Articles tagged with Growth Hormone
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Researchers found that MLL4 controls the production of neurons vital to growth, leading to delayed growth and short stature in patients. Small chemicals mimicking epigenetic actions of MLL4 may help restore GHRH neuron production, offering a potential treatment strategy.
Researchers at Clemson University have identified two genetic variations associated with small body size and lance canine, a dental anomaly common in Shetland Sheepdogs. The study found that dogs with these variations are on average one inch shorter and six pounds lighter than unaffected breeds.
A study of over 180 girls found that those entering puberty early have a longer window of susceptibility to breast cancer, with higher growth hormone levels and slower pubertal progression. This can be mitigated through healthy lifestyle habits, such as exercise, balanced diet, and reduced exposure to endocrine disruptors.
A Nagoya University team has discovered a process called allosteric regulation in plants, which helps maintain the balance of phytohormones gibberellin and auxin. This finding could lead to improved rice crop productivity and provide a solution for food security.
A study at The University of Queensland Diamantina Institute found that growth hormone boosts liver regeneration in mice by suppressing inflammatory responses. Mice with normal growth hormone receptors survived liver surgery and experienced full liver regeneration.
A phase 3 clinical trial found that oral octreotide capsules effectively control symptoms of acromegaly in adults without pain or lost workdays. The treatment has the potential to expand options for patients beyond injectables.
Researchers found that hormone implants increased weight gain and feed intake by 10% in Holstein steers, making them comparable to beef breeds. This technology can be a game-changer for dairy farmers struggling financially.
Researchers at the University of Texas Medical Branch have discovered that traumatic brain injuries can lead to a cascade of health issues, including fatigue, depression, and memory problems. Growth hormone replacement therapy has been shown to improve symptoms, but the mechanisms behind its effectiveness are still not fully understood.
Researchers at Hospital for Special Surgery found that insulin-like growth factor 1 (IGF1) plays a crucial role in tendon growth and adaptation. The study suggests targeting IGF1 may be useful in treating painful tendon injuries, and clinical trials are underway to test this approach.
A recent animal study identified IGF1 as essential for adult tendon growth and adaptation. Researchers found that removal of the IGF1 gene prevented tendons from growing properly.
A study published in the Journal of Endocrinology found that high levels of caffeine during pregnancy can lead to lower birth weights, altered growth hormone levels, and impaired liver development. The study suggests that excessive prenatal caffeine consumption may increase the risk of fatty liver disease in adulthood.
A new study reveals that patients and their families have borne an increased financial burden for growth hormone treatment since its FDA approval in 2003. The cost burden has risen by 234% due to increased copayments, deductibles, and insurance restrictions.
A study by researchers found that growth hormone insurance strategies reduced total and insurer costs, but patient savings were minimal. The cost of treatment decreased for insurers, while average copayments, deductibles, and patient financial burden increased.
A UCL-led study confirms that some vials of discontinued hormone used in medical treatments contained seeds of a protein implicated in Alzheimer's disease. The research found that these seeds can seed amyloid pathology in mice and supports the team's hypothesis that amyloid beta was accidentally transmitted to patients via this treatment.
A synthetic compound based on a brain hormone has shown surprising benefits in treating lung and other cancers in mice, but its effect on human cells was the opposite. The compound, MR409, is one of several GHRH analogs that spur healthy tissue growth and may alleviate concerns about stimulating cancer cell growth.
A new NIH-funded research project at Ohio University aims to extend human lifespan and improve health in old age. The study, led by Dr. John Kopchick, will investigate the molecular mechanisms behind the remarkable health benefits seen in genetically modified mice.
Researchers found that growth hormone treatment improved cognition, reduced brain tissue loss, and promoted plasticity in the brain of mice with induced strokes. The treatment showed promise for facilitating rehabilitation and improving quality of life after a stroke.
The $900,000 NSF grant enables researchers to analyze large datasets describing gene responses to ethylene in Arabidopsis thaliana, revealing patterns and relationships. This work has significant agricultural implications as root structure affects plant water and nutrient uptake.
Researchers found that prolonged maternal stress can alter placental metabolism and accelerate fetal growth, potentially leading to mental or physical illnesses. The study suggests seeking support from a therapist for pregnant women experiencing longer-term stress situations.
Researchers found that activating or deactivating a hormone in roundworms stimulates or stunts growth, mirroring human TRH regulation. This discovery offers new possibilities for research into human growth mechanisms.
A University of Illinois study reveals which production attributes matter most to consumers when buying beef and chicken, with 'no growth hormones' topping the list. The study found that organic was ranked lowest in importance, sparking surprise among researchers who attribute this to a lack of understanding about the term's meaning.
A group of medical experts has issued new clinical guidelines for managing children and adolescents with growth failure, recommending hormonal treatments for certain conditions but cautioning against routine use in cases of unknown cause. The guidelines aim to balance medical needs with potential risks and long-term consequences.
Researchers found that juvenile IGF-1 concentrations predict heavier weight, greater survival to reproductive maturity and earlier birth, but also shorter adult lifespans. Measuring IGF-1 during the first year of life can be used to predict later-life traits in wild mammals.
Researchers discovered that ants share proteins and hormones through trophallaxis, allowing them to collectively influence colony growth and development. This process enables ants to cast 'quantitative ballots' for their colony's future by administering different amounts of growth-promoting components to their larvae.
Researchers at Washington University in St. Louis isolated an enzyme GH3.5 that regulates the levels of two plant hormones, auxin and salicylic acid, simultaneously. The study reveals how this single enzyme controls distinct classes of hormones, providing new insights into the molecular pathways for growth and defense.
Research suggests doctors are more likely to prescribe growth hormones for slow-growing children if the child's family requests it or if they believe in its intangible benefits. This raises concerns about access, overuse, and cost of life-enhancing products, which can be expensive and create financial burdens.
A Japanese research team has identified a hormone that limits liver fibrosis in nonalcoholic steatohepatitis (NASH) and cirrhosis. Administering growth hormone alleviated NASH conditions caused by adult growth hormone deficiency, and treatments were effective on model animals.
The Endocrine Society recommends treating hypopituitarism by replacing hormones at natural patterns, with accurate hormone measurements crucial for diagnosis and treatment monitoring. The guideline also addresses special circumstances like pregnancy care and post-surgical care.
A new study from McMaster University found that lifting lighter weights many times can be as efficient as lifting heavy weights for fewer repetitions in building muscle and strength. Researchers analyzed muscle and blood samples and found gains in muscle mass and fibre size were virtually identical between the two groups.
A recent ESHRE study found that human growth hormone did not improve live birth rates in women having difficulty conceiving, with a clinical pregnancy rate of 14% in the treatment group and 11% in the placebo group. Poor responders are a challenging group to treat, accounting for up to 30% of patients who respond poorly to treatment.
Research suggests that combining aromatase inhibitors with growth hormone can effectively and safely increase height in very short adolescent boys. The study found significant gains in height and lean body mass when using this combination therapy.
A study showed that transferring healthy gut microbial species from children to mice can counter the negative effects of malnutrition, suggesting a possible therapeutic approach. Certain microbe species offset malnutrition's detrimental effects, enabling normal growth in undernourished children.
Researchers have identified a new drug target that can restore healthier lipid levels in people with type 1 diabetes. By blocking the growth hormone receptor, MIA-602 has been shown to reduce unhealthy lipids and improve vascular function.
A new study led by Adda Grimberg proposes to reframe the debate on treating short stature in children. The research team found that psychosocial issues such as self-esteem and future adult success dominate parent discussions, with treatment characteristics and health concerns playing a significant role in decision-making.
A new study from the University of Manchester found that children treated with growth hormone for deficiency show varying rates of growth depending on their latitude and summer daylight exposure. The study of 118 children aged 5-11 from 14 countries suggests a complex relationship between sunlight, genetics, and bone growth.
A decade-long study shows growth hormone continues to reduce fracture risk and maintain bone density in postmenopausal women with osteoporosis. The treatment's effects were found to last for years after it was administered.
Researchers found that short boys are 2-3 times more likely than short girls to receive recombinant human growth hormone treatment for idiopathic short stature (ISS). This gender bias may lead to overzealous treatment in healthy boys and delayed diagnoses of underlying diseases in short girls.
A two-year clinical trial will study whether human growth hormone can safely improve recovery and prevent long-term osteoarthritis after an ACL tear. The trial aims to help professional athletes recover more easily and maintain their quality of life.
Researchers have found that diatoms grow faster in the presence of Sulfitobacter bacteria, which release a growth hormone beneficial to land plants. This discovery sheds light on the complex interactions between marine microbes and their environment, with potential implications for understanding ocean productivity and climate change.
The marketing, prescribing, and selling of testosterone and growth hormone as solutions for aging-associated problems is considered disease mongering. The FDA has recently acknowledged that these treatments are not indicated for age-related decline in serum testosterone, with potential risks outweighing benefits.
Researchers at KU Leuven discovered genetically modified mice producing human growth hormone, altering insulin production and previous research findings. This unexpected turn reveals the need for reinterpretation of 250+ published diabetes studies.
Acromegaly is usually caused by a non-cancerous tumor in the pituitary gland, leading to excessive growth hormone production and various health complications. The Endocrine Society recommends surgery as the primary therapy for most patients, offering an opportunity to examine the tumor sample and immediately lower growth hormone levels.
A new study suggests that growth hormone treatment in children with idiopathic short stature may exacerbate feelings of depression and emotional distress. The research found that children treated with GH showed worsening symptoms of depression and withdrawal compared to those not receiving the treatment.
A study found that individuals with growth hormone receptor deficiency have increased insulin sensitivity, preventing Type 2 diabetes and lowering their risk for cancer. Despite higher body fat content, their bodies were more responsive to insulin, suggesting a potential protective effect against these diseases.
A new study found that blast traumatic brain injury may be linked to pituitary dysfunction, particularly in overweight patients. The study suggests that treating hormone deficiencies may help alleviate symptoms in veterans with this condition.
Children and adolescents with chronic kidney disease from lower-income families were less likely to grow to normal height ranges. Researchers found that more aggressive intervention or programs to support treatment adherence could help improve outcomes.
Researchers at MIT discovered that ghrelin, a stress-induced hormone, primes the brain for post-traumatic stress disorder (PTSD). Chronic stress elevates ghrelin levels, making the brain more vulnerable to traumatic events. Blocking ghrelin receptors or growth hormone may help protect people at high risk for PTSD.
A study by Dr. Chen's research group reveals that sericin can alleviate diabetic hippocampal damage by improving disorders in the growth hormone/insulin-like growth factor 1 axis, decreasing blood glucose levels and apoptosis of hippocampal neurons in diabetic rats.
Researchers at Cardiff University have linked hormonal imbalance in the womb to anxiety and possible vulnerability to poor mental health in adults. Changes in placental function have been implicated in emotional behavior and brain gene expression related to this type of behavior.
Researchers at Stanford University and Akira University in Japan have discovered a new hormone called R-spondin2 that promotes follicle development and stimulates ovary growth. The hormone, produced by human female eggs, may lead to new infertility treatment options when used with traditional Follicle Stimulating Hormone (FSH).
A study found that growth differentiation factor 11 (GDF11) declines with age and can reverse signs of cardiac aging in old mice. The discovery sheds light on the underlying causes of age-related heart failure, offering a potential treatment strategy.
A team of researchers from the University of Copenhagen has discovered that PICK1 protein plays a crucial role in regulating hormones such as insulin and growth hormone. This finding has significant implications for understanding diabetes and poor growth, and may lead to better prevention and treatment in the future.
A new study has found that about 42% of veterans returning from Afghanistan and Iraq with blast injuries have irregular hormone levels indicative of hypopituitarism. The condition can mimic symptoms of PTSD, depression, and other conditions, but is often unrecognized and treatable by replacing deficient hormones.
A study found that growth hormone therapy can help reverse growth problems in children with kidney failure by increasing bone turnover. However, treatment may not benefit overall bone health and may interrupt the relationship between bone turnover and parathyroid hormone markers.
A study by IRB Barcelona researchers has identified a key miRNA called bantam that regulates the relationship between hormones controlling growth and sexual maturity. Reduced levels of bantam lead to increased steroid hormone levels, causing growth to stop.
Scientists at Salk Institute have discovered a new way for plants to coordinate their growth by sharing chemical messages, overturning conventional views of metabolic regulation. This finding has implications for breeding better crops and treating metabolic diseases.
A study published in PLOS Genetics reveals that insulin and IGF1/IGF2 growth factors play a vital role in sexual development. In the absence of these hormones, embryos fail to differentiate into male or female, highlighting their essential role in primary sex determination.
A new study from Nationwide Children's Hospital found that adenotonsillectomy is effective in most children with Prader-Willi syndrome who have mild to moderate obstructive sleep apnea, but may not be curative for those with severe forms. The procedure helped normalize sleep patterns in 89% of patients.
A randomized clinical trial found that treatment with growth hormone-releasing hormone improved cognitive function in both healthy older adults and those with mild cognitive impairment. The study also showed increased insulin-like growth factor 1 levels, which may play a role in brain health.
A recent study published in the Journal of Pediatrics found that babies born to overweight or obese mothers gained less weight and grew less in length than those born to normal-weight mothers. This delayed growth may be attributed to inflammation and an underdeveloped pituitary gland, which plays a crucial role in fetal development.