Articles tagged with Genetic Analysis
A genetic study conducted by 23andMe has identified four genetic markers associated with the development of non-syndromic striae distensae (stretch marks), a skin condition affecting approximately 50-80% of people. The study suggests that elastin, a key component of elastic fibers in the skin, plays a crucial role in the formation of s...
Researchers from RIKEN have developed a highly efficient molecular probe, Eprobe, for real-time PCR monitoring and genetic testing. The new technology enables advanced assays for DNA-based genetic testing and helps bring genome-wide sequencing studies to patients in the clinic.
A UC Irvine study has found that breath analysis may be an accurate way to quickly determine the severity of bacterial infections. The researchers correlated inflammation levels in laboratory mice with carbon monoxide and other gases in breath samples, making carbon monoxide a reliable biomarker for infection presence and intensity.
A study found that more than half of parents misunderstood key concepts of genetic biobanking consent, highlighting the need for clearer explanations and inclusive consent models. Researchers are exploring alternative methods of consent delivery to improve understanding and empower families as partners in genetic research.
A study has identified two networked groupings from 26 genes associated with autism that are overexpressed in the cerebellar cortex. The findings suggest specific brain regions implicated in pathology and complement genomic and neuroimaging analyses to obtain a broader picture of the autistic brain.
A new genome sequencing technique has been used to select embryos for IVF, resulting in the first birth following embryo screening. The 'next generation sequencing' method reveals information on genetic disorders and chromosomal abnormalities, increasing the chances of successful pregnancies.
The study identified 16 new genetic associations related to pollen, dust-mite, and cat allergies, highlighting key pathways in the biological basis of common allergies. This research provides a significant step towards understanding the genetic link between allergens and allergic reactions.
Researchers at Rice University analyzed thousands of mutant worms to identify genes controlling movement, revealing 87 new links in the process. The study also uncovered evidence for a protein-signaling pathway regulating locomotion, with implications for prioritizing genetic tests in humans.
Scientists at NC State University have discovered the first example of a micro-RNA controlling lignin biosynthesis, which gives wood its strength. The research found that reducing lignin content by over 20% can increase the efficiency of paper and biofuels production.
Chang Lu, associate professor at Virginia Tech, is awarded a $710,000 NIH grant to advance cancer research technology using chromatin immunoprecipitation (ChIP) assay on microchip devices. The new test provides ultrahigh sensitivity and aims to study tumor-initiating cells and molecular dynamics.
Researchers analyzed North Pacific killer-whale strandings, finding 88% fatal and 12% surviving, providing clues on species' overall life history, genetics, and health. The standardized necropsy system increased data collection from 2% to 33%, shedding light on the causes of death and human impact on orca populations.
Researchers found King Richard III in a hastily dug, lozenge-shaped grave under a Leicester car park, suggesting gravediggers were in a hurry to bury him. The grave was too short for the king's body, and his torso was crammed in, with evidence of hands being tied during burial.
A pan-European study found that certain signs of motor disorders can appear years before the actual disease manifests. The researchers detected these signs using a mathematical model and extensive tests, including standardized tests of muscular coordination and magnetic resonance imaging.
A new report highlights the challenges of collecting DNA for human rights purposes, such as protecting victims of human trafficking. The authors propose multiple approaches and solutions to combat this issue, including collaboration among government authorities, law enforcement, social services, academics, and victim advocates.
A new species of green palm-pitviper was described from a cloud forest reserve in northern Honduras. Genetic analysis revealed that the closest relatives are found over 600 km away in Costa Rica, indicating a relict lineage.
Researchers analyze over 1,000 genes from 23 yeast species to identify reasons for conflicting phylogenetic trees and propose new methods to improve accuracy. They find that genetic data is less reliable during periods of rapid radiation and that the value of DNA data may have a similar limit.
Researchers found that genes controlling circadian clock rhythms are profoundly altered in the brains of people with severe depression, suggesting a physical basis for many symptoms. The study provides clues for potential new classes of compounds to rapidly treat depression by resetting abnormal clock genes.
Ancient DNA analysis confirms Yersinia pestis as the cause of the Justinianic Plague. The results provide insights into the phylogeny and origin of this plague, contradicting previous theories. This breakthrough sheds new light on a major pandemic in European history.
Genetic analysis reveals potential origins of novel avian influenza A H7N9 virus, suggesting at least four possible evolutionary paths. The virus has evolved into two distinct lineages, with unknown intermediate hosts implicated, highlighting the need for global surveillance and close monitoring of domestic-poultry-to-person transmission.
Advaita, a Wayne State University startup, is participating in the new Michigan I-Corps program to turn its biotechnology innovation into commercial opportunities. The company aims to streamline drug-discovery methods, saving time and money for academia and pharmaceutical industries.
Research found that specific DNA regions contribute to prostate cancer development and early death, with patients having two of these changes at high risk. The study identifies key genes PTEN and MYC as linked to prostate cancer lethality.
A phase 1 clinical trial of Rigosertib, a dual kinase inhibitor, demonstrated the drug's effectiveness in patients with head and neck cancer who have failed platinum-based therapies. The results led to an 80-patient multi-institutional Phase II trial to explore biomarkers for accurate patient matching.
This April issue of the Genetics Society of America's journal features research on genotyping-by-sequencing, a novel gene silencing system in fungi, and the role of protein chaperone HSP90 in facilitating gene duplicate divergence. Additionally, studies explore genome integrity and RNA editing in mice.
A study by Johns Hopkins Medicine has identified DNA-damaging toxins in commonly consumed plant-based foods, including liquid smoke flavoring, black and green teas, and coffee. The toxins, pyrogallol and gallic acid, can activate the p53 gene, which is associated with cancer.
A study by MIT and Université Catholique de Louvain found that just four points of reference were enough to uniquely identify 95% of cellphone users in a data set of 1.5 million users. The researchers used statistical physics tools to uncover a simple mathematical relationship between data resolution and identification probability.
Two new species of mouse lemurs have been identified by Duke University scientists, one named Anosy mouse lemur and the other Marohita mouse lemur. The genetic analysis reveals that these species are distinct and do not interbreed with other recognized mouse lemur species.
Two genes associated with rare autism-related disorders are also jointly linked to more general forms of autism, according to a new study published in Molecular Psychiatry. The findings suggest a new genetic pathway to investigate in general autism research.
A genome-wide association study identifies 20 new genetic associations for myopia, a refractive error resulting from increased axial length of the eye. The study suggests that complex interactions underlie the development of myopia, with extracellular matrix remodeling and neuronal development playing key roles.
A new DNA-based technique allows early identification of Geomyces destructans, a fungus causing White Nose Syndrome (WNS), in bats, soils, and cave walls. The test is 100-times more sensitive than previous ones, detecting single spores of the fungus.
Researchers at Ohio State University have discovered the genetic mechanism that led to the development of wings in fruit flies, a key to their survival. By analyzing 20 cells present in the larval stage, they found that a specific gene, Dpp, triggers the growth of wings by activating another gene, vn.
A 33,000-year-old Siberian fossil, known as the 'Altai dog', is found to be more closely related to modern dogs and prehistoric canids on the American continents than wolves. This challenges previous theories suggesting a recent emergence of modern dogs from wolf ancestors.
A comprehensive study has identified seven new regions of the human genome associated with increased risk of age-related macular degeneration (AMD). The study, led by Case Western Reserve University School of Medicine, found that AMD is not caused by a single genetic change but rather by many events that accumulate over time.
A team of researchers found that bacteria in Bangladesh's aquifers use surface-derived organic carbon, which is naturally released from sediment into groundwater. This process predates recent human interaction and suggests that intensive pumping has not yet significantly affected arsenic release.
The study identified seven new loci near genes that are associated with increased risk of age-related macular degeneration. The analysis included data from over 17,000 people with advanced AMD and 60,000 without, revealing a variety of biological functions implicated in the disease.
Researchers have discovered seven new genetic loci associated with increased risk of age-related macular degeneration (AMD), a condition that affects central vision and can lead to blindness. The study, supported by the National Eye Institute, represents the most comprehensive genome-wide analysis of AMD genetics.
A University of Utah study found a significant genetic connection to surgical site infections (SSIs) in families, suggesting personalized health care through genome analysis could be available soon. Researchers analyzed 651 hospital patients with SSIs and matched controls using the Utah Population Database.
Researchers have found genetic variants linked to alcoholism in the Spanish population, including women. The study identified polymorphisms in genes related to metabolism and the dopaminergic system, which are associated with increased risk of hazardous drinking and dependence.
The novel TP PCR test yields accurate results without unnecessary additional testing, improving diagnosis and prognosis by accurately sizing the genetic abnormality characteristic of HD. The test correctly sized 240 of 246 samples, including those with a wide range of CAG repeats.
A recent study published in PLOS Medicine found a strong association between obesity and vitamin D deficiency. The research, led by Dr Elina Hypponen, used genetic markers to explore the link between body mass index (BMI) and genes associated with vitamin D synthesis and metabolism.
A team of plant geneticists successfully demonstrated that weakening the FEA2 gene can increase meristem size and lead to more rows and kernels in maize plants. This research has significant implications for increasing yields of essential food crops as the global population is projected to reach 8-9 billion by mid-century.
Researchers at Imperial College London have developed a rapid method to create new parts for biological factories, which could lead to the mass production of sophisticated devices and unlock their potential in society. This breakthrough brings scientists one step closer to an 'industrial revolution' in synthetic biology.
The new age of proteomics brings a comprehensive understanding of cellular proteins, shedding light on their role in illnesses. The next-generation proteomics technology enables improved biomarker search, personalized therapies, and enhanced cancer diagnosis.
Researchers identified a genetic marker in over 300 women with breast cancer, finding that those with this marker were more likely to experience recurrence. This breakthrough could enable doctors to tailor treatment strategies for high-risk patients based on their unique genetic profiles.
A study on rhesus macaques found that their social network behavior is influenced by genetics and heritability. Pro-social monkeys with strong networks had greater reproductive success, while aggression had a weaker link to heritability.
Researchers have developed a technique to overcome inhibitory plant compounds, allowing PCR to successfully amplify DNA from problematic plants. The additive TBT-PAR, containing trehalose, bovine serum albumin, and polysorbate-20, enhances PCR for DNA extracted from various plant species, including tropical and temperate species.
Researchers identified three genetic variants associated with abnormal insulin production, increasing the risk of developing diabetes. The study's exome array genotyping analysis revealed the involvement of genes TBC1D30, KANK1, and PAM in insulin processing and secretion.
Forensic experts at Uppsala University identified the remains of Carin Göring, wife of Nazi leader Herman Göring, through DNA analysis. The researchers matched mitochondrial and nuclear DNA with historical records, confirming her identity.
Among eligible women, 19.1% underwent risk-reducing salpingo-oophorectomy (RRSO) and 39.6% used screening procedures, with women receiving a positive BRCA test result having increased odds of these interventions, while true-negative results were associated with reduced odds.
The new feature uses DNA inherited from all ancestors on both sides of the family to indicate an individual's ancestral origins. Ancestry Composition offers state-of-the-art detail for people with European ancestry and accurate breakdowns for individuals of mixed ancestry.
The Genographic Project has launched a new phase, utilizing advanced genetic technology to explore human migration patterns. Participants can learn about their migratory history, regional affiliations, and even Neanderthal or Denisovan ancestry.
Researchers developed a new method to analyze genetic data to learn about population history, using the Ashkenazi Jews and Masai people as test subjects. This approach allows for detailed events in recent history to be recovered within the last few centuries.
Researchers have identified a link between inflammation and heart disease through the largest genetic study of Coronary Artery Disease (CAD) to date. The study found that lipid metabolism and inflammation play a significant role in CAD, providing evidence for a novel pathway for prevention and treatment.
Researchers compared the genomes of domestic pigs with wild boars to reveal genetic differences that could improve pig health and combat diseases like diabetes, obesity, and Alzheimer's. The study also identified genes linked to smell, shedding light on human diseases.
Scientists have confirmed the existence of a new tick-borne disease in Switzerland, neoehrlichiosis, which has infected eight patients with severe symptoms. A DNA test has been developed to detect the infection quickly, allowing for timely treatment.
Whitehead scientists found that traditional approaches ignore differences in mRNA amounts between cells, which can lead to misinterpretations in cancer research. The team proposes using RNA spike-ins as a standardized control to eliminate assumptions.
Advaita Corporation, a startup based on Wayne State University tech, received $125,000 from the Michigan Emerging Technologies Fund program. Its Pathway-Guide software solution provides cutting-edge gene pathway analysis technology for researchers.
A new genus of ferns has been discovered, with 19 species named after pop star Lady Gaga. The 'Gaga' ferns were recognized for their unique characteristics, including fluid definitions of gender and a distinct DNA sequence spelling GAGA.
A multidisciplinary approach combining radiocarbon analysis, anthropological analysis, and forensic DNA techniques has been used to identify the remains of a missing child 41 years after discovery. The method was successful in pinpointing birth dates and death dates for the child, providing a breakthrough in solving cold cases.
A variant in the NFKB1 gene has been associated with a 44% reduced risk of lung cancer, according to a new analysis of 378 patients and 450 healthy controls. The study suggests that inflammation may play a role in lung cancer development.
Scientists sequenced nearly all genes in an underground microbe community at a contaminated uranium mill site, assigning them to 80 different microbes. The findings could help improve clean-up methods for heavy metal contamination, including arsenic and mercury.