Articles tagged with Tertiary Structure
Researchers at UT MD Anderson Cancer Center have made significant advances in understanding cancer biology, developing AI-powered atlas of tertiary lymphoid structures as prognostic biomarkers, and uncovering drivers of resistance to KRAS inhibitors. Additionally, they have discovered a molecular pathway that drives stressed cells to b...
Scientists have discovered a novel way to block an enzyme involved in regulating blood pressure, called ACE. Ciprofloxacin binds selectively to a different site, blocking angiotensin I but not inhibiting the enzyme's other functions.
Researchers have discovered double negative memory B cells, a novel subset of immune cells that are more dysfunctional when in close contact with tumors. These cells may be a useful diagnostic marker and a potential target for developing new immunotherapies.
Researchers identified a previously unknown form of lymph node-like structures in liver tumors that are associated with greater treatment response and lower recurrence rates. The structures, found in patients treated with immune checkpoint inhibitors, contain infection-fighting immune B cells and tumor-killing immune T cells.
A new catalyst developed by researchers at Nagoya University successfully synthesized a key intermediate for the incontinence drug oxybutynin in 5-30 minutes, significantly faster than existing methods. The discovery represents a major advance in chiral drug synthesis and holds great promise for future drug discovery efforts.
A team of researchers created five unique all-α protein structures with non-uniformly arranged α-helices, holding immense potential for designing functional proteins. The novel approach enables the generation of a diverse set of all-α protein structures by combining typical motifs and canonical α-helices.
A recent study conducted at the University of São Paulo's Medical School found that isolating patients with carbapenem-resistant Enterobacteriaceae (CRE) in emergency departments (ER) for over two days can significantly reduce CRE transmission. The researchers also discovered that the ER structure, including bed layout and hand hygiene...
A Phase II trial led by researchers from the University of Texas MD Anderson Cancer Center demonstrated that adding ipilimumab to a neoadjuvant combination of nivolumab plus platinum-based chemotherapy resulted in a major pathologic response in half of all treated patients with early-stage non-small cell lung cancer. The treatment also...
Researchers at Moffitt Cancer Center have identified the molecular and cellular mechanisms that control the formation of tertiary lymphoid structures within tumors. These structures contain immune cells and can promote anti-tumor activity when Tfh cells are introduced, leading to improved outcomes in patients with certain types of cancer.
Researchers at Uppsala University discovered lymph node-like structures in brain cancer patients where immune cells can be activated. Immunotherapy enhanced these structure formation in a mouse model, suggesting new ways to regulate the anti-tumour response.
Scientists have discovered that re-purposing existing drugs or combining therapies may help treat patients with difficult-to-treat autoimmune diseases. The research, published in Proceedings of the National Academy of Sciences, found that fibroblasts play a critical role in the formation and maintenance of tertiary lymphoid structures.
Researchers at Johns Hopkins University have made a groundbreaking discovery, capturing the first atomic-level resolution of a protein-RNA complex from the ribosome. The study reveals the intricate 3D structure of RNA and how it's held together by a protein lynchpin.