A study at the Garvan Institute of Medical Research found that inactivation of a stress pathway makes ER+ breast cancer cells ignore stress signals, allowing them to evade treatment. The JNK pathway acts as a cellular alarm system, and its disruption leads to treatment resistance.
This study investigates the immunomodulatory effects of Ejiao on chronic obstructive pulmonary disease (COPD), focusing on its impact on inflammatory pathways and macrophages. Ejiao significantly improves lung function in COPD model mice, reduces inflammation, and modulates the ER/AKT/NF-κB pathway.
Researchers at Baylor College of Medicine found that postpartum female mice prefer cooler temperatures due to changes in the preoptic area of the brain, particularly a decrease in estrogen receptor alpha neurons. These changes affect the animal's warmth-seeking behavior and are regulated by reproductive experience.
A preclinical study led by Weill Cornell Medicine scientists found that estrogen surges promote binge drinking in females, causing them to 'pregame' and consume large quantities of alcohol. The study identifies a neural circuit in the brain where estrogen increases activity, leading to enhanced binge drinking behavior.
Researchers have identified a subset of brain cells in mice that act as the master regulators of urination, coordinating bladder contraction and relaxation. These estrogen receptor-expressing neurons (ESR1+) work as a reliable master switch to initiate or suspend bladder emptying with precise timing.
A new study by UCLA investigators found that Manuka honey contains compounds that can help reduce tumor growth in preclinical models. The research suggests that Manuka honey could potentially be developed into a natural supplement or standalone treatment for ER-positive breast cancer, which accounts for most breast cancer cases.
A new study published in JAMA Network Open found that hormone modulating therapy (HMT) used to treat breast cancer was associated with a 7% lower risk of developing Alzheimer's disease and related dementias. The protective effect of HMT decreased with age, particularly for women over 80.
Researchers at Huntsman Cancer Institute discovered that estrogen receptor mutations in endometrial cancers cause large changes in gene expression and cellular behavior. Inhibitors of CDK9, a protein that works with estrogen receptors, were found to be effective at reducing the growth and aggressiveness of endometrial cancer cells.
Researchers have discovered that estrogen promotes tumor growth in ERα-negative cancers, such as triple-negative breast cancer. Anti-estrogenic therapies, when combined with immune checkpoint inhibitors, drastically suppress tumor progression in mice models.
A new study shows that estrogen receptor (ER) expression in ductal carcinoma in situ (DCIS) is multi-clonal, meaning it varies across different cells. This finding has significant clinical implications, as it may help avoid overtreatment and undertreatment in DCIS patients.
A new study by researchers at Dartmouth Cancer Center shows that a combination of estrogen and PARP inhibitors can effectively treat advanced ER+ breast cancer by damaging cancer cells and preventing DNA repair. The treatment strategy has been shown to be effective regardless of BRCA1 or BRCA2 genetic mutations.
New research analyzed data on 8,007 patients with stage I–III breast cancer to predict recurrence risk based on cancer stage and receptor status. Patients with certain receptor combinations had higher or lower risks of recurrence at different stages.
Researchers at Rice University have discovered a new way protein structures communicate with each other to regulate hormone activity. This finding could lead to improved therapies for breast cancer and other diseases.
The phase 1 and phase 2 studies showed that ARV-471 was well-tolerated and could promote substantial estrogen receptor degradation in patients with advanced disease. The study has led to a randomized phase 3 trial comparing ARV-471 with a SERD in patients with ER-positive/HER2-negative advanced breast cancer.
Researchers discovered a novel interaction between the SARS-CoV-2 Spike protein and human Estrogen Receptor Alpha, which may contribute to severe coagulopathy in COVID-19 patients. The study suggests that modulating ER signaling could mitigate rare vaccine side effects.
A mutated gene in more than 20% of breast cancer recurrences promotes metastasis and resistance to hormone therapy. Researchers identify potential vulnerabilities, leading to the development of personalized treatment approaches.
A recent study found that patients with hormone receptor-positive breast cancer who experience rising ESR1 mutations before disease progression can benefit from an early switch to fulvestrant plus palbociclib. This approach yields a statistically and clinically significant gain in progression-free survival, potentially justifying its a...
In a phase III trial, elacestrant showed significant benefits in decreasing death or disease progression and increasing progression-free survival compared to standard of care. The treatment was well-tolerated with manageable side effects, offering hope for patients with ER-positive/HER2-negative metastatic breast cancer.
A new study from the University of Eastern Finland and Kuopio University Hospital found that liquid biopsy can accurately identify patients with poor breast cancer prognosis. High integrity of circulating DNA is associated with a poor prognosis, enabling earlier and more accurate detection of breast cancer. The study's findings have si...
A new PET imaging agent has been shown to solve 87% of diagnostic dilemmas in breast cancer patients, providing valuable information for personalized treatment decision-making. The agent's ability to visualize estrogen receptor expression across the body may improve patient outcomes and support broader implementation in clinical practice.
Recent study by Okayama University researchers reveals three photoinitiators cause faster increase in breast tumor growth in mice, with tamoxifen pretreatment reducing toxicity. The findings suggest photoinitiators could act as hormonal disruptions, raising concerns for patients and healthy individuals.
A small proportion of women with anti-estrogen treatment after breast cancer surgery have worse outcomes due to mutations in the estrogen receptor gene. Research found that 1% of breast cancer cases already at initial diagnosis have these resistant mutations, leading to poorer response to hormonal treatment and higher risk of recurrence.
Researchers found a significant association between estrogen receptor α PvuII polymorphisms and dementia in a Brazilian cohort. The study suggests that this polymorphism may contribute to the development of dementia, particularly in elderly populations.
A study found that a cell-surface estrogen receptor called GPER1 plays a critical role in protecting the fetus from maternal inflammation caused by viral infections. The researchers discovered that GPER1 helps to suppress type I interferon signaling, which can lead to serious developmental abnormalities and fetal death.
Researchers found that some PFASs mimic estrogen's ability to activate transcription, while others inhibit expression, but block natural hormone activity when present. A computational model predicted that PFASs bind to distinct sites on the receptor surface, potentially blocking estrogen's action
A recent study published in the Journal of Neuroscience found that high estrogen levels may increase feelings of reward in response to alcohol in female mice. The research suggests that treatment for alcohol use disorder may be more effective if sex differences are considered.
Research suggests fluctuating estrogen levels make alcohol more rewarding to female mice, potentially increasing susceptibility to alcohol use disorders. Activating estrogen receptors increases dopamine release and binge drinking behavior in female mice.
A University of New Mexico Health Sciences Center-led research team has discovered a cancer-fighting compound that also reduces fat in obese mice. The team found that the compound, G-1, increases energy expenditure and targets brown fat cells, leading to weight loss and improved diabetes symptoms.
A single cholesterol-derived molecule, 27-hydroxycholesterol (27HC), has been found to increase body fat even without a high-fat diet. The molecule affects white adipose tissue and expands the capacity of existing fat cells.
Scientists at EPFL have found that half of luminal epithelial breast cells express estrogen receptor at low levels, affecting cell function and cancer development. The estrogen receptor plays a biphasic role in breast cell growth and inhibition during pregnancy.
Researchers have identified estradiol as a potential new treatment for triple-negative breast cancer with estrogen receptor beta expression, effectively inhibiting tumor growth in studies. Estradiol stimulates the expression of cystatins, which exhibit tumor-suppressing effects on neighboring and distant cancer cells.
Researchers at Stevens Institute of Technology have designed a novel molecule that uses a unique mechanism to halt or destroy breast cancer tumors. The molecule, developed by Abhishek Sharma, could potentially add to the arsenal of drugs targeting estrogen receptors in breast cancer therapy.
Researchers discovered a novel mechanism of estrogen receptor signaling regulated by fibronectin, which boosts cancer cell growth and survival. Fibronectin prolongs the activity of estrogen receptors in breast cancer cells, allowing them to become resistant to common endocrine therapy drugs.
Researchers at the University of Pennsylvania have identified a new therapeutic target for melanoma, G protein-coupled estrogen receptor (GPER), which shows promise in combination with anti-PD-1 inhibitors. Activation of GPER may explain why women who have been pregnant have better survival outcomes when facing deadly skin cancer.
Researchers discovered a novel mechanism of estrogen action on heart physiology, revealing that xenoestrogens can influence cardiac function by regulating thyroid hormone production. This study highlights the potential risks of environmental estrogens on human health.
Researchers at Cold Spring Harbor Laboratory have identified the specific hormone receptors and brain regions responsible for masculinization in mice. The study found that estrogen receptor alpha is essential in inhibitory neurons for male sexual and aggressive behaviors to emerge, while deleting it had no impact on excitatory neurons.
A team of researchers at Baylor College of Medicine has identified two compounds that may be safer alternatives to bisphenol A (BPA), a chemical linked to health concerns. The study used an automated microscopy and image analysis-based technology to screen potential BPA substitutes, which could lead to safer plastics in everyday products.
Researchers at Université de Genève discovered that healthy fibroblasts surrounding breast cancer cells have a unique variant of the estrogen receptor GPER in their nuclei. This genetic variation promotes tumor cell migration and invasiveness through the secretion of molecules that stimulate malignant growth.
A new study from Lund University found that women with a high expression of the ER-beta estrogen receptor in their tumours had better outcomes after undergoing chemotherapy. The research could lead to more frequent check-ups and additional treatment for high-risk patients.
Researchers at Scripps Research Institute have developed a new structure-based drug design strategy to target the estrogen receptor, reducing resistance and side effects in hormone-driven breast cancer treatments. The approach uses x-ray crystallography to visualize how drugs interact with the receptor, allowing for the creation of bio...
A new study has identified a high prevalence of estrogen receptor mutations in patients with metastatic breast cancer, which are linked to poorer outcomes. The research found that 29 percent of patients had a mutation in the estrogen receptor, leading to reduced overall survival rates.
Researchers investigate how changes in light exposure may contribute to breast cancer development. Extended periods of nighttime illumination disrupted normal cellular behaviors and gene expression, particularly in hormone-dependent tissues like the breast.
Postmenopausal African American women who use female hormone supplements containing estrogen and progestin are at a 50% increased risk of estrogen receptor positive breast cancer. The study found greater increases in risk for recent and long-term users, highlighting the importance of limiting combination therapy.
Researchers at Baylor College of Medicine discovered that estrogen receptor β promotes the growth of endometriosis by allowing abnormal cells to escape immune surveillance. Elevated levels of this protein were found in human tissues and studies in mice showed a similar effect, highlighting a new target for effective treatment.
Researchers found significantly decreased estrogen receptor beta expression in autistic male brains, which may explain the disorder's higher prevalence in boys. Estrogen receptor agonists could potentially reverse autism's behavioral deficits, such as reclusiveness and repetitive behavior.
A study published in JCI Journals suggests that estrogen replacement therapy can suppress binge-eating behaviors in mice. The effect required the presence of estrogen receptors in serotonin neurons, and direct delivery of an estrogen conjugate also reduced binge eating in these animals.
Researchers have uncovered a new gene fusion that may contribute to the development of luminal B breast cancer, a subtype associated with more aggressive forms and higher recurrence rates. The study found that this fusion is present in approximately 8% of tumor samples and can lead to increased cell motility and invasion.
Researchers have identified a common gene variant, GPER, that makes women more prone to high blood pressure and increased risk of heart attack and stroke. The study found that many women with the less functional form of GPER had higher blood pressure, highlighting a genetic basis for heart disease in women.
Researchers have developed new tests to classify compounds' activity with great detail and speed, identifying safer replacements for BPA. The advance could offer a fast and cost-effective way to identify safe alternatives, as millions of tons of BPA and related compounds are produced each year.
Resveratrol has been found to control the body's inflammatory response by binding to the estrogen receptor without stimulating cell proliferation. This study reveals a new pathway for resveratrol's beneficial effects in aging, inflammation, and metabolism.
A recent study published in Cancer journal found that smoking is significantly linked with an increased risk of estrogen receptor positive breast cancer among young women. Young women who have smoked a pack a day for 10 years or more experience a 60% higher risk of developing this type of breast cancer.
A recent study found that lung cancer in women who have never smoked is more frequently associated with EGFR mutations and estrogen receptor (ER) overexpression. The researchers observed a higher percentage of these genetic abnormalities in patients who had not previously smoked, suggesting potential new treatment targets for this group.
Researchers at UC Irvine have discovered a new mechanism by which estrogen suppresses lipid synthesis in the liver, revealing potential new approaches for treating certain liver diseases. The study found that estrogen acts on cell membrane-based receptors to inhibit lipid synthesis, changing long-held views in the field.
Researchers at UC San Diego School of Medicine found that BPA's metabolite MBP interacts more strongly with estrogen receptors than BPA itself, posing a greater health threat. This discovery could lead to the development of new drugs targeting excessive estrogen activity linked to diseases.
Scientists have made new discoveries about the shape and structure of biological molecules, potentially leading to new treatments for neurodegenerative diseases. The research found that two protein channels are similar in structure and function, with one 'unlocking' calcium flows inside cells.
A UT Southwestern study found that estrogen acts on two hypothalamic neural centers to regulate hunger and energy expenditure in female mice, keeping their body weight in check. This discovery has potential implications for postmenopausal women, who may benefit from targeted hormonal replacement therapies.
Researchers have engineered new sensors that can detect estrogenic compounds in human cells, which is crucial for understanding the potential health risks associated with these substances. The sensors, developed by a team led by Huimin Zhao, were found to reliably detect estrogenic compounds within hours, even at low levels.
Researchers found that women with estrogen receptor negative cancers who did not receive radiation were 91% more likely to die from breast cancer. There is a corresponding increase in the use of radioactive implants for these patients.
Researchers discovered that estrogen receptors in the brain help turn off genes leading to chronic inflammation. This finding may lead to new treatments for multiple sclerosis and other neurodegenerative conditions.
A new study reveals that estrogen receptors in the liver are critical for maintaining fertility, with dietary protein playing a crucial role. The researchers found that mice on calorie-restricted diets showed reduced reproductive cycles, but those given more protein restored normal function.