Articles tagged with Hormone Therapy
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
EpiVax receives $351,000 from JDRF to develop Epi-13, a novel therapeutic that reduces harmful immune responses and preserves insulin production. The approach uses natural regulatory T cells to induce antigen-specific adaptive tolerance induction.
A Swiss study suggests that surgery is the most effective treatment option for long-term prostate cancer survival, particularly among younger patients and those with poorly differentiated tumors. The study found higher 10-year survival rates for men who underwent prostatectomy compared to radiotherapy or watchful waiting.
A study led by Pauline Maki found that hormone therapy increased sexual interest and reduced hot flashes in younger mid-life women, but did not improve memory performance. The therapy combination of estrogen and progesterone showed a 32% increase in sexual thoughts and a 44% increase in sexual interest compared to the placebo group.
A study published by the American Academy of Neurology found that hormone therapy taken in early post-menopause has no effect on women's memory, but may lead to increased sexual interest. The research involved 180 women who underwent tests on cognitive function, emotional status, and sleep.
Researchers found that hair follicles on the head have the potential to become erythropoietin factories, potentially treating EPO-related anemia. This discovery opens doors to a new approach for treating severe anemia associated with kidney failure and chemotherapy.
Only 29% of women surveyed knew about the landmark hormone therapy study two years after its announcement, highlighting a flawed mechanism for communicating crucial health information to patients. The study found that discussions with physicians were key to retaining this knowledge, but many women reported never having such conversations.
Scientists at the University of Sheffield have developed a long-acting growth hormone that can promote growth over ten days with just one injection. This technology could reduce the need for frequent injections in children and adults with growth hormone disorders.
The study found that women who had both ovaries removed but were treated with estrogen until age 50 did not have an increased risk of cognitive impairment or dementia. Women who had one or both ovaries removed before menopause faced a higher long-term risk of cognitive impairment or dementia compared to those who retained their ovaries.
A pilot study by Mayo Clinic researchers found that flaxseed therapy decreased hot flashes in postmenopausal women by 50% and improved their quality of life. The study also showed improvements in mood, joint pain, and overall health.
A recent decline in breast cancer incidence is attributed to a drop in postmenopausal hormone therapy use. This finding contradicts the assumption that decreased mammography screening is responsible for the decline.
Scientists at Georgetown University Medical Center have discovered a new gene, XBP1, that contributes to Tamoxifen resistance in breast cancer cells. This finding may enable oncologists to screen women for responsiveness to these treatments and provide a clue for reversing resistance.
Researchers at Thomas Jefferson University found that colon cancer is caused by a lack of hormones that regulate intestinal epithelial cells. Hormone replacement therapy may prevent or treat the disease, shifting the focus from genetic to endocrine aspects.
A recent study found a significant decline in breast cancer incidence in 2003, coinciding with a drop in hormone therapy use. Breast density and sex hormone levels are also independent risk factors for breast cancer in postmenopausal women.
A new study published in CANCER journal found that group therapy does not prolong the lives of women with metastatic breast cancer. However, women with estrogen receptor-negative tumors showed a survival benefit from group therapy.
A meta-analysis of 29 studies found that incretin-based therapy improves glycemia, particularly postprandial glycemia, and has a favorable or neutral effect on weight. However, glucagon-like peptide 1 analogues are associated with gastrointestinal adverse effects, while DPP4 inhibitors have an increased risk of infection.
A pilot study found that gonadotropin-releasing hormone antagonists can suppress ovarian function in women receiving chemotherapy, protecting their fertility. The treatment was well-tolerated with minimal side effects and restored ovarian function after chemotherapy stopped.
A new algorithm for personalized ovarian stimulation therapy has been developed, demonstrating improved pregnancy rates in women undergoing fertility treatment. The formula, based on four easily measured patient characteristics, was tested in a prospective clinical study involving 161 patients.
A new study conducted at Mount Sinai School of Medicine found that cyclical estrogen injections protected brain cells from age-related deterioration. The research suggests that a critical window of opportunity exists in which estrogen therapy may be helpful in preventing memory loss, and that timing is crucial.
A follow-up study shows that estrogen use is associated with lower levels of calcified plaque in coronary arteries, a potential indicator of heart disease. However, other health risks, such as increased risk of blood clots and stroke, must still be considered before starting estrogen therapy.
New data from the Women's Health Initiative study show that women aged 50-59 taking oral estrogen therapy have significantly less coronary artery calcification compared to those taking placebo. This finding supports the initiation of estrogen therapy in these younger menopausal women to reduce bone loss and alleviate symptoms.
A substudy of the Women's Health Initiative found that younger postmenopausal women on estrogen-alone hormone therapy had 30-40% less coronary artery calcium than those without hormone therapy. However, the benefits of estrogen for preventing cardiovascular disease are uncertain and should not be used as a preventive measure.
The recent WHI-CACS study confirms estrogen therapy is cardioprotective, reducing atherosclerosis and coronary events. Early initiation of hormone therapy may even reduce the risk of coronary artery disease.
Researchers at the University of Edinburgh have shown that hormone therapy can prolong the life of some ovarian cancer patients by up to three years. The study found that targeted use of an anti-oestrogen drug could slow the growth and spread of disease in highly sensitive cancers.
Researchers at Mayo Clinic have discovered that low doses of gabapentin substantially reduce hot flashes in patients undergoing anti-hormonal treatment for prostate cancer. The study found that gabapentin reduced the frequency and intensity of hot flashes by up to 46% in men receiving androgen deprivation therapy.
A recent survey found that three-quarters of women with breast cancer were not informed about their risk of recurrence, despite 96% relying on their healthcare provider for information. The study highlights the need for better communication between healthcare professionals and patients to ensure they receive life-saving information.
Researchers found that COX inhibitors like traditional nonsteroidal anti-inflammatory drugs (NSAIDs) may counteract the potential heart-protective effects of estrogen therapy. Women who used NSAIDs with hormone replacement therapy had a lost protective effect against heart attack and stroke.
Researchers are investigating the best time to start hormone therapy, its impact on cognition and mood, and the most beneficial form of estrogen. The $3.4 million KEEPS study aims to clarify the safety and effectiveness of hormone therapy in perimenopausal women.
Researchers found that traditional nonsteroidal anti-inflammatory drugs (NSAIDs) may counteract the heart-protective effect of hormone replacement therapy in women. Current use of hormone replacement therapy was associated with a significantly lower risk of heart attack than non-use, but NSAID use negated this benefit.
A meta-analysis of 16 trials found LHRH agonists effective in reducing breast cancer recurrence by nearly 13% and death after recurrence by 15%. The treatment was only beneficial for premenopausal women with hormone-sensitive breast cancer under 40.
The International Menopause Society has updated its recommendations on hormone therapy for postmenopausal women, highlighting the importance of individualized treatment and a balanced approach. The new guidelines take into account the latest scientific evidence and aim to provide a global framework for menopause management.
Researchers found that a lifestyle change intervention significantly decreased weight, cholesterol, and LDL-C in women who discontinued hormone replacement therapy. This non-pharmacological approach is safe and effective for reducing CVD risk factors in postmenopausal women.
A small pilot study suggests that testosterone treatment is safe and well-tolerated and may reduce symptoms, slow brain degeneration, and increase muscle mass in men with relapsing-remitting multiple sclerosis. Testosterone treatment showed a possible neuroprotective effect on the brain.
The AGA Institute's Obesity Task Force Report highlights the need for a comprehensive approach to addressing obesity, considering its impact on healthcare budgets and societal practices. The report emphasizes the role of gastroenterology in treating obesity, with novel therapies and policies being developed.
A pilot study at UCLA found that testosterone gel reduced MS symptoms, slowed brain degeneration, and increased muscle mass in men with relapsing-remitting multiple sclerosis. The study suggests a possible neuroprotective effect of testosterone treatment in men with MS.
Researchers at the University of North Carolina Health Care identified protein Ack1 as a trigger for advanced prostate cancer recurrence in men undergoing hormone treatment. This finding may lead to the development of targeted therapies against this protein.
Research presented at the American Academy of Neurology's meeting found that women using estrogen hormone therapy before age 65 had a nearly 50% lower risk of developing Alzheimer's disease or dementia. The study followed over 7,000 healthy women aged 65-79 for an average of five years.
A randomized clinical trial found that topical testosterone cream did not improve libido in postmenopausal female cancer survivors compared to a placebo. The study suggests that estrogen levels may be a crucial factor in the effectiveness of testosterone therapy for sexual desire in women.
A sharp decline in breast cancer cases in 2003 may be linked to a decrease in hormone replacement therapy (HRT) use, with prescriptions dropping by 60% between 2001 and 2004. HRT use was associated with an increased risk of breast cancer, particularly among postmenopausal women.
A sharp decline in breast-cancer incidence in 2003, followed by relative stabilization, is attributed to the drop in hormone-replacement therapy among postmenopausal women. Researchers estimate a 44,000 fewer breast cancers over two years, with the reduction most evident in estrogen-receptor-positive tumors.
Researchers found a strong association between HRT use and decreased breast cancer incidence, with a 6.7% decline between 2002 and 2003. The lowest rate seen since about 1987 was maintained in 2004, primarily in estrogen-receptor-positive cancers.
Researchers found females outperform males in using landmarks for navigation, even with blocked testosterone levels. This study provides insight into brain development and may lead to better treatments for disorders like ADHD and Alzheimer's.
A study of 372 men with prostate cancer found that 49% had osteoporosis, with those receiving hormone therapy and having undergone radical prostatectomy being at highest risk. The authors suggest that daily calcium intake could be used as a prognostic factor for osteoporosis in these patients.
Research suggests that women initiating hormone therapy closer to menopause may have a reduced risk of coronary heart disease, but this effect was not statistically significant. The study found no increased risk of stroke in younger women or those with fewer years since menopause.
Secondary analyses suggest that hormone therapy may have less risk of coronary heart disease (CHD) for women starting treatment close to menopause, while increasing risk is seen in older or farther-from-menopause women. Hormone therapy also increases stroke risk and breast cancer risk, even in younger women.
A study on rheumatoid arthritis found that flexible use of drugs with close patient follow-up can effectively control the disease. Additionally, a trial on men with prostate cancer showed that an osteoporosis drug strengthens bones and reduces bone loss.
Postmenopausal women with minor or major ECG abnormalities are at increased risk for future cardiovascular events and death. The presence of these abnormalities should prompt physicians to consider further risk stratification and more intensive therapeutic interventions.
A new study found that androgen deprivation therapy for prostate cancer may increase the risk of death from heart disease in patients over age 65. After adjusting for other cardiovascular risk factors, researchers found a significant link between ADT use and cardiac-related deaths among older men.
A new study reveals that breast cancer patients taking tamoxifen who switch to an aromatase inhibitor within three years experience significant improvements in survival rates. The treatment demonstrates a clear survival benefit without an increased risk of death from other causes.
The NHLBI has awarded 12 new contracts to the Women's Health Initiative (WHI) to investigate genetic and biological markers of common diseases in postmenopausal women. The studies will help explain hormone therapy findings and explore associations between physical activity, obesity, and inflammation with cardiovascular disease risk.
A Stanford study systematically reviewed medical literature on growth hormone therapy for the elderly, concluding that it has minimal to no benefit and potential adverse side effects. The research found modest effects on body composition but no impact on clinically important outcomes such as bone density or cholesterol levels.
Researchers have developed a new breed of transgenic mice with autoimmune responses similar to human RA patients, revealing a significant sex bias. The study found that female mice developed arthritis at a higher rate than male mice, exhibiting all disease hallmarks at higher levels.
Researchers at USC discovered a link between low testosterone and the development of an Alzheimer's-like disease in mice. Testosterone treatment slowed progression of the disease, predicting potential benefits for humans.
The study found that herbal supplements including black cohosh did not reduce menopausal symptoms. In contrast, hormone therapy significantly reduced symptoms in postmenopausal women, highlighting the importance of well-designed research to evaluate complementary and alternative medicine approaches.
A study on black cohosh found no significant benefit in reducing hot flashes and night sweats during menopause, contradicting its long-held status as a treatment option. In contrast, enzyme replacement therapy for Fabry disease slowed progression of complications, but high costs remain a concern.
A federally funded study found that black cohosh was no better than a dummy pill in reducing hot flashes and night sweats in women with menopause. Symptoms declined by about 30 percent over 12 months, regardless of treatment.
A study by Group Health researchers found that black cohosh did not relieve hot flashes among women going through menopause. In contrast, hormone therapy significantly reduced the frequency of hot flashes. The researchers concluded that herbal supplements like black cohosh have little potential as an alternative to hormone therapy.
A new study demonstrates the effectiveness of Pfizer's Aromasin for early breast cancer treatment, with improved relapse-free survival and disease-free survival rates. The B-33 trial found that Aromasin was well-tolerated and showed a significant improvement in patients who received it after five years of tamoxifen.
A new analysis suggests that the decline in breast cancer incidence between 2002 and 2003 was largely due to the reduction of hormone replacement therapy (HRT) use. The study found a 7% relative decline in breast cancer cases, with an absolute decline of about 14,000 fewer women diagnosed in 2003 compared to 2002.
A new study from the University of Michigan Health System suggests that hormone therapy may help retain certain memory functions in postmenopausal women. The research found increased brain activity in the prefrontal cortex of participants taking combined estrogen-progestin hormone therapy, compared to those on placebo.
A study found that testosterone replacement therapy had little effect on prostate tissue, contrary to previous concerns. The treatment increased serum testosterone levels but showed no significant changes in prostate histology or cancer incidence.