Articles tagged with Lung Cancer
A study suggests that evaluating gene expression changes in nasal cells can serve as a non-invasive approach for early detection of lung cancer. The researchers identified 170 genes that were differentially expressed between patients with and without lung cancer, including genes linked to colon cancer and tumor suppression.
Research by Dr. Inés Ibañez-Tallon and her team at MDC Berlin-Buch reveals that the midbrain habenula region plays a key role in nicotine dependence. The study found that only a balanced activity of two genes can rein in nicotine use.
Researchers identified characteristic patterns of molecules called microRNA (miRNA) in the blood of people with lung cancer that may reveal its presence and aggressiveness. These patterns could potentially lead to a blood test for early detection, even up to two years before tumor formation.
A study published in the Journal of the National Cancer Institute found that patient reports of family cancer history are not highly accurate. The study revealed low to moderate accuracy rates for breast, colorectal, prostate, and lung cancer diagnoses, with higher accuracy rates for first-degree relatives
UCLA researchers have discovered a novel method to stimulate the immune system against lung cancer by delivering an immune-stimulating protein via nanoscale containers called vaults. The approach showed potent inhibition of cancer growth in pre-clinical studies and has the potential to be a game-changer in cancer immunotherapy.
Researchers discovered that immune cells play a crucial role in the worsening of atopic dermatitis when exposed to food allergens, with implications for prevention and treatment. Additionally, studies identified TIF1-gamma as a tumor suppressor in mouse and human chronic myelomonocytic leukemia.
Researchers found that temsirolimus strongly blocked mTOR-mediated signals and had a cytostatic effect on all mesothelioma cells. The study suggests using mTOR inhibitors as a novel anti-mesothelioma strategy, particularly in combination with chemotherapy.
The American Society for Radiation Oncology (ASTRO) has developed a guideline for palliative thoracic radiation therapy to treat advanced lung cancer. The guideline recommends various regimens of thoracic external beam radiation therapy as effective for symptom palliation, but not endobronchial brachytherapy or concurrent chemotherapy.
The National Institutes of Health has funded a study to develop an inhaled lung cancer treatment using the drug 5-azacytidine. Researchers at Albert Einstein College of Medicine aim to target premalignant lung cancer by reactivating genes that suppress tumors.
The number of AIDS-defining cancers decreased, while non-AIDS-defining cancers increased significantly between 1991-2005. Lung cancer emerged as the most common malignancy in people with HIV but not AIDS.
A Wayne State University study found that soy isoflavones can sensitize cancer cells to radiation while protecting normal tissue. The study demonstrated that soy isoflavones can block DNA repair mechanisms in cancer cells, leading to increased killing of lung cancer cells by radiation
Researchers at MIT have identified a genetic change that helps lung tumors metastasize, with reduced NKX2-1 activity associated with higher death rates for lung-cancer patients. Understanding this gene's role may help scientists develop drugs to counteract its loss.
Researchers found significantly higher rates of HPV antibodies in people with lung cancer compared to those without the disease. High-risk types of HPV were particularly prevalent, suggesting a potential link between HPV infection and lung cancer development.
A recent study presents a promising serum test that can identify lung cancer in people who have never smoked. The test uses a panel of biomarkers to analyze blood samples and has shown high sensitivity and specificity in distinguishing lung cancer from non-cancerous conditions.
A recent study published by the American Association for Cancer Research found that nicotine at doses similar to those found in most nicotine replacement therapies did not increase lung cancer tumor incidence, frequency or size. The researchers concluded that nicotine replacement therapy is probably a safe option.
Researchers have identified a biomarker for measuring the success of lung cancer chemoprevention, using abnormal cell development (endobronchial dysplasia). The study found that measurements of endobronchial dysplasia can predict how well a chemoprevention agent is working in former smokers.
Researchers at UT MD Anderson Cancer Center developed two sets of gene expression profiles that predict response to erlotinib treatment for patients with no guiding indicators. The biomarkers, which cover 88% of patients without EGFR mutations, may have a broad impact on identifying patients who benefit from the drug.
A recent study published in the Journal of Thoracic Oncology found that soy isoflavones can sensitize cancer cells to radiation, increasing killing efficiency while protecting normal lung tissue from damage. Researchers used a soy mixture consisting of genistein, daidzein and glycitein to demonstrate this effect.
The new TNM 7 lung cancer staging system better predicts local or regional recurrence after surgery, according to a study published in the Journal of Thoracic Oncology. The updated system improved accuracy for predicting disease recurrence among patients with non-small cell lung cancer.
The annual report to the nation on cancer trends finds a slight decline in brain tumor incidence rates, with a notable increase in non-malignant tumors among adults. Non-malignant tumors were found to be twice as common as malignant tumors in this age group.
A new therapeutic target for lung cancer has been identified by researchers at Seoul National University. The variant of the protein AIMP2 is highly expressed in lung cancer cells and has been shown to compromise the tumor-suppressing activity of AIMP2, suggesting its potential as a new treatment option.
A large prospective study of black and white smokers found that mentholated cigarettes are associated with a lower lung cancer incidence and fewer lung cancer deaths than regular cigarettes. The researchers also found that menthol smokers reported smoking fewer cigarettes per day, but had similar quit rates as non-menthol smokers.
New research explores the role of microRNAs in understanding immunoregulation, inflammation, and autoimmune diseases. MicroRNAs are also being investigated as therapeutic targets in cancer and potential biomarkers for various diseases.
Researchers identified two previously unreported resistance mechanisms and found that resistance-conferring mutations can disappear after treatment is discontinued. Repeat biopsies provide critical information for guiding treatment decisions.
A new oral drug intended to protect healthy tissue from radiation effects has been found safe for use in advanced non-small cell lung cancer patients. The agent, called manganese superoxide dismutase plasmid liposome, boosted antioxidant levels and reduced inflammation without protecting tumor cells.
Researchers found that MeSeCys killed more lung cancer cells than SeMet, which may explain conflicting results on selenium's health benefits. The study could provide insight into the chemopreventive properties of different selenium forms.
Researchers at the University of Texas M. D. Anderson Cancer Center have identified a new mechanism driving lung cancer metastasis, involving the suppression of microRNA miR-200 by Jagged2. The study found that low levels of miR-200 may indicate susceptibility to Notch inhibitors currently in clinical trial.
Researchers have discovered that T cells from elite HIV controllers upregulate a protein called p21, which inhibits viral replication. This finding may inform the development of new treatments for patients susceptible to HIV's devastating effects. Meanwhile, two new studies shed light on pediatric brain tumors and lung cancer metastasis.
A new treatment strategy using chemotherapy drugs Erlotinib and Gefitinib has been found to be effective in treating a subset of patients with advanced non-small-cell lung cancer. The drugs, which target the EGFR mutation, produced a response rate of over 70% and had fewer side effects compared to traditional treatments.
A recent study published in the Journal of Thoracic Oncology has revealed that pemetrexed, an established chemotherapy drug, can produce significant responses in patients with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer. The treatment was found to be effective in over half of these patients, offering n...
A Australian researcher has been awarded a $4 million fellowship to continue her work on the origin of breast, ovarian and lung cancers. The research aims to understand the basic biology of epithelial organs and identify molecular pathways that go awry in these cancers.
A recent study discovered a blood protein linked to lung adenocarcinoma, which could serve as a diagnostic marker for the disease. Elevated levels of serum amyloid A (SAA) were found in patients with lung cancer, making it a promising target for developing drugs that stop cancer spread.
Small-screen detected lung cancers with maxSUV of 2.0 or smaller nodules than 10mm have low risk of nodal metastases, suggesting some patients can avoid invasive procedures. This reduces operating time and morbidity associated with lymph node dissection.
Researchers found that high levels of CYP24A1 enzyme can predict lung cancer survival, with patients having higher levels experiencing nearly half the survival rate as those with low levels. The study suggests using vitamin D to prevent or delay cancer recurrence after surgery.
Researchers suggest that quitting smoking suddenly may be an early symptom of lung cancer. A study found that 48% of patients with lung cancer had quit before diagnosis, most without noticing any symptoms.
A new phase III trial has shown that erlotinib has comparable efficacy to chemotherapy in non-small cell lung cancer patients whose disease has progressed after first-line treatment. The study found no difference in overall survival or progression-free survival time between the two groups.
Researchers successfully localized single pulmonary nodules in all 19 patients using radio-guided surgery, detecting primary and secondary lung cancers. The technique took an average of 6 minutes to detect the nodule, with no complications during or after surgery.
Researchers identified AEG-1 as a strong predictor of progression-free survival in patients with EGFR-mutant non-small cell lung cancer treated with erlotinib. Patients with low AEG-1 expression had longer progression-free survival compared to those with high expression.
Researchers discovered that zoledronic acid can prevent lung cancer metastases from recruiting new blood vessels. The drug showed a statistically significant reduction in VEGF and b-FGF levels, suggesting potential anti-angiogenic effects.
Researchers predict nearly 1.3 million cancer deaths in Europe in 2011, with a 7% drop in men's death rates and a 6% decrease in women's mortality. The number of lung cancer deaths is increasing steadily, particularly among Polish and UK women, while breast cancer mortality falls.
Cancer rates are expected to nearly double globally by 2030 due to demographic changes and adoption of unhealthy lifestyles. Preventive measures must be widely applied to mitigate the impact.
Research suggests that high levels of circulating DNA, specifically human telomerase reverse transcriptase (hTERT), can indicate a faster progression of lung cancer and lower overall survival. Patients with lower hTERT levels had improved time to progression and higher overall survival rates compared to those with higher levels.
The report finds progress in reducing cancer death rates for lung and prostate cancers among African American men. However, disparities remain, with higher mortality rates from breast, colorectal, and lung cancers in women. The study highlights the critical role of socioeconomic status in cancer disparities.
A study by Elisabetta Rapiti found that women taking tamoxifen had 87% fewer lung cancer deaths than the general population. The research supports a hormonal influence on lung cancer and estrogen's role in patients' prognosis.
Research highlights the importance of symptom management in improving quality of life for patients with stage IIIb or IV lung cancer. A study found that symptom distress was the strongest determinant of quality of life, followed by symptom severity and frequency.
A China Medical University study shows a 10.9-fold increased risk of lung cancer among people with tuberculosis compared to those without the disease. The study followed over 1 million patients and found a mortality rate of 51.1 per 10,000 person-years in the tuberculosis group, nearly six times that of non-tuberculosis patients.
A new UCSF study reveals that older men with high-risk prostate cancer are frequently under-treated, leading to higher mortality rates. The researchers argue that age should not be a barrier to more aggressive treatments that could lead to potential cures.
Patients who develop an acne-like skin rash after starting chemotherapy and cetuximab treatment have better overall survival, progression-free survival, and response rates compared to those without a rash. The study suggests that an early skin rash could be a predictor of treatment success in lung cancer patients.
A cluster-randomized clinical trial in Ethiopia found significantly higher nasopharyngeal pneumococcal resistance to macrolides in communities randomized to receive azithromycin compared to untreated control communities. This study highlights the impact of antibiotic selection pressure on developing antibiotic resistance.
Researchers at Boston University School of Medicine have received grants to develop novel tests for early detection of lung cancer in high-risk patients. The grants will focus on identifying subtle differences in cells from the nose or mouth that can detect disease.
Researchers at UT Southwestern Medical Center discovered gene expressions in lung tumors and normal tissue that predict patient survival time and guide effective treatments. The study found specific nuclear receptors associated with good prognosis and identified potential drug targets for personalized therapy.
A study found that combining epigenetic therapy and molecular targeted therapy can improve outcomes for patients with elevated E-cadherin levels in advanced lung cancer. The treatment achieved significantly improved overall survival rates compared to erlotinib alone.
Researchers found that adding ipilimumab to paclitaxel/carboplatin improved progression-free survival rates for stage IIIb/IV non-small cell lung cancer patients. The study suggests that ipilimumab may be a valuable addition to standard treatments, potentially leading to better patient outcomes.
Researchers identified six gene markers in early-stage non-small cell lung cancer that can predict tumor relapse and survival rates. The six-gene classifier stratifies patients into low-, intermediate- and high-risk groups with significantly different relapse rates.
Researchers compared treatment outcomes of elderly patients with early-stage lung cancer treated with either surgery or stereotactic radiation therapy. The study found that both treatments had similar long-term survival rates, but surgery had a higher risk of mortality in the first 30 days.
The Lancet criticizes Canada and Quebec governments for exporting asbestos, a cause of deadly mesothelioma, to developing countries. The export will continue due to a loan guarantee, sparking protests and concerns about the exploitation of vulnerable populations.
A study published in The Lancet found that low-dose aspirin reduces mortality from various cancers, including oesophagus, lung, stomach, pancreas, and possibly brain cancer, by 20-30% regardless of dose or smoking status. Benefit is seen with increasing age and may require at least five years of use for significant impact.
A study found that PET/CT scans can predict local recurrence in lung cancer patients treated with radiofrequency ablation by analyzing lesion size, tumor type, and glucose metabolic activity. This non-invasive tool may help improve diagnosis and treatment of lung cancer.
Researchers at VCU Massey Cancer Center discovered a previously unknown mechanism in NSCLC cells that contributes to their ability to maintain and grow tumors. The study found that a protein factor regulates the expression of caspase-9, a main player in apoptosis, which could provide a new target for therapies.
Researchers at SomaLogic describe a breakthrough technology that detects biomarkers for lung cancer in its early stages, revealing the presence of a panel of 12 proteins. The SOMAmer technology enables accurate detection and measurement of proteins in just a few drops of blood.