Articles tagged with Viral Infections
New findings show STELARA significantly inhibits structural damage progression at week 24 and maintains effect through two years. Treatment with STELARA results in reduced total psoriatic arthritis modified vdH-S scores compared to placebo.
Researchers at the University of Illinois Chicago have discovered a common food additive that can block a deadly new strain of avian influenza virus from infecting healthy cells. The compound, tert-butyl hydroquinone, targets a previously untapped region of the flu virus called hemagglutinin.
A study published in Nature Communications reveals that evolution can favor mutations making avian flu more transmissible in mammals. The research found that even rare mutants can be transmitted if they have an evolutionary advantage, highlighting the potential for H5N1 viruses to infect humans.
New research reveals that African buffalo are a key source of the SAT 2 virus responsible for foot and mouth disease in sub-Saharan Africa. The study shows that the virus can spread over relatively short distances through infected hosts, highlighting the importance of genetic tracking for predicting future outbreaks.
A team of scientists discovered that a single amino acid change in the human BK polyomavirus enables it to bind to a different sugar on host cell surfaces. This mutation allows the virus to potentially adapt to new species by changing its binding target preference.
Researchers at Whitehead Institute discovered that the flu virus infects host cells by killing off immune system's best-equipped cells that can neutralize the virus. This allows the virus to replicate efficiently before the immune system mounts a second wave of defense.
Scientists at the Monell Chemical Senses Center and USDA have discovered that avian influenza virus can be detected based on odor changes in infected birds. The study identified specific chemical compounds associated with the odor changes, which may also serve as potential biomarkers for diagnosing gastrointestinal diseases in humans.
Researchers have isolated viruses that specifically target the highly infectious hospital superbug C. diff, which can cause severe diarrhoea and dehydration. The discovery could lead to a new treatment for this condition, with the potential to revolutionise the way it is treated in clinics.
Researchers at ETH Zurich have discovered a new antiviral response in mammals, utilizing the RNA interference pathway to combat viral infections. This discovery sheds light on a previously overlooked aspect of innate immunity and highlights the simplicity and universality of this system.
Scientists have discovered that mammals use the RNA interference (RNAi) process to destroy viruses within their own cells, similar to plants and invertebrate animals. This finding could lead to the creation of vaccines against deadly infections such as SARS, West Nile, dengue, hepatitis C, and influenza.
The study reveals that the nonstructural protein 3 (NS3) protease of classical swine fever virus is capable of self-cleavage, generating two smaller proteins with distinct activities. This discovery sheds light on the complex regulation of viral replication and has significant implications for understanding persistent infections.
The study reveals that JC polyomavirus uses specific serotonin receptors to gain entry into cells, contrary to initial hypotheses. This discovery could lead to improved treatment options for patients with PML by informing how existing drugs work.
A universal infant vaccination campaign in China has led to a doubling of Hepatitis B virus (HBV) mutations, which may enable the virus to evade the vaccine. The mutations have risen from 6.5% in 1992 to nearly 15% in 2005, necessitating new vaccination strategies.
Research on an aerosol that induces a rapid immune response to prevent viral respiratory infections and asthma attacks has earned major funding from the National Institutes of Health. The NIH-funded project aims to translate preclinical findings to clinical trials to prevent asthma attacks.
Researchers at Virginia Tech aim to improve understanding of how environmental conditions affect the influenza virus's ability to survive and infect others while airborne. The project seeks to clarify why humidity affects the virus's transmission.
Researchers found a novel hepatitis virus that was mistakenly believed to be a genuine disease-causing agent. The team used next-generation DNA sequencing and data mining to track down the true source of the contamination, which was traced back to tiny oceanic algae called diatoms.
A study published in Cell Host & Microbe reveals that H7N9 avian flu viruses evolved from distinct H9N2 viruses through a two-step process. The viruses originated in wild birds and then continued to evolve in domestic birds, resulting in genetically diverse strains that could potentially spread among humans.
A genomic test developed by researchers at Duke University Medical Center shows over 90% accuracy in distinguishing between viral and bacterial infections. The test detects a specific genetic signature expressed by the immune system in response to viruses, providing a potential new method for diagnosing infectious diseases.
A recent study has revealed a significant increase in coeliac disease cases among Scottish children under the age of 16. The rate of new diagnoses rose from 1.7 per 100,000 to 11.8 per 100,000 between 1990 and 2009.
A new study published in PLOS ONE reveals that copper and copper alloys rapidly destroy norovirus, a highly-infectious sickness bug responsible for over 267 million cases worldwide. Copper surfaces can effectively shut down one avenue of infection, reducing the risk of outbreaks.
Medical scientists at the University of Alberta have made a key discovery about how the immune system kills healthy cells while attacking infections. Their research could lead to better solutions for cancer and anti-viral treatments by manipulating the immune system response to block collateral damage.
A combination of two licensed antiviral drugs reduces MERS-CoV replication and improves clinical outcomes in rhesus macaques. The treatment group showed no breathing difficulties, minimal pneumonia, lower virus amounts, and less severe tissue damage.
Researchers suggest that anti-PD-1 antibodies could be effective in treating hepatitis C and other persistent viral infections. The study found that animal models with HCV infection showed improved immune function after treatment with PD-1 blocking antibodies.
Researchers at KU Leuven have identified a series of chemical compounds that are highly potent inhibitors of dengue virus replication. The compounds will be further developed by Janssen into a first-in-class drug candidate for the prevention and treatment of dengue infections.
A combination of sofosbuvir and ribavirin achieved high sustained virologic response rates in patients with unfavorable treatment characteristics, including advanced liver disease and high baseline HCV RNA levels. The regimen was well-tolerated and safe, with a lower relapse rate compared to traditional interferon-based therapy.
Researchers identified that protease inhibitors prevent virus entry and affect reverse transcription and post-transcription stages of HIV-1 life cycle. Viral envelope protein mutations were associated with resistance to protease inhibitor treatment.
A significant outbreak of eastern equine encephalitis occurred in Panama in 2010, marking a change in the virus's behavior in Latin America. The outbreak confirmed 13 human cases and one dual infection case, with a low case-fatality rate compared to US standards.
Scientists successfully treated the Ebola virus in infected animals following onset of disease symptoms, demonstrating promise for developing therapies against the virus. The experimental treatment, known as MB-003, protected 43% of infected non-human primates.
Scientists have created a novel system to safely study the transmission of Crimean-Congo hemorrhagic fever virus through ticks. By carefully tracking each tick's movement and feeding pattern, researchers can examine the complete cycle of virus transmission between infected animals and uninfected ticks.
The study showed that the Ebola VP40 protein exists as a dimer and rearranges its structure to assemble filaments for the virus shell or bind RNA, controlling various steps of the life cycle with multiple functions.
Researchers at WashU Medicine have identified a new therapeutic target for COPD by linking acute viral infections to chronic obstructive pulmonary disease. Viral infection triggers the production of IL-33, a signaling molecule that activates immune cells to produce excess mucus in the lungs.
Scientists at Salk Institute find that enveloped viruses use phosphatidylserine to activate TAM receptors, disabling the interferon response and allowing infection. This discovery may lead to novel antiviral therapies that target this mechanism.
A study found that CDV infected at least 1% of Amur tigers since 2009, causing fatal neurological disease. The virus is spread through contact with domestic dogs or other wild carnivores, posing a significant threat to the critically endangered species.
Scientists have discovered a new strategy that cripples the dengue virus's ability to escape the host immune system. By introducing a genetic mutation to deactivate the MTase enzyme, researchers created a weakened virus that generates a strong protective immune response while preventing the virus from spreading in mosquitoes.
Researchers from The Mount Sinai Hospital have developed a new strategy to safely study deadly influenza viruses, including H5N1 bird flu. By harnessing the power of human lung cells, they create 'viral scissors' that can cut these viruses into pieces, preventing effective transmission to humans.
Researchers report a family cluster of two patients with H7N9 infection, suggesting direct transmission from father to daughter. However, the authors stress that the ability to transmit itself is limited and non-sustainable.
Researchers have developed a new laboratory model to study hepatitis C by infecting monkey stem cells with the virus. The model may lead to new treatments and vaccines for the disease, which affects over three million people in the US.
Scientists at the University of Bristol found significant differences in viral proteins for all four DENV types, which may impact anti-viral therapy design. This discovery could lead to more effective treatments for dengue disease, a mosquito-borne infection affecting millions worldwide.
A recent study published in the Journal of Antimicrobial Chemotherapy found that more than 60% of antibiotic prescriptions in the US are for broad-spectrum drugs, which can be ineffective against viral infections. The overuse of these antibiotics contributes to the development of antibiotic-resistant bacteria and side effects.
UCSF researchers have discovered a new adenovirus that can spread from primate to primate and potentially from monkeys to humans. The study suggests that adenoviruses may pose a risk for cross-species infections, highlighting the need for vigilance in tracking animal viruses.
Researchers at University of Bristol suggest combining antiviral treatment, opiate substitution therapy, and high-coverage needle and syringe programs to achieve substantial reductions in HCV prevalence among people who inject drugs. This approach can lead to a 45% reduction in HCV prevalence over ten years.
Researchers have found a virus in South African bats that is genetically more closely related to MERS-CoV than any other known virus. This discovery suggests that African bats may play a role in the evolution of MERS-CoV predecessor viruses, potentially leading to human infection through intermediate hosts such as camels.
Researchers developed a monoclonal antibody effective against human norovirus, which can prevent infection in susceptible host cells. The study aims to explore the antibody as both treatment and disease prevention strategy for outbreaks, particularly among vulnerable populations like healthcare workers and travelers.
A recent study by a MU, K-State research team disproved the theory that Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) binds to CD169 molecules in pigs. This discovery will help scientists narrow their search for an ultimate cure.
Researchers at Mount Sinai identified a critical protein called VP35 that deactivates the innate immune system, allowing Ebola viruses to spread. Overexpressing a cellular protein called PACT inhibited viral replication, providing a potential target for new treatments.
A fatal case of raccoon rabies virus exposure has been linked to a kidney transplant 18 months earlier, suggesting a long incubation period. The study emphasizes the importance of increased awareness and modified organ donor screening and recipient monitoring for infectious encephalitis.
Researchers isolated Heartland virus in tick populations in northwestern Missouri, confirming its role as a human pathogen. The virus causes severe illness with fever, headaches, and low white blood cell counts, with no treatment available.
U of M researchers identified infection-fighting and inflammation-suppressing functions for the PTPN22 gene, which could impact treatment strategies for autoimmune diseases. The study found that a variant of PTPN22 impacts immune system function in health and disease.
Researchers developed a modified prion protein that resists changing its shape, preventing the propagation of neurodegenerative diseases. The study provides a novel pharmacologic strategy to develop new drugs targeting prion protein and stabilizing its normal shape.
Researchers analyzed decade of West Nile infections, weather, and housing data to identify optimal time for intervention. The study found that using a mosquito vector index can nip outbreaks in the bud, but late intervention may still be necessary if data are unavailable.
Researchers aim to identify genetic elements that enable animal hepatitis E strains to infect humans, with potential implications for fighting cross-species virus infections. The study will also investigate host immune factors that defend against the virus.
A study at WashU Medicine distinguished between viral and bacterial infections in children with fever using gene profiling, achieving a 90% accuracy rate. This new method could help identify the cause of illness and ensure targeted treatment.
A new study reveals the H7N9 avian influenza virus can infect and replicate in human cells, suggesting it has pandemic potential. The virus also transmits efficiently in ferrets and other mammalian species, raising concerns about a potential global outbreak.
The H7N9 avian flu strain has a tendency to become established in bird, horse, and swine populations, leading to repeated spillover into humans. The virus's unusual characteristics, such as its ability to mutate and infect conjunctival cells, make it a cause for heightened concern.
Researchers estimate MERS-CoV's basic reproduction number (R0) is 0.69, compared to SARS' 2.2-3.7, suggesting a lower risk of pandemic potential.
Researchers analyzed a unique 40-year data set to estimate short-term cross-protection between multiple dengue strains. The findings suggest that after an initial infection, a person is protected from other strains for 1 to 3 years.
Researchers at the IRCM isolated two important mechanisms that improve antibody quality, providing a new model for studying auto-immune diseases. The study found that these mechanisms, class switching and affinity maturation, are crucial for immune responses to infections and diseases.
Researchers found that single men and smokers are more likely to acquire cancer-causing oral human papillomavirus (HPV), while healthy men with newly acquired HPV infections rarely persist beyond one year. The study suggests a potential link between persistent oral HPV16 infection and oropharyngeal cancer.
Researchers mapped how critical molecules regulate inflammation during flu infection, discovering new targets for therapies. The study provided a holistic view of the host-pathogen interaction, revealing lipid mediators' dual role in controlling inflammation.
Researchers at Brookhaven Lab identified two promising candidates for antiviral drugs against human adenovirus. The compounds target the viral enzyme proteinase, essential for virus maturation and replication. These inhibitors may provide effective treatment against all strains of adenovirus.