Articles tagged with Growth Hormone
A Stanford study systematically reviewed medical literature on growth hormone therapy for the elderly, concluding that it has minimal to no benefit and potential adverse side effects. The research found modest effects on body composition but no impact on clinically important outcomes such as bone density or cholesterol levels.
A study published in Nature found that mice lacking a critical gene for repairing damaged DNA grow old rapidly and exhibit physical and genetic changes similar to those of normal-aged mice. The researchers discovered a new type of human progeria, a rare inherited disease characterized by accelerated aging.
Women's long-term weight training programs increase biologically active growth hormone, a key factor in muscle development and bone strength. The study found that heavy loading cycles or workouts with moderate to heavy intensity regimens stimulate growth hormone production.
A study by Children's Hospital of Philadelphia researchers found that p53 regulates insulin-like growth factor-I (IGF-I) signaling, which may contribute to cancer progression and aggressiveness. The study also suggests that inhibiting IGF-I signaling could lead to novel therapies for cancer.
Researchers discovered a novel mechanism controlling human growth hormone (hGH) gene expression through non-coding RNAs. This finding may lead to the development of therapeutics for hGH defects and a better understanding of genetic disorders.
Researchers at the Salk Institute found that specific plant hormones activate different factors rather than a common target, contradicting the long-held assumption that they converge on a central growth regulatory module. This discovery was made using gene-chip technology and analysis of microarray data from the AtGenExpress project.
Researchers found that participants receiving growth hormone secretagogues (GHS) experienced improved physical function and increased lean body mass. The treatment also led to higher levels of growth hormone and IGF-1 in the bloodstream, suggesting potential benefits for reducing aging-related effects.
Research suggests a protein derived from fat tissue, adiponectin, may play an important role in longevity. Boosting growth hormone production also shows promise in extending independent living among the elderly.
A recent study has identified a hormone called juvenile hormone that inhibits the growth of imaginal discs in insects, which can have implications for understanding cancer treatment and long-term effects of early infant malnutrition. Without this hormone, the discs can form and grow at the expense of the rest of the animal.
A new study from UNC Health Care suggests that loss of function in the SOCS2 gene may lead to colon polyps in individuals with excessive growth hormone. The research also identifies a possible molecular marker for predicting risk, which could inform growth hormone therapy for gastrointestinal conditions.
Researchers found that more growth hormone is produced in females than males and in adults, with the hormone responding to estrogen. The study has implications for menopausal women using estrogen replacement therapy and athletes taking growth hormone and anabolic steroids.
Researchers found that growth hormone treatment can worsen or trigger sleep apnea in obese children exposed to colds, potentially leading to death. Doctors are urged to perform sleep studies on these patients before and during treatment to monitor their health.
A recent study reveals that human growth hormone (HGH) is illegal for off-label anti-aging use and can accelerate aging. The researchers warn that many people are unknowingly receiving the drug, which has high rates of serious adverse effects and may increase cancer risk.
The studies demonstrated that rhIGF-1 administration causes a prompt increase in blood IGFBP-3 levels in patients with IGF-1 deficiency. The findings suggest that IGFBP-3 is recruited into the bloodstream or IGF-1 is stabilized by binding to IGFBP-3, which may help guide optimal dosing of rhIGF-1.
Tercica has presented human and animal safety data showing no immunotoxic effects with long-term rhIGF-1 treatment. The data also demonstrate a reduction in the incidence of some endocrine cancers in animals, providing further evidence supporting the long-term safety of rhIGF-1 therapy.
A new dosing approach for growth hormone based on serum levels of insulin-like growth factor-I (IGF-I) shows improved height increases in children with growth hormone deficiency or short stature. The study found that increasing IGF-I levels resulted in significant gains in height, particularly in those receiving higher doses.
A study found that a life-long deficiency of insulin-like growth factor-1 (IGF-1) decreased cancer risk by approximately 45 percent and decreased cancer deaths by 12-15 percent. Low-calorie diets may also reduce IGF-1 levels, potentially reducing cancer risk.
A study found that approximately 30,000 US children have short stature due to non-growth hormone deficiency Primary IGF-1 deficiency. This suggests one-third to half of idiopathic short stature cases can be re-classified as Primary IGFD.
Researchers found that a deficiency in growth hormone and IGF-1 reduced cancer and kidney disease risk, but impaired cognitive function and accelerated cartilage degeneration. Lifelong treatment with growth hormone actually increased lifespan by up to 14.6%.
A one-year study found growth hormone treatment significantly reduced intra-abdominal fat and improved insulin sensitivity in postmenopausal women with abdominal adiposity. The treatment also increased thigh muscle area and lowered LDL cholesterol concentration.
UCL surgeons successfully performed phalloplasty to rebuild micropennises in nine men, with four able to urinate standing up and four have regular sex. However, complications arose in several cases, highlighting the need for awareness and careful monitoring.
Researchers found that growth hormone reduces STAT3 activation, modulates cellular apoptosis and proliferation, and improves weight gain in mice with colitis. The study suggests using growth hormone as a new therapeutic approach to improve growth and intestinal healing in IBD.
Researchers found that using growth-hormone-releasing hormone (GHRH) therapy can increase normal growth hormone production and regulation in men with HIV lipodystrophy. This approach resulted in improved body composition, reduced fat deposits, and better cardiovascular health outcomes.
Researchers discovered that growth hormone activates the Foxm1b gene, a critical regulator of tissue repair and regeneration. The study suggests that declining growth hormone levels in older adults may contribute to reduced healing capacity.
Researchers found decreases in genes producing growth hormone and prolactin, key to development and immune system function, in aged mice compared to young mice. This suggests specific genetic changes in the cerebellum area of the brain may contribute to loss of motor control and balance with age.
Researchers have found significant decreases in growth hormone and prolactin gene expression in the cerebellum of aged mice, suggesting a possible link between these hormones and age-related declines in motor control and balance. Further study is needed to understand the role of genetic pathways in aging.
Researchers found that younger adults with growth hormone deficiency require higher doses of the hormone to maintain healthy bones and reduce the risk of heart disease. The study's findings could change clinical practice in the US and abroad, suggesting that treatment should be restarted at a lower dose for older adults.
Researchers at Saint Louis University found that daily injections of growth hormone helped obese patients lose an average of five pounds. The weight loss was primarily due to the reduction of body fat, particularly in the abdominal area.
A recent study found that a combination of growth hormone and sex steroids showed significant increases in lean body mass and decreases in fat mass, but also reported common side effects such as joint pain and swelling. The study suggests that the treatment is not yet ready for prime time due to its adverse effects.
Research by Thomas Chen at the University of Connecticut has shown that a new growth hormone treatment can increase fish size by up to 600 percent. The treatment involves using a synthetic peptide to stimulate growth, with potential applications in reducing feed costs and increasing fish yields.
The ACP Annals Tip Sheet discusses growth hormone deficiency treatment, exercise counseling effectiveness, and West Nile virus prevention strategies. The USPSTF found mixed evidence on exercise counseling's impact on patient activity, while recommending public mosquito control programs for virus prevention.
A UK population study suggests a possible link between colorectal cancer and human growth hormone therapy, with treated patients at an increased risk of death from the disease. The study found significant risks of incidence and mortality associated with colorectal cancer in patients treated during childhood and early adulthood.
A new study suggests that growth hormone therapy can significantly enhance human thymic function and increase the production of new T cells in HIV-infected patients. This could potentially help preserve and restore their immune systems. However, more research is needed to confirm these findings and ensure the benefits outweigh the risks.
The pituitary gland develops from a common primordium into multiple endocrine cell types through intricate signaling and nuclear events. Researchers describe the complex interactions of transcriptional regulatory factors controlling this process.
Researchers at the University of Pennsylvania School of Medicine have found a remote control mechanism that sets human growth hormone into action, operating from 15 kilobases away. This discovery could lead to an eventual gene therapy for type of dwarfism resulting from pituitary gland's inability to manufacture hGH.
Researchers found that growth hormone therapy stimulated immunity-promoting cells in bone marrow and other organs of aging rats, increasing red and white blood cell production by up to three times. This approach could lead to increased reserve capacity for immune cells in the elderly.
A new study published in The Lancet reveals that pegvisomant normalized IGF-I concentrations in 97% of patients with acromegaly after 12 months of treatment. Patients experienced improved symptoms and a better quality of life, highlighting the potential benefits of this innovative drug.
Researchers at Johns Hopkins Children's Center found a faulty releasing hormone receptor gene in three families with isolated growth hormone deficiency type 1-B, the most common type of growth hormone-deficient dwarfism. The study suggests that this condition is not caused by a defect in human growth hormone production.
A recent study published in Endocrinology found that mice engineered without the receptor for growth hormone lived almost one year longer than normal mice, suggesting that the natural hormone may actually shorten lifespan. The researchers are now searching for genes regulated by growth hormone that might play a specific role in life span.
Researchers discovered growth hormone inhibitor octreotide, treating acromegaly and gastroenteropancreatic tumors. The drug has also shown promise in preventing eye damage in patients with type I diabetes.
Researchers found two stages of age-related deterioration of sleep quality: the first between young adulthood (16-25) and mid-life (35-50), and the second after age 50. Changes in sleep quality were mirrored by changes in hormone secretion, particularly growth hormone, which declined significantly with age.
Researchers successfully differentiated human placental cells by adjusting gap size in a fibrous-bed bioreactor, mimicking the body's natural process. The breakthrough may aid organ production for transplantation and has implications for tissue engineering and cancer research.
Researchers at UNC-CH will investigate prostate cancer mechanisms, including the role of androgens, to develop a potential cure. The team aims to understand why black men develop prostate cancer twice as often as white men do.
Researchers investigated how two proteins, Nodal and Pitx2, direct organ growth in mice, finding that Pitx2 plays a crucial role in determining lung leftness. The study also showed that a single transcription factor does not account for the entire left-right asymmetry in humans, highlighting the need for further research.
A new study at Ohio University found that growth hormone is important in the development of Type I diabetes-induced kidney damage. The researchers induced Type I diabetes in mice and found that those with disrupted growth hormone receptors did not develop diabetic kidney disease.
Researchers found that stimulating growth hormone production in healthy older men and women can reduce body fat by approximately 5% and increase IGF-I levels. This effect was observed in both men and women, with some suggestions that estrogen replacement may partially block certain effects.
A new study by researchers at University at Buffalo found that babies born with a congenital growth hormone deficiency are of normal length at birth. The study suggests that growth hormone deficiency does not affect fetal growth, and that persistence of hypoglycemia and jaundice are clues for evaluation of pituitary hormones. Replacing...
Certain plant species can trigger an adaptive reaction to flooding by producing life-saving shoots, but the exact process is unclear. Dutch biologists hope to unravel this process at the physiological and molecular level to develop crops that can cope with floods.
Researchers discovered a genetic mutation responsible for a rare form of treatable dwarfism, affecting 105 family members in northeastern Brazil. The study suggests the mutation could be used as a prenatal screening test for the disorder.
Researchers discovered that green tea's EGCg compound inhibits an enzyme required for cancer cell growth and can kill cultured cancer cells. Drinking more than four cups of green tea a day may provide enough of the active compound to slow and prevent cancer cell growth.
A new form of inherited dwarfism, known as Dwarfism of Sindh, has been identified in a large Pakistani family. The condition is caused by a genetic mutation in the growth hormone-releasing hormone receptor (GHRH-R), leading to growth hormone deficiency and dwarfism.
A comprehensive study of 195 short children found a strong link between shortness and behavioral adjustment problems. Growth hormone treatments improved behavior scores and conduct in many cases, with significant improvements in anxiety, depression, and attention deficit disorders.
A new study from the University at Buffalo found that adults treated for growth-hormone deficiency as children have similar quality of life to their healthy same-sex siblings. Despite expecting benefits, the study revealed little relationship between adult height or growth hormone treatment and reports of psychological and social funct...
Human growth hormone increases bone size in mice but compromises bone quality, leading to increased brittleness and fracture risk with age. This study highlights the need for caution when prescribing human growth hormone, especially in individuals without specific medical needs.
Researchers find that competition for resources affects organ growth, leading to changes in traits like wings and horns. This phenomenon resolves a conundrum identified by Charles Darwin, suggesting that genes are not the sole determinant of development.
Researchers found that lutenizing hormone (LH) plays a critical role in sustaining the growth of egg follicles until ovulation. The discovery has important implications for women undergoing fertility treatments, as it may be possible to reduce the risk of multiple births by manipulating LH and FSH levels.
Researchers discovered a growth hormone antagonist that reduces eye disease by 33-44% in mice. The findings suggest the use of this antagonist or a drug inhibiting growth hormone release may help prevent retinal neovascularization and treat related eye diseases.
Researchers identified specific receptors for interleukin-1 on somatotrope cells in the pituitary gland, suggesting a direct link between the immune and endocrine systems. This discovery may help understand how the immune system regulates animal growth and disease.
Researchers at Johns Hopkins Medicine found that squalamine, a shark liver substance, nearly stops the growth of new blood vessels that nourish solid brain tumors. The study showed a significant reduction in tumor cell growth and slowed the formation of new blood vessels by up to 83% after two days.