Articles tagged with Hormone Therapy
A new analysis suggests that the decline in breast cancer incidence between 2002 and 2003 was largely due to the reduction of hormone replacement therapy (HRT) use. The study found a 7% relative decline in breast cancer cases, with an absolute decline of about 14,000 fewer women diagnosed in 2003 compared to 2002.
A new study from the University of Michigan Health System suggests that hormone therapy may help retain certain memory functions in postmenopausal women. The research found increased brain activity in the prefrontal cortex of participants taking combined estrogen-progestin hormone therapy, compared to those on placebo.
A study found that testosterone replacement therapy had little effect on prostate tissue, contrary to previous concerns. The treatment increased serum testosterone levels but showed no significant changes in prostate histology or cancer incidence.
A study of healthy women has found that stress-related cortisol administration can reduce fatigue and increase vigor. The research may help fine-tune treatments for illnesses linked to low cortisol levels, such as chronic fatigue syndrome and post-traumatic stress disorder.
Researchers developed an immunological purification method to detect synacthen in low concentrations, providing a gap-closing solution for drug testing authorities. This new test confirms the presence of the protein and produces a unique chemical fingerprint.
Researchers developed a potential vaccine targeting HER-2/neu overexpression in early stage breast cancer, yielding promising results for women at high-risk. The study found that nearly all patients exhibited an immune response and many developed protein antibodies to fight the cells.
A new study suggests that a rapidly rising PSA level before treatment is a key indicator of cancer spread in men with clinically localized prostate cancer. The study found that men with a high PSA velocity (PSAV) are at greater risk of metastatic disease and should receive hormone therapy in addition to radiation.
A new classification system, called the Phoenix definition, provides a better evaluation method for predicting patient outcomes in recurrent prostate cancer. The study demonstrates significant improvement in predicting endpoints such as distant metastasis and overall mortality.
Researchers developed a formula that takes into account various risk factors, including age, cancer size and grade, and treatment options. The new computer tool helps doctors evaluate the potential benefit of additional radiation therapy for patients with early stage breast cancer.
The study found that men with aggressive locally advanced prostate cancer who received additional hormones lived longer, with a 31.9% increase in survival compared to those without further hormone therapy. The benefits also extended to men with less aggressive cancers, with improved disease-free and disease-specific survival rates.
A study found that longer-term hormone therapy does not extend survival for high-risk prostate cancer patients. Instead, it may lead to a lesser degree of treatment side effects and improved quality of life.
A new study by Joslin Diabetes Center has shown that with proper training and follow-up, over 80% of children and teens can successfully use insulin pumps to manage type 1 diabetes. The study identified key risk factors for failure, including infrequent blood glucose monitoring and high rates of severe hypoglycemia.
A study found that women with premenopausal breast cancer and 4+ positive lymph nodes may experience improved 10-year cancer-free survival with aromatase inhibitors. However, patients over 60 years old or those with advanced age, comorbidities, or fewer positive lymph nodes may not benefit from additional therapy.
A study by Oregon Health & Science University found that women on hormone therapy are more sensitive to negative events and can process emotions similarly to younger women. However, hormone therapy does not improve memory for negative events, suggesting that the brain's arousal system is modified with age.
A recent European survey of post-menopausal women with early breast cancer found that information needs are not being met, leading to low levels of patient involvement in treatment decisions. The survey revealed significant knowledge divides among patients, particularly older women and those with lower education levels.
A mathematic formula has been developed to predict a woman's risk of osteoporotic fracture, accurately identifying 75% of fractures two years after initial measurements were taken. The equation takes into account various risk factors beyond bone mineral density, allowing physicians to tailor treatment strategies to prevent fractures.
Researchers found that third-generation aromatase inhibitors increased the survival time for patients with advanced breast cancer. The meta-analysis suggests that these inhibitors should be used as an initial therapy for these patients.
A large prospective cohort study found that extremely high levels of lipoprotein(a) in women are associated with an increased risk for cardiovascular events, particularly those with high LDL-C levels. The study included over 27,000 initially healthy women and followed them for 10 years.
A recent study by researchers at UCLA and the University of Oslo suggests that breast discomfort during hormone therapy may be an early warning sign for breast cancer. The findings indicate that women experiencing breast pain or tenderness while on hormone replacement therapy should consult their healthcare provider promptly.
Prostate cancer cells resist hormone treatment by activating three survival strategies involving the protein BAD. The discovery may lead to new treatments or ways to monitor treatment's intended effect, such as developing a drug to prevent BAD inhibition.
A review of 70 studies found insufficient evidence to support complementary and alternative therapies for menopause-related symptoms. The studies showed mixed results, with some individual treatments suggesting benefits but overall quality and quantity of data was not sufficient to recommend any treatment.
Women taking estrogen and testosterone therapy may have a higher risk of developing breast cancer compared to those not using hormone therapy. The study found that women on long-term use of estrogen plus testosterone had a 77% increased risk of breast cancer.
A study of elderly male twins found that eating fish frequently may decrease the risk of age-related macular degeneration, while smoking nearly doubles the risk. The benefits were most apparent among individuals who consumed two or more servings of fish per week.
A new study published in European Journal of Nutrition found that soy germ isoflavones supplementation decreased bone loss in postmenopausal women. The study used SoyLife&Reg; EXTRA and showed a dose-dependent effect on reducing bone loss in non-obese women.
Researchers are testing a new drug combination that targets male-specific hormone levels to slow the progression of male breast cancer. The treatment, which involves anastrozole and goserelin, aims to lower overall estrogen levels in men, limiting breast tumor growth.
A new study has found that gabapentin is as effective as estrogen in reducing hot flashes in postmenopausal women. The medication was tested against estrogen and a placebo in a randomized, double-blind trial over 12 weeks, with significant reductions in symptom severity reported.
A study at UCLA found that pomegranate juice can increase doubling times of PSA levels in men with prostate cancer, allowing for delayed use of hormone therapy. The study involved 50 men who experienced increases in PSA levels after surgery or radiation.
A study found that cognitive behavioural therapy can restore ovulation in infertile women by reducing cortisol levels and improving the hypothalamic-pituitary-thyroid axis. The therapy was effective in reversing stress-induced ovulation, offering a cost-effective and safe alternative to hormonal treatments.
A study by Vahakn B. Shahinian and colleagues found that urologist input significantly influences the use of hormone therapy for prostate cancer patients, with up to 21% of variance attributed to their decisions. This suggests that urologists can be targeted for interventions to modify treatment recommendations.
A new study suggests that cortisol levels alone may not be as useful for predicting the ability to quit smoking as the ratio of DHEA to cortisol. Research also found that oxytocin deficiency contributes to sweet tooth cravings, but not fatty snack preferences.
The accelerated decline in fertility over the past 2.8 million years is an evolutionary adaptation that helped humans survive. However, this shift has created challenges for modern society, particularly in regards to teenage pregnancy, delayed childbearing, and hormone replacement therapy.
A Stanford survey of 781 US women aged 40-60 found that nearly all reported experiencing menopausal symptoms, with many turning to herbal products and soy supplements instead of hormone therapy. Despite risks associated with hormone therapy, the study highlights the need for physicians to learn more about alternative therapies.
A study comparing Japanese American and white male patients who received hormone treatment for prostate cancer found that the former had a significantly higher five-year overall survival rate of 66% compared to 42%. The result was not affected by cancer stage or PSA levels, suggesting genetic and lifestyle factors may play a role.
Researchers have developed a new treatment protocol combining radionuclide therapy and chemotherapy that induces regression of prostate cancer in patients with metastatic disease. The combination regimen has been shown to alleviate bone pain and produce clinical benefit, including prolonged survival and reduced PSA levels.
Early breast cancer patients switching from tamoxifen to Aromasin experience a 17% lower chance of dying and a 25% lower risk of breast cancer recurrence. The study's findings also suggest long-term safety benefits, with no clinically meaningful changes in the side effect profile.
Research suggests strontium ranelate strengthens bone architecture for at least five years, reducing fracture risk. Bisphosphonates remain effective for extended periods, but may pose risks to young patients with osteoporosis.
A new clinical trial called TAILORx aims to determine whether chemotherapy is necessary for women with early-stage breast cancer. The study will use OncotypeDXTM, a genetic test that estimates a patient's risk of recurrence and predicts treatment outcomes.
Researchers found 322 genes in the adrenal gland with rhythmic functions, separate from the master body clock. This discovery may impact therapies for diseases and improve treatment outcomes.
A recent study conducted by the UCLA School of Medicine found that testosterone replacement therapy does not negatively affect the prostate or its tissues in hypogonadal men. The six-month trial involved 41 men with low testosterone levels and showed no changes in prostate tissue, PSA, or DHT levels.
A study of 403 premenopausal women with estrogen receptor-positive breast cancer found that increased Pak1 expression correlates with reduced sensitivity to tamoxifen therapy, leading to decreased survival rates. Researchers suggest targeting Pak1 as a potential strategy to improve treatment response in breast cancer.
A study of postmenopausal women found that those taking estrogen for more than 20 years had a significantly increased risk of developing estrogen receptor-positive and progesterone receptor-positive breast cancers. The risk was strongest in those who used estrogen for longer periods.
Research found that selective serotonin reuptake inhibitors (SSRIs) and clonidine may provide some evidence of efficacy for reducing menopausal hot flashes. However, the effectiveness of these therapies is less than estrogen therapy and may be limited by adverse effects and cost.
Researchers have found that hormonal male contraception can be fully reversible in just a few months, with all men regaining fertility. The study, which analyzed data from over 1,500 men, showed that sperm production can be fully inhibited by hormone treatment combinations, allowing for reliable contraception.
A study of over 39,000 women found that hormone therapy reduced the risk of heart attacks by 32% for those starting treatment in their 50s. However, the risk increased in older women within the first year of treatment before it decreased after two years.
A new study finds that estrogen-only therapy does not increase the risk of breast cancer in postmenopausal women, contradicting previous findings. In contrast, hormone therapy combining estrogen and progestin was linked to a 26% higher risk of breast cancer.
Researchers found that chemotherapy improvements reduced recurrence risk by 21-55% in ER-negative tumors, while 9-26% in ER-positive tumors. This suggests that newer chemotherapies offer substantial benefits for patients with ER-negative disease.
Women taking estrogen had fewer breast cancer tumors, but the difference was not statistically significant. Participants also underwent more mammograms and biopsies, which may be related to changes in breast tissue.
A study analyzing data from the Women's Health Initiative found that postmenopausal hormone therapy may increase the risk of developing venous thromboembolism, particularly in women with higher physical activity levels and lower HDL cholesterol. The risk was significantly increased for deep vein thrombosis, but not for pulmonary embolism.
A new study from UNC Health Care suggests that loss of function in the SOCS2 gene may lead to colon polyps in individuals with excessive growth hormone. The research also identifies a possible molecular marker for predicting risk, which could inform growth hormone therapy for gastrointestinal conditions.
Researchers found a higher risk of developing lobular and tubular breast cancer in women taking HRT, with combined HRT increasing the risk even more. No increase in ductal breast cancer risk was observed, and some cancers were more hormone-receptive than others.
A recent study published by the Mayo Clinic found that MPA was more effective than venlafaxine in reducing hot flashes by 79% versus 55%. The single dose of MPA showed long-lasting benefits, with many patients still experiencing a 90% reduction in symptoms after six months.
Researchers found that a common osteoporosis treatment helped men with prostate cancer recover significant bone mass after two years of androgen deprivation therapy. The study suggests that bone density tests should be encouraged for men at risk, and bone-preserving therapy could prevent debilitating fractures.
Researchers found that administration of a bisphosphonate called zoledronic acid every three months significantly increased bone density in men with advanced prostate cancer. The study supports guidelines for monitoring bone density and initiating treatment to prevent fractures.
A new study found that androgen deprivation therapy is ineffective in preventing the spread of localized prostate cancer, despite its increasing use among men with non-spreading disease. Researchers suggest that men may endure significant side effects for uncertain benefits.
The study found a small but significant increase in hip bone density among women taking calcium combined with vitamin D. However, the supplements had no detectable effect on colorectal cancer incidence or spine fractures.
A large clinical trial found that estrogen therapy did not significantly reduce the risk of coronary heart disease in postmenopausal women. However, there was a suggestion of lower risk in women aged 50-59 years, and fewer cases of revascularization and combined endpoints were reported among those taking estrogen.
A new study from UCSD found that macrophage signaling can activate processes in both cancer cells and immune cells, altering the activity of androgen antagonists and allowing tumor growth. The research identifies a novel binding site on steroid receptors that makes them responsive to inflammatory signals.
A study of 93 critically ill patients found that hydrocortisone supplementation improved ventilator weaning success rates, especially in those with renal insufficiency. The treatment reduced mortality and morbidity in mechanically ventilated patients with adrenal insufficiency.
A new study reveals that high fitness levels can enhance the effects of short-term hormone treatment and offset declines associated with long-term use. Researchers analyzed brain tissue volume in 54 postmenopausal women and found a significant association between higher fitness levels and greater tissue volume in key areas.
Belgian and Italian researchers developed a new imaging technique that can predict breast cancer patients' response to hormonal treatment with high accuracy. The technique uses 99mTc-depreotide scintigraphy to assess hormone sensitivity in tumors, allowing for early selection of patients likely to benefit from hormonal therapy.