Articles tagged with Colorectal Cancer
Researchers have discovered that nonsteroidal anti-inflammatory drugs (NSAIDs) block the IL-6 activation of STAT1, a protein that triggers malignant growth in colorectal cancer cells. The findings could lead to new treatments for the disease.
A study found that 75% of men aged 50 and older reported undergoing PSA testing, compared to 63% for colorectal cancer screening. The mismatch between screening rates highlights the need for better patient education on effective cancer tests.
A new study by Dartmouth researchers finds that more American men are screened for prostate cancer than for colorectal cancer, contradicting scientific evidence. The study, which analyzed data from over 50,000 men, reveals a significant disparity in screening rates between the two cancers.
Despite preferring virtual colonoscopy due to its less invasive nature, patients generally dislike the bowel preparation required for both tests. The study found that most patients reported little pain or difficulty with either procedure, but many expressed discomfort with the advance bowel preparation.
A major study shows that taking 325 milligrams of aspirin daily can reduce the risk of developing polyps in the colon by 35%, a significant step towards preventing colorectal cancer. The study involved over 100 medical centers and clinics across the US, with patients who had previously suffered from colorectal cancer.
A daily aspirin regimen was found to significantly reduce the occurrence of pre-cancerous polyps in patients with a history of colorectal cancer, lowering their risk by about one-third. Aspirin's protective effect also prevented the development of new adenomas and reduced the number of existing polyps.
Researchers at the University of Pittsburgh Cancer Institute are testing acupuncture's efficacy in alleviating symptom distress and promoting emotional well-being in terminally ill colorectal cancer patients. The four-year study will compare acupuncture, sham acupuncture, and usual care to determine its benefits.
Researchers at University of Pittsburgh Medical Center found that deleting the PUMA gene in colorectal cancer cells prevents cell death. The study builds on previous findings and suggests that increasing PUMA levels could lead to new cancer therapies.
Scientists at Thomas Jefferson University found that a bacterial toxin opens a cellular door, allowing calcium to flow into tumor cells, which slows cell division and may lead to new methods of treating colorectal cancer. The discovery could also enable the use of the toxin as an intravenous infusion to treat metastatic tumors.
A study found that colonoscopy perforation rates are twice as high as those of sigmoidoscopy. The risk of perforation from sigmoidoscopy was about half that of colonoscopy, with 5% of perforations resulting in death within 14 days.
Researchers have discovered that combining Avastin with chemotherapy provides superior treatment for advanced colorectal cancer, increasing median survival by 8.3 months and response rates. The study's findings suggest a more effective and less toxic option for patients with this devastating form of cancer.
The study analyzed data from the National Health Interview Survey (NHIS) between 1980 and 2001, revealing increases in cancer screening test usage since 1987. Key factors influencing screening use include age, sociodemographic status, healthcare source, and knowledge of cancer risk factors.
The SCORE trial shows that sigmoidoscopy screening can reduce colorectal cancer incidence and mortality, with a high yield of advanced lesions and early cancers. The procedure is relatively safe, with low rates of perforation and hemorrhage.
A recent study published in the Journal of the National Cancer Institute found that a high-fiber diet did not affect the recurrence rate of adenomatous polyps in participants. The researchers separated the participants into four groups based on their baseline fiber consumption and calculated the risk of polyp recurrence in each group.
The USC consortium has received a $15 million NCI grant to determine the causes of colon cancer. The registry, which now consists of over 8,000 families, will focus on genetic factors, gene-environment interactions, and launching prevention trials.
Screening for colorectal cancer is vital for early detection, with a significant reduction in mortality rates associated with early detection. Current techniques like colonoscopy are effective but expensive, prompting the need for alternative methods.
A new study found that genetic test results for HNPCC may motivate colonoscopy screening among those who test positive, increasing screening rates. The American Association for Cancer Research recommends more targeted training on screening recommendations for underserved communities.
Dr. Albert de la Chapelle, an Ohio State University scientist, has spent 40 years studying the complex relationship between genetic mutation and disease. He has made groundbreaking discoveries on inherited diseases, including leukemia and lymphoma, as well as rare disorders like diastrophic dysplasia and Usher syndrome.
A study recalculated cancer incidence rates from SEER data and found significant percentage changes (3-14%) between reporting-adjusted and unadjusted rates. The authors emphasize the importance of considering these corrections to accurately monitor trends in cancer incidence.
A study published in Science reveals a new risk factor for colon cancer, associated with the Bloom syndrome gene mutation. Researchers found that individuals carrying the mutated gene had nearly three times the risk of developing colon cancer compared to those without the mutation.
A genetic mutation common among Ashkenazi Jews can double the risk of colorectal cancer. Researchers discovered this relationship through an international study analyzing DNA from nearly 3,100 individuals.
A UK population study suggests a possible link between colorectal cancer and human growth hormone therapy, with treated patients at an increased risk of death from the disease. The study found significant risks of incidence and mortality associated with colorectal cancer in patients treated during childhood and early adulthood.
The US Preventive Services Task Force recommends that all adults over 50 be screened for colorectal cancer using methods like the fecal occult blood test or flexible sigmoidoscopy. The Task Force also notes that clot-busting drugs and angioplasty are underused in certain patient groups, particularly women and specific types of heart at...
A new assessment method using a patient questionnaire and computer-generated risk score has been developed to identify people at high risk of colorectal cancer. The system was tested on 2268 patients with adverse colorectal symptoms, detecting nearly all cancers (99%) by investigating just over half (57%) of the patients referred.
The American College of Physicians recommends screening adults over 50 for colorectal cancer. The Task Force identified two screening methods that have been shown to reduce death from colorectal cancer: the fecal occult blood test and flexible sigmoidoscopy.
A CDC report confirms that residents of Appalachia, particularly those in rural areas, face higher risks of dying from cancer. The study, conducted by the Appalachian Cancer Network, shows significantly higher death rates for lung and cervical cancers in rural Appalachia compared to the national average.
A new clinical trial, led by Scott Waldman, aims to determine if a test for the protein guanylyl cyclase C can accurately diagnose colorectal cancer spread. The test may improve diagnoses and treatment outcomes by detecting tiny amounts of cancer in lymph nodes.
The study found that between 1950 and 1960, male cancer mortality was nearly 50% greater in high socioeconomic areas compared to low areas. By 1998, this gap had narrowed and even reversed, with the lowest socioeconomic groups experiencing higher mortality rates.
A study of 906 individuals between 40-49 years old found no cancer cases despite low-risk profiles. Age is identified as a good predictor of colorectal cancer risk, with 7% of cancers occurring in individuals under age 50.
A new diagnostic faecal test detected MCM2-positive cells in 37 of 40 patients known to have colorectal cancer, but not in healthy individuals. The findings suggest that the test could be suitable for population screening, either alone or in combination with other tests.
Researchers have found that a new FOLFOX4 regimen significantly improves outcomes for patients with advanced colorectal cancer, leading to longer survival times and reduced side effects. The regimen has been shown to extend median patient survival by four months and reduce tumor progression time.
A study by Michigan Medicine researchers found that Katie Couric's 2000 colonoscopy on-air campaign significantly increased colon cancer screenings, with a 19% rise and sustained increases for 40 weeks. The 'Couric Effect' suggests celebrity influence can drive public behavior change.
The National Cancer Institute has awarded a $13 million grant to Vanderbilt University Medical Center to support research into molecular targets for colorectal cancer. The five-year project will focus on translational research using various molecular targets for prevention and therapy, with the goal of improving patient outcomes.
A UK trial suggests that flexible sigmoidoscopy is a suitable tool for population screening of colorectal cancer, with high attendance rates and low perforation risks compared to colonoscopy. The study's findings highlight the need for tailored approaches to screening, taking into account individual risk factors and efficiency.
A new study found that PET scans can reduce unnecessary colorectal surgeries by detecting disease earlier than other imaging modalities. The study analyzed 96 patients and found that PET scans led to active treatment for 12% of them, while conventional imaging indicated rising cancer markers in 10 cases.
A new study by researchers at Thomas Jefferson University found that the protein GCC is present in intestinal metaplasia, a sometimes precancerous condition in the esophagus and stomach. GCC's presence was detected in five of five cases of esophageal cancer and eight of nine cases of stomach cancer.
Researchers discovered that COX-2 inhibition can prevent Barrett's esophageal cell proliferation and that p16 mutations may impair melanocyte senescence. Additionally, a common polymorphism in the GH1 gene may be associated with a decreased risk of colorectal cancer.
The incidence of second primary colorectal cancer is high despite regular surveillance colonoscopy after treatment of the initial cancer. Many second cancers were diagnosed within one year after a normal colonoscopy, indicating the need for further research to determine the best schedule for surveying the colon.
The innovative procedure uses a 40-second CT scan to identify colon polyps, reducing the risk of puncturing and sedation. Virtual Colonoscopy has been shown to detect polyps as small as 3mm in diameter with high accuracy.
A new study reveals a reliable method for identifying proximal colorectal cancers through faecal DNA analysis. The test, which detected mutations in the BAT26 gene, showed zero false positives and high specificity.
Researchers found that genetic imbalances on chromosomes 8 and 18 were better predictors of colorectal cancer prognosis than conventional assessments. The study used a new approach to investigate chromosome imbalances in early-stage cancers, with patients experiencing varying disease-free survival rates based on their tumour balance.
Researchers found that aspirin is not cost-effective addition to national strategy for reducing death from colorectal cancer. Screening methods, such as flexible sigmoidoscopy and yearly fecal occult blood testing, remain highly effective and cost-efficient options.
Researchers found that aspirin does not reduce costs and increase life expectancy for colorectal cancer prevention. Regular screening tests remain highly effective and cost-effective, even for patients taking aspirin for other reasons.
Screening for colorectal cancer could lead to a 20% reduction in mortality rates, but its effectiveness depends on various factors. The UK government has set up pilot centres to evaluate the potential of faecal occult blood testing (FOBT) as a screening method.
A systematic overview of 22 trials found that preoperative radiotherapy reduces local recurrences by half compared to surgery alone, with a third reduction in postoperative radiotherapy. Fewer patients who received preoperative radiotherapy died from rectal cancer, but early deaths increased.
A study of 2,437 HIV-infected adults found that patients with case managers had fewer unmet needs and higher use of HIV medications. Screening for hereditary colorectal cancer has been shown to work and may be cost-effective, particularly for relatives of affected individuals.
Researchers Dorret Boomsma, Hans Clevers, Bert Meijer, and Hans Oerlemans were awarded for their pioneering work in human behavioural genetics, the discovery of cancer causes, molecular architecture, and icecap dynamics. Their findings have significant implications for our understanding of intelligence, anxiety, and climate change.
A five-year research project investigates the quality of life of older adult long-term cancer survivors, revealing that while cancer can affect their identity and relationships, it does not fundamentally change who they are. Many survivors report positive family dynamics and hope for the future after treatment.
Research suggests that bowel cancer screening strategies targeting solely individuals with a family history may have limited impact on reducing mortality from colorectal cancer. In fact, the study found that around 85% of bowel cancers develop in people without a family history, highlighting the need for more widespread screening.
Researchers discover bacterial toxin ST can slow down metastatic colorectal cancer tumor growth by targeting GCC receptor. GCC is a protein marker on cancer cells that allows scientists to detect if they have spread, and it can also be used as a diagnostic tool.
A genetic defect in the alpha-1 antitrypsin gene is associated with a threefold increased risk of developing sporadic colorectal cancer. Carriers who smoke have a significantly higher risk of developing this type of cancer compared to non-smokers.
Mayo Clinic researchers developed a new, non-invasive DNA test that detected 91% of colorectal cancers and 73% of polyps. The test shows promise for reducing unnecessary colonoscopies and costs associated with colorectal cancer screening.
A mathematical model suggests that one-time colonoscopy at age 55 can significantly reduce colorectal cancer mortality. The study found that this strategy is cost-effective and can achieve up to 50% reduction in CRC mortality, depending on compliance.
A University of North Carolina at Chapel Hill study found that regular garlic consumption reduces stomach cancer risk by half and colorectal cancer risk by two-thirds. The researchers pooled data from 22 studies worldwide to confirm the protective effect, but note that supplements may not be as effective.
Researchers at Memorial Sloan-Kettering Cancer Center developed a new combination therapy of irinotecan, fluorouracil, and leucovorin that nearly doubled the tumor response rate and improved overall survival for patients with metastatic colorectal cancer. The study showed significant benefits with no increased incidence of serious side...
Researchers at Mayo Clinic have discovered a new gene, AXIN2, linked to colorectal cancer development. Mutations in this gene elevate Beta-catenin levels, contributing to the disease.
A study analyzing data from 28 countries found that a diet rich in olive oil was associated with a decreased risk of bowel cancer. The researchers discovered that meat and fish consumption, particularly high amounts, increased the risk of the disease, whereas cereal and vegetable intake had a protective effect.
Researchers have discovered a protein called p110g that suppresses colorectal cancer growth in mice and human cell cultures. The absence of the protein leads to spontaneous development of colorectal cancer, while its presence stops tumour growth.
A genetic program has been identified that constructs the pipeline supplying blood and nutrients to colorectal tumors. This program involves a group of 46 genes known as tumor endothelial markers (TEMs), which are elevated tenfold or more in tumor endothelium.
A UCSD researcher has been awarded a grant to study the incidence and impact of microsatellite instability on colon cancer in African-Americans. The research aims to understand why African-Americans have a higher death rate from colorectal cancer despite lower incidence rates.