Articles tagged with Myocardial Infarction
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The study found that levels of biomarkers linked to arterial inflammation and heart attack risk decreased after taking the drug DG-031. The drug reduced production of leukotriene B4 by 26 percent and myeloperoxidase by 12 percent, suggesting a potential reduction in cardiovascular events.
Researchers found that morphine increased mortality rates by 6.8% compared to nitroglycerin, even after adjusting for clinical risk. The study calls for a randomized clinical trial to confirm the findings and advises cardiologists to prioritize nitroglycerin treatment.
A new study found that computerized risk stratification tools, like ACI-TIPI, may not accurately diagnose heart attacks in patients from different ethnicities. The researchers compared the tool's performance in a mixed-race US population and an Asian population in Singapore.
A recent US study found no benefit from treating C. pneumoniae bacteria with an antibiotic in reducing the risk of heart attack or improving overall cardiac outcomes. The Azithromycin coronary events study (ACES) assigned over 4,000 participants to receive either antibiotics or a placebo for one year.
A new study found that antibiotic treatment with azithromycin did not reduce the risk of heart attacks, unstable angina, or other cardiac events. The study enrolled over 4,000 participants and followed them for nearly four years, with no significant difference in outcomes between those receiving antibiotics and placebo.
Researchers at Monash University have developed a new class of drugs that stop the formation of blood clots without increasing bleeding risk, offering a safer alternative to aspirin. The PI 3-kinase inhibitors may prove vital in treating heart attack and stroke patients, with promising results from animal studies and phase I trials.
A new study found that low concentrations of sodium nitrite prevent cell death in the hearts and livers of mice undergoing experimental heart attack and liver injury. The potent protective effect reduced dead tissue by 67% compared to control animals given nitrate.
A recent study has found that patients who received incorrect doses of fibrinolytic agents were more likely to have underlying health conditions, such as lower systolic blood pressure and body weight. These findings suggest that adverse outcomes from blood clot therapy may be due to patient characteristics rather than dosing errors.
A study analyzing ASSENT-2 clinical trial data found no significant association between small dosing errors and increased mortality rates among heart attack patients. However, patients with certain factors such as advanced age, female gender, and lower blood pressure were more likely to experience adverse events.
Researchers found a strong association between high levels of C. pneumoniae antibodies and the occurrence of heart attacks in young men. The study suggests that C. pneumoniae may play a role in the pathogenesis of heart disease, but further research is needed to confirm the link.
The study found that women who received stents experienced a significant reduction in major adverse cardiac events and death rates compared to those treated with balloon angioplasty. Stenting was also shown to decrease the need for re-intervention, a critical factor contributing to higher mortality risk in women.
A new study from Rice University found no independent relationship between Lp(a) levels and coronary calcium in either whites or African-Americans, suggesting an unknown mechanism may be at work. The study used a large multiethnic dataset of Dallas County residents to examine the link between Lp(a) and heart-attack risk.
Researchers at Cincinnati Children's Hospital Medical Center discovered that blocking cyclophilin D protects the heart from injury due to loss of blood flow. A class of drugs already exists that blocks cyclophilin D and has been shown to protect against stroke in animal models.
A study used optical coherence tomography (OCT) to visualize coronary arteries and identify vulnerable plaques in cardiac patients. The technology revealed that heart attack and acute coronary syndrome patients had more lipid and thinner fibrous caps than stable angina patients.
The Hopkins team is conducting a Phase I study to test the safety of injecting donor adult stem cells into patients who have recently suffered a heart attack. The study aims to determine if the stem cells can repair damage to the heart muscle and restore its function.
A review of studies published in Psychosomatic Medicine found that physically fit people have a reduced risk of heart attacks, while inactive cardiac patients who engage in vigorous activity are at higher risk. Strong emotions and stress can also trigger heart attacks in vulnerable individuals.
The new guidelines emphasize the importance of timely thrombolysis and PCI, with a focus on reducing delays in treatment. They also highlight the benefits of primary PCI over thrombolysis in certain situations.
Yale researchers question the feasibility of regionalized heart attack care in the US, citing differences in healthcare systems and clinical accuracy. They estimate that transferring over 500,000 patients could be necessary for access to interventional treatments.
A new study published in Heart found that individuals with giant cell arteritis (GCA) have a significantly higher risk of cardiovascular disease compared to healthy adults. The prevalence of GCA is estimated at one per every 500 seniors, and patients with this condition are more than twice as likely to experience heart attacks or strokes.
A study published in Heart found that antidepressants may explain the increased risk of heart attack associated with their use. Patients who recently started antidepressants were twice as likely to have a heart attack within seven days compared to those who hadn't taken the medication before.
A new study found that emergency use of clopidogrel could reduce the risk of death and repeat heart attacks by up to 10%, without increasing serious bleeds. However, early treatment with metoprolol may increase the risk of cardiac shock, and its benefits tend to cancel out those of clopidogrel.
The Women's Health Study found that low-dose aspirin lowered the incidence of a first major cardiovascular event by 9 percent, with a statistically significant difference in stroke prevention. For women aged 65 and older, the risk was reduced by 26 percent, but the benefits must be weighed against the risk of internal bleeding.
Researchers found a significant association between depression and ventricular tachycardia, a precursor to sudden cardiac death, in hospitalized heart attack patients. The risk of ventricular tachycardia increased with increased levels of depression.
A recent study published in JAMA found that distal microcirculatory protection devices used during angioplasty procedures in heart attacks failed to improve patient outcomes. Despite successfully removing debris from arteries, the treatment did not reduce major adverse cardiac events or affect ST segment normalization.
Researchers confirm Vioxx increased cardiovascular risk by nearly doubling events, including heart attacks and strokes, in patients with recurrent colon polyps. The trial was stopped early due to safety concerns.
Researchers at Johns Hopkins Medicine have discovered 'broken heart' syndrome, a condition where emotional stress triggers severe but reversible heart muscle weakness. The study found that patients experienced rapid improvement in heart function within days and complete recovery within two weeks.
Researchers found that rheumatoid arthritis patients are three times more likely to have been hospitalized for an acute heart attack during the two years before diagnosis. They were also twice as likely to experience unrecognized heart attacks and sudden cardiac deaths after diagnosis.
Researchers have discovered a single human stem cell population derived from the bone marrow that can regenerate myocardium after myocardial infarction. This breakthrough has significant implications for treating heart failure and major morbidity associated with myocardial infarction.
A study by McGill University researchers found that COX-2 inhibitors like Vioxx increase the risk of heart attack by 24% in users who have not previously suffered a heart attack. Aspirin use can help mitigate this risk, but only in those taking low doses of Vioxx.
At least 33% of patients with congestive heart failure who receive specialized pacemakers fail to respond, highlighting the need for more research in selecting candidates. This study suggests that traditional pacemaker implantation may not be effective for patients with previous heart attacks.
The American College of Physicians recommends one-time ultrasound examination for abdominal aortic aneurysm screening in men aged 65-75 who are smokers. New evidence suggests that large abdominal aneurysms may reduce deaths from ruptured aneurysms. Meanwhile, a study found that the COX-2 inhibitor rofecoxib increases heart attack risk ...
Researchers found that nicotine caused a significant increase in atrial interstitial fibrosis and electrical remodeling in hearts with myocardial infarction, leading to atrial flutter. The study suggests a causal link between nicotine and atrial flutter, potentially informing new therapeutic strategies.
A survey found that nearly half of US adults aged 40 and over who are at increased risk of heart disease do not take aspirin to reduce their risk. The study suggests a need for improved communication between doctors and patients about the importance of aspirin therapy.
The Insulin Resistance Intervention after Stroke (IRIS) trial aims to investigate the effectiveness of pioglitazone in reducing recurrent stroke and myocardial infarction among eligible participants. The trial will enroll 3,136 participants over three years and tests the hypothesis that pioglitazone reduces risk by 20 percent.
A meta-analysis of two trials suggests that COX-2 inhibitor Bextra elevates the combined incidence of heart attack and stroke three-fold in patients undergoing coronary artery bypass graft surgery. The researchers also found that another COX-2 inhibitor caused changes in atherosclerotic plaques, potentially increasing the risk of rupture.
Researchers found that depressed patients are twice as likely to die within two years after their first heart disease episode compared to non-depressed patients. The study also discovered a stronger link between depression and higher risk of death in studies published before 1992.
In an animal study, stem cells from human umbilical cord blood significantly reduced the size of heart damage and restored pumping function to near normal after a heart attack. The researchers suggest that these stem cells could be a new treatment for limiting or repairing heart muscle damaged by a heart attack.
A new study links higher MBL protein levels to reduced risk of heart attack, particularly in individuals with diabetes. The protein's role in clearing oxidized cholesterol from arteries may be a key factor.
Researchers are conducting a study to examine the effects of fish oil supplements and increased fish consumption on blood vessel function in men. The study aims to investigate whether fish oil supplementation can counteract the negative effects of smoking on heart health.
A study of 1,718 people found that COX-2 inhibitor rofecoxib was associated with a higher risk of heart attack compared to celecoxib and older non-selective non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs). In contrast, those who used NANSAIDs had a decreased risk for myocardial infarction.
A recent Penn epidemiological study found a marked difference in heart-attack risk between COX-2 inhibitors rofecoxib and celecoxib, with celecoxib linked to a lower risk. The study compared the cardiovascular effects of these drugs to nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen.
A study by the Mayo Clinic found a direct correlation between high aortic calcium scores and heart attacks in patients who underwent virtual colonoscopy for colon cancer screening. The research suggests that CT colonography may identify cardiovascular disease risk, encouraging individuals to take advantage of diagnostic tools.
Researchers discovered that Thymosin beta-4 prevents cell death after a heart attack and limits scar tissue formation in mice. The protein promotes survival and migration of heart muscle cells, which could lead to new treatments for heart disease in humans.
Researchers from Rutgers University found that acetaminophen significantly reduced infarct size in treated dogs, with reductions of up to 63% compared to untreated control groups. The study also suggested anti-arrhythmic action of acetaminophen, with treated hearts appearing more stable electrically during ischemia and reperfusion.
Binge drinking was associated with a 73% higher death rate after heart attacks compared to non-binging patients. The study also found that survivors who binged during the year prior to their heart attack were 1.91 times more likely to die of any cause in the next several years.
A recent analysis of over 57,000 high-risk heart attack patients found that those who received morphine had a 6.8% death rate, compared to 3.8% for those receiving nitroglycerin. Morphine use was linked to an increased risk of mortality and another heart attack in the hospital.
Researchers at the University of Alberta have discovered that certain non-steroidal anti-inflammatory drugs, such as celecoxib, can inhibit bicarbonate transporters, compromising the body's ability to balance pH in cells. This can negatively impact recovery from heart attacks.
Researchers found that injections of bone marrow stem cells into damaged heart muscle produced nearly full recovery after two months. The study showed no recovery in the control group, with worsened conditions leading to congestive heart failure.
Researchers found that cardiac tamponade has decreased in incidence since widespread use of fibrinolytic drugs began. However, treatment delays are still a risk factor for the condition, and physicians should closely monitor acute heart attack patients to prevent it.
Research found that African-Americans had higher blood pressure and heart rates, but also better artery response to treatment, leading to worse overall outcomes. The disparity in long-term mortality remains even when adjusting for patient characteristics and cardiovascular risk factors.
A new study reveals women with heart attacks wait significantly longer than men to receive emergency angioplasty, resulting in higher death rates. Patients who received treatment within 90 minutes of arrival had a 50% lower risk of dying in the hospital.
A study found that people with type 2 diabetes are not being optimally managed for their cardiovascular risk. Fewer than 25% of patients were on medication needed to control high cholesterol and less than 50% received treatment for high blood pressure.
A study found that higher levels of alpha-linolenic acid (ALA) intake were associated with a significantly lower risk of dying from sudden cardiac death or coronary heart disease in women. Women who consumed the most ALA had a 46% reduced risk of dying from sudden cardiac death compared to those with the lowest intake.
Duke University researchers found that heart surgery patients receive less aggressive discharge care, with gaps in the use of life-saving medications and behavior modifications. The study, based on data from a national registry, revealed underuse of aspirin, beta-blockers, and statins among surgical patients.
A new study published in the New England Journal of Medicine found that ACE inhibitors do not provide added cardiovascular protection for patients with coronary heart disease who have normal or only mildly reduced heart function. These findings suggest that many patients with this condition may not need to take ACE inhibitors, potentia...
A systematic review of studies found that atenolol had no significant effect on reducing death from all causes, cardiovascular causes, or incidence of heart attack. However, it showed a trend towards reduced stroke incidence and increased mortality compared to other antihypertensive drugs.
Researchers found that patients who were diagnosed with non-cardiac chest pain and then had heart events were older, more likely to be men, and had high-risk features such as high cholesterol. Further evaluation should be considered for these patients, says lead researcher Chadwick Miller.
A new study published in the American Journal of Epidemiology found that intra-abdominal fat is a significant predictor of heart attack risk. Researchers discovered that as people age, fat tends to accumulate in the abdomen more than other areas, increasing the risk of heart attacks.
A recent study reports four cases of angiographically-confirmed stent thrombosis after elective implantation of drug-eluting stents, resulting in myocardial infarction. The authors emphasize the need for careful long-term follow-up to assess late thrombosis risk
A study found that hormone therapy can limit heart muscle damage to 5% or cause permanent damage to 35%. Researchers are exploring how estrogen alone and other anti-inflammatory treatments may impact muscle damage. The study suggests different hormone therapies may have varying effects on postmenopausal women.