Articles tagged with Viral Infections
The adult antiviral drug tenofovir disoproxil fumarate (tenofovir DF) has been found to be safe and effective in treating adolescents with hepatitis B virus (HBV), with a virologic response rate of 89% in pediatric participants. This study contributes to the growing body of evidence on the management of chronic HBV in children and teens.
Scientists warn of a growing threat from emerging zoonotic diseases as human activities such as land use change, globalization, and social upheaval drive their emergence. The disease burden can be eased by combining efforts between clinicians and public health officials to address the ecological drivers of transmission.
Emerging infectious diseases can be split into two types: introduced and locally emerging. Introduced diseases often cause a spike in infections, while locally emerging diseases show a steady increase. Climate change is not a major driving force behind emerging diseases.
A new study reveals how Human Cytomegalovirus (HCMV) co-opts cells' abilities to repair themselves, leading to preferential repair of the viral genome. The research, published in PLOS Pathogens, shows that HCMV-infected cells can efficiently repair their own DNA but not the viral DNA, with implications for developing antiviral therapies.
A new study published in PLOS ONE reveals that human stem cells are resistant to human cytomegalovirus (HCMV), a leading cause of congenital intellectual disability and deafness. The research findings suggest that HCMV infection distorts cell differentiation, leading to impaired brain maturation and intellectual ability.
The US Preventive Services Task Force has updated its recommendations for hepatitis C screening in asymptomatic adults. The new guidelines suggest that targeted screening may be beneficial, as up to two-thirds of infected patients are missed by routine screening methods. However, there is currently no direct evidence that screening imp...
Researchers at Scripps Research Institute describe the structure and function of influenza's ribonucleoprotein (RNP) complex, which is essential for viral replication. The study provides new insights into the flu virus's vulnerabilities, including a shape-change during gene transcription and key interactions between proteins.
Researchers used ribosome-mapping technique to investigate HCMV's proteome, discovering hundreds of previously unidentified proteins and exceptionally short protein sequences. These findings provide new understanding of how the virus manipulates human cells during infection.
A new strain of avian pox has been identified in British bird species, particularly affecting great tits. The disease causes severe growths that can prevent feeding and increase predation susceptibility, with survival rates significantly reduced.
A novel coronavirus most closely related to viruses found in bats has been identified, prompting concern over potential human transmission. The virus is believed to have originated from an animal source, with similarities to viruses isolated from Asian and European bat species.
Two new research projects have been awarded £12.2 million in funding to tackle Foot-and-Mouth Disease Virus and emerging poultry viruses. The projects will focus on developing novel solutions for disease control, including the use of weakened viruses to prompt an immune response.
Researchers compare three immunoassay methods to detect EBV infection in patients with mononucleosis or immunosuppressed adult liver transplant recipients. The study suggests that molecular tests identifying early protein markers may have value for diagnosing active infection.
Researchers found that severe disease risk is mainly age-related, not due to lack of immunity. Vaccinating families or vaccinating pregnant women can extend protection to infants, reducing RSV infection. The study highlights the potential for alternative strategies to traditional baby vaccines.
A team of immunologists found that the flu virus alters host immune systems, compromising its capacity to effectively fight off bacterial infections. The molecule TLR7 recognizes viral genomes and signals scavenger cells to ingest fewer bacteria, leading to increased risk of superinfections.
Research on emerging tick-borne diseases reveals an expanding list of illnesses, including babesiosis and encephalitis-causing infections. The range of these diseases is growing, posing a threat to human health in the northeast United States.
Researchers found that intravaginal immunization significantly increased immune cells in the vaginal mucosa, enhancing local immune response. This site-specific vaccination technique may be useful in developing effective STD vaccines.
A new equine vaccine, Equivac HeV, has been developed to prevent clinical disease caused by Hendra virus in horses. The vaccine, derived from the original work of Christopher C. Broder and Katharine Bossart, is now available for use in Australia.
A new study found that over 80% of flu-positive pigs showed no signs of illness, highlighting the risk of transmission between pigs and humans. The research also identified genetic similarities between human and pig viruses, confirming interspecies transmission.
Researchers identified two cell receptors, TIM and TAM, essential for the Dengue virus to enter cells. Inhibiting these receptors reduces infection and provides a new therapeutic strategy.
Researchers identified molecular pathways involved in both systemic and arthritic components of SJIA, revealing differences in affected organs. The study found that glucocorticoid signalling was more heavily involved in inflammation associated with SJIA, highlighting the need for tailored treatment plans.
Treating chronic hepatitis C with antiviral drugs could reduce liver cancer risk by half, according to a meta-analysis of published research. In some cases, treatment can even prevent the development of hepatocellular carcinoma, the most common form of liver cancer worldwide.
Researchers found that viruses work together to break down plant defenses, causing more severe disease. This phenomenon has important implications for controlling these viruses.
A new Ebola virus study demonstrates a proof-of-concept for using monoclonal antibodies to prevent lethal disease in rhesus macaques. The plant-based production method offers potential for an economical and effective medical countermeasure.
Researchers found that common polymorphisms in the T2R38 gene were correlated with the incidence of bacterial sinus infections, demonstrating a genetic link to individual differences in respiratory infection susceptibility. In companion pieces, studies on PSD-95 expression and progranulin deficiency shed light on potential therapeutic ...
A randomized controlled trial of 377 premature infants found no significant differences in clinical outcomes between fresh and standard red blood cell transfusions. The study suggests that prolonged RBC storage may not have as great an impact on neonatal illness and death as previously thought.
A large study found that the quadrivalent HPV vaccine was associated with fainting and skin infections in the days following vaccination. The study of over 189,000 females suggests that these side effects are relatively common but not serious, supporting the safety of routine vaccination.
A Penn State researcher found that public health messages about a disease can elicit responses like disgust and anger, shaping stigma development and influencing people to share stigma messages or endorse interventions.
A recent study found that treating hepatitis C in prison can be just as effective as treatment for non-incarcerated patients, with 43% of prisoners achieving a sustained viral response. The research highlights the importance of providing antiviral therapy to incarcerated individuals to curb the spread of hepatitis C.
A collaborative project will analyze the impact of environmental conditions and management tactics on mite populations and disease incidence in wheat. The team aims to develop an accurate forecasting model to help growers anticipate and take action against wheat streak mosaic virus, high plains virus, and triticum mosaic virus.
Researchers found that urban infants had lower rates of human rhinovirus and respiratory syncytial virus infections than suburban infants. Adenovirus infections were more common in urban babies, suggesting a potential link to altered lung development or airway function.
Researchers at MU developed a technique using bacteriophages to selectively kill harmful bacteria in water treatment facilities. This method could save taxpayers money by reducing cleaning costs and has potential applications against deadly antibiotic-resistant bacteria.
Researchers have discovered a harmless mosquito virus that's closely related to some of the world's most dangerous mosquito-borne pathogens. The Eilat virus could aid in the development of new alphavirus vaccines, therapies, and diagnostic techniques, potentially offering a unique tool for studying other alphaviruses.
Researchers tested blood samples from 300 people for the presence of XMRV and pMLV genes, eliminating potential contamination that led to earlier false positives. No correlation between these viruses and chronic fatigue syndrome was found, refuting previous speculation.
A multi-site study of 293 patients with chronic fatigue syndrome (CFS) and 146 matched controls found no evidence of XMRV or pMLV infections. The researchers tested for the presence of these viruses using molecular, culture, and serological methods, but none were detected in CFS samples.
Researchers at Scripps Research Institute and Sea Lane Biotechnologies discovered an unusual antibody, C05, that can neutralize various flu viruses by targeting the receptor binding site. The unique antibody uses only a single loop to grab this site, making it potentially useful for developing universal flu vaccines and therapies.
Scientists at Scripps Research Institute have determined the structure of a critical protein from the Marburg virus, which blocks the human immune system. The breakthrough provides a major step forward in understanding how the deadly virus works and may be useful in developing potential treatments for those infected.
Scientists have identified a substance that primes the body's immune system to fight infections, including flu, in a nasal spray. The synthetic form of Pam2Cys has shown promise in activating the innate immune system without replacing a normal response.
The reconstructed 1918 influenza virus has provided key insights into how to prevent and control future pandemics. By studying the virus's structure and evolution, researchers have identified potential targets for universal influenza vaccines that can protect against multiple viruses.
The US has seen a dramatic increase in West Nile Virus cases, exceeding 2012 levels. Experts urge health care professionals and the public to take mosquito-prevention measures to avoid life-threatening diseases.
A broadly protective, fully human monoclonal antibody targeting a conserved region on the influenza hemagglutinin protein provides 100% protection against all H1N1 and H3N2 strains in mouse models. This antibody approach may be a turning point for seasonal and pandemic influenza prevention and treatment.
Researchers have developed a novel oral antiseptic spray, Halo, effective in killing 99.9% of infectious airborne germs, including influenza and rhinovirus. The spray prevents germs from entering the system and kills them, providing sustained protection for up to six hours.
Researchers tracked parasite-induced disease and death in reintroduced wolf packs in Yellowstone National Park, finding that mange did not infect wolves until 2007. The diseases that infected the wolves quickly were all viral, including canine distemper and parvovirus, while mange is a skin infection caused by scabies mites.
Researchers found Hematodinium sp. and its sister species are a major problem for crab fisheries, causing 'bitter crab' disease. The parasites have bacteria-like endosymbionts that increase their chances of survival outside the shrimp, leading to significant damage to infected crustaceans.
A new study suggests that children and young adults with chronic Hepatitis B Virus infection have a protective immune response, making them suitable treatment candidates. Young patients respond better to treatment and are more able to clear the virus due to their stronger immune system.
Researchers at Tel Aviv University have developed a treatment for coral infected with White Plague disease, a deadly bacterium that causes 9% of Favia favus corals to die. The treatment uses viruses that infect bacteria, providing a breakthrough in developing regionalized treatments.
Researchers developed a monoclonal antibody that protects chimpanzees from HCV infection in a dose-dependent manner. The study provides preclinical proof-of-concept for the use of neutralizing antibodies to prevent HCV transmission, which could lead to improved treatment options for patients with end-stage liver disease.
A study suggests that influenza can be transmitted before symptoms appear in ferrets, a model commonly used for flu research. The findings have significant implications for pandemic planning strategies and the control of epidemics.
Researchers found that climate change could disrupt the interactions between ruddy turnstone shorebirds and horseshoe crabs at Delaware Bay, leading to increased avian influenza infection rates. This could drive up the infection rate in resident ducks, potentially spreading novel subtypes among North American wild bird populations.
Cytomegalovirus (CMV) infection is a significant risk factor for type 2 diabetes in the elderly, according to new research. CMV infection can cause inflammation and damage pancreatic cells, leading to insulin resistance and increased glucose levels.
A recent study found that waiting to treat cytomegalovirus infections in transplant recipients until they reach a certain threshold is more beneficial than prophylactically treating all recipients. This approach led to less kidney scaring and better long-term organ survival among patients.
The West Nile virus has caused 26 deaths and nearly 700 cases in the US this year, with Texas being a hotspot. The cause of the increased cases remains unclear, but experts emphasize the need for continued research and public health efforts.
New CDC guidelines recommend universal HCV screening for all Americans born between 1945 and 1965, with strong evidence supporting the association between sustained virologic response and reduced liver cancer risk. Brief alcohol screening and intervention are also recommended for those diagnosed with HCV.
Researchers identified a whole new class of arenaviruses in snakes with Inclusion Body Disease (IBD), a deadly condition causing bizarre behavior and eventual death. The discovery could lead to development of treatments, vaccines, diagnostics, and prevention policies for IBD.
A novel arenavirus has been identified as the possible cause of inclusion body disease in snakes, a devastating illness that spreads easily among boas and pythons in captivity. The discovery may lead to the development of diagnostic tools and treatments to eradicate the disease from snake collections worldwide.
Researchers developed a targeted antisense approach to treat toxoplasmosis, reducing viable parasites by over 90% in mice. The therapy combines short nucleic acid strands with peptides to disrupt genetic signals, with potential applications in non-parasitic diseases.
Researchers have developed a vaccine that protects African green monkeys from Nipah virus, with all nine vaccinated animals surviving a lethal challenge. The vaccine is based on a Hendra virus surface protein and is in commercial development for use in horses.
Researchers successfully developed a highly effective vaccine against the deadly Nipah virus, which has shown complete protection in African green monkeys with no evidence of disease. The vaccine, known as Hendra-sG, is a recombinant piece of the virus produced in the laboratory and can be used safely for human treatment.
A comprehensive review of the recent medical literature evaluates the potential for reducing HPV-related illness burden by expanding routine vaccination to include young males. The authors present their recommendations on the cost-effectiveness of male HPV vaccination, which could lead to significant public health benefits.
Australian scientists have discovered a new bat virus, Cedar, which is closely related to deadly Hendra and Nipah viruses. The virus does not cause illness in several animal species normally susceptible to Hendra and Nipah, providing a surprising key difference.
A new study has found that 11% of people in remote Amazonian communities regularly exposed to vampire bats have natural protection against rabies. Ten percent appear to have survived exposure to the virus without medical intervention, suggesting a potential route for developing effective treatments.