Research on viral diseases and the response to them. Covers Ebola and mpox, diagnostics, post-viral fatigue, and outbreak control strategies.
Researchers identified that protease inhibitors prevent virus entry and affect reverse transcription and post-transcription stages of HIV-1 life cycle. Viral envelope protein mutations were associated with resistance to protease inhibitor treatment.
A significant outbreak of eastern equine encephalitis occurred in Panama in 2010, marking a change in the virus's behavior in Latin America. The outbreak confirmed 13 human cases and one dual infection case, with a low case-fatality rate compared to US standards.
Scientists successfully treated the Ebola virus in infected animals following onset of disease symptoms, demonstrating promise for developing therapies against the virus. The experimental treatment, known as MB-003, protected 43% of infected non-human primates.
Scientists have created a novel system to safely study the transmission of Crimean-Congo hemorrhagic fever virus through ticks. By carefully tracking each tick's movement and feeding pattern, researchers can examine the complete cycle of virus transmission between infected animals and uninfected ticks.
The study showed that the Ebola VP40 protein exists as a dimer and rearranges its structure to assemble filaments for the virus shell or bind RNA, controlling various steps of the life cycle with multiple functions.
Researchers at WashU Medicine have identified a new therapeutic target for COPD by linking acute viral infections to chronic obstructive pulmonary disease. Viral infection triggers the production of IL-33, a signaling molecule that activates immune cells to produce excess mucus in the lungs.
Scientists at Salk Institute find that enveloped viruses use phosphatidylserine to activate TAM receptors, disabling the interferon response and allowing infection. This discovery may lead to novel antiviral therapies that target this mechanism.
A study found that CDV infected at least 1% of Amur tigers since 2009, causing fatal neurological disease. The virus is spread through contact with domestic dogs or other wild carnivores, posing a significant threat to the critically endangered species.
Scientists have discovered a new strategy that cripples the dengue virus's ability to escape the host immune system. By introducing a genetic mutation to deactivate the MTase enzyme, researchers created a weakened virus that generates a strong protective immune response while preventing the virus from spreading in mosquitoes.
Researchers from The Mount Sinai Hospital have developed a new strategy to safely study deadly influenza viruses, including H5N1 bird flu. By harnessing the power of human lung cells, they create 'viral scissors' that can cut these viruses into pieces, preventing effective transmission to humans.
Researchers report a family cluster of two patients with H7N9 infection, suggesting direct transmission from father to daughter. However, the authors stress that the ability to transmit itself is limited and non-sustainable.
Researchers have developed a new laboratory model to study hepatitis C by infecting monkey stem cells with the virus. The model may lead to new treatments and vaccines for the disease, which affects over three million people in the US.
Scientists at the University of Bristol found significant differences in viral proteins for all four DENV types, which may impact anti-viral therapy design. This discovery could lead to more effective treatments for dengue disease, a mosquito-borne infection affecting millions worldwide.
A recent study published in the Journal of Antimicrobial Chemotherapy found that more than 60% of antibiotic prescriptions in the US are for broad-spectrum drugs, which can be ineffective against viral infections. The overuse of these antibiotics contributes to the development of antibiotic-resistant bacteria and side effects.
UCSF researchers have discovered a new adenovirus that can spread from primate to primate and potentially from monkeys to humans. The study suggests that adenoviruses may pose a risk for cross-species infections, highlighting the need for vigilance in tracking animal viruses.
Researchers at University of Bristol suggest combining antiviral treatment, opiate substitution therapy, and high-coverage needle and syringe programs to achieve substantial reductions in HCV prevalence among people who inject drugs. This approach can lead to a 45% reduction in HCV prevalence over ten years.
Researchers have found a virus in South African bats that is genetically more closely related to MERS-CoV than any other known virus. This discovery suggests that African bats may play a role in the evolution of MERS-CoV predecessor viruses, potentially leading to human infection through intermediate hosts such as camels.
Researchers developed a monoclonal antibody effective against human norovirus, which can prevent infection in susceptible host cells. The study aims to explore the antibody as both treatment and disease prevention strategy for outbreaks, particularly among vulnerable populations like healthcare workers and travelers.
A recent study by a MU, K-State research team disproved the theory that Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) binds to CD169 molecules in pigs. This discovery will help scientists narrow their search for an ultimate cure.
Researchers at Mount Sinai identified a critical protein called VP35 that deactivates the innate immune system, allowing Ebola viruses to spread. Overexpressing a cellular protein called PACT inhibited viral replication, providing a potential target for new treatments.
A fatal case of raccoon rabies virus exposure has been linked to a kidney transplant 18 months earlier, suggesting a long incubation period. The study emphasizes the importance of increased awareness and modified organ donor screening and recipient monitoring for infectious encephalitis.
Researchers isolated Heartland virus in tick populations in northwestern Missouri, confirming its role as a human pathogen. The virus causes severe illness with fever, headaches, and low white blood cell counts, with no treatment available.
U of M researchers identified infection-fighting and inflammation-suppressing functions for the PTPN22 gene, which could impact treatment strategies for autoimmune diseases. The study found that a variant of PTPN22 impacts immune system function in health and disease.
Researchers developed a modified prion protein that resists changing its shape, preventing the propagation of neurodegenerative diseases. The study provides a novel pharmacologic strategy to develop new drugs targeting prion protein and stabilizing its normal shape.
Researchers analyzed decade of West Nile infections, weather, and housing data to identify optimal time for intervention. The study found that using a mosquito vector index can nip outbreaks in the bud, but late intervention may still be necessary if data are unavailable.
Researchers aim to identify genetic elements that enable animal hepatitis E strains to infect humans, with potential implications for fighting cross-species virus infections. The study will also investigate host immune factors that defend against the virus.
A study at WashU Medicine distinguished between viral and bacterial infections in children with fever using gene profiling, achieving a 90% accuracy rate. This new method could help identify the cause of illness and ensure targeted treatment.
A new study reveals the H7N9 avian influenza virus can infect and replicate in human cells, suggesting it has pandemic potential. The virus also transmits efficiently in ferrets and other mammalian species, raising concerns about a potential global outbreak.
The H7N9 avian flu strain has a tendency to become established in bird, horse, and swine populations, leading to repeated spillover into humans. The virus's unusual characteristics, such as its ability to mutate and infect conjunctival cells, make it a cause for heightened concern.
Researchers estimate MERS-CoV's basic reproduction number (R0) is 0.69, compared to SARS' 2.2-3.7, suggesting a lower risk of pandemic potential.
Researchers analyzed a unique 40-year data set to estimate short-term cross-protection between multiple dengue strains. The findings suggest that after an initial infection, a person is protected from other strains for 1 to 3 years.
Researchers at the IRCM isolated two important mechanisms that improve antibody quality, providing a new model for studying auto-immune diseases. The study found that these mechanisms, class switching and affinity maturation, are crucial for immune responses to infections and diseases.
Researchers found that single men and smokers are more likely to acquire cancer-causing oral human papillomavirus (HPV), while healthy men with newly acquired HPV infections rarely persist beyond one year. The study suggests a potential link between persistent oral HPV16 infection and oropharyngeal cancer.
Researchers mapped how critical molecules regulate inflammation during flu infection, discovering new targets for therapies. The study provided a holistic view of the host-pathogen interaction, revealing lipid mediators' dual role in controlling inflammation.
Researchers at Brookhaven Lab identified two promising candidates for antiviral drugs against human adenovirus. The compounds target the viral enzyme proteinase, essential for virus maturation and replication. These inhibitors may provide effective treatment against all strains of adenovirus.
Researchers at Pitt and MWRI found that placental cells can resist viral infection by transferring genetic material called microRNAs through tiny spheres called exosomes. This trait could lead to new approaches to combat viral infections during pregnancy.
Researchers developed a novel DNAzyme-gold nanoparticle test to detect dengue virus in mosquitoes, detecting as little as 10 viruses per sample. The assay is stable at high temperatures and can be easily transported and used in remote regions.
A University of Michigan-led study found that influenza infection significantly increases the likelihood of developing pneumococcal pneumonia, with a risk increase of up to 100-fold. The study suggests that vaccination against both flu and pneumococcal disease is crucial in reducing bacterial pneumonia incidence.
The USPSTF recommends screening for hepatitis C virus (HCV) infection in persons at high risk for infection. One-time screening for all adults born between 1945 and 1965 may identify infected patients at an earlier, more treatable stage of disease.
Research suggests H7N9 has a lower fatality risk than H5N1 but higher risk than pandemic H1N1. Between 0.16% and 2.8% of symptomatic patients are at risk of dying, highlighting the need for continued vigilance against the virus.
A combination of myxoma virus and rapamycin has been shown to infect and kill both brain cancer stem cells and differentiated compartments of glioblastoma multiforme, overcoming drug resistance. This study offers promising possibilities for overcoming barriers to treating the deadliest malignant brain tumor.
Researchers at Scripps Research Institute found a way for intrinsically disordered proteins to modulate their functionality. They used single-molecule FRET technique to study the dynamics of an adenovirus protein and discovered that it can employ allostery to regulate its interactions with other proteins.
Joshua Obar has been honored with the ICAAC Young Investigator Award for his groundbreaking research on immunological memory responses. His work focuses on understanding how latent viral infections affect CD8 T cells and the formation of immune memories.
Researchers have identified a new virus, CyCV-VN, in patients with severe brain infections in Vietnam. The virus was found in 28 out of 644 patients, but not in those with non-infectious brain disorders. Further research is needed to determine its role in causing the symptoms.
Researchers detected a new virus, CyCV-VN, in 4% of patients with central nervous system infections and up to 58% of farm animal fecal samples, raising concerns about animal-to-human transmission
Saint Louis University researchers developed a technology that can detect new, previously unknown viruses using transcriptome subtraction. The approach eliminates the need for lab-grown tissues or prior knowledge of a virus's origin.
Researchers used advanced mathematical modelling to devise strategies for making cancer cells exquisitely sensitive to virus infection, killing them without affecting normal cells. The models were remarkably accurate, predicting experimental outcomes in a mouse model of the disease and creating a useful framework for further research.
Researchers have found that common mutant forms of the JC polyomavirus are not infectious, but may still contribute to disease. The mutants appear to be up to no good by only being found in immunocompromised patients and possibly helping the main virus evade the immune system.
A study found that an intervention improving clinician education and personalized audit and feedback reduced broad-spectrum antibiotic prescribing for common pediatric bacterial ARTIs by nearly half. Antibiotic prescribing for viral infections remained low, with no significant change after the intervention.
A team of researchers plans to model how humans respond to viral pathogens like influenza, Ebola and West Nile, aiming to provide a detailed molecular understanding for drug development. The study will focus on the host response during infection, using high-throughput screening and advanced data processing methods.
Two studies identify specific HA mutations in H5N1 and H7N9 viruses that enhance infectivity in the human respiratory tract. These findings can inform monitoring and vaccine development for emerging bird flu strains.
A recent study published in PLOS Neglected Tropical Diseases found that mosquitoes reared in cooler temperatures have weakened immune systems, making them more vulnerable to viral diseases like West Nile fever and chikungunya fever. The research suggests that temperature may play a significant role in the transmission of these diseases.
A study led by Johns Hopkins investigators found that long-term couples need not change their sexual practices due to low oral HPV infections among spouses/partners. Persistent oral HPV infections are a risk for developing oropharyngeal cancers, but the study suggests these risks remain low.
Scientists discover protein c-FLIP-R that confers protection on immune cells against apoptosis, a type of cellular suicide. The discovery reveals mice with elevated c-FLIP levels are less susceptible to Listeria infections, sparking hope for potential therapeutic approaches.
Researchers have shown that interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection. The study suggests that interleukin-22 may play an important role in maintaining epithelial integrity, providing a potential benefit for patients with flu.
Researchers developed optics-based methods for determining viral load by counting individual virus particles, allowing for faster and cheaper testing. These new methods could conduct measurements in a medical office or hospital instead of a laboratory, providing rapid results and fast turnaround.
A randomized trial found that giving double doses of oseltamivir to patients with severe influenza infection offers no clinical or virological advantages over a standard dose. The study has implications for global guidelines on clinical management and stockpiling drugs for pandemic preparedness.
A new study in The Lancet details two MERS-CoV cases in France, revealing a longer incubation period than previously thought. The virus was detected in patients through lower respiratory tract samples, and initial negative results should be confirmed with further samples taken days later.
Researchers found that treatment with Tamiflu did not reduce viral load in three patients who became severely ill, leading to concerns about resistance. Genetic testing confirmed the presence of a mutation characteristic of neuraminidase inhibitor resistance.
New research from the University of Southampton reveals copper can rapidly destroy norovirus on surfaces, potentially disrupting infection cycles and lowering outbreak risks. The virus can remain infectious on solid surfaces, but copper alloy surfaces containing over 60% copper prove highly effective in destroying it.