Articles tagged with Hormone Therapy
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A study published by the American Physiological Society suggests that as body mass index (BMI) increases, so do platelet reactivity and thrombogenic microvesicles, contributing to cardiovascular disease. Higher BMI groups also showed increased traditional cardiovascular risk factors such as blood pressure and triglycerides.
A new analysis found that prostate cancer treatment choices significantly impact long-term care costs. Watchful waiting had the lowest initial and five-year total costs, while hormonal therapy plus radiation and surgery were associated with higher costs.
Researchers compared four progestins and found that N-EL and N-One strongly inhibited tumor development, while MPA promoted it. Progestins like N-EL and N-One may have potential as preventive agents in women with no breast disease or family history.
A new study suggests that oral contraceptives and hormone replacement therapy may reduce the incidence of brain aneurysms in women. The study, conducted at Rush University Medical Center, found strong similarities between women with unruptured and ruptured aneurysms, including lower estrogen levels.
UT Southwestern researchers found blocking a specific enzyme step can halt tumor growth. The study suggests this approach may provide new therapy options for patients with end-stage prostate cancer, which has limited treatment choices.
Research reveals soy phytoestrogens reduce weight gain and increase energy expenditure in post-menopausal rats, highlighting potential natural treatment for obesity. Further human studies are needed to confirm the long-term effects of a soy-rich diet on food intake.
A study found that women with a genetic variation in their hormone receptor are more likely to have a poor response to FSH during fertility treatment. The abnormal receptor impairs the function of normal receptors, resulting in fewer oocytes produced.
A new study found that nearly 49% of women with early-stage breast cancer did not complete their full hormone therapy regimen. Younger women were more likely to discontinue treatment. The study highlights the need for better understanding and interventions to reduce treatment non-compliance.
A new study reveals that oral micronized progesterone relieves hot flashes and night sweats in postmenopausal women, with a 56% improvement rate. The natural hormone form offers an effective alternative to estrogen for those who cannot or prefer not to use it.
Menopausal hormone therapy may offer significant benefits to some women, particularly those starting treatment a short time after menopause. The Endocrine Society's new statement suggests that MHT can lead to a 30-40% decrease in mortality and a 90% reduction of menopausal symptoms.
A large UK study found that genetic variations associated with an increased risk of breast cancer do not interact with environmental factors such as hormone replacement therapy, age at first birth, or obesity. The study's authors conclude that genetic and environmental risks for breast cancer are independent.
Researchers found thymoquinone induces oxidative stress in prostate cancer cells, leading to increased cell death and decreased tumor growth. The study suggests a new potential treatment option for highly aggressive prostate cancers.
A nationwide study confirms the benefit of estrogen-lowering drugs before surgery for breast cancer patients. The treatment increased the likelihood that women could undergo breast-conservation surgery instead of mastectomy. After 16-week aromatase inhibitor therapy, 82% of women had successful breast-conservation surgery.
Researchers from Georgetown University Medical Center identify a potential new combination therapy to increase or 'rescue' sensitivity to fulvestrant in ER+ breast cancers. The study found that the cytokine IFNγ appears to increase IRF1 expression, leading to increased apoptosis of cancer cells.
Researchers at Mount Sinai School of Medicine have found a potential new treatment for osteonecrosis, a debilitating disease caused by steroid use. Injecting ACTH significantly reduced bone death in rabbits with osteonecrosis, promoting increased blood flow to bone cells and preventing cell death.
Researchers from Georgetown University Medical Center are studying multiple ways to address treatment-resistant breast cancers. A third approach involves triggering vulnerable cells to respond to existing treatments, while another study focuses on targeting orphan nuclear receptors to prevent resistance.
The European Association of Urology (EAU) has launched new and updated clinical guidelines for urological conditions, including muscle-invasive and metastatic bladder cancer and prostate cancer. The guidelines provide evidence-based recommendations on diagnosis, staging, treatment options, and follow-up care.
A study published in The Lancet Oncology found that men with prostate cancer are at increased risk of potentially life-threatening blood clots. Patients receiving endocrine therapy had the highest risk, especially younger men and those with advanced disease.
An international expert group recommends individualized treatment for patients with type 2 diabetes, citing the need to address underlying physiological and genetic differences. The recommendations aim to improve glycemic control, minimize risk, and reduce diabetes complications by tailoring therapies to specific patient subgroups.
Researchers discover how breast cancer cells become resistant to hormone-dependent treatments like tamoxifen by activating a specific biochemical cascade. The study reveals the permanent stimulation of cyclic AMP in cells refractory to therapy, providing key answers to understanding resistance.
Researchers found that hormone replacement therapy in joint fluid may be beneficial for treating late-stage human osteoarthritis by regenerating damaged cartilage tissue. Estrogen and testosterone were shown to influence the expression of genes in chondrogenic progenitor cells, which are present in arthritic tissue.
A study found Raloxifene improves psychosis symptoms and enhances memory in postmenopausal women with schizophrenia. The therapy may revolutionize treatment options for women suffering from the condition.
Magnetic resonance-guided focal therapy offers a new treatment choice for patients with recurrent prostate cancer, providing an alternative to radiation therapy and hormone manipulation. The procedure involves tailored treatment modality and duration based on lesion size and location, preserving sexual and urinary function.
A study found that prostate cancer treatment options differ based on the type of specialist consulted. Men who see a radiation oncologist are more likely to receive radiation therapy, while those who consult with a urologist with or without a medical oncologist are treated more frequently with hormone therapy, watchful waiting, or radi...
Monash University scientists have identified a new way to treat castrate-resistant prostate cancer cells using estrogen receptors. The study shows that activating these receptors can cause cell death in patients with advanced prostate cancer.
Recent research highlights the existence of multiple placebo effects, influenced by psychological and neurobiological factors. Placebo effects can be robust in both laboratory and clinical settings, and can even enhance the efficacy of treatments.
A recent study published in Cancer journal by HealthCore confirms disparities in breast cancer treatment between African-American and white women. White women were more likely to receive anti-estrogen therapy compared to African-American women, despite both groups having similar cancer stages. The study highlights the need for improved...
New analyses confirm that combination hormone therapy increases the risk of heart disease in healthy postmenopausal women, particularly those who begin therapy within 10 years of menopause. The risk is more pronounced among women who start therapy 10 years or more after menopause.
Researchers identified a gene variant that affects mice's response to natural hormone fluctuations, leading to increased anxiety and impaired memory. The study suggests the gene may play a role in premenstrual dysphoric disorder (PMDD) and other menstrual cycle-related disorders.
A large-scale study found that estrogen-only hormone replacement therapy (HRT) may increase the risk of developing asthma after menopause. Women who used estrogen-only HRT were 21% more likely to develop asthma than those who never used HRT, with a significant increased risk among non-smokers and those with previous allergies.
A Tel Aviv University study found that restoring normal estrogen levels can alleviate schizophrenia-like behavior in female rats. The researchers also discovered that estrogen increases the effectiveness of anti-psychotic drugs, providing potential hope for treating psychosis in women vulnerable to schizophrenia.
Researchers found prescribed opioids associated with significant overdose risk. Leptin therapy holds promise for long-term weight loss. Atrial fibrillation risk is lower with certain antihypertensives, while higher statin doses may not always prevent coronary artery disease.
Researchers suggest progesterone as a viable treatment option for traumatic brain injuries due to its ability to protect damaged cells and reduce swelling. The hormone has been shown to improve behavioral outcomes and protect neurons after injury.
Researchers at University of California, Berkeley have discovered a new human reproductive hormone called gonadotropin inhibitory hormone (GnIH), which has the opposite effect from gonadotropin releasing hormone. GnIH may lead to the development of novel contraceptives and treatments for cancer or other diseases.
A recent study found that black women with hormone receptor-positive breast cancer have worse disease-free and overall survival rates than women of other races. This disparity persists even after controlling for other factors such as medical care and comorbidities.
A new study published in the Journal of the National Cancer Institute found that treatment with gonadotropin-releasing hormone agonists increases the risk of incident diabetes among men of all ages diagnosed with local or regional prostate cancer. The study also found an increased risk of cardiovascular disease, including coronary hear...
A randomised trial found that medroxyprogesterone acetate is significantly more effective than venlafaxine at reducing hot flushes in men treated with androgen suppression therapy. Cyproterone acetate was also effective, but medroxyprogesterone is recommended as the standard treatment due to its fewer side effects.
Dr. Donald F. Steiner has made significant contributions to the understanding of insulin secretion and related disorders through his research on proinsulin and C-peptide measurement. His work has led to major improvements in therapeutic insulin development, diagnosis of pancreatic tumors, and islet transplants.
Women with a history of preeclampsia may be at increased risk for reduced thyroid functioning, according to researchers. The study found that women who developed preeclampsia during pregnancy had higher levels of thyroid-stimulating hormone (TSH) and were more likely to have hypothyroidism later in life.
Researchers at Johns Hopkins Medicine found that migraine headaches are associated with more than two-fold higher chances of ischemic stroke. Women with migraines have a particularly high risk, with a 2.9 times higher risk compared to men.
A large national study on testosterone's effectiveness will be conducted at LA BioMed, focusing on its impact on anemia, cardiovascular disease, and other health conditions in older men with low testosterone levels. The Testosterone Trial will involve 800 men across 12 sites, including LA BioMed, to evaluate the treatment's benefits.
Researchers Darío Acuña-Castroviejo and Germaine Escames found that melatonin is an effective sleep regulator, regulating the biological clock and synchronizing the body's circadian rhythms. Taking melatonin at specific hours can correct chronobiological alterations of the cycle sleep/wakefulness.
Researchers found proton therapy to have excellent early tolerance with minimal urinary and rectal toxicity. The study showed a low rate of Grade 3 genitourinary and gastrointestinal side effects, with the most common being minor rectal bleeding.
A phase III study found that short-term hormone therapy added to radiation treatment significantly increases survival in medium-risk prostate cancer patients by 51% compared to those receiving radiation alone. In contrast, low-risk patients showed no significant benefit from this combination.
Researchers have identified a molecular mechanism underlying DES-induced male infertility in mice, which may be linked to increased incidence of human reproductive disorders. The study found that neonatal exposure to DES disrupts the protein NR0B2, leading to reduced fertility and protected males against negative effects.
A phase III study found that short-term hormone therapy given prior to and during intermediate dose radiation treatment significantly increases the chance of living longer (51 percent) compared to those who receive radiation alone. The benefit appeared to be greatest for men at medium-risk for disease failure.
The American College of Physicians recommends initiating therapy with a PDE-5 inhibitor in men with ED unless there's a contraindication. Treatment with PDE-5 inhibitors results in statistically significant improvements in sexual intercourse and erectile function, regardless of cause or baseline severity.
Researchers from Boston University School of Medicine recommend that women on hormone therapy continue their treatment before annual mammogram screenings. The increase in breast density due to hormone therapy is unlikely to mask early cancer detection, making it unnecessary to stop treatment prior to screening.
Research identifies women who entered menopause recently may be at higher risk of joint pain caused by breast cancer drugs. Electro-acupuncture proves helpful for alleviating symptoms, improving fatigue and anxiety.
A new study found that hormone therapy for prostate cancer increases the risk of developing heart problems, including coronary heart disease and heart attacks. The study suggests that doctors should consider heart-related side effects when prescribing endocrine therapy and refer patients to a cardiologist before starting treatment.
A large study on adjuvant endocrine treatment for postmenopausal, hormone-positive breast cancer found that patients who continued to take exemestane or tamoxifen had significantly better outcomes than those who stopped taking the medication. Non-compliance was higher in countries with less stringent guidelines.
A large trial found that hormone replacement therapy (HRT) increases the risk of death from lung cancer, especially non-small-cell lung cancer. Women taking HRT were 71% more likely to die from lung cancer than those on placebo, with higher risks also seen in current and long-term past smokers.
New research from Purdue University raises concerns about estrogen supplements claiming to improve bone health in postmenopausal women. While some plant-derived isoflavones show modest effects, many supplements lack efficacy or are less effective than current treatments for osteoporosis.
A new molecule has been discovered that can treat type 2 diabetes and reduce weight gain by activating the protein TGR5. The study found that INT-777, a selective TGR5 activator, increases GLP-1 secretion and energy expenditure, leading to improved blood sugar control and weight loss.
Research by Christopher Li and colleagues found a more than four-fold increased risk of ER-negative second cancers among breast cancer survivors taking long-term tamoxifen. The study confirms earlier findings suggesting a link between tamoxifen use and increased risk of aggressive second breast cancer.
Men with coronary artery disease-induced congestive heart failure or heart attack who receive hormone therapy before or along with radiation therapy for prostate cancer have a higher risk of death, according to a study. However, in men without comorbidities, hormone therapy was not associated with an increased risk of all-cause mortality.
The PLOS Medicine journal has made all 1500 ghostwriting documents publicly available, revealing a coordinated campaign by Wyeth and medical writing companies to promote hormone drugs. The editors call for action to eradicate ghost-writing, including retraction of papers and investigation by academic institutions.
A recent study found that low-dose estrogen treatment can stop disease progression in patients with metastatic breast cancer, with 87% of those without PET flare reactions showing no response. The treatment was also well-tolerated, with fewer severe side effects compared to high doses.
A two-week course of erythropoietin injections has shown promising results in preventing brain damage in oxygen-deprived newborns. The treatment, which can be started up to two days after birth, improves the prognosis and reduces side effects compared to cooling.
A new study found that denosumab significantly increased bone density at all monitored sites and reduced new vertebral fractures by 62% in men receiving androgen-deprivation therapy for prostate cancer. The treatment also showed improvements in bone density at the radius, one of the bones in the forearm.