Articles tagged with Hormone Therapy
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The prescription of testosterone in older men is associated with unclear cardiovascular risk. Despite the benefits in younger men, ongoing studies are unlikely to provide reliable safety data due to limited sample sizes and power.
A clinical trial found that six months of hormone therapy added to radiotherapy significantly reduces the risk of prostate cancer relapse and progression. Men who received both treatments had a nearly 50% lower risk of biochemical progression compared to those treated with radiotherapy alone.
The European Menopause and Andropause Society (EMAS) has published a position statement on menopause for medical students, emphasizing the importance of managing postmenopausal health. The statement provides guidance on stages of reproductive aging, menopause terminology, and treatment options, including menopausal hormone therapy and ...
Researchers have identified genetic markers that can predict late recurrence of ER+ breast cancer, allowing for personalized treatment decisions. Women with tumours highly sensitive to oestrogen may benefit from extended hormone therapy beyond five years.
A comprehensive study of over 15,000 men with localized prostate cancer found that primary androgen deprivation therapy does not extend survival. The treatment is associated with serious adverse events and mitigates against its use as a primary treatment option.
A new study found that estradiol hormone therapy prevented degeneration in key brain regions of postmenopausal women at heightened dementia risk. In contrast, Premarin was far less protective. The study suggests that early intervention with estradiol may help stave off dementia.
A recent study found that female hormone therapy, particularly estrogen plus progesterone, significantly improved survival among women with non-small cell lung cancer. The combination of hormone therapy and long-term use showed the most notable improvements in median survival time.
Research finds that moderate-intensity exercise, such as brisk walking or tennis, significantly reduces women's stroke risk. Moderate exercise also helps offset the increased risk seen in postmenopausal women taking menopausal hormones, but not completely.
Researchers at the University of East Anglia have made a significant advance in understanding genetic changes associated with terminal prostate cancer. A genetic mutation has been identified as a key factor in the development of aggressive cancer later in life. This discovery could help identify patients who are at risk of developing f...
Researchers identify androgen and vitamin D receptors as potential targets for breast cancer hormone therapy, offering new treatment options for patients with hormone-dependent breast cancer. The study's findings suggest that triple hormone treatments may be more effective than single hormone treatments.
A new Penn study found that moderate to severe hot flashes continue for nearly five years after menopause and affect over a third of women. The findings challenge current guidelines recommending hormone therapy not exceed 5 years.
A large health care database study has found a twofold increase in the risk of heart attacks among men under 65 using testosterone therapy. The research also confirmed earlier findings that men over 65 experience a similar increased risk.
A study found that adding testosterone to hormone therapy did not significantly improve quality of life, self-esteem, or mood in women with primary ovarian insufficiency. Normalizing testosterone levels may not address underlying factors contributing to mood problems.
A new study found that postmenopausal hormone replacement therapy (HRT) may increase the risk of acute pancreatitis. The risk was higher among women who used systemic therapy and those who had used HRT for more than 10 years.
A new study published in the Journal of Urology reports that prostate cancer patients treated with androgen deprivation therapy (ADT) experienced changes in mental and emotional well-being during treatment, with no significant decline in emotional quality of life two years after treatment. Investigators recommend counseling men about p...
A large population-based study published in Annals of the Rheumatic Diseases found that hormone replacement therapy (HRT) taken regularly after knee or hip replacement reduces the risk of repeat surgery by around 40%. The research also showed that taking HRT for 12 months or more after surgery further decreases the risk, with those rec...
Researchers identified four subtypes of HER2+ breast cancer, including Luminal A, Luminal B, HER2-enriched, and Basal-Like, with varying responses to anti-HER2 therapy and chemotherapy. The study suggests that personalized treatment strategies may improve treatment outcomes for patients.
A new study by the University of British Columbia finds that progesterone poses little or no cardiovascular risk for post-menopausal women experiencing hot flashes and night sweats. The treatment has been shown to be effective in alleviating symptoms without increasing the risk of heart disease.
A study found that testosterone use has increased sharply among older men in the US and UK, with many having normal testosterone levels and non-specific symptoms. The Endocrine Society's guidelines recommend a clinical diagnosis of low testosterone only for men with consistent symptoms and unequivocally low hormone levels.
A new study by LA BioMed finds that daily antibiotic use is the most effective method for preventing recurrent urinary tract infections, reducing recurrence rates to 0.4 per year. Cranberry pills and estrogen therapy also showed benefits, with acupuncture treatments reducing recurrence rates to 0.7 per year.
A phase III clinical trial presented at the 2013 San Antonio Breast Cancer Symposium found that bisphosphonate zoledronate had no effect on event-free survival in women with chemoresistant breast cancer. Researchers also reported that patients with hormone receptor-positive disease were more common, which may impact treatment outcomes.
Research found that women with HER2- and hormone receptor-positive breast cancer treated with neoadjuvant therapy had lower pathologic complete response rates if their tumors had PIK3CA gene mutations. These mutations were more common in HER2-positive breast cancers.
A double-blind, randomized trial found that anastrozole significantly reduced breast cancer incidence among postmenopausal women at high risk for developing the disease. The study showed a 53% reduction in breast cancer incidence with few side effects.
Researchers have found that omitting radiotherapy in older patients with hormone-receptor positive breast cancer who undergo surgery and hormone therapy is a viable option, resulting in a lower rate of unnecessary treatment. The study suggests that these patients are at low risk of recurrence, making radiotherapy optional.
Researchers at A*STAR's Institute of Medical Biology and Institute of Molecular and Cellular Biology have identified a gene encoding a hormone called ELABELA, which is crucial for heart formation in zebrafish embryos. The discovery holds great promise for the development of targeted therapies for heart disease and blood pressure control.
A study found that cognitive behavioral therapy for PTSD reduces symptoms and affects underlying biology, reversing changes in gene expression and brain volume. The therapy was associated with improved symptoms and increased hippocampal volume and FKBP5 gene expression.
A new study by MU researchers recommends that women on hormone replacement therapy with progestin avoid ingesting pure apigenin as a supplement. Apigenin, found in celery and other plants, can increase the incidence of breast cancer tumors when combined with synthetic hormones.
A new hormone therapy has been shown to improve the integration of bone grafts used in head and facial reconstruction surgeries. The treatment, which uses parathyroid hormone, enhances bone formation around the grafts and prevents scar tissue from forming, leading to better outcomes for patients.
A new study found that hormone therapy has no significant impact on the quality of life for recently menopausal women without hot flashes. Women with moderate to severe hot flashes did experience improvements in sleep and other symptoms, but not overall health or sexual well-being.
Researchers at UT Southwestern have found that a cholesterol metabolite called 27-hydroxycholesterol promotes tumor growth in estrogen-receptor positive breast cancers. The discovery may explain why endocrine-based therapies are often unsuccessful, providing a new target for therapy.
A recent study found that men using testosterone therapy have a 29% higher risk of death, heart attack, and stroke compared to those not using the treatment. The study, which analyzed data from over 8,000 patients, highlights the need for caution when prescribing testosterone therapy.
A study found that testosterone therapy was associated with a higher risk of adverse outcomes, including death, heart attack, or ischemic stroke, in men who underwent coronary angiography. The use of testosterone therapy was also linked to an increased risk of these events even among patients without underlying coronary artery disease.
A study found that six patients with estrogen receptor-positive breast cancer developed mutations in the estrogen receptor after taking anti-estrogen therapies, leading to treatment resistance. The discovery sheds light on why patients become resistant to hormonal therapy and offers new insights into developing targeted treatments.
Researchers found that a quick neck injection of local anesthesia can reduce severe hot flashes in women by as much as 50 percent for at least six months. The treatment uses bupivacaine hydrochloride to target the stellate ganglion nerve bundle, providing symptom relief without hormonal therapy.
Researchers at Indiana University have developed a molecule combining GLP-1 and GIP peptides, which shows improved therapeutic effects in controlling glucose levels and weight loss. The study demonstrates the potential of this combination as an effective treatment for adult-onset diabetes and obesity.
Scientists have developed a new therapeutic approach for Type 2 diabetes using a novel single molecule hormone that acts on GLP-1 and GIP receptors. The hormone reduces weight and improves blood sugar levels, and may offer unprecedented potential for personalized therapies.
The Endocrine Society publishes a Clinical Practice Guideline for diagnosing and treating polycystic ovary syndrome (PCOS), a leading cause of infertility in women. The guideline provides clear criteria for diagnosis and treatment recommendations, aiming to address the complexities of this hormone disorder.
An observational study found that testosterone treatment reduced total cholesterol, LDL, triglycerides, and increased HDL in hypogonadal men. Testosterone therapy also lowered systolic and diastolic blood pressure, suggesting a reduction in hypertension.
Scientists at ETH Zurich have created a genetic module that can be controlled via dopamine, which activates the production of an antihypertensive agent. The researchers found that contact with a female mouse triggered feelings of happiness in male mice, correcting hypertension and lowering blood pressure to normal levels.
A comprehensive analysis of hormone therapy trials did not support its use for chronic disease prevention. The study found that menopausal hormone therapy may be suitable for managing symptoms in some women.
A study published in JAMA Internal Medicine compared the cardiovascular safety of conjugated equine estrogens (CEEs) and oral estradiol. The research found a greater risk of venous thrombosis associated with CEEs, but no increased risk of heart attack or ischemic stroke.
Researchers at Wake Forest Baptist Medical Center studied 120 men undergoing hormone therapy for prostate cancer and found that neither soy protein nor an antidepressant provided relief from hot flashes. The study highlighted the need for treatments specifically developed for men with hot flashes.
Researchers at the University of Wisconsin-Madison have discovered a promising vitamin D-based treatment for multiple sclerosis (MS) that can halt and even reverse the course of the disease in a mouse model. The treatment involves giving mice with MS symptoms a single dose of calcitriol, followed by ongoing vitamin D supplements throug...
A recent study found a modest connection between low testosterone and an increased risk of developing or dying from heart disease. However, treating low testosterone with hormone replacement therapy did not have any beneficial effect on cardiovascular health.
A secondary analysis of the historic RTOG 9202 prostate cancer trial found no additional benefits with long-term hormonal therapy compared to short-term therapy in intermediate-risk patients. The study suggests that administering less treatment can reduce side effects and healthcare costs without compromising survival rates.
A study by American Society for Radiation Oncology found that proton therapy can prevent costly side effects in children with medulloblastoma, making it both cost-effective and cost-saving compared to photon therapy. Proton therapy reduced the risk of hearing loss, secondary malignancy, and heart failure.
A new observational study suggests that bioidentical hormones in transdermal patches may be associated with a lower risk of heart attack, while FDA-approved products may carry a slightly lower risk of stroke compared to synthetic hormones. The findings are inconclusive and require confirmation by randomized trials.
The NIH's Therapeutics for Rare and Neglected Diseases program aims to develop treatments for rare diseases affecting fewer than 200,000 Americans. Four new pre-clinical projects target retinitis pigmentosa, hypoparathyroidism and LEOPARD syndrome, marking the first use of stem cells and collaboration with Eli Lilly.
A new gene-expression-based biomarker, the Breast Cancer Index (BCI), accurately identifies patients at continued risk of breast cancer recurrence after five years of treatment. The BCI distinguishes between high and low-risk patients, enabling prolonged treatment for those who remain at risk and avoiding unnecessary side effects.
A new study found that hormone replacement therapy (HRT) use is associated with an increased risk of breast cancer among postmenopausal women, but the relationship varies depending on factors such as race/ethnicity, body mass index (BMI), and breast density. The study suggests that HRT may be used for some women without increasing thei...
The North American Menopause Society (NAMS) has published new guidance for diagnosing and treating vulvovaginal atrophy (VVA), a condition affecting up to 45% of women after menopause. The guidance emphasizes the importance of effective treatments, including simple vaginal lubricants, estrogen therapy, and nonhormonal options.
A Baylor University study found that hypnotic relaxation therapy improves sexual satisfaction and pleasure, as well as reduces discomfort in postmenopausal women with hot flashes. The therapy is a safe alternative to hormone replacement therapy, which carries risks of cancer and heart disease.
A study published in Mayo Clinic Proceedings documents 146 contemporary medical practices that have been reversed due to lack of evidence. The study analyzed 10 years of original articles from the New England Journal of Medicine, finding that only a minority tested current medical practices, and 40% found them ineffective.
A combined therapy of adrenocorticotropic hormone, topiramate, vitamin B6, and immunoglobulin effectively improves infantile spasms prognosis. This treatment is superior in cryptogenic children compared to symptomatic ones. The study published in Neural Regeneration Research
A study in rats reveals that nicotine exposure temporarily changes the brain's response to alcohol, increasing its reinforcing properties through stress hormones. This finding highlights the mechanisms underlying the link between smoking and alcohol abuse, providing a foundation for developing strategies to mitigate this risk.
A Yale University study reveals that nearly 50,000 unnecessary deaths among women aged 50-69 with hysterectomies could have been avoided if they used estrogen-only therapy instead of combined hormone therapy. The decline in estrogen usage was linked to the 2002 WHI study's findings on women with a uterus, but not those without one.
A study of over 10,000 men with nonmetastatic prostate cancer found that use of androgen deprivation therapy (ADT) was associated with a significantly increased risk of acute kidney injury. The association remained consistently elevated across different types of ADTs, particularly in the first year of treatment.
A recent study published in the American Journal of Neuroradiology found that women with mild cognitive impairment experience higher rates of cognitive decline than men, while all women exhibit greater regional brain loss over time. The study's authors suggest that hormonal differences may play a role in these findings.
Researchers at the University of Montreal found that a liver protein plays a crucial role in pregnancy and the human menstrual cycle. The study, published in Nature Medicine, showed that mice genetically engineered to lack the protein had defective placentas and failed pregnancies.
A large analysis of the Women's Health Initiative trial found that combining hormone therapy with calcium and vitamin D supplements significantly reduces the risk of hip fractures. The study suggests that women taking postmenopausal hormone therapy should consider taking these supplements to boost bone health.