Articles tagged with Genetic Analysis
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A recent study published in PLOS Medicine found a strong association between obesity and vitamin D deficiency. The research, led by Dr Elina Hypponen, used genetic markers to explore the link between body mass index (BMI) and genes associated with vitamin D synthesis and metabolism.
A team of plant geneticists successfully demonstrated that weakening the FEA2 gene can increase meristem size and lead to more rows and kernels in maize plants. This research has significant implications for increasing yields of essential food crops as the global population is projected to reach 8-9 billion by mid-century.
Researchers at Imperial College London have developed a rapid method to create new parts for biological factories, which could lead to the mass production of sophisticated devices and unlock their potential in society. This breakthrough brings scientists one step closer to an 'industrial revolution' in synthetic biology.
The new age of proteomics brings a comprehensive understanding of cellular proteins, shedding light on their role in illnesses. The next-generation proteomics technology enables improved biomarker search, personalized therapies, and enhanced cancer diagnosis.
Researchers identified a genetic marker in over 300 women with breast cancer, finding that those with this marker were more likely to experience recurrence. This breakthrough could enable doctors to tailor treatment strategies for high-risk patients based on their unique genetic profiles.
A study on rhesus macaques found that their social network behavior is influenced by genetics and heritability. Pro-social monkeys with strong networks had greater reproductive success, while aggression had a weaker link to heritability.
Researchers have developed a technique to overcome inhibitory plant compounds, allowing PCR to successfully amplify DNA from problematic plants. The additive TBT-PAR, containing trehalose, bovine serum albumin, and polysorbate-20, enhances PCR for DNA extracted from various plant species, including tropical and temperate species.
Researchers identified three genetic variants associated with abnormal insulin production, increasing the risk of developing diabetes. The study's exome array genotyping analysis revealed the involvement of genes TBC1D30, KANK1, and PAM in insulin processing and secretion.
Forensic experts at Uppsala University identified the remains of Carin Göring, wife of Nazi leader Herman Göring, through DNA analysis. The researchers matched mitochondrial and nuclear DNA with historical records, confirming her identity.
Among eligible women, 19.1% underwent risk-reducing salpingo-oophorectomy (RRSO) and 39.6% used screening procedures, with women receiving a positive BRCA test result having increased odds of these interventions, while true-negative results were associated with reduced odds.
The new feature uses DNA inherited from all ancestors on both sides of the family to indicate an individual's ancestral origins. Ancestry Composition offers state-of-the-art detail for people with European ancestry and accurate breakdowns for individuals of mixed ancestry.
The Genographic Project has launched a new phase, utilizing advanced genetic technology to explore human migration patterns. Participants can learn about their migratory history, regional affiliations, and even Neanderthal or Denisovan ancestry.
Researchers developed a new method to analyze genetic data to learn about population history, using the Ashkenazi Jews and Masai people as test subjects. This approach allows for detailed events in recent history to be recovered within the last few centuries.
Researchers have identified a link between inflammation and heart disease through the largest genetic study of Coronary Artery Disease (CAD) to date. The study found that lipid metabolism and inflammation play a significant role in CAD, providing evidence for a novel pathway for prevention and treatment.
Researchers compared the genomes of domestic pigs with wild boars to reveal genetic differences that could improve pig health and combat diseases like diabetes, obesity, and Alzheimer's. The study also identified genes linked to smell, shedding light on human diseases.
Scientists have confirmed the existence of a new tick-borne disease in Switzerland, neoehrlichiosis, which has infected eight patients with severe symptoms. A DNA test has been developed to detect the infection quickly, allowing for timely treatment.
Whitehead scientists found that traditional approaches ignore differences in mRNA amounts between cells, which can lead to misinterpretations in cancer research. The team proposes using RNA spike-ins as a standardized control to eliminate assumptions.
Advaita Corporation, a startup based on Wayne State University tech, received $125,000 from the Michigan Emerging Technologies Fund program. Its Pathway-Guide software solution provides cutting-edge gene pathway analysis technology for researchers.
A new genus of ferns has been discovered, with 19 species named after pop star Lady Gaga. The 'Gaga' ferns were recognized for their unique characteristics, including fluid definitions of gender and a distinct DNA sequence spelling GAGA.
A multidisciplinary approach combining radiocarbon analysis, anthropological analysis, and forensic DNA techniques has been used to identify the remains of a missing child 41 years after discovery. The method was successful in pinpointing birth dates and death dates for the child, providing a breakthrough in solving cold cases.
A variant in the NFKB1 gene has been associated with a 44% reduced risk of lung cancer, according to a new analysis of 378 patients and 450 healthy controls. The study suggests that inflammation may play a role in lung cancer development.
Scientists sequenced nearly all genes in an underground microbe community at a contaminated uranium mill site, assigning them to 80 different microbes. The findings could help improve clean-up methods for heavy metal contamination, including arsenic and mercury.
Researchers developed EvoD to sift meaningful variants from thousands of mutations in personal genomes, improving diagnostic accuracy. The technique capitalizes on comparative genomics and exome analysis, showing promise for detecting functionally damaging gene variants associated with Mendelian diseases.
The Cancer Genome Atlas study identifies four main breast cancer subtypes defined by PAM50, with diverse genetic and epigenetic alterations converging into these phenotypes. The study's findings advance understanding of breast cancer biology and support the use of PAM50 as a gold standard for categorizing breast cancer by subtype.
Researchers have developed a new analysis framework to help clinicians spot 'medically actionable findings' from genetic tests, streamlining the process and providing more timely results. The approach classifies genetic variations into three categories, prioritizing those linked to treatable or preventable conditions.
Studies show that some structural features of languages are relatively stable over time, while others exhibit individual family-specific factors. Researchers found probable connections between the Americas and NE Eurasian languages dating back to peopling of the Americas 12,000 years ago.
Researchers at Whitehead Institute identified four genetic markers that predict pluripotency in single cells, allowing for more efficient reprogramming. The team also discovered six new combinations of factors that activate Sox2, leading to full reprogramming and potentially healthier iPSCs.
The Innocence Project has helped free nearly 300 wrongfully convicted prisoners due to improper use of forensic science. Improved sensitivity in DNA testing has highlighted issues of cross-contamination, affecting accuracy.
The ENCODE project reveals a massive control panel in the human genome, with 4 million gene switches, to regulate gene expression and prevent disease. The comprehensive data will help researchers pinpoint specific areas for human disease research.
The study suggests that three-quarters of the human genome can be transcribed into RNA, leading to a redefinition of what defines a gene. This implies that many regions previously thought to be non-functional may have functional roles.
Researchers at UC Riverside have developed a test called CTAB, which examines how DNA modifications lead to aberrant transcription and disruption in protein synthesis. The method could help explain how environmental chemicals cause cancer development and lead to the development of new effective drugs.
A new genetic analysis maps the Jewish Diasporas, focusing on North African Jews. The study supports historical records of Middle Eastern Jews settling in North Africa and forming distinct populations.
Researchers at Wayne State University are working on a new technique to analyze fetal chromosomes in the first trimester, which could lead to healthier outcomes for mothers and babies. The approach involves collecting placental cells from the cervix using a safe and non-invasive method.
Researchers at Michigan State University have developed a computational technique that reduces memory requirements by 40-fold, allowing scientists to analyze large genomic sequence datasets without supercomputers. This breakthrough enables the efficient examination of complex microbial communities living in soil or the ocean.
A new study reveals that Native-Americans' high rates of diabetes may be attributed to their ancestors' high-fiber diet, which was rich in foods like maize and sunflower seeds. This diet, characterized by low fat and glycemic index, could have given rise to 'thrifty genes' that now contribute to the disease.
A team of scientists has discovered an epigenetic enzyme that doubles the output of thousands of different genes in male fruit flies to compensate for their single X chromosome. The study found twice as many DNA-transcribing proteins attached to the male X chromosome compared to females.
The Iberian wolf's distribution in Galicia is primarily driven by landscape characteristics offering refuge from humans. Landscape attributes account for 48% of animal safety, while human presence and food availability contribute to a lesser extent.
23andMe's acquisition of CureTogether expands its capacity for people-powered research and community-driven projects. The combined platforms will facilitate the sharing of genetic and phenotypic data to accelerate research discoveries.
Researchers found that parasitic plant Rafflesia cantleyi has 'stolen' genes from its host Tetrastigma rafflesiae, including those related to respiration and metabolism. This horizontal gene transfer has replaced the parasite's own gene activity in three-quarters of the cases.
Researchers have identified three types of fetal cells in maternal organs: trophoblasts, mesenchymal stem cells, and immune system cells. These cells may help the mother's immune system tolerate the fetus and aid in organ repair.
Researchers successfully sequenced the fetal genome without invasive sampling, enabling the detection of thousands of disorders. They overcame obstacles by applying statistical modeling and technical advances to resolve maternal haplotypes with high accuracy. The breakthrough paves the way for comprehensive prenatal genetic screening.
An interdisciplinary team has completed the most comprehensive genetic analysis of corn, shedding light on its genetic diversity and evolution. The study provides a foundation for developing improved varieties equipped to resist pests and disease, addressing global food security challenges.
Scientists have developed a method to analyze noisy X-ray data, revealing details of molecular structure previously discarded due to low signal quality. This breakthrough could lead to more accurate models and improved understanding in biology, medical diagnostics, nanotechnology and other fields.
Two studies led by University of Pennsylvania scientists uncover new information about Native American and First Nations migration patterns, genetic impact of cultural practices and historical relationships among groups. The research provides the first clear evidence of shared markers in DNA of people living in the circumarctic region.
Scientists have found a 60-million-year-old giant turtle with a shell measuring 172 centimeters long, making it one of the largest turtles ever discovered. The turtle's massive size allowed it to thrive in its ecosystem, where other giant reptiles like snakes also existed.
A Stanford University School of Medicine study has identified a homegrown genetic variant responsible for naturally blond hair in the indigenous people of the Solomon Islands, distinct from European genes. The research found that the gene variant accounted for 50% of the variance in hair color among the islanders.
A new method developed by the University of Copenhagen allows researchers to track mammal species in Southeast Asian rainforests using DNA-analysis from collected leeches. The technique has been successfully tested on local Vietnamese mammals, including rare species, and could revolutionize the monitoring of threatened wildlife.
The study reveals that roads cause significant harm to midwife toad and palmate newt populations in Asturia, Spain. The results suggest that traffic alleviation measures can help protect the newts but are insufficient for the midwife toads.
A new study finds that many species of reef-building corals can adapt to warming waters by relying on multiple algal symbionts. This ability may help corals survive future losses due to ocean temperatures increases.
A Mayo Clinic study identified two genes that are optimal targets for a new noninvasive colon cancer test, developed by Mayo Clinic and Exact Sciences Corporation. The test uses stool sample analysis to detect specific DNA changes associated with cancer development.
Researchers reveal a genetic mutation behind the distinctive double-flowered sunflowers depicted in Van Gogh's paintings, which has been hidden for over a century. The study identifies a disrupted gene responsible for creating the mutated trait.
Biobank researchers emphasize the need for defined systems to handle incidental findings and individual research results, aiming to ensure patient safety with genomic technologies
Researchers analyzed 100,000 molecular components from a patient's genome, revealing genetic risks and biomarkers for diseases. The study provides insights into the correlation between individual genetic profiles and environmental interactions in disease development.
Scientists discover new leopard frog species in New York City's Staten Island ponds and marshes, identified through DNA analysis. The unusual species has a distinct genetic lineage, separate from other leopard frog species in the region.
Research reveals that some Scandinavian conifers survived the harsh ice age climate in small ice-free pockets for tens of thousands of years. The study found two distinct types of spruce trees with different histories, which could have economic significance for tree plantation owners.
A new DNA-based method analyzed genetic material from 81 fecal samples, showing that most snow leopards ate wild animals (79%), with a relatively low proportion of domestic livestock (19.7%). The study aims to inform conservation strategies for the endangered species.
Researchers Elizabeth Archie and Patrick Chiyo investigate elephant social behavior, finding strong female bonds and male crop raiding patterns. Their fieldwork and genetic analysis reveal how human activities alter elephants' social and genetic structures, threatening the species' survival.
A pilot study shows promise for analyzing bladder pain syndrome by analyzing cells shed into the urine, providing a noninvasive alternative to bladder biopsies. The results show distinct gene signatures for inflammation in patients with Hunner lesions, similar to those found in previous studies of bladder biopsies.
Scientists at the University of Leeds create a biosensor technology that can detect Adenovirus viruses, identify individual strains, and count virus particles. This breakthrough could lead to faster, simpler, and less costly testing for viruses, ultimately benefiting patients.
A recent large and comprehensive analysis of 50,000 genetic variants has identified four genes associated with type 2 diabetes and six independent disease-associated variants at previously known loci. The study provides valuable insight into the genetic risk for T2D across multiple ethnicities.