Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
A new study by American Society of Nephrology confirms that intensive insulin therapy (IIT) protects kidneys in critically ill patients, reducing the risk of acute kidney injury (AKI) and death. IIT was found to be more effective in preventing AKI after surgery compared to medical ICU patients.
Researchers at Cleveland Clinic Lerner College of Medicine developed an AMD animal model using oxidative chemicals, which closely represents the disease in people. This breakthrough could lead to better treatments and potentially a cure for age-related macular degeneration, affecting millions of Americans.
A new study found that deep brain stimulation (DBS) of the hypothalamus can evoke detailed autobiographical memories in a patient with morbid obesity. After three weeks of continuous stimulation, the patient showed significant improvements in learning tests and was more likely to remember unrelated objects.
Cutaneous leishmaniasis is a non-lethal but potentially severe disease that can be prevented with rapid and accurate diagnosis and treatment. New techniques, such as the QT-NASBA technique and real-time Reverse Transcriptase PCR, have been developed to detect and quantify Leishmania parasites, leading to improved treatment outcomes.
A study found that individuals with fewer years of education are more likely to have a delayed realization of cognitive problems that could be Alzheimer's disease. Patients with lower education levels were also more severely impaired on their first visit, suggesting they may only seek medical attention after symptoms become unbearable.
A new classification system of 15 lip zones can help cosmetic surgeons better control lip shape and size, leading to high patient satisfaction and no adverse effects. The study involved 137 treatments on 66 patients and found an average score of 4.5 for patient satisfaction.
A recent study found that 60% of psychotherapy clients felt their therapy either lasted too long or ended too soon. Clients who experienced a positive termination were more satisfied and reported feeling an expression of independence, reflection of positive therapeutic gains, and a sense of positive gains.
A new study found that levo-thyroxine treatment did not lower weight or BMI in children with acquired hypothyroidism. Most subjects gained weight, while about a third experienced short-term weight loss due to extremely severe cases of the disease.
A review published in Dermatologic Therapy reveals that men need higher doses of Botox due to greater muscle mass, leading to inadequate results from under-dosing. The study suggests that larger, stronger men require more units per treatment area than slender, small-boned men.
A nationwide collaborative study found that emergency department patients who underwent alcohol screening and brief intervention reported lower rates of risky drinking than those who received only written information. The study enrolled over 7,751 patients and showed that more than one-fourth exceeded low-risk drinking limits.
A NIH panel emphasizes the importance of removing stigma associated with fecal and urinary incontinence, recommending increased public awareness and provider education. The panel also highlights the need for research studies to fill knowledge gaps and develop effective prevention and treatment strategies.
A new study published in BMC Medicine suggests that patients with chronic patellofemoral syndrome may not benefit from arthroscopic surgery, instead finding relief through therapeutic exercise. The randomized controlled trial compared the efficacy of arthroscopy and exercise in reducing knee pain and improving mobility.
A recent Editorial highlights the growing concern of traumatic brain injury (TBI) in soldiers returning from Afghanistan and Iraq. The condition affects an estimated 60% of all combat-injured soldiers, with over half caused by explosive devices.
A systematic review of over 5,500 patients found that both single-drug antifungal prophylaxis (SAP) and selective digestive tract decontamination (SDD) reduce yeast-related morbidity and mortality. SDD was more effective in reducing yeast colonization and infection, while SAP responded best to candidemia.
Researchers discovered Giardia's attachment mechanism relies on an osmotic suction cup, which can be disrupted by 'tonic shock'. The parasite's grip on intestinal tissue can be broken using a timed pattern of high and low tonicity, suggesting new treatment options.
A study suggests that honey is more effective than over-the-counter cough medicines in relieving children's coughs and improving sleep during colds. Honey was found to yield the greatest improvement compared to no treatment or dextromethorphan, an over-the-counter medication commonly used for children's coughs.
Citrus growers in eastern Australia can now export to Japan with greater market flexibility thanks to the development of cold storage regimes effective against fruit fly. The new method kills Queensland Fruit Fly in citrus stored for 14-16 days at temperatures of 2° or 3°C, reducing damage and improving fruit quality.
A study of 60 people with lymphatic filariasis in southern Sri Lanka found that the disease causes significant loss of income, social isolation, and emotional distress due to stigma. The authors call for expanded control programs beyond transmission reduction to provide support for affected households.
American soldiers with facial fractures can now undergo surgery to repair their injuries in the war zone, avoiding evacuation. The procedure has shown no complications or infections, leading to improved patient outcomes.
This special issue of JRRD examines the clinical characteristics of military personnel with TBI and describes healthcare models providing care and support to them and their families. Topics include posttraumatic stress disorder, telemedicine systems, and neuropsychiatric perspectives on TBI.
A systematic review found that the risk of major stroke within a week after a minor stroke is substantial at 5.2%. Studies with emergency treatment in specialist stroke units showed the lowest risks, while population-based studies without urgent treatment had the highest risks.
A recent study published in the British Medical Journal found that adults insured through Mexico's Seguro Popular program are more likely to receive antihypertensive treatment and have their blood pressure controlled than those without health insurance. Insured individuals had a 50% higher odds of receiving antihypertensive treatment, ...
A statewide program in North Carolina significantly improved the rate of coronary reperfusion for heart attack patients, reducing median door-in to door-out times by up to 49 minutes. While clinical outcomes remained unchanged, the study demonstrates that coordination of care can improve quality of care.
Two new studies, led by the University of Michigan Stroke Program, reveal that 69% of stroke victims don't reach the hospital within three hours of symptom onset, resulting in delayed tPA treatment. A middle-school education program shows promising results in improving recognition and response to stroke symptoms.
The American Academy of Sleep Medicine has released practice parameters for the evaluation and treatment of circadian rhythm sleep disorders. The guidelines recommend various treatments, including melatonin administration, timed light exposure, and actigraphy, to improve alertness and performance in night shift workers.
Researchers found that injecting a dextrose solution under ultrasound guidance can reduce pain in patients with chronic Achilles tendinosis. After treatment, 20 of 30 patients remained asymptomatic, while nine had only mild symptoms.
Researchers at the University at Buffalo are investigating the effectiveness of mindfulness-based stress reduction (MBSR) in treating alcohol dependence. The four-year study aims to develop an increased ability to cope with stress and enhance psychological well-being among alcohol-dependent individuals.
A £1 million donation from The Vocational Training Charitable Trust (VTCT) will support groundbreaking research at Cardiff University's Centre for Burns Research. The VTCT Professor of Burn Injury Study will investigate the body's immunological response to burns to develop new treatments.
A study published in JCSM found that CPAP therapy significantly decreases symptoms of depression in OSA patients. Long-term follow-up assessments revealed sustained improvement in depressive symptoms after institution of CPAP therapy.
Researchers found that behavioral skills maintenance and social facilitation interventions improved weight loss maintenance in childhood overweight population, with some evidence for sustained long-term efficacy among more socially adept children. The studies demonstrated the importance of continued treatment contact to improve weight ...
Medical identity theft can lead to erroneous entries in existing records, causing long-lasting harm to victims' medical and financial lives. Experts emphasize the importance of protecting patient information and privacy, as current protections for medical identify theft are lacking.
Scientists have developed a mouse model of age-related macular degeneration to study the disease's progression and develop potential treatments. The model, caused by a mutation known to produce AMD in people, will help researchers understand the biochemical details of how AMD occurs.
Research in Medical Decision Making explores how patients select optimal treatments by weighing factors such as health outcomes, side effects, and cost. New approaches and best practices for assessing and conveying risk information are also discussed to improve decision-making processes.
Researchers found that only 35% of eligible patients had an implantable cardioverter defibrillator (ICD) installed or planned. Women and minorities are less likely to receive ICDs than white men, highlighting a need for improved treatment options.
Researchers found that corrective lenses can successfully treat bilateral amblyopia in children when diagnosed and treated early. The study showed significant improvement in visual acuity after one year, with most children reaching 20/25 or better.
Infection with West Nile Virus increases plasma and spinal fluid MIF levels, improving survival in mice; delayed viral neuroinvasion allows clearance of the virus.
Researchers found that treating OSA patients with CPAP significantly decreases atherosclerosis markers in just months. This study links OSA directly to artery hardening, providing new evidence for the causal connection between OSA and cardiovascular events.
Researchers at Texas A&M University are developing an aloe vera-based nosespray vaccine that has shown promising results in animal trials. The vaccine uses a gel-like substance to cling to the inside of the nose, allowing it to stay longer and work more effectively than traditional liquid sprays.
A recent study found that a simple and cost-effective percutaneous method can effectively treat calcific tendinitis by reducing inflammation and promoting tendon healing. The treatment resulted in improved shoulder mobility and resolution of calcifications in over 90% of patients.
A study found that skin cooling during laser treatment increased the risk of hyperpigmentation in dark-skinned individuals. The cooled sides were three times more likely to become hyperpigmented than the uncooled sides, according to a report published in Archives of Dermatology.
A recent study published in The Lancet found that urbanization significantly increases the risk of major depressive disorder among elderly Nigerians. The study also highlights a significant gap in treatment for this condition, with only 37% of lifetime cases receiving any form of treatment.
A recent study published in The Lancet has found that oral dabigatran etexilate is as effective as enoxaparin in reducing the risk of venous thromboembolism (VTE) after total hip replacement surgery. The study involved 3494 patients and found no significant difference in major bleeding rates between the two treatments.
A new peanut butter-based program has shown remarkable success in treating severe malnutrition in children in Malawi, with 89% of severely malnourished children and 85% of moderately malnourished children recovering after treatment. The treatment, known as Ready-to-Use Therapeutic Food (RUTF), was implemented at 12 rural health centers...
A recent study published in The Lancet found that unmet mental health treatment needs vary widely between countries, with lower proportions of respondents using services in developing countries. The study suggests that addressing these gaps will require expanded treatment resources and targeted interventions.
A University of Iowa professor has identified a new eating disorder called purging disorder, which is characterized by women eating normal or small amounts of food and then purging. The disorder differs from bulimia nervosa in terms of the amount of food consumed and the compensation methods used.
A global shortage of mental health resources has severe consequences, including inadequate care for those who need it. The authors emphasize the need for increased investment in mental health to address these obstacles.
A study published in Archives of General Psychiatry found that family-based treatment was more effective than supportive psychotherapy in reducing binge eating and purging behaviors in adolescents with bulimia. The treatment showed promising results, with 39% of patients achieving remission after treatment.
The Lancet Global Mental Health Group urges governments, agencies, and donors to scale up mental health services worldwide due to inadequate treatment rates. The cost is estimated at $2-$4 per person in low-income countries, a modest investment compared to other global disease burdens.
A study found that unconscious racial biases among doctors can lead to disparities in medical treatment, with doctors showing a preference for treating white patients over black patients. The bias is not based on conscious attitudes but rather on implicit stereotypes of cooperativeness by race.
Researchers found that less than a third of treatment guidelines are based on high-quality evidence, highlighting the need for transparent grading systems. The study concludes that clinicians should be aware of this limitation and apply guideline recommendations appropriately to individual patients.
A study of 468 multiple sclerosis patients found that early treatment with interferon beta-1b can prevent disabling condition development. Early treatment reduced the risk of confirmed disability and clinically definite multiple sclerosis by 41%.
Mayo Clinic physicians found that obese patients who received an obesity diagnosis were more likely to form a weight loss management plan than those without a diagnosis. The study highlights the importance of proactive discussion between physicians and patients about obesity, a risk factor for diabetes and cardiovascular diseases.
Two studies published in The New England Journal of Medicine found that progesterone treatment reduced the rate of preterm birth among women with short cervix. However, weekly injections of 17P did not show similar benefits for women carrying twins. Researchers hope to identify underlying causes of prematurity to improve progesterone t...
Researchers discovered a novel molecular pathway involved in bone healing and found that lithium can activate it, but only when treatment is given after the fracture occurs. The study showed accelerated bone healing in mice with activated '-catenin signaling pathway.
A new treatment protocol has shown increased survival in very young infants with acute lymphoblastic leukaemia. The hybrid regimen, which incorporates elements of acute myeloid leukaemia treatment, resulted in improved event-free survival rates.
A gene variant in the complement C3 gene has been found to more than double the risk of developing age-related macular degeneration, a leading cause of visual loss and blindness. The study, published in the New England Journal of Medicine, suggests that inflammation plays a key role in the disease process.
Researchers at Johns Hopkins University found that nasal insufflation using a nasal cannula significantly reduced symptoms in patients with obstructive sleep apnea and hypopnea. The treatment, known as TNI, delivered warm, humidified air at a high flow rate, showing marked improvements in patients with both mild and severe disorders.
The March of Dimes reports that nearly 90% of US babies are screened for life-threatening disorders, up from 38% in 2005. However, 500,000 babies remain uninsured, highlighting the need for federal guidelines and increased funding to support states' newborn screening programs.
A study by Dr. Jacky Boivin found that women using complementary therapies had a lower pregnancy success rate and were more negatively affected by their fertility problems than non-users. The researchers suggest that women may use complementary therapies for stress reduction, but further research is needed to determine its effectiveness.
A recent study by Cardiff University found that social stress and marital stress increase over time for men with male factor infertility, while mental health decreases. Despite the common misconception that men experience more emotional distress when infertile, the research shows that men in all four categories suffer equally.