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New tool enhances control of cellular activity

Researchers at Stanford University have developed a new synthetic receptor, PAGER, that can accommodate a broader range of inputs and produce a more diverse set of outputs. The tool enables control of neuronal activity, immune responses, and therapeutic treatments in lab experiments.

Apple iPhone 17 Pro

Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.

Conformational dynamics and allostery elucidate how GPCR couple to multiple G-proteins, offering mechanistic insights into coupling-promiscuity and novel drug discovery strategies

The study elucidated the mechanisms behind G protein selectivity and efficacy in the human adenosine A2A receptor, discovering changes in activation conformations as the primary cause of coupling promiscuity. The research team used experimental and computational techniques to understand allosteric mechanisms and their role in selective...

A new way to develop drugs without side effects

Scientists discovered a novel method to activate G protein-coupled receptors from inside cells, which can help develop drugs with fewer or no side effects. This new process uses a non-peptide message molecule called PCO371 that binds to the intracellular region of the receptor and interacts directly with G protein subunits.

The link between electrical voltage and brain flexibility a new study by Tel Aviv university found, for the first time; a direct and significant link between changes in G-protein-coupled receptors and the brain’s ability to adapt to external changes

A Tel Aviv University study found a significant link between changes in G-protein-coupled receptors and brain adaptability. Disabling the voltage sensor of these proteins caused uncontrolled brain flexibility, leading to excessive habituation to odors.

SAMSUNG T9 Portable SSD 2TB

SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.

Duke team identifies new 'mega-complex' involved in cell signaling

Researchers at Duke Health have discovered a new paradigm for how G protein-coupled receptors activate cell signaling mechanisms. The formation of 'mega-plexes' explains how signals can continue to be sent after internalization, opening up possibilities for targeted drug therapies.

CalDigit TS4 Thunderbolt 4 Dock

CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.

Dinosaur ancestor's vision possibly nocturnal

Researchers recreated a 240-million-year-old protein to study the vision of dinosaur ancestors, finding evidence that they may have had dim-light vision. The discovery offers insights into how biologically important molecules evolved over time and paves the way for further studies on ancient species.

Apple AirPods Pro (2nd Generation, USB-C)

Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.