Research on hormone therapy and its effects. Covers menopause symptom relief, bronchiectasis risk, dementia links, and Alzheimer's risk.
In a phase III trial, combining endocrine treatment with radiotherapy reduced prostate cancer mortality by half compared to endocrine treatment alone. The study found significant superiority of the combined treatment over hormone therapy alone in reducing prostate cancer-specific mortality and overall survival.
Studies show hormone supplements, such as estrogen-progestin and letrozole, can reduce breast cancer mortality risk by up to 63% and improve overall survival. Meanwhile, tamoxifen is found to be superior for quality of life measures, with patients paying a price in quality of life when switching from anastrozole.
A study found that estrogen therapy can stop the growth of tumors or cause them to shrink in about a third of women with metastatic breast cancer that has developed resistance to standard estrogen-lowering therapy. The high-dose regimen had significant side effects, while the low-dose regimen was well tolerated.
Researchers are studying new treatments, including zoledronic acid, aromatase inhibitors and monoclonal antibodies, with encouraging results. Exemestane has been shown to be more effective in postmenopausal women than current treatment with tamoxifen.
A study of over 140,000 babies found late preterm births are associated with increased risk of cerebral palsy and mental retardation. The research highlights the need for early neurological assessments and cautious approach to elective deliveries before 39 weeks.
A recent study led by Massachusetts General Hospital researchers found that hormone therapy for prostate cancer does not appear to increase the risk of death from cardiovascular disease. However, other adverse effects such as diabetes and heart disease still exist, necessitating careful treatment strategies.
SLU researchers found a way to get a promising treatment for Alzheimer's and stroke into the brain, reversing symptoms. They discovered a unique approach to delivering drugs past the blood-brain barrier, which had blocked treatments in the past.
Chronic kidney disease exacts a significant toll on women's sexuality and gynecologic health, with hormonal changes affecting body functions. Experts will explore the impact of CKD on women's sexual life cycle, fertility, and pregnancy from adolescence through menopause.
A study published in the New England Journal of Medicine found that testosterone administered by a skin patch improves sexual well-being in post-menopausal women. The research involved over 800 participants from across the globe and suggests testosterone as a potential treatment for low libido in this demographic.
Researchers at Baylor College of Medicine have developed a new high throughput microscopy technique that enables analysis of hormone receptors on a cell-by-cell basis. This allows for personalized medicine applications, such as identifying the most effective drug treatments for mutated cells.
SmartCells' SmartInsulin is a once-a-day, glucose-regulated insulin that maintains continuous blood glucose control while reducing hypoglycemia risk. JDRF's $1M funding supports preclinical safety and efficacy testing for this treatment, aiming to improve patient safety and quality of life.
A team of researchers has discovered a mechanism for the rapid growth of infantile hemangioma, a common childhood tumor. The study found that endothelial cells, which line the blood vessels, are responsible for the tumors' growth and can be targeted with anti-VEGF therapy.
Breast cancer cells can recycle their components to survive antiestrogen therapy, with macroautophagy playing a key role in this survival strategy. Researchers now believe targeting the autophagosome function could significantly improve hormonal treatment for estrogen-positive breast cancer.
A large Danish observational study found that women taking hormone replacement therapy (HRT) who used it on a cyclical basis, through skin or vaginal application, had a reduced risk of heart attacks. This contradicts previous research and suggests that certain HRT regimens may be safer than others.
Researchers found that older men with high-risk prostate cancer who received hormone therapy lived longer and experienced fewer PSA increases compared to those without treatment. A longer duration of hormone therapy resulted in improved overall survival rates, especially among those over 70.
A recent observational study published in the Journal of the National Cancer Institute suggests that hormone therapy may be safe for postmenopausal women with BRCA mutations. The study found a 42% relative reduction in breast cancer risk among women who used hormone therapy, although further research is needed to confirm these findings.
A new Fox Chase Cancer Center study suggests men with early stage prostate cancer treated with radiation therapy should begin hormone therapy immediately if their PSA level rises quickly and doubles within six months at any time after treatment. The study also supports foregoing hormones if the PSA doesn't rise as quickly. These findin...
A large cohort study found that hormone therapy before radiation seed implants for prostate cancer increases the risk of death by 20% in men over 70 years old with early-stage cancer. This treatment approach may have negative effects on survival, particularly for older patients.
Researchers at Fox Chase Cancer Center have developed a prediction tool that estimates the benefit of adding androgen deprivation therapy to radiation therapy for high-risk prostate cancer patients. The tool takes into account disease burden and individual patient characteristics, allowing for personalized treatment recommendations.
Researchers developed a preoperative endocrine prognostic index (PEPI) to predict relapse risk in women with stage 2 or 3 estrogen receptor-positive breast cancer. The model incorporates tumor characteristics and is statistically significant in predicting relapse-free survival.
A new predictive measurement, called a PEPI score, can help determine the treatment of breast cancer patients. A low PEPI score indicates little risk of relapse and allows patients to safely avoid chemotherapy after surgery. Women with high PEPI scores are at high risk of having their cancer return and require aggressive therapy.
A randomized clinical trial shows acupuncture reduces hot flashes and vasomotor symptoms in breast cancer patients, providing additional benefits like increased energy and well-being. The treatment has no side effects compared to commonly used drugs.
A randomized study found that adding radiation therapy to hormone treatment reduces the risk of dying from prostate cancer by 50% compared to hormone therapy alone. The quality of life at four years after treatment was similar between the two groups, with decreased social function in patients who received combined treatment.
A study found that estrogen therapy reduced the risk of fractures after menopause, particularly in women aged 50-64 years. The use of post-menopausal hormone replacement therapy increased greatly during this period and was estimated to cause nearly half of the decline in fracture rates among women.
Research from Michigan Medicine found that estrogen treatments stimulate collagen production in non-sun damaged skin, but have no effect on sun-damaged skin. The study suggests it's difficult to repair photoaged skin due to altered skin response to topical estrogen treatment.
Researchers at Mount Sinai Hospital have developed a new once-weekly treatment for type 2 diabetes that mimics the action of GLP-1, a naturally occurring hormone. The treatment showed significant improvements in glucose control and reduced side effects compared to twice-daily injections.
A large trial found significant improvements in quality of life, sleep and joint pain for post-menopausal women on hormone replacement therapy. Researchers also noted improved sexuality among participants.
Researchers have found that a common treatment for advanced prostate cancer can actually cause some cancer cells to grow, rather than stopping them. The androgen receptor plays a versatile role in the disease, acting as both a tumor promoter and suppressor in different cell types.
Despite five years of systemic therapy, breast cancer patients remain at risk for disease recurrence. Women with hormone receptor-positive cancer have a higher risk of relapse, highlighting an unmet clinical need for new strategies to reduce this risk.
A retrospective analysis of postmenopausal women with early-stage breast cancer found that previous use of hormone replacement therapy (HRT), hormone-receptor positivity, and treatment with anastrozole versus tamoxifen were associated with joint symptoms. Obesity was also linked to increased joint symptoms in these patients.
Research suggests that increased testosterone in male mice increases their ability to transmit diseases, driving transmission through close social contact. The study found that treated mice made significantly more contacts with both males and females than untreated mice, leading to a higher risk of disease spread.
Asterion Ltd.'s patented ProFuse technology enables the creation of longer-acting drugs to tackle major diseases. The company's platform can also be used to develop pairings between therapeutic hormones and protective receptor domains to address conditions like some cancers, anaemia, infertility, and diabetes.
A randomized, double-blind study involving 102 women with schizophrenia found that estrogen estradiol improved psychotic symptoms more effectively than antipsychotic medications alone. No significant difference was observed in negative symptoms, suggesting potential for longer-term treatment or alternative approaches.
A low-dose growth hormone treatment reduced abdominal fat deposits and improved blood pressure and triglyceride levels in HIV patients with lipodystrophy. However, growth hormone treatment appeared to increase blood glucose levels, particularly in those with impaired glucose tolerance.
A recent review of the literature found that hormone deprivation therapy can have subtle adverse effects on cognition in prostate cancer patients. Studies indicate that between 47% and 69% of men treated with androgen depletion therapy decline in at least one cognitive area, primarily in spatial ability and high-order capacities.
A recent review of literature found that hormone deprivation therapy can have subtle adverse effects on cognition in prostate cancer patients, affecting recall, concentration, and high-order capacities. Between 47% and 69% of men treated with androgen depletion therapy decline in cognitive function.
For elderly men with localized prostate cancer, androgen deprivation therapy does not improve survival rates compared to conservative management. The study found lower 10-year prostate cancer-specific survival rates among those using PADT.
Men with breast cancer often experience poor outcomes due to delayed diagnoses, with 50% of cases reaching advanced stages. Early detection and treatment are crucial, as hormone therapy can be highly effective in treating the disease.
Difficulty sleeping and waking up early are more common in certain ethnic groups during menopause. The study found that Caucasian women were more likely to experience difficulty staying asleep, while Hispanic women were less likely to wake up frequently at night.
The Damon Runyon Cancer Research Foundation has awarded $2.25M to five outstanding young clinical investigators, including Dr. Ronald Buckanovich, Andrew Chan, Rachael Clark, Vassiliki Karantza-Wadsworth, and Elahe Mostaghel, to support their cancer research programs.
Restoring normal testosterone levels in hypogonadal men leads to major improvements in metabolic syndrome features. Older men (63+) benefit equally as younger men from testosterone treatment, according to studies presented at The Endocrine Society's 90th Annual Meeting.
A study found that radiation treatment after radical prostatectomy was associated with a significant increase in prostate cancer-specific and overall survival. Men with rapid PSA doubling time or high Gleason score benefited from early salvage radiotherapy, which improved survival by over 75%.
Researchers found that hormone replacement therapy maintained coronary endothelial function, while those without HRT experienced worsening endothelium function. Postmenopausal women who gave up HRT demonstrated the most severe drop in endothelial function.
A new animal study suggests that estrogen treatment is not toxic per se, but its effects on the brain depend on an individual's reproductive age. In rats, estrogen therapy reduced brain damage when given before menopause, but increased it after, highlighting a narrow window of time for neuroprotective benefits.
Women who have taken menopausal hormone therapy before are at a 37% higher risk of breast cancer than those who never used it. The risk is highest when taking combined estrogen and progestin therapies, with an increased risk by 73% during use.
Low testosterone levels in men are often untreated, even among those with sufficient healthcare access, according to a study of Boston-area men. Despite this, treated and untreated men report similar healthcare visits, suggesting barriers may lie in diagnosis or prescription issues.
A new analysis suggests that healthy postmenopausal women with normal blood cholesterol levels are at no increased short-term risk for heart attack when taking hormone therapy. Women with a low LDL to HDL ratio have an even lower risk of heart attack or death from hormone therapy.
A research study has found that a simple blood test can indicate whether post-menopausal hormone therapies increase the risk of a heart attack. Women with favorable cholesterol levels were not at increased risk of developing heart problems while taking hormones, whereas those with unfavorable cholesterol levels were at higher risk.
Researchers have identified a unique genetic signature that can alert physicians to high-risk breast tumors masquerading as low-risk tumors. The genetic signature is associated with a higher chance of cancer recurrence and standard anti-estrogen therapy being ineffective.
A Phase II clinical trial led by researchers at The University of Texas M. D. Anderson Cancer Center found that Iressa enhanced the effectiveness of hormonal therapy in treating specific types of metastatic breast cancer. The combination resulted in a 45% reduction in risk and improved clinical benefits for patients.
A study of 121,700 women found that postmenopausal hormone therapy is associated with a higher risk of stroke, even in younger women taking hormones near menopause. The risk was strongest for those taking larger doses and longer durations of hormone therapy.
Researchers found that hormone therapy started around menopause onset may have similar benefits as those without risk factors for heart disease. The study suggests that current guidelines may need to be revised for younger women taking hormone therapy.
A study found that testosterone spray increased frequency of sexually satisfying events in premenopausal women, but the effect was only significant for the middle dose. Conventional treatments like cognitive behavioral therapy and sex therapy are recommended over hormone replacement therapy.
Two studies published in Blood journal provide insights into the regulation of red blood cell production, linking it to the Hls5 gene and thyroid hormone. This knowledge may lead to new treatments for anaemias that don't respond to current hormone therapy.
Preliminary study results show testosterone administration reduces bone turnover, with potential protective effects on existing bone mass. Testosterone replacement therapy may benefit older men with low-to-normal testosterone concentrations.
A new study in mice found that moderate and high doses of estrogen replacement therapy increased problems in the kidney and heart. The results suggest that ERT dosage may be an important determinant in a woman's overall health.
A new study has found that hormone replacement therapy (HRT) increases the risk of breast cancer recurrence in women who have survived breast cancer. The HABITS trial, which followed over 200 breast cancer survivors for four years, found that HRT significantly increased the risk of disease recurrence.
Regular aerobic exercise significantly decreases oxidative stress levels and improves cardiovascular health in postmenopausal women. The study found that both HRT users and non-users benefited equally from the exercise program, reducing the risk of heart disease and stroke.
Researchers found that MPA decreased endothelial function in premenopausal women, raising questions about long-term effects on cardiovascular health. The study suggests that exposure to synthetic hormones may reduce blood vessel flexibility, potentially leading to heart disease.
A recent study found that post-menopausal women who stopped taking combined hormone therapy experienced an increased risk of all cancers, including lung cancer. The research, led by Rowan T. Chlebowski, confirms previous findings on the risks of hormone therapy.