Articles tagged with Clinical Trials
The EXPLORER-HCM trial demonstrated that mavacamten significantly improves exercise capacity, symptoms, and quality of life in patients with obstructive hypertrophic cardiomyopathy. The treatment was found to be generally well-tolerated, with a favorable safety profile.
The RACE trial demonstrated that adding Eltrombopag to standard immunosuppressive treatment increases response rates in patients with Severe Aplastic Anaemia. The study found significant improvements in complete response rates, sustained at 6 months, and showed Eltrombopag was generally well-tolerated.
A new palliative care model, known as Short-Term Integrated Palliative Care (SIPC), has been shown to improve quality of life for patients with long-term neurological conditions while reducing costs. The study found no significant difference in patient-reported outcomes between SIPC and standard care.
Researchers developed computational models of patients with COVID-19 to enhance assessment and analysis tools in CT and radiography. These models were combined with imaging simulators for COVID-19 studies, yielding realistic results.
A randomized trial compared remdesivir with standard care in patients with moderate pneumonia and SARS-CoV-2 infection. Remdesivir treatment resulted in improved clinical status, with no increased risk of adverse events.
A nationwide study of convalescent plasma as a treatment for COVID-19 will be conducted at Vanderbilt University Medical Center. The randomized trial aims to test whether infusions of plasma can help hospitalized patients with COVID-19.
A clinical trial found that consuming 44mg of proanthocyanidins (PACs) per day in cranberry juice resulted in a 20% reduction in H. pylori infection rates in Chinese adults. The study suggests that twice-daily consumption of this specific amount of PACs may be an effective natural management strategy for adults infected with H. pylori.
The Phase 2 clinical trial will evaluate the safety, immunogenicity, and efficacy of NVX-CoV2373 in approximately 2,650 healthy adults and 240 medically stable HIV-positive adults. The trial aims to provide early data on vaccine protection against Covid-19 in South Africa.
Researchers identified a link between female authors and increased enrollment of women in heart failure clinical trials. The study, published in Circulation: Heart Failure, found that clinical trials with female first or senior authors had a higher proportion of enrolled female participants.
A clinical trial by Oregon State University found that lipoic acid supplements caused significant weight loss and fat reduction in overweight but otherwise healthy participants. The study also showed improvements in inflammation markers and oxidative stress, with notable benefits for women and heaviest participants.
Majority of patients in remdesivir trials were Caucasians, raising concerns about medication efficacy in people of color. The study emphasizes the need for diverse clinical trial participants to accurately represent the US population and inform treatments.
A new study reveals racial disparities in high-cost proton radiotherapy for childhood cancer treatment, with Black and low-income children facing barriers to access. The research highlights the urgent need for equitable healthcare policies to ensure all children receive quality cancer care regardless of their race or socioeconomic status.
A study published in The Lancet found that plaster casts are as effective as surgery in healing scaphoid waist fractures in the wrist. Patients who received a plaster cast showed similar outcomes to those who underwent surgery, with no significant difference in pain, function, or complications.
A Phase 2 clinical trial is testing the safety and efficacy of synthetic monoclonal antibodies to treat COVID-19. The study aims to reduce the duration of symptoms and increase the proportion of participants with undetectable virus in nasopharyngeal swabs.
The ACTIV-3 clinical trial tests the safety and efficacy of a monoclonal antibody treatment in hospitalized COVID-19 patients. The trial aims to enroll approximately 300 volunteers with mild to moderate symptoms, who will receive either an intravenous infusion of LY-CoV555 or a saline placebo infusion.
A potential treatment for yellow fever has shown promise in early-stage clinical trials in Singapore, using a novel approach to develop an engineered monoclonal antibody that targets the virus. The therapy was developed in seven months, significantly reducing the time required for drug development.
A novel cell therapy using patient T cells has shown preliminary effectiveness in treating relapsed or treatment-resistant multiple myeloma. The treatment, which is safer than existing CAR T cells, improved survival rates and objective clinical responses in patients with active disease.
GW University will participate in a Phase 3 clinical trial of the mRNA-1273 vaccine to test its safety and efficacy in humans. The trial aims to enroll 500 participants, including those at high risk for severe illness due to age or comorbidities, to develop a vaccine that can effectively protect these populations.
A Phase 3 clinical trial has begun to test the safety and efficacy of the mRNA-1273 vaccine in preventing symptomatic COVID-19. The trial enrolls approximately 30,000 adult volunteers and aims to determine if the vaccine can provide long-lasting protection against the virus.
Changing healthcare payment for one insurer can impact patients covered by others, a nationwide randomized trial suggests. The study found lower hospital readmissions and care intensity among TM patients and those with private insurance through Medicare Advantage.
The Predictive Safety Testing Consortium and Duchenne Regulatory Science Consortium have developed a glutamate dehydrogenase (GLDH) biomarker to detect drug-induced liver injury in patients with inherited muscle disorders. The FDA has agreed to accept the Qualification Plan for GLDH as an important and accurate measurement of DILI.
A clinical trial by Newcastle University found that levothyroxine does not improve cardiac function in patients who have had a heart attack and are suffering from mild or subclinical hypothyroidism. The treatment, which is commonly recommended for these patients, may actually be of no benefit.
A USC-led team found a fasting-mimicking diet combined with hormone therapy may increase the power of cancer hormone drugs and delay resistance in small clinical trials and mouse studies. Researchers observed reduced insulin, IGF1, and leptin levels, leading to potential anti-cancer activity.
The National Pediatric Rehabilitation Resource Center aims to promote clinical trials research in pediatric rehabilitation. The center will fund up to $150,000 per year for pilot studies and offer educational resources to support the growth of the field.
A Chinese phase 2 trial found that a recombinant adenovirus type-5-vectored COVID-19 vaccine is safe and induces an immune response in over 500 participants. The trial, which evaluated the safety and immunogenicity of the vaccine candidate, provides data on the efficacy of the vaccine against SARS-CoV-2 infection.
The phase 1/2 trial found the vaccine induces strong antibody and T cell immune responses, and causes minor side effects more frequently than a control group. Further clinical studies are needed to confirm the vaccine's effectiveness in protecting against SARS-CoV-2 infection.
A new randomized trial published in Annals of Internal Medicine found that hydroxychloroquine showed no benefit in reducing symptom severity or duration in outpatients with early, mild COVID-19. The study suggests that the treatment may not be effective in populations at higher risk for severe COVID-19.
A large international study found that starting dialysis early in critically ill patients with acute kidney injury did not reduce mortality after three months. The accelerated renal-replacement therapy strategy did not show significant difference in survival between the two treatment approaches.
A recent study by UNLV researchers found that while the success rate of Alzheimer's drugs in development remains low, there is increased hope due to repurposed agents and advancements in biomarkers. The team also emphasized the critical role of patient participation and the need for investment in new therapies.
A major multinational trial found that fast-tracking dialysis for critically ill patients with severe acute kidney injury did not improve outcomes. The study included over 3,000 patients in 168 hospitals across 15 countries and suggested a more conservative approach to treatment may be warranted.
Researchers at UC San Diego highlight nanotechnology's role in COVID-19 vaccine development, including peptide-based vaccines and molecular farming. The first candidates in clinical trials utilize novel nanotechnologies.
The Phase 1 trial of mRNA-1273 vaccine showed neutralizing antibody activity in healthy adults, with high levels observed after two doses. The vaccine was generally well-tolerated, with side effects including fatigue and pain at the injection site.
A 10-year study found that radiotherapy in five larger doses, rather than daily doses, is equally effective and safe in the long term. This approach benefits patients with low risk of relapse who cannot tolerate daily radiation due to frailty or chronic conditions.
The review analyzes the design and implementation of RCTs for COVID-19 treatments, identifying common characteristics and limitations. Key takeaways include the importance of standardized reporting and the need for further research on treatment outcomes.
The National Institutes of Health has established a new clinical trials network to enroll thousands of volunteers in large-scale clinical trials testing various COVID-19 vaccines and monoclonal antibodies. The COVPN will leverage existing infrastructure and engage communities to secure participants for late-stage clinical trials.
Tofersen, an experimental drug for a rare inherited form of amyotrophic lateral sclerosis (ALS), has shown early promise in a phase 1/phase 2 clinical trial. The study found that the drug is generally well-tolerated and lowers levels of a disease-causing protein in people with SOD1 ALS.
The UCSC-led research center aims to understand the basic biological mechanisms of botanical natural products and address challenges in studying their variability and clinical trial design. The center will use innovative screening platforms to measure the effects of complex botanical natural products on cells.
A clinical trial found that breast augmentation with ASC-enriched fat grafts resulted in significantly better outcomes compared to non-enriched grafts. The study showed improved retention rates and histological appearance of the grafts, making ASCs a promising tool for increasing graft success.
A randomized trial of a multifactorial fall injury prevention strategy found an approximately 8-10% reduction in serious fall injuries, lower than expected. The study enrolled 5,451 people aged 70 and older and evaluated the effectiveness of a nurse-delivered intervention.
A large randomized trial has found that endometrial scratch is not beneficial in women having their first cycle of IVF. The study involved over 1000 women under 37 years old and showed no significant difference in live birth rates between those who received endometrial scratch and those who did not.
A clinical trial is underway to test an immune booster, IMM-101, in cancer patients to prevent severe COVID-19. The study aims to boost the innate immune system and protect vulnerable populations from lung infections.
PRRT is an approved treatment modality for gastroenteropancreatic neuroendocrine tumours, particularly in midgut NETs. In Australia, PRRT is used more widely than previously thought, despite limited Phase III trial data for lung NETs.
Plant pathologists at Auburn University conducted a field trial to assess the economic damage of reniform nematodes on cotton yields. The study found that cotton yields were 50% lower in fields infested with the nematode compared to clean fields.
A pooled analysis of DEFINE FLAIR and iFR SWEDEHEART trials reveals similar safety profiles for iFR and FFR in deferring revascularisation. However, FFR-based deferral shows a strong interaction with age, which may be related to varying age-related responses to adenosine.
A meta-analysis of randomized trials found routine revascularization associated with lower non-procedural MI and unstable angina risk, but higher procedural MI rates. The benefits of routine revascularization compared to medical therapy are still uncertain.
The study found that colchicine treatment was associated with reduced levels of inflammatory biomarkers and improved clinical outcomes in patients hospitalized with COVID-19. Colchicine's effectiveness in managing cardiac-related complications was also observed, suggesting potential benefits for these patients.
A new international trial published in the Journal of Clinical Oncology suggests that carboplatin-paclitaxel is the optimal chemotherapy regimen for treating inoperable anal cancer. The study found a trend toward improved survival and less toxicity compared to cisplatin-5FU, with overall survival rates of 20 months vs 12.3 months.
The InterAAct trial found carboplatin-paclitaxel to be the optimal chemotherapy regimen for inoperable anal cancer, with a lower risk of adverse events and improved overall survival. Patients treated with this regimen experienced a trend towards better survival rates, suggesting it should become the standard of care.
The COVID-19 pandemic has significantly impacted the design and analysis of oncology trials, presenting challenges for cancer researchers and clinicians. As a result, cancer treatment options and patient care have been disrupted, highlighting the need for new strategies to overcome these obstacles.
Researchers are testing virtual care and remote monitoring technology to reduce unplanned hospitalizations and emergency department visits after surgery. Patients use tablet computers to record vital signs at home, which are sent instantly to nurses for review.
A major study published in Nature Communications reveals that normothermic machine perfusion assessment can recover enough livers from discarded donors to allow successful transplantation. This breakthrough technique has significant implications for the liver transplant waiting list and demand for transplants far outstrips supply.
A combination of physical activity, not smoking, light-to-moderate alcohol consumption, high-quality diet, and cognitive activities reduced the risk of Alzheimer's disease by 60% among those with four or five healthy behaviors. The study included data from nearly 3,000 participants from two NIH-funded longitudinal study populations.
Annals of Internal Medicine publishes new COVID-19 research, highlighting the importance of high-quality clinical trials and informative multi-group trials to counteract misleading information. The journal also emphasizes the potential for the pandemic to transform medical care, education, and work.
A study published in JAMA Neurology reports successful delivery of micro-dystrophin to patients with Duchenne muscular dystrophy (DMD), resulting in functional improvements. The therapy showed robust gene expression and localization, as well as improved muscle function measured by North Star Ambulatory Assessment scores.
A new nonsurgical treatment decreases errant blood flow in the shoulder to quickly reduce pain and improve function in patients with adhesive capsulitis, also known as 'frozen shoulder'. The treatment was successfully completed in 16 patients whose symptoms had not responded to conservative treatment over 30 days.
A randomized clinical trial investigated treating patients with relapsing multiple sclerosis using a therapeutic hookworm infection, comparing it to placebo. The study aimed to determine if gut worms could induce immune responses that protect against multiple sclerosis.
A randomised clinical trial has shown that a chemotherapy combination of carboplatin and paclitaxel is more effective and better tolerated than previously recommended treatments for patients with advanced anal cancer. The study found that these patients lived seven months longer overall, experiencing less treatment side effects.
Researchers from University of Washington and Fred Hutchinson Cancer Research Center propose using multigroup, adaptively randomized trials to compare multiple COVID-19 interventions. This design may reduce adverse outcomes during trials and enable faster implementation of effective treatments.
A review published in Neurology clarifies the different courses of multiple sclerosis (MS) and disease activity, aiming to improve patient care and clinical trial outcomes. The experts define four subtypes: clinically isolated syndrome, relapsing remitting MS, secondary progressive MS, and primary progressive MS.
Early human challenge trials of SARS-CoV-2 vaccines may be the correct test of ethics, meeting equitable distribution principles. An international governance system is proposed to oversee access to Covid-19 vaccines and treatments.