Articles tagged with Lung Cancer
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A clinical trial led by Dr. Joseph Friedberg at Thomas Jefferson University Hospital is exploring the effectiveness of photodynamic therapy (PDT) on non-small cell lung cancer, with patients showing survival times between three and four times the usual six to nine months after surgery.
A study of 156 spouses of people with lung cancer found that those using moderate levels of religious coping had lower depressive symptoms. High levels of religious coping were linked to higher depression scores, suggesting a complex relationship between the two.
Researchers discovered deguelin's ability to selectively block the growth of precancerous and cancerous human bronchial epithelial cells. The study suggests deguelin may inhibit Akt activation, a critical cell survival signal for tumor progression.
Researchers have found that a specific carcinogen in cigarette smoke causes mutations in the K-RAS gene, leading to lung cancer. The study uses a mapping technique pioneered by Dr. Tang to pinpoint the exact site of damage, providing concrete proof that smoking is a cause of lung cancer.
A new phase III multi-national European trial involving 618 patients with advanced non small-cell lung cancer found that cisplatin and paclitaxel improved survival rates compared to carboplatin and paclitaxel. The study suggests that cisplatin-based chemotherapy remains the preferred standard treatment for lung cancer in Europe.
The National Lung Cancer Screening Trial (NLST) is a randomized, controlled study aiming to determine the effectiveness of spiral CT scans versus chest X-rays in reducing deaths from lung cancer. Participants will receive annual screenings for three years and their health will be monitored until 2009.
The National Lung Screening Trial will enroll 50,000 current or former smokers in the US to compare the effectiveness of CT scans and chest X-rays in detecting lung cancer. The trial aims to determine if early detection can lead to a reduction in lung cancer deaths.
A phase III trial found that darbepoetin alfa reduced blood transfusions by half and increased hemoglobin levels, while decreasing fatigue. The treatment also showed similar adverse events to those in cancer patients receiving chemotherapy.
A new study from Duke University Medical Center found that smokers who knew they were genetically susceptible to smoking-related cancers were no more likely to quit than those who didn't know. However, the study also showed that this knowledge did not undermine motivation to quit, contrary to initial concerns. The research suggests tha...
Sir Richard Peto and Sir Richard Doll have been pioneers in mapping the health hazards caused by smoking, with their study identifying a link between smoking and various causes of death. Their research has led to a huge body of knowledge reinforcing anti-tobacco efforts.
In developed countries, cancer mortality is more than twice as high as in developing countries due to factors like tobacco consumption and Western nutrition. In contrast, up to 25% of malignancies in developing countries are caused by infectious agents, whereas chronic infections account for only 8% in developed nations.
This study found that paclitaxel- and carboplatin-based regimens can prolong survival of patients with advanced non-small cell lung cancer, with two-year survival rates similar to those achieved at one year with best supportive care. However, three-drug regimens were slightly more toxic and did not provide additional benefits.
A new study suggests that taking aspirin three or more times a week for six months may reduce the risk of developing non-small cell lung cancer in women. However, larger studies are needed to confirm these findings and determine the optimal dose due to potential side effects like gastrointestinal bleeding.
The study found that between 1950 and 1960, male cancer mortality was nearly 50% greater in high socioeconomic areas compared to low areas. By 1998, this gap had narrowed and even reversed, with the lowest socioeconomic groups experiencing higher mortality rates.
Researchers at Ohio State University identified 14 genes over-expressed and 12 genes under-expressed in lung cells affected by cancer. The study provides new insights into the genetic basis of lung cancer and could lead to earlier detection methods.
Researchers argue that the NY-ELCAP program cannot determine if screening saves lives due to a lack of control group. The study may harm participants, lead to overdiagnosis and make it harder to learn the true effect of spiral CT screening.
Researchers argue that NY-ELCAP cannot determine if spiral CT screening saves lives due to a lack of control group. The study's design flaw could lead to overdiagnosis and unnecessary treatment for some participants.
A retrospective study of 21,232 farmers in Xuanwei, China found that switching from unvented to vented stoves resulted in a 41% reduction in lung cancer risk for men and 46% for women. Indoor air pollution levels decreased by 65% with the new stove installations.
Researchers discovered unique genetic differences between lung cancer patients that correlated with cancer relapse rates. A 22-gene cluster was identified as a key predictor of treatment outcome, providing unprecedented insight into individual lung tumors.
A study found that 40% of patients experienced improved lung cancer symptoms after taking the experimental pill ZD 1839, leading to a longer survival and better quality of life. The pill, which targets the epidermal growth factor receptor, was found to be well-tolerated with minimal side effects.
The study demonstrated that gemcitabine was well-tolerated in patients with superficial bladder cancer, with no or very low levels of the drug found in plasma samples. The results suggest that gemcitabine may be a suitable alternative to current standard treatments, which often cause toxic side effects.
Research findings link insulin-like growth factor I (IGF-I) to decreased lung cancer risk when bound by IGFBP-3. Environmental factors influence DNA methylation patterns in tumor suppressor genes, which may impact cancer incidence. Electro-gene therapy enhances IL-12 protein delivery, triggering long-lasting antitumor responses.
Researchers found that blocking ICAM-1 reduced inflammation and fibrosis in lungs treated with radiation. Mice genetically engineered to lack ICAM-1 showed fewer infiltrating leukocytes and less respiratory distress.
Researchers found that premenopausal women who underwent mastectomy alone had similar survival outcomes regardless of the menstrual cycle phase. In contrast, those who received adjuvant oophorectomy and tamoxifen during the luteal phase experienced better disease-free and overall survival rates. Additionally, studies suggest socioecono...
Researchers at UT Southwestern and M.D. Anderson have identified eight genes on chromosome 3 that act as tumor suppressors in lung cancer. These genes were found to inhibit tumor growth and induce cell death in human lung cancer cells, suggesting a potential new approach for treating the disease.
A nationwide study found long-term exposure to air pollution with high concentrations of tiny particles increases the risk of dying from lung cancer and heart disease. Fine particulate matter levels comparable to second-hand smoke pose significant health risks in polluted cities.
A study of 228 lung cancer patients aged 65+ found that severe symptoms and social functioning are strong predictors of depression. Patients who had not received radiation therapy within 40 days were also more depressed, highlighting the importance of symptom management in older cancer patients.
A recent study found that social factors can significantly affect the survival rates of lung cancer patients, with African Americans facing higher mortality rates due to poorer physical performance and weight loss. The researchers adjusted for these factors in their analysis, finding no difference in outcomes between ethnic groups.
African-American patients with non-small-cell lung cancer have a significantly lower one-year survival rate compared to non-African-American patients. Despite similar disease stages and health care disparities, researchers found no difference in outcomes after adjusting for factors such as performance status and socioeconomic status.
Researchers found that response rates, survival rates, and quality-of-life outcomes are similar between elderly patients (ages 70+) and younger patients with non-small-cell lung cancer. Additionally, studies report an increased risk of lung cancer after Hodgkin's disease treatment, especially in smokers, and analyzed cost-effectiveness...
A retrospective analysis of 574 patients with non-small cell lung cancer found that older patients tolerated chemotherapy regimens comparable to younger patients. However, psychological distress and neutropenia were more prevalent in the elderly population. The study suggests that functional status is a key factor in determining treatm...
A study found that Chinese-Americans take in less nicotine per cigarette and metabolize it more slowly than whites and Latinos, possibly explaining lower lung cancer rates. This correlation suggests slow nicotine metabolism may contribute to reduced nicotine intake, a factor linked to lower lung cancer incidence.
A study by UCSF scientists has found that Chinese-American smokers metabolize nicotine more slowly than Latinos and Caucasians, leading to lower lung cancer rates. This slower metabolism helps explain why they smoke fewer cigarettes and are less likely to develop lung cancer.
Two conditional mouse models of human lung adenocarcinoma have been developed, shedding new light on the disease's development. The models replicate spontaneous mutations found in human lung cancer, enabling researchers to track cancer progression and test therapeutic agents.
A new study from Duke University challenges the common assumption that small lung tumors represent early-stage cancers. Despite their small size, these tumors can still be advanced stages of cancer with a high chance of spreading.
A retrospective study found that 87% of smokers who underwent low-dose CT scanning for lung cancer screening reported an increase in motivation to quit. Twenty-three percent of participants quit smoking after screening, with a median time between screening and quitting being six months.
Dana-Farber Cancer Institute scientists have developed a new biological classification of adenocarcinomas using miniaturized gene chips. The technique groups tumors by their genetic 'signatures', which can capture distinctive patterns of active and inactive genes, allowing for more accurate diagnoses and treatments.
The study found that PET scans changed treatment for 63% of patients with recurrent lung cancer, with a significant impact on patient care and well-being. For newly diagnosed patients, PET results led to changes in staging and treatment planning, impacting 42% of cases.
Researchers found that small doses of suramin enhanced chemotherapy effectiveness in treating advanced stage IIIB/IV lung cancer. The tumors halved in seven patients and didn't progress in eight, showing a potential treatment option for patients with metastatic lung cancer.
The ERS 11th Annual Congress presents first hard evidence on the dangers of passive smoking in adults, highlighting a significant link between exposure and asthma development. Women are particularly at risk due to greater exposure at home and workplace.
The use of asbestos continues to pose a significant health risk, particularly in developing and industrialized countries. According to recent data, millions of people worldwide continue to suffer daily exposure to asbestos, leading to an alarming increase in asbestos-related cancers.
Patients with lung cancer who undergo lung resection surgery at high-volume hospitals experience significantly better outcomes, including higher five-year survival rates (44%) compared to low-volume hospitals (33%). Complication rates are also reduced in high-volume facilities.
The University of Pittsburgh Cancer Institute has received a $12 million grant to examine innovative detection and treatment strategies for patients with early- to late-stage lung cancer. The grant will focus on improving survival outcomes and quality of life through the use of newest diagnostic tools and latest treatments.
Two large studies followed US and British factory workers for extended periods, finding associations between formaldehyde exposure and increased risk of leukemia and lung cancer. However, the authors caution against drawing definitive conclusions about the carcinogenicity of formaldehyde in humans.
A study found that PET scans are more accurate than traditional diagnostic techniques in determining how far lung cancer has spread. PET scans revealed cancer in 27 patients that had spread farther than thought, sparing them from futile attempts at aggressive therapy.
A study at Northwestern University aims to assess whether an experimental drug can reduce carcinogens produced by cigarette smoke, potentially preventing lung cancer. Participants must be heavy smokers with a history of failed quit attempts and no medical problems.
A study of 18,244 Chinese males found that consuming cruciferous vegetables like broccoli was protective against lung cancer. The benefit depends on genetic factors, with subjects lacking the metabolism enzyme GSTM1 showing a 64% decrease in risk of lung cancer.
A recent UI study found that long-term exposure to radon in the home is associated with an increased risk of lung cancer. The study, which included 1,027 Iowa women, found that close to 60% of homes exceeded the EPA's action level for radon, leading to a significant increase in lung cancer risk.
Researchers found that concurrent chemotherapy and daily chest radiation can help lung cancer patients live longer, with an average survival of 17 months. In contrast, sequential treatment resulted in an average survival of 14.6 months.
A chemoprevention regimen containing myoinositol and dexamethasone has been shown to effectively prevent lung tumors in male mice exposed to cigarette smoke. The regimen worked when given daily during exposure or after the mice had returned to clean air, reducing tumor incidence by nearly 40%.
The American Thoracic Society announces new research findings highlighting significant differences in lung function test results between Asian Americans and European Americans. Additionally, experts discuss the potential of gene therapy for treating lung cancer, while studying lung changes caused by smoking and aging.
The UK Markey Cancer Center will establish local coalitions and develop community outreach programs to address cancer barriers in Appalachian regions. The network aims to increase public awareness of clinical trials and promote participation among rural, medically underserved patients.
Researchers found greater numbers of estrogen receptors on lung cancer cells, suggesting a role for this hormone in enhancing tumor growth. Estrogen was shown to increase cell division and tumor growth in both cultured lung cancer cells and animal models.
Scientists at Johns Hopkins have developed a novel approach for detecting cancer based on genetic mutations in mitochondrial DNA. The new test uses bodily fluids such as urine, saliva, and sputum to identify cancer-specific mutations.
Researchers found that office staff, drivers, and unloaders were exposed to similar levels of diesel exhaust due to poor ventilation. This challenges traditional risk assessments based on occupational groups, emphasizing the need for individual testing.
Researchers at Thomas Jefferson University have used gene therapy to replace a damaged Rb2 gene with a healthy version, dramatically shrinking lung cancer tumors in mice. The study provides direct evidence that Rb2 is a tumor suppressor and demonstrates its potential as a target for human gene therapy trials.
A University of Pittsburgh-led research team discovered that the gene for gastrin-releasing peptide receptor is more active in women than men, leading to increased cell proliferation and lung cancer growth. Nicotine from cigarettes also stimulates this gene expression, explaining why women are at a higher risk of developing lung cancer...
Researchers found that women smokers are three times more likely to have the K-ras mutation and nearly four times more likely to die from lung cancer if they have it. The study suggests a link between estrogen and the initiation of K-ras mutant cells in lung tumors.
The NYU Medical Center is launching a large-scale study to determine the effectiveness of combining CT scans with gene markers in detecting early-stage lung cancer in women. The study aims to identify reliable screening tools for women at high risk of developing this deadly disease.
Lung cancer treatment disparities between blacks and whites are attributed to racial attitudes and biases, affecting surgical resection rates and survival outcomes. UCSF specialists emphasize the importance of addressing these inequities through improved communication, screening tests, and clinical trials.