Articles tagged with Estrogen Receptors
A team at UC San Diego School of Medicine may lead to a contraceptive for female sea lampreys, a jawless fish considered an invasive pest species in the Great Lakes. The researchers' findings suggest that compounds could bind specifically to the lamprey estrogen receptor, potentially acting as contraceptives.
Researchers investigated estrogen's action in the brain, finding that it protects neurons and enables learning and memory throughout life. Estrogen receptors are present in both men and women, and a protein called PELP-1 enables rapid hormone action.
Researchers at the University of Florida have discovered a way to improve thought processes in female mice by recharging a naturally occurring estrogen receptor in the brain. This breakthrough suggests that drugs can be developed to offset cognitive decline related to low estrogen levels, protecting against neurological diseases.
Researchers at Baylor College of Medicine used high throughput microscopy to study the regulation of estrogen receptor-alpha, finding that its response depends on the manner of regulation. The technique enabled them to analyze thousands of images of cells and differentiate between ligand- and steroid-dependent regulation.
Scientists at Emory University's Winship Cancer Institute discovered a new regulation mechanism in breast cancer cells responding to estrogen. The study found that methylation on estrogen receptors prolongs their life and effectiveness in driving tumor growth.
A new study found that estradiol helps protect against auditory damage, particularly in mice with deficiencies in estrogen receptors. Treatment with ER-beta-binding drugs also showed promise in preventing hearing loss.
A 15-year study found women with low bone mineral density and a previous vertebral fracture had a higher risk of new vertebral fractures compared to those with normal bone density and no previous fracture. Women who experienced a new fracture were more likely to have a positive fracture history, weigh less, and report lower estrogen use.
A recent study published in Nature Medicine found that a byproduct of cholesterol metabolism, 27-hydroxycholesterol (27HC), interferes with the protective effects of estrogen on the cardiovascular system. When 27HC levels are high relative to estrogen, it blocks estrogen's function and leads to a loss of protection against heart disease.
Scientists have developed a new 'knock-out' gene model that provides molecular clues to breast cancer, focusing on the role of estrogen receptors in mammary gland development. The study suggests that estrogen expression is essential for normal duct development during puberty, pregnancy and lactation.
Research reveals that estrogen receptors in the hypothalamus serve as a master switch to control food intake, energy expenditure, and body fat distribution. The study shows that when these receptors are destroyed, animals immediately begin to eat more, burn less energy, and gain weight.
Researchers at Temple University's Sbarro Institute have made progress in understanding how ER-α is silenced in certain breast cancer cell lines. The findings could lead to new treatments for hormone-receptor positive breast cancers.
Researchers found that Src, a protein that cooperates with estrogen to break down ER-alpha, is overexpressed in ER-alpha–negative breast cancers. Src inhibition was shown to impair estrogen-stimulated ER-alpha proteolysis, suggesting that Src may stimulate estrogen-dependent ER-alpha degradation in these tumors.
A novel estrogen receptor, GPR30, is linked to breast tumor progression and increased tumor size. The receptor's expression was positively associated with tumor size and metastatic disease, suggesting it could influence treatment decisions for hormone therapy.
Researchers found a known Caveolin-1 gene mutation present in 19% of breast cancers fed by estrogen. They also discovered six new mutations associated with estrogen-driven breast cancers. The study suggests that Caveolin-1 mutations may play a role in the development of these cancers.
Researchers at NIEHS discovered that the beta estrogen receptor plays a significant role in ovarian function, potentially leading to new treatments for infertility. A simple blood test could diagnose genetic mutations affecting the receptor's function, improving treatment options and chances of having a healthy child.
Researchers develop method to modify existing proteins by adding intermediate functions followed by stepwise directed evolution, creating new protein functions in a couple of months. The approach has potential applications in therapeutics and other fields.
Scientists have discovered that elevated estrogen levels can reduce the severity of asthma by preventing abnormal airway constriction. Selective estrogen receptor modifiers (SERMs) also showed similar effects, suggesting a new molecular target for asthma therapy.
Scientists have identified new breast tumor subtypes associated with poor clinical outcomes, which can be recognized and matched with therapies. The discovery uses genomic approaches and microarray analysis to classify tumors into distinct subtypes based on patterns of gene interaction.
Researchers found that tamoxifen-resistant breast cancers grow due to PKA-activated estrogen receptor modification. Identifying patients with activated PKA may lead to alternative treatments with aromatase inhibitors or fulvestrant.
Researchers at Emory University Health Sciences Center identified a critical molecular link between estrogen receptors and invasive growth in breast cancer. The study reveals that a protein called MTA3 regulates cell adhesion molecule E-cadherin expression, leading to cancer progression.
A recent study reveals that estrogen receptors are regularly stripped off DNA to make room for new receptors, enabling cells to continuously sense changes in estrogen levels. This mechanism is essential for the proper functioning of genes and may offer new avenues for therapies in estrogen-related diseases.
A research team led by Dr. Rakesh Kumar has discovered a new form of a protein associated with aggressive forms of cancer, including breast cancer. MTA1s appears to intercept the key protein receptor responsible for communicating with estrogen inside cells.
A recent study has found that women with a particular gene sequence are at a higher risk of developing cognitive impairment and Alzheimer's disease. The study, conducted by researchers at UCSF and Axys Pharmaceuticals, followed over 2,800 women for seven years and found that those with the high-risk polymorphism were 30-40% more likely...
The study found that estrogen receptors are more widely expressed in the brain during fetal and neonatal periods, influencing brain development. Antisense oligodeoxynucleotide treatment decreased brain estrogen receptor levels, leading to changes in ventilation and body growth in male and female rats.
Scientists generate mutant mice with disrupted estrogen receptors, resulting in adult female ovaries transforming into male-like cells. This discovery advances our understanding of the action of estrogen and its role in human fertility and cancer.