health literacy among Hispanics/Latinos to address the significant disparities in Alzheimer's disease development and treatment. The largest ethnic minority group in the US, H/Ls are 50% more likely to develop AD, yet they comprise less than 1% of clinical trials.
The NRG-CC001 trial found that lowering radiotherapy dose to hippocampal stem cells reduces cognitive toxicity and neurologic symptoms in patients with brain metastases. Patients who received whole-brain radiotherapy with hippocampal avoidance reported improved cognitive function, reduced fatigue, and fewer cognitive symptoms.
A meta-analysis of five controlled trials including 471 patients found that vitamin C administration shortened ventilation time by 25% on average, with the effect dependent on the severity of illness. Vitamin C has been shown to have various biochemical effects, including influencing cardiovascular and energy metabolism.
A randomized clinical trial evaluated subconcussive head impacts in soccer players, finding those who received heading shots performed worse on eye movement tests compared to a control group. The study suggests that such impacts may cause short-term effects on neuro-eye function.
A novel injectable drug, NOV004, is being developed by Novosteo Inc. to heal broken bones faster and strengthen weak bones. The treatment concentrates at the fracture site while reducing exposure to the rest of the body, potentially reducing mortality rates among older adults.
A randomized controlled trial found that T'ai Chi was feasible and acceptable for improving chronic low back pain in adults over 65. High attendance rates and perceived benefits were observed among participants, suggesting a potential treatment option for this population.
A randomized clinical trial found that outpatient palliative care was associated with better patient and caregiver outcomes for patients with Parkinson disease. The study included 210 patients and 175 caregivers and examined the effects of palliative care on quality of life, mood, and sleep.
The CD19 CAR NK-cell therapy achieved a 73% response rate in patients with relapsed or refractory non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL), with no major toxicities reported. The treatment was administered in an outpatient setting, and responses were evident within one month following infusion.
A new study finds that rosiglitazone increases the risk of heart failure and cardiovascular events by 33% compared to controls. The research highlights the importance of access to raw clinical trial data for accurate drug safety assessments.
A new device can automatically manage glucose levels and deliver needed insulin quickly, eliminating the need for constant blood sugar checks and insulin injections. The adhesive patch, about the size of a quarter, has been successfully tested on mice and pigs, showing promise as a potential diabetes treatment.
Recent clinical trials of Prolonged Exposure Therapy and Cognitive Processing Therapy show limited effectiveness in treating active duty military personnel and veterans with PTSD. The studies suggest that emotionally demanding therapies may not be beneficial for all patients, and more personalized treatment approaches are needed to acc...
A phase I clinical trial has confirmed the safety and effectiveness of a monoclonal antibody in neutralizing henipaviruses, which have pandemic potential. The antibody, m102.4, was found to be well-tolerated in healthy volunteers, with no serious adverse events reported.
A new study shows that a single dose of the Army-developed Zika vaccine can induce potent cross-neutralizing antibody responses against both Zika and dengue viruses. Researchers found that these antibodies, called MZ4, protected against both viruses in a mouse model of infection.
Researchers have established new guidelines for analyzing patient-reported outcomes (PROs) in cancer clinical trials, aiming to provide more consistent and comparable Quality of Life (QoL) results. The adoption of these standards will ensure that trial results are more reliable and beneficial for patients.
A gene therapy trial conducted in US and UK patients with X-linked Chronic Septic Granulomatosis, a rare genetic disease causing severe infections, has shown success. Six of nine patients are free of treatment complications, offering hope for sustainable treatment.
A study by Johns Hopkins Bloomberg School of Public Health found that people on high fiber diets are 40% more likely to experience bloating if they consume protein-rich diets. The researchers suggest that substituting high-quality carb calories for protein calories may reduce bloating and make these diets more tolerable.
Researchers found daratumumab to be safe and successful in treating patients with relapsed AL amyloidosis, a condition characterized by organ failure. The treatment was well-tolerated and effective when used with appropriate pre- and post-infusion medications.
A Phase 1 clinical trial tests the safety and effectiveness of mAb CIS43LS in preventing malaria infection. Volunteers will receive a single dose of the antibody and then be exposed to malaria-carrying mosquitoes to assess protection.