Articles tagged with Cryopreservation
Researchers from the University of Tokyo successfully developed a high-pressure freezing method that reduces CPA concentration to 20-30% and improves cell viability and metabolic activity. The method holds promise for cryopreservation in regenerative medicine research, with potential applications in drug testing and cell transplantation.
Researchers have developed a method to preserve brain tissue in a functional state using vitrification, allowing for long-term preservation and re-examination of neural networks. The technique enables the recovery of electrical signals and long-term potentiation, crucial for learning and memory processes.
Researchers at Kobe University developed a method to preserve iPS cells directly in their culture dishes using D-proline as a cryoprotectant. This allows for easy automation of the process, reducing costs and increasing efficiency in regenerative medicine and drug discovery research. The breakthrough enables the direct freezing, thawin...
A study published in JAMA found that cryopreserved platelets were less effective than liquid-stored platelets in achieving hemostasis, particularly at 24 hours after ICU admission. The research suggests that alternative storage methods may be needed for efficient surgical bleeding treatment.
A study found cryopreserved platelets to be a cost-effective option for managing surgical bleeding in cardiac surgery, dominating liquid-stored platelets in this setting. Further investigation is required to assess the economic benefits of cryopreserved platelets in broader populations.
Researchers investigate cryopreservation as a tool for conservation, using the European subspecies of the Swallowtail to assess its viability. If effective, it could support long-term strategies like breeding programs and reintroduction efforts.
Researchers from Texas A&M University have developed a novel approach to cryopreservation that may prevent organ cracking in larger organs. The breakthrough involves adjusting the makeup of vitrification solutions to achieve higher glass transition temperatures, reducing thermal stress cracking.
A team of researchers at Kyoto University successfully cryopreserved mouse stem cells and sent them to the International Space Station, where they returned healthy offspring after thawing. The study suggests that cryopreservation can maintain fertility for at least six months, paving the way for future human spaceflight.
Researchers develop new techniques for volume electron microscopy (vEM) and cryo-electron tomography to study plant cellular processes. The project aims to unlock new possibilities for crop development with enhanced resilience, productivity, and sustainability.
The Antarctic midge employs a unique survival mechanism by undergoing quiescence in its first year and obligate diapause in its second. This adaptation allows the insect to quickly resume development when temperatures rise.
A first-of-its-kind adaptive 3D printing system developed by the University of Minnesota Twin Cities researchers can identify organism positions and safely move them to specific locations for assembly. This technology saves time and money in bioimaging, cybernetics, and cryopreservation.
The study proposes a lunar biorepository to store genetic material of at-risk species, which can be preserved without electricity or liquid nitrogen. The moon's permanently shadowed craters are cold enough for cryogenic preservation, and the team has successfully cryopreserved skin samples from a fish.
A new platform enables full-cycle cryogenic protection for mouse oocytes, reducing gene variations and improving offspring birth rates. The platform uses nanomaterials to inhibit ice formation, resulting in higher quality preserved oocytes.
A study of 67,000 freezing cycles reveals a low rate of return to use previously vitrified oocytes, with patients having poor ovarian response more likely to utilize cryopreserved oocytes.
The BioRescue project evaluated 65 advanced assisted reproduction procedures in white rhinos, showing the technology is safe for donor females and yields successful embryo generation. Regular OPUs improve reproductive health in individual female rhinos.
A study found that more than 40% of women who froze their eggs in their 30s were able to have babies when they returned to the fertility clinic. However, many didn't return or used other fertility treatments. Women who used frozen eggs had a lower miscarriage rate compared to those using fresh eggs.
Research found that women treated for childhood Hodgkin lymphoma may experience declining fertility and longer wait times to become pregnant, but overall success rates are high. The majority of women in the study who had tried to become pregnant were successful, with some being able to conceive at a younger age.
Researchers developed a low-concentration cryoprotective agent vitrification method to preserve mouse preantral follicles, improving survival rates by 1/3. The approach integrated microencapsulation and physical heating techniques for enhanced cell protection.
Research found that male rats exposed to ifosfamide during adolescence had offspring and grand-offspring with increased incidence of diseases, including kidney and testis problems. The study's epigenetic analysis revealed changes passed down through sperm and ova, indicating a potential risk for future generations.
A Swedish study of 1,275 women with breast cancer found no increased risk of disease recurrence or death after fertility preservation procedures. The research provides new hope for women who want to preserve their fertility after cancer treatment.
Researchers develop new method to preserve organs by freezing them partially, allowing for longer storage duration and improved organ matching. This breakthrough could lead to more successful transplants and increased organ availability.
A large-scale study of intrauterine insemination cycles found that frozen sperm samples have similar clinical pregnancy rates to fresh samples. However, time-to-pregnancy was slightly longer for the frozen sperm group. The results provide reassurance to patients undergoing fertility treatment.
Researchers have developed a cryoprotectant that can effectively store organs and tissues for years, not just hours. The discovery could lead to the development of thousands of new cryoprotective agents tailored to specific cell types, reducing organ shortages and waiting lists.
A new study reveals funding for fertility preservation policies varies across the UK, with Scotland offering the most inclusive approach. The study highlights the need for standardization of policies to ensure equal access to care for patients.
Researchers at the University of Minnesota developed a new method of islet cryopreservation that enables high viability and function in a clinically scalable protocol. This breakthrough discovery could revolutionize the supply chain for islet isolation, allocation, and storage before transplant.
Researchers have developed a cream that prevents frostbite injuries in mice when applied to the skin before severe cold exposure. The cream, called SynAFP, reduces frostbite wound size and speeds healing compared to no treatment. Further studies are needed to determine its effects on humans.
Researchers have pushed the limit of when water will freeze to -44 C by using soft interfaces like gels or lipids. This discovery has significant implications for climate prediction, cloud conditions, cryopreservation of organs, and technologies exposed to icing conditions.
A new computer model developed by researchers at Oregon State University predicts the optimal vitrification method for preserving 3D tissues and organs at low temperatures. The model, which takes into account tissue size changes, could enable the cryopreservation of brain slices, pancreatic cells, and even whole organs.
Scientists from the University of Tsukuba have developed a new technique to preserve Drosophila primordial germ cells, which can be used to produce new offspring. The cryopreserved PGCs were found to be effective after up to 400 days of long-term storage.
A new assessment tool has been found to predict ovarian damage in girls with cancer, helping doctors determine which patients should undergo fertility preservation. The Edinburgh selection criteria identify high-risk patients who are more likely to develop premature ovarian failure.
Researchers at the University of Minnesota have developed a method to cryopreserve fruit fly embryos, preserving their viability for up to generations. This breakthrough enables genetic research, disease modeling, and potential pest control applications, such as combating the invasive Drosophila suzukii.
Researchers have developed a new method to prevent ice crystal formation during cryopreservation, enabling cells and organs to survive and even proliferate after thawing. The technique uses nanocomposites to regulate ice nucleation and reduce damage caused by crystallization.
Researchers at JAIST and RIKEN identify COOH-PLL as an effective cryoprotectant that prevents cellular damage during freezing. The team uses NMR spectroscopy to characterize the molecule's behavior, enabling the design of new polymeric cryoprotectants.
A new cryopreservation technique has been developed to preserve genetically modified rat spermatozoa, which are difficult to store due to their large size and sensitivity to temperature changes. The method, tested on genetically modified rats, successfully produced over 300 offspring from a single male rat.
Researchers at NYU Abu Dhabi have developed a new technique to preserve human cells using filter paper, offering advantages over traditional methods. The method requires less storage space and allows for easy loading and efficient freezing of cells, with viability rates comparable to conventional methods.
A study on learning health organizations highlights the paradox of bystander ethics, where researchers must navigate ethical principles with quality improvement research. The authors propose a workaround to address this challenge, but critics argue it is inadequate.
Researchers at the University of Warwick have developed a new polymeric cryoprotectant that protects cells during freezing, leading to more cells being recovered and less solvent-based antifreeze being required. The material was shown to be very potent in protecting cell monolayers, which is crucial for biomedical research.
Scientists have successfully preserved frozen animal cells without using cryoprotectant agents (CPAs), which can be toxic and cause cell damage. The new method relies on ultrarapid cooling, achieving vitrification and cryopreservation with minimal damage to the cells.
A study of 150 women who froze their eggs found that partnership problems were the primary motivation for freezing eggs, not career planning. The majority of women in the study were single or had unstable relationships, and many had completed their education and career goals but still struggled to find a partner.
PanTHERA CryoSolutions has discovered a small molecule inhibitor that prevents ice recrystallization, a process causing cell death and damage when freezing cells and tissues. This technology results in faster engraftment and increased incidence of engraftment for clinical settings.
Researchers at the University of Minnesota and Smithsonian Conservation Biology Institute have developed a new method for preserving zebrafish embryos using gold nanotechnology and lasers. This breakthrough technique has significant implications for human health, wildlife conservation, and aquaculture.
Researchers found that particle surfaces can impact ice crystallization and encourage different ice crystal orientations. This discovery could help improve understanding of climate science, air travel, and cryopreservation.
Researchers leverage magnetically heated nanoparticles to overcome heat transfer limitations in cryopreservation, enabling rapid thawing of large biomaterials. The technology offers tunable heating rates and can accommodate unloaded sections up to several millimeters in dimension.
Researchers have gained new insights into tissue cryo-injury mechanisms, revealing that gap junctions are not the primary pathway for ice crystal propagation between cells. Intercellular connections also play a significant role in cell crystallization during freezing.
A study of egg banking for anticipated gamete exhaustion found that many women believe they'll never use their stored eggs, but still consider the experience positive. Most wish they had done so at an earlier age to preserve fertility.
Researchers found that Cell Banker 3 outperformed other cryopreservation solutions in preserving induced pluripotent stem (iPS) cell viability and proliferation. The solution allows iPS cells to be preserved for up to a year without significant loss of function.
The European Society of Human Reproduction and Embryology announces a breakthrough in fertility preservation, with Italy's first successful pregnancy and live birth after cryopreserving ovarian tissue. The technique has shown promising results, even after lengthy storage periods.
Yoed Rabin is developing biothermal technologies for cryopreservation and cryosurgery using vitrification, glassy materials, and wireless temperature sensors.
Researchers at the University of Helsinki have discovered that sulphuric acid and water mixture droplets can be cooled and heated without forming ice. This finding has implications for cloud physics, suggesting that cirrus clouds are not completely solid ice, but contain a layer of liquid water.
Researchers have made a significant breakthrough in cryopreservation by discovering a way to slow down the formation of ice crystals in cells. This discovery, published in the Journal of Physical Chemistry B, could pave the way for preserving organs and tissues without damage.
Researchers are working on developing engineering tools to monitor breakups in tissues and organs, with the goal of improving storage methods for transplant tissues. The team aims to create systems that can safely store complex tissues and organs, which could lead to breakthroughs in disease treatment and expand organ availability.