Researchers discovered that disordered regions enhance specific RNA interactions in FUS protein-RNA complexes, revealing a breakthrough strategy for nucleic acid binding. The study suggests that intrinsically disordered regions actively contribute to the RNA-binding mechanism.
SourceInstitute of Science Tokyo·JournalJournal of Chemical Information and Modeling·TypeComputational simulation/modeling·DateAug 28, 2025
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Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Scientists at the Max Planck Institute for the Science of Light developed a new method to resolve specific sites within mechanosensitive protein PIEZO1 in its native cell membrane state. The technique, using cryogenic conditions and rapid freezing, sheds light on how the protein flexes and expands in response to mechanical stimuli.
SourceMax Planck Institute for the Science of Light·JournalScience Advances·TypeImaging analysis·DateAug 21, 2025
A new in-cell characterization method allows for the direct analysis of protein structures and conformations within living cells. The study reveals three main conformational forms of calmodulin, with the extended form being significantly more abundant than in purified form.
SourceDalian Institute of Chemical Physics, Chinese Academy Sciences·JournalJournal of the American Chemical Society·TypeCommentary/editorial·DateMar 3, 2025
Researchers at Institute of Science Tokyo designed a protein cage system that can control and visualize orientational changes in aromatic side chains through strategic binding of fluorescent ligands. This approach enables precise control over protein dynamics while enhancing fluorescence properties, with potential applications in biomo...
SourceInstitute of Science Tokyo·JournalAdvanced Science·TypeExperimental study·DateFeb 26, 2025
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Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A new deep learning model predicts protein conformational changes by leveraging a large-scale database of protein dynamics. The PATHpre model demonstrates robust predictive capabilities across proteins with varying sequence lengths, revealing new insights into protein function and regulation.
SourceUniversity of Science and Technology of China·JournalAdvanced Materials·DateOct 28, 2024
Researchers at U of T have developed a deep-learning model called PepFlow that can predict the full range of conformations for peptides, which are shorter than proteins but perform similar biological functions. The model combines machine learning and physics to capture precise and accurate conformations within minutes.
SourceUniversity of Toronto·JournalNature Machine Intelligence·DateJun 27, 2024
Researchers at Insilico Medicine developed COSMIC, a new framework for molecular conformation space modeling that provides accurate insights into molecule positioning and activity. This enables faster and more efficient drug design decisions.
SourceInSilico Medicine·JournalJournal of Chemical Information and Modeling·DateApr 29, 2024
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SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers have developed PaCS-Toolkit to facilitate accessible parallel cascade selection MD (PaCS-MD) simulations. The software package automates the simulation process via a single configuration file, allowing users to explore different conformations and investigate molecular interactions more efficiently.
SourceTokyo Institute of Technology·JournalThe Journal of Physical Chemistry B·TypeExperimental study·DateApr 23, 2024
Researchers develop AI-powered method to rapidly predict multiple protein configurations, understanding protein dynamics and functions. This breakthrough has the potential to revolutionize drug discovery by uncovering more targets for new treatments.
SourceBrown University·JournalNature Communications·TypeComputational simulation/modeling·DateMar 27, 2024
Researchers have unraveled the activation mechanism of GBP1, a protein that encapsulates bacterial pathogens with an antimicrobial coat. The study reveals how GBP1 forms a protein coat around invaders, destroying their membrane and preventing multiplication.
SourceMax Delbrück Center for Molecular Medicine in the Helmholtz Association·JournalThe EMBO Journal·DateJan 24, 2024
Researchers have unveiled a previously unknown conformational state of OxlT transporter protein using advanced computational methods. This discovery offers new insights into the protein's function and potential therapeutic targets for preventing kidney stone formation.
SourceNational Institutes of Natural Sciences·JournalThe Journal of Physical Chemistry Letters·TypeExperimental study·DateJan 23, 2024
Researchers used molecular dynamics simulations to study how urea and alcohol induce structural changes in proteins, with a focus on stabilizing helices and coils. The team identified preferential binding parameters for both cosolvents, demonstrating opposing effects that can be predicted using computational methods.
SourceOkayama University·JournalProtein Science·TypeComputational simulation/modeling·DateOct 19, 2023
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Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers used solid-state NMR to study the Fluc channel protein and discovered a new fluoride ion permeation model. The findings provide insights into the gating mechanisms in the Fluc channel, shedding light on its functionality.
SourceUniversity of Science and Technology of China·JournalScience Advances·DateSep 22, 2023
A team at Osaka University used neutron crystallography to image the atom-by-atom structure of a copper amine oxidase enzyme, revealing unprecedented structural insights. The study provided details on the protonation/deprotonation state and motions of key cofactors, facilitating single-electron transfer.
SourceOsaka University·JournalACS Catalysis·TypeExperimental study·DateSep 19, 2023
Researchers used super-resolution microscopy to study the sensory receptor PIEZO1, revealing its expanded conformation in response to mechanical stimuli. This finding could lead to future drug discovery applications for diseases associated with PIEZO1 defects.
SourceScripps Research Institute·JournalNature·DateAug 16, 2023
Researchers at KAUST have discovered the molecular mechanisms of DNA repair by studying the interaction between two enzymes, Lig1 and PCNA. Lig1 seals nicks in DNA by attaching to a ring-shaped protein called PCNA, which dislodges another enzyme FEN1 to prepare for sealing.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalNature Communications·DateJan 24, 2023
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Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers found that antibodies against one of the two main domains of the SARS-CoV-2 viral entry machinery elicit a broad antibody response against many variants. This suggests strategies for clinical development of variant-resistant vaccines.
SourceUniversity of Washington School of Medicine/UW Medicine·JournalScience Immunology·TypeExperimental study·DateNov 29, 2022
The study reveals the structure of the 15-subunit IFT-B complex, a crucial component in cilia formation and maintenance. The complex's elongated and flexible nature is consistent with previous low-resolution reconstructions, and two configurations are identified that may drive bi-directional movement.
SourceAarhus University·JournalThe EMBO Journal·TypeExperimental study·DateNov 10, 2022
Amanda Woerman's research aims to disrupt tau misfolding, a common thread in fatal neurodegenerative disorders PSP and CBD. The grant-funded study seeks to test a proof-of-concept gene therapy for these conditions, potentially leading to personalized medicine breakthroughs.
SourceUniversity of Massachusetts Amherst·DateNov 2, 2022
A USTC research team has elucidated the high-resolution structures of the PIN1 protein and its interaction with auxin and inhibitor NPA, shedding light on the mechanism of auxin transport. The study provides a new method for studying auxin transport using mammalian HEK293F cells.
SourceUniversity of Science and Technology of China·JournalNature·DateAug 3, 2022
A recent review highlights the potential of structural proteomics in understanding pathological processes and predicting drug candidates for neurodegenerative diseases. The field combines protein chemistry and mass spectrometry to determine protein structure and interactions, which can lead to breakthroughs in treating serious health c...
SourceSkolkovo Institute of Science and Technology (Skoltech)·JournalChemical Reviews·DateJan 27, 2022
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers found two prion gene variants in Père David's deer that may reduce susceptibility to CWD. The genetic variants were surprising given the population's small founder size and conserved prion protein gene. Studies are needed to confirm whether these variants provide protection against CWD.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalConservation Genetics·DateNov 24, 2021
Researchers developed a new online portal, DINC-COVID, to speed up the identification of potential pandemic treatments. The platform incorporates models of three drug targets and uses ensemble docking to score ligands' success in binding.
SourceRice University·JournalComputers in Biology and Medicine·TypeComputational simulation/modeling·DateNov 1, 2021
Scientists at UNC School of Medicine have developed a method to pinpoint and track proteins in specific shapes or conformations within living cells. This 'binder-tag' technique allows researchers to visualize protein dynamics in real-time, enabling the study of normal biology and diseases.
SourceUniversity of North Carolina Health Care·JournalCell·TypeExperimental study·DateOct 18, 2021
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers at Arizona State University have refined cryogenic electron microscopy to produce more accurate structures of biological samples. The new method uses a statistical approach to model transitory structures, which can play a vital role in biological processes.
SourceArizona State University·JournalMatter·TypeData/statistical analysis·DateOct 13, 2021
A team of researchers used computational biology and leading-edge experiments to study alpha-synuclein, a protein linked to Parkinson's disease. They found stable conformations that can form complexes with other biomolecules, offering possibilities for developing drugs to regulate the protein's function.
A new mouse model study by USF Health researchers reveals that chaperone protein imbalance can initiate toxic tau accumulation in the aging brain, a key step in Alzheimer's disease development. The study aims to identify therapeutic targets by restoring chaperone protein balance.
SourceUniversity of South Florida (USF Health)·DateApr 20, 2021
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
The researchers report two new cryo-EM structures representing the pre- and postfusion conformations of the full-length SARS-CoV-2 spike protein. The findings suggest that current vaccine strategies may be relying on limited information about the natural state of the protein, highlighting the need for further evaluation.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience·DateJul 21, 2020
Researchers review TFE's role as a structuring agent for unfolded peptides, inducing helical conformations, while also enhancing protein denaturation. The study details recent applications of TFE in conformational studies, including antimicrobial and aggregation-prone peptides.
SourceBentham Science Publishers·JournalCurrent Protein and Peptide Science·DateApr 4, 2019
Researchers discovered tiny islands in yeast cell membranes where transport proteins are stored before use. The study reveals how these proteins move slowly through the membrane and provides new insights into protein localization and trafficking.
SourceUniversity of Groningen·JournalNature Communications·DateFeb 5, 2018
The recipients are selected based on scientific merit and will present their research during the meeting, receive a travel grant, and be recognized at a reception. The awardees include students and postdoctoral fellows from various institutions.
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
A new tilted microscopy technique reveals better protein structures, resolving missing information and improving disease research. This approach could lead to a deeper understanding of proteins' conformations and their role in various diseases.
SourceSalk Institute·JournalNature Methods·DateJul 3, 2017
Researchers at Duke University used single-molecule force-spectroscopy to study Protein S, a large protein found in nature. They discovered a previously unknown stable conformation made possible by the interaction between two domains, which may help explain why some proteins are more stable than others.
SourceDuke University·JournalJournal of Biological Chemistry·DateAug 9, 2016
Tracy Clinton and Michael Thompson received the Protein Society's Year 2015 'Best Paper' awards for their work on Ebola drug target mimics. The researchers, who came from diverse backgrounds, were chosen for their innovative approaches to solving complex protein problems.
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Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Scientists develop a new statistical mechanics model to explain protein folding and unfolding in an aqueous environment. The study confirms the validity of their calculations using experimental measurements for two proteins, providing insights into high-energy ions therapy on biological cells.
SourceSpringer·JournalThe European Physical Journal D·DateJun 26, 2014
Scientists at Scripps Research Institute develop new probes to detect functional, normally folded, and disease-associated misfolded conformations of proteins in cells. The technology paves the way for discovering new drugs for misfolding diseases such as Alzheimer's and Parkinson's.
SourceScripps Research Institute·JournalProceedings of the National Academy of Sciences·DateMar 4, 2014
Researchers at SISSA investigated the structural elements of prion proteins, finding that misfolding originates in the N-terminal region. This knowledge is crucial for developing drugs and therapeutic strategies against diseases like Creutzfeldt-Jakob disease.
SourceInternational School of Advanced Studies (SISSA)·JournalJournal of the American Chemical Society·DateJan 24, 2014
The Biophysical Society announced the winners of its 2014 International Travel Awards to foster collaboration between American biophysicists and scientists in countries with financial difficulties. The recipients were chosen based on scientific merit and proposed presentations at the annual meeting.
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers at Brown University used a novel approach to nuclear magnetic resonance spectroscopy to resolve the key interaction between two proteins. The study reveals that the GroEL chaperone is a permissive captor, allowing the smaller protein to bind at two hydrophobic sites and detach, resulting in conformational heterogeneity.
SourceBrown University·JournalProceedings of the National Academy of Sciences·DateJun 24, 2013
Researchers developed a structural comparison map for small angle X-ray scattering (SAXS), enabling quick identification of protein structures under various conditions. This technique highlights factors making the biggest difference in structural conformations, allowing for high-throughput screening and tracking of trends.
SourceDOE/Lawrence Berkeley National Laboratory·JournalNature Methods·DateApr 29, 2013
Researchers have successfully studied the shape of proteins using a novel strategy combining computational modeling and experimental techniques. This breakthrough has implications for understanding protein functions and diseases such as cancer, Parkinson's, and Alzheimer's.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·JournalProceedings of the National Academy of Sciences·DateMar 27, 2013
Researchers at CIC bioGUNE have developed a new pathway to create more reliable glucose-measuring biosensors that can detect glucose in various fluids, including urine. The discovery challenges the long-held paradigm of protein binding mechanisms and offers a promising avenue for improving diabetes diagnosis.
SourceElhuyar Fundazioa·JournalJournal of the American Chemical Society·DateJan 15, 2013
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Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers investigated how bacteria like <i> Bacillus subtilis </i> respond to oxygen changes by studying protein HemAT. The study reveals a signal transduction chain that connects the sensor domain to the signalling domain, allowing the protein to transmit information about rising oxygen levels.
SourceRuhr-University Bochum·JournalJournal of Biological Chemistry·DateJun 25, 2012
Scientists have developed an instrument that tracks protein conformation and translocation with nanoscale precision. This breakthrough enables researchers to study proteins that regulate DNA replication and transcription, revealing new insights into their mechanisms.
SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalNature Methods·DateMar 2, 2011
A recent Argonne National Laboratory study found that proteins can move in more configurations than previously thought, especially in dilute solutions. The researchers discovered that environmental conditions influence which state a protein prefers to enter, and this knowledge may help understand how proteins interact with drugs.
SourceDOE/Argonne National Laboratory·JournalJournal of Molecular Biology·DateJan 15, 2008
Researchers find that HSP 90 inhibitors can degrade proteins perpetuating inflammation, restoring lung function and reducing blood vessel leakage in ICU patients. The study suggests a potential new treatment for sepsis using these cancer-fighting compounds.
SourceMedical College of Georgia at Augusta University·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateAug 27, 2007
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CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers at UCLA have made an important advancement in protein engineering by developing a new method to control proteins using nanotechnology. They successfully replaced the natural chemical mechanism controlling protein function with mechanical control, opening up possibilities for reduced side effects and improved treatment options.
SourceUniversity of California - Los Angeles·JournalJournal of the American Chemical Society·DateJun 9, 2006
Researchers solved the structure of a viral harpoon protein, revealing its role in viral entry and fusion with host cells. The discovery sheds light on how viruses hijack cellular machinery to produce and spread more virus, and may lead to new treatments for infections caused by enveloped RNA viruses.
SourceNIH/National Institute of Allergy and Infectious Diseases·JournalNature·DateJan 4, 2006
The EMBO/HHMI Startup Grants will provide resources and ongoing support for six promising scientists in Central Europe. The initiative aims to strengthen the scientific pipeline in the region, building on previous programs that supported established science.
SourceEuropean Molecular Biology Laboratory·DateDec 7, 2005
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
The EMBO/HHMI Startup Grants program aims to establish promising young scientists in Central Europe with resources and space. The joint initiative provides ongoing support for researchers after the grant period ends, helping to strengthen science in the region.
Scientists create artificial mechanism of allosteric control based on mechanical tension, allowing for controlled switching of proteins in living cells. The breakthrough could lead to targeted pharmaceutical drugs with reduced side effects and improved understanding of protein molecular architecture.
SourceUniversity of California - Los Angeles·JournalPhysical Review Letters·DateFeb 15, 2005