Articles tagged with Clinical Trials
The study found that colchicine treatment was associated with reduced levels of inflammatory biomarkers and improved clinical outcomes in patients hospitalized with COVID-19. Colchicine's effectiveness in managing cardiac-related complications was also observed, suggesting potential benefits for these patients.
A new international trial published in the Journal of Clinical Oncology suggests that carboplatin-paclitaxel is the optimal chemotherapy regimen for treating inoperable anal cancer. The study found a trend toward improved survival and less toxicity compared to cisplatin-5FU, with overall survival rates of 20 months vs 12.3 months.
The InterAAct trial found carboplatin-paclitaxel to be the optimal chemotherapy regimen for inoperable anal cancer, with a lower risk of adverse events and improved overall survival. Patients treated with this regimen experienced a trend towards better survival rates, suggesting it should become the standard of care.
The COVID-19 pandemic has significantly impacted the design and analysis of oncology trials, presenting challenges for cancer researchers and clinicians. As a result, cancer treatment options and patient care have been disrupted, highlighting the need for new strategies to overcome these obstacles.
Researchers are testing virtual care and remote monitoring technology to reduce unplanned hospitalizations and emergency department visits after surgery. Patients use tablet computers to record vital signs at home, which are sent instantly to nurses for review.
A major study published in Nature Communications reveals that normothermic machine perfusion assessment can recover enough livers from discarded donors to allow successful transplantation. This breakthrough technique has significant implications for the liver transplant waiting list and demand for transplants far outstrips supply.
A combination of physical activity, not smoking, light-to-moderate alcohol consumption, high-quality diet, and cognitive activities reduced the risk of Alzheimer's disease by 60% among those with four or five healthy behaviors. The study included data from nearly 3,000 participants from two NIH-funded longitudinal study populations.
Annals of Internal Medicine publishes new COVID-19 research, highlighting the importance of high-quality clinical trials and informative multi-group trials to counteract misleading information. The journal also emphasizes the potential for the pandemic to transform medical care, education, and work.
A study published in JAMA Neurology reports successful delivery of micro-dystrophin to patients with Duchenne muscular dystrophy (DMD), resulting in functional improvements. The therapy showed robust gene expression and localization, as well as improved muscle function measured by North Star Ambulatory Assessment scores.
A new nonsurgical treatment decreases errant blood flow in the shoulder to quickly reduce pain and improve function in patients with adhesive capsulitis, also known as 'frozen shoulder'. The treatment was successfully completed in 16 patients whose symptoms had not responded to conservative treatment over 30 days.
A randomized clinical trial investigated treating patients with relapsing multiple sclerosis using a therapeutic hookworm infection, comparing it to placebo. The study aimed to determine if gut worms could induce immune responses that protect against multiple sclerosis.
A randomised clinical trial has shown that a chemotherapy combination of carboplatin and paclitaxel is more effective and better tolerated than previously recommended treatments for patients with advanced anal cancer. The study found that these patients lived seven months longer overall, experiencing less treatment side effects.
Researchers from University of Washington and Fred Hutchinson Cancer Research Center propose using multigroup, adaptively randomized trials to compare multiple COVID-19 interventions. This design may reduce adverse outcomes during trials and enable faster implementation of effective treatments.
A review published in Neurology clarifies the different courses of multiple sclerosis (MS) and disease activity, aiming to improve patient care and clinical trial outcomes. The experts define four subtypes: clinically isolated syndrome, relapsing remitting MS, secondary progressive MS, and primary progressive MS.
Early human challenge trials of SARS-CoV-2 vaccines may be the correct test of ethics, meeting equitable distribution principles. An international governance system is proposed to oversee access to Covid-19 vaccines and treatments.
A recent study led by Washington State University's Carrie Cuttler found that cannabis reduces the severity of post-traumatic distress disorder (PTSD) symptoms by about 62% for intrusions, 51% for flashbacks, and 67% for irritability. However, the symptom reductions were not permanent.
A study analyzing 201 registered COVID-19 clinical trials found that many lacked key features such as control groups and blinding. The majority were also designed to enroll fewer than 100 patients, limiting their usefulness. This has raised concerns about the quality of evidence for potential treatments.
A new study by Bocconi University researchers finds that the majority of phase III trial results are not significantly above threshold, contrary to previous findings. The researchers suggest that transparency and registration processes are key factors in maintaining trial integrity.
BIOCAD presents results of clinical trial showing netakimab decreases disease activity and reduces skin manifestation of psoriatic arthritis through 24 weeks of therapy. The treatment was well-tolerated, with significant improvement in skin manifestations and quality of life.
The SWOG Cancer Research Network is sparking discussion and creating consensus on how cancer clinical trial stakeholders can best interact on social platforms. The growing role of social media in raising awareness about trials and boosting accrual highlights both promises and challenges, including legal, ethical, and logistical hurdles.
The COVID-19 outbreak led to a significant decrease in national enrollment in cancer clinical trials, according to a new study. The research found that the pandemic disrupted clinical trials, resulting in a substantial drop in participation.
SYNB1891, an engineered E. coli Nissle strain producing cyclic di-AMP, demonstrates anti-tumor activity and generates immunological memory in preclinical models of cancer. The therapy is being evaluated in a Phase 1 clinical trial for patients with advanced solid tumors or lymphoma.
A Phase 2 clinical trial has shown a novel treatment protocol to be effective in patients with intravascular large B-cell lymphoma (IVLBCL), achieving two-year survival rates of up to 76% and overall survival rates of 92%. The treatment, combining conventional drugs with high-dose methotrexate and intrathecal chemotherapy, has been fou...
The NRG Oncology trial RTOG 1010 found that adding trastuzumab to neoadjuvant trimodality treatment did not improve disease-free survival for patients with HER2-positive local and locally advanced esophageal adenocarcinoma. The study also showed no significant differences in treatment-related toxicity between the two arms.
Researchers at University of Turku find glucocorticoids inhibit interferon signalling, leading to increased mortality rates. Glucocorticoids have been banned by WHO for COVID-19 treatment due to their harmful effects.
The NRG Oncology trial NSABP B-43 found a statistically non-significant, modest reduction in the rate of recurrence among women that received trastuzumab. The study showed an annual IBTR event rate of 0.80% per year in the RT+T group compared to 0.99% per year in the RT group.
A randomized phase 3 trial found no improvement in progression-free survival for carfilzomib compared to the standard treatment bortezomib. Carfilzomib was associated with higher very good partial response rates but more severe toxicities, including cardiac and renal issues.
A phase 3 trial found that surgery and radiation after initial systemic therapy did not improve overall survival for women with stage IV breast cancer. The study suggests that these treatments should not be routine practice, instead focusing on proven therapies to prolong life.
The Ivy Brain Tumor Center is conducting a Phase 0 clinical trial to evaluate the combination of two targeted therapy drugs, abemaciclib and LY3214996, in patients with recurrent glioblastoma. The study aims to confirm that these drugs can effectively cross the blood-brain barrier and block cancer cell growth.
The study found that women and racial minorities were significantly underrepresented in pivotal trials supporting approval of new cardiometabolic medicines. This underrepresentation may lead to variation in treatment outcomes and survival, emphasizing the need for increased diversity in clinical trial participants.
A randomized clinical trial found a workplace wellness program significantly improved employee health and reduced medical use. The program, which included health screenings, wellness activities, and financial incentives, showed sustained benefits after 12 and 24 months.
Investigating potential adverse effects and antibody-dependent enhancement is crucial for vaccine development. Comprehensive safety tests are necessary before widespread implementation.
A study by Johns Hopkins Medicine found that women and older adults are still vastly underrepresented in lipid lowering therapy trials, despite their high disease burden. The researchers analyzed 60 studies from 1990 to 2018 and reported a modest increase in representation of women, but many trials excluded pregnant or breastfeeding wo...
Researchers developed a framework using an epidemiological model of COVID-19 to calculate the optimal statistical threshold for approving a drug during a pandemic. This allows regulators to make a trade-off between false positives and false negatives, prioritizing the need for more timely approvals during outbreaks.
Prazosin, a low-cost FDA-approved alpha blocker, shows promise in reducing the risk of death from COVID-19-associated hyperinflammation by targeting cytokine storm syndrome. Early clinical trials are recommended to confirm its safety and effectiveness.
The Harmony TPV Pivotal Trial demonstrated favorable outcomes for the use of TPV device in patients with severe pulmonary regurgitation. The trial showed high procedural success, safety, and favorable device performance, with 100% freedom from procedure-related mortality at 30 days.
The COVID-19 Trial Finder system generates user-specific questionnaires to filter out applicable trials, reducing a large set of potential trials to a handful within 5-6 survey questions.
The Melody transcatheter pulmonary valve (TPV) has demonstrated favorable outcomes for long-term function, safety, and efficacy in congenital patients. At 10-year follow-up, the study found high freedom rates from all-cause mortality, surgical reintervention, and catheter intervention.
A new study has shown that patients with intermediate left main coronary artery disease are at a higher risk of cardiovascular events compared to those without the condition. The ISCHEMIA trial sub study found no significant difference in outcomes between invasive and conservative strategies for these patients.
Researchers conducted a two-center trial of autologous CD34+ cell therapy in 20 NOCAD patients with persistent angina, showing significant improvement in coronary flow reserve, angina frequency, and quality of life. The results demonstrate the potential of CD34+ cell therapy as a promising therapy for CMD patients with angina and NOCAD.
The NIH is sponsoring a Phase 2b trial to evaluate the safety and effectiveness of hydroxychloroquine and azithromycin in preventing hospitalization and death from COVID-19. The trial will enroll approximately 2,000 adults across the US with confirmed SARS-CoV-2 infection.
A Moffitt Cancer Center study found that CAR T-cell therapy, Yescarta, is effective in patients with relapsed/refractory large B cell lymphoma who would not have qualified for clinical trials. The study showed an overall response rate of 82% and durable response rate of 47%, suggesting that these patients can benefit from the therapy.
The HIV Vaccine Trials Network (HVTN) and HIV Prevention Trials Network (HPTN) launched a new clinical trial to study immune responses in SARS-CoV-2 infected individuals. The trial aims to develop antibody assays for reliable detection of SARS-CoV-2 infection, which will aid in the development and testing of a safe and effective vaccine.
The trial found that reduced postoperative radiation therapy in intermediate-risk patients with HPV+ oropharynx squamous cell carcinoma is safe and effective, with very good oncologic outcomes. Patients at low risk had favorable two-year progression-free survival without postoperative therapy.
Novotech was recognized for its expertise in Asia-Pacific and commitment to meeting customer needs. The CRO won awards in key categories including Compatibility, Capabilities, Quality, and Reliability.
The authors propose a strategic approach to research and development that would generate essential data for multiple vaccine candidates in parallel. They emphasize the need for unprecedented cooperation from governments, academic institutions, industry, and philanthropic partners to develop COVID-19 vaccines.
The NIH is enrolling hospitalized adults with COVID-19 in a trial testing the safety and efficacy of remdesivir plus anti-inflammatory drug baricitinib. Patients who received remdesivir had a statistically significant shorter time to recovery compared to those on placebo.
A team of researchers argues that repurposing existing medicines for COVID-19 treatment could be a rapid alternative to vaccine development. The focus is on targeting key proteins on cell surfaces, such as ACE2 and TMPRSS2, with approved or clinical trial drugs like remdesivir.
A face-aging mobile app reduced UV exposure awareness in Brazilian teens, increasing sunscreen use and protective behaviors.
A $10 million grant enables the Murdoch Children's Research Institute's clinical trial of the BCG vaccine against COVID-19 to expand to 10,000 healthcare workers across Australia and Europe. The BRACE trial aims to test whether the BCG vaccine can protect those exposed to SARS-CoV-2 from developing severe symptoms.
The Altman Clinical and Translational Research Institute at UC San Diego has received a five-year, $54.7 million Clinical and Translational Science Award from the National Institutes of Health. This grant will refine fundamental work and provide new resources to launch a wave of discovery and transformation.
A study of 22,655 patients found that taking a PCSK9 inhibitor with a statin to achieve very low LDL-C levels did not cause increased incidence of neurocognitive impairments, including memory loss or reduction in executive functions. This confirms the safety of intensive LDL-C reduction for high-risk patients.
A new AI-supported test, called DARC, can detect glaucoma progression 18 months earlier than the current gold standard method. The technology involves injecting a fluorescent dye into the bloodstream and illuminating damaged retinal cells using artificial intelligence.
A study of patients with glomerular disease and their caregivers reveals that they highly value kidney function, mortality, and need for dialysis or transplant. They also stress the importance of addressing factors related to life participation, fatigue, anxiety, and family impact.
A new study published in JAMA Network Open found that cancer patients with no health insurance or Medicaid do not receive the same trial benefits as those with private insurance. The research highlights the importance of expanding insurance coverage to ensure all Americans access life-saving treatments.
New clinical trial in the UK will test bemcentinib's antiviral activity against SARS-CoV-2, a potential treatment for early COVID-19 infection. The drug targets AXL, a cell surface receptor used by different enveloped viruses to enter cells.
Researchers say COVID-19 restrictions can be used to increase access to clinical trials for rural populations, who face significant health disparities and limited internet access. By using digital technology and community partnerships, researchers can include more people in studies and promote rural health equity.
A randomized clinical trial investigates the safety and efficacy of two chloroquine diphosphate dosages in patients with severe COVID-19. The study suggests that high-dose chloroquine diphosphate may be effective in treating SARS-CoV-2 infection.
A nationwide trial tests video counseling to help cancer patients quit smoking, addressing a significant public health concern. The study aims to provide evidence for tobacco treatment as standard care in community hospitals and clinics.
The Asia-Pacific region has launched expedited review processes for COVID-19 treatment and vaccine trials, with South Korea offering approval in under 9 days. Novotech is a leading contract research organization (CRO) in the region, supporting vital research with its fast-track services.