Articles tagged with Genetic Analysis
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The MRC Integrative Epidemiology Unit will conduct cutting-edge research to improve understanding of biological mechanisms and environmental factors underlying common diseases. Researchers will develop novel approaches to analyze data from 'omics' technologies and identify true causes of disease.
A new study published in Human Genetics found that 180 DNA variants predict tall stature in Europeans with an accuracy of 0.75.
A study by Washington University School of Medicine found that healthy children have numerous antibiotic resistance genes in their gut microbes. The research highlights the need for responsible antibiotic use to prevent the spread of resistance and serious illness.
A new study finds that 65% of Americans agree clinicians should be involved in explaining DTC genetic test results. This concern is shared by physician groups and medical journals, highlighting the importance of doctor guidance on interpreting genetic risks.
A new study found that tigers are dispersing over much greater distances than previously recorded, with long-range connectivity reduced by human settlements and roads. Genetic approaches combined with landscape ecology revealed evidence of tiger populations connected across 650 km in Central India.
Research shows that chronic stress alters gene expression in immune cells, making them pro-inflammatory and prone to excessive inflammation. This can lead to various health issues, including cardiovascular diseases, diabetes, and obesity.
A recent genetic study published in Scientific Reports reveals that Israel's wild boars descended from European pigs brought by the Philistines approximately 3,000 years ago. The research analyzed DNA samples from over 25 modern-day wild boars and found a dominant European genetic signature.
Researchers identified 11 new genes associated with late-onset Alzheimer's disease, including SORL1 and CASS4, which affect amyloid and tau protein accumulation. The study also found connections between these genes and inflammation, synaptic function, and brain cell activity.
Researchers have devised a model of DNA's close environment under threat from low-energy electrons, revealing their effects on DNA in natural conditions. The study aims to improve current uses of radiation, such as in cancer treatments and diagnostic procedures.
A genome-wide meta-analysis of COPD patients has identified novel gene variants associated with bronchodilator responsiveness. The study used data from over 6,000 patients and found that genetic determinants likely influence response to inhaled medication.
Researchers at the University of Basel have identified a new compound that reduces aversive memory, a trait central to anxiety disorders like PTSD. The compound, a known antihistamine, was found to significantly reduce memory recall of negative pictures but not neutral or positive ones.
A study published in BMC Medicine found that nearly 60% of herbal products contained plant species not listed on the label, while 32% showed product substitution. This can lead to health risks due to toxicity and interactions with other herbs, supplements, and medications.
A massive DNA study has uncovered 157 genetic changes that alter cholesterol and blood fat levels, potentially leading to new medications. Triglycerides play a larger role in heart disease risk than previously thought, and the research provides strong foundation for further investigation.
A new study conducted at the University of Nottingham has found that strong genetic factors do not influence handedness. The researchers examined nearly 4,000 subjects and were unable to detect a single major genetic determination for handedness.
Researchers have identified 48 new genetic variants linked to multiple sclerosis, nearly doubling the number of known risk factors and shedding light on the immune system's role in the disease. The study, led by the University of Miami Miller School of Medicine, confirms the critical involvement of genetic factors in MS development.
The Pan-Cancer Initiative has identified common genetic patterns across various tumor types, enabling researchers to extend therapies effective in one cancer type to others with a similar genomic profile. This breakthrough has the potential to revolutionize cancer treatment by recognizing similarities between seemingly distinct tumors.
A new study found that elite power athletes are more likely to have the AGT 'CC' genotype, which may predispose them to improved power and strength capacity. However, the functional significance of this genetic variant remains unclear.
A new technique for single-cell analysis of gene expression, named Smart-seq2, has been developed to identify rare cell subpopulations in tumors. This method captures three to four times as many RNA molecules as current methods, allowing for a more granular analysis of how subtle differences contribute to biology and disease.
Researchers analyzed blood samples from over 1800 participants and found that specific DNA segments were associated with altered metabolic processes. The study provides new insights into how lifestyle factors impact metabolism via epigenetic changes.
Scientists have identified genes responsible for bedbug pesticide resistance, enabling them to thrive in homes and hotels. The discovery highlights the need for a multi-faceted approach to manage bedbug infestations, including integrated pest management and non-chemical measures.
Researchers from the University of York and Czech institutions discovered five new species of Vesper bats in Senegal, showcasing unexpected genetic diversity. The discovery confirms that West Africa may represent a bio-geographic hotspot with many more species to discover.
University of Arizona researchers have discovered a new secret in spider venom, finding that the venom produces a different chemical product in the human body than previously thought. This discovery has implications for understanding how brown recluse spider bites affect humans and developing possible treatments.
A genetic study conducted by 23andMe has identified four genetic markers associated with the development of non-syndromic striae distensae (stretch marks), a skin condition affecting approximately 50-80% of people. The study suggests that elastin, a key component of elastic fibers in the skin, plays a crucial role in the formation of s...
Researchers from RIKEN have developed a highly efficient molecular probe, Eprobe, for real-time PCR monitoring and genetic testing. The new technology enables advanced assays for DNA-based genetic testing and helps bring genome-wide sequencing studies to patients in the clinic.
A UC Irvine study has found that breath analysis may be an accurate way to quickly determine the severity of bacterial infections. The researchers correlated inflammation levels in laboratory mice with carbon monoxide and other gases in breath samples, making carbon monoxide a reliable biomarker for infection presence and intensity.
A study found that more than half of parents misunderstood key concepts of genetic biobanking consent, highlighting the need for clearer explanations and inclusive consent models. Researchers are exploring alternative methods of consent delivery to improve understanding and empower families as partners in genetic research.
A study has identified two networked groupings from 26 genes associated with autism that are overexpressed in the cerebellar cortex. The findings suggest specific brain regions implicated in pathology and complement genomic and neuroimaging analyses to obtain a broader picture of the autistic brain.
A new genome sequencing technique has been used to select embryos for IVF, resulting in the first birth following embryo screening. The 'next generation sequencing' method reveals information on genetic disorders and chromosomal abnormalities, increasing the chances of successful pregnancies.
The study identified 16 new genetic associations related to pollen, dust-mite, and cat allergies, highlighting key pathways in the biological basis of common allergies. This research provides a significant step towards understanding the genetic link between allergens and allergic reactions.
Researchers at Rice University analyzed thousands of mutant worms to identify genes controlling movement, revealing 87 new links in the process. The study also uncovered evidence for a protein-signaling pathway regulating locomotion, with implications for prioritizing genetic tests in humans.
Chang Lu, associate professor at Virginia Tech, is awarded a $710,000 NIH grant to advance cancer research technology using chromatin immunoprecipitation (ChIP) assay on microchip devices. The new test provides ultrahigh sensitivity and aims to study tumor-initiating cells and molecular dynamics.
Scientists at NC State University have discovered the first example of a micro-RNA controlling lignin biosynthesis, which gives wood its strength. The research found that reducing lignin content by over 20% can increase the efficiency of paper and biofuels production.
Researchers analyzed North Pacific killer-whale strandings, finding 88% fatal and 12% surviving, providing clues on species' overall life history, genetics, and health. The standardized necropsy system increased data collection from 2% to 33%, shedding light on the causes of death and human impact on orca populations.
Researchers found King Richard III in a hastily dug, lozenge-shaped grave under a Leicester car park, suggesting gravediggers were in a hurry to bury him. The grave was too short for the king's body, and his torso was crammed in, with evidence of hands being tied during burial.
A pan-European study found that certain signs of motor disorders can appear years before the actual disease manifests. The researchers detected these signs using a mathematical model and extensive tests, including standardized tests of muscular coordination and magnetic resonance imaging.
A new report highlights the challenges of collecting DNA for human rights purposes, such as protecting victims of human trafficking. The authors propose multiple approaches and solutions to combat this issue, including collaboration among government authorities, law enforcement, social services, academics, and victim advocates.
Researchers analyze over 1,000 genes from 23 yeast species to identify reasons for conflicting phylogenetic trees and propose new methods to improve accuracy. They find that genetic data is less reliable during periods of rapid radiation and that the value of DNA data may have a similar limit.
A new species of green palm-pitviper was described from a cloud forest reserve in northern Honduras. Genetic analysis revealed that the closest relatives are found over 600 km away in Costa Rica, indicating a relict lineage.
Researchers found that genes controlling circadian clock rhythms are profoundly altered in the brains of people with severe depression, suggesting a physical basis for many symptoms. The study provides clues for potential new classes of compounds to rapidly treat depression by resetting abnormal clock genes.
Ancient DNA analysis confirms Yersinia pestis as the cause of the Justinianic Plague. The results provide insights into the phylogeny and origin of this plague, contradicting previous theories. This breakthrough sheds new light on a major pandemic in European history.
Genetic analysis reveals potential origins of novel avian influenza A H7N9 virus, suggesting at least four possible evolutionary paths. The virus has evolved into two distinct lineages, with unknown intermediate hosts implicated, highlighting the need for global surveillance and close monitoring of domestic-poultry-to-person transmission.
Advaita, a Wayne State University startup, is participating in the new Michigan I-Corps program to turn its biotechnology innovation into commercial opportunities. The company aims to streamline drug-discovery methods, saving time and money for academia and pharmaceutical industries.
Research found that specific DNA regions contribute to prostate cancer development and early death, with patients having two of these changes at high risk. The study identifies key genes PTEN and MYC as linked to prostate cancer lethality.
A phase 1 clinical trial of Rigosertib, a dual kinase inhibitor, demonstrated the drug's effectiveness in patients with head and neck cancer who have failed platinum-based therapies. The results led to an 80-patient multi-institutional Phase II trial to explore biomarkers for accurate patient matching.
This April issue of the Genetics Society of America's journal features research on genotyping-by-sequencing, a novel gene silencing system in fungi, and the role of protein chaperone HSP90 in facilitating gene duplicate divergence. Additionally, studies explore genome integrity and RNA editing in mice.
A study by Johns Hopkins Medicine has identified DNA-damaging toxins in commonly consumed plant-based foods, including liquid smoke flavoring, black and green teas, and coffee. The toxins, pyrogallol and gallic acid, can activate the p53 gene, which is associated with cancer.
A study by MIT and Université Catholique de Louvain found that just four points of reference were enough to uniquely identify 95% of cellphone users in a data set of 1.5 million users. The researchers used statistical physics tools to uncover a simple mathematical relationship between data resolution and identification probability.
Two new species of mouse lemurs have been identified by Duke University scientists, one named Anosy mouse lemur and the other Marohita mouse lemur. The genetic analysis reveals that these species are distinct and do not interbreed with other recognized mouse lemur species.
Two genes associated with rare autism-related disorders are also jointly linked to more general forms of autism, according to a new study published in Molecular Psychiatry. The findings suggest a new genetic pathway to investigate in general autism research.
A genome-wide association study identifies 20 new genetic associations for myopia, a refractive error resulting from increased axial length of the eye. The study suggests that complex interactions underlie the development of myopia, with extracellular matrix remodeling and neuronal development playing key roles.
A new DNA-based technique allows early identification of Geomyces destructans, a fungus causing White Nose Syndrome (WNS), in bats, soils, and cave walls. The test is 100-times more sensitive than previous ones, detecting single spores of the fungus.
Researchers at Ohio State University have discovered the genetic mechanism that led to the development of wings in fruit flies, a key to their survival. By analyzing 20 cells present in the larval stage, they found that a specific gene, Dpp, triggers the growth of wings by activating another gene, vn.
A 33,000-year-old Siberian fossil, known as the 'Altai dog', is found to be more closely related to modern dogs and prehistoric canids on the American continents than wolves. This challenges previous theories suggesting a recent emergence of modern dogs from wolf ancestors.
A team of researchers found that bacteria in Bangladesh's aquifers use surface-derived organic carbon, which is naturally released from sediment into groundwater. This process predates recent human interaction and suggests that intensive pumping has not yet significantly affected arsenic release.
A comprehensive study has identified seven new regions of the human genome associated with increased risk of age-related macular degeneration (AMD). The study, led by Case Western Reserve University School of Medicine, found that AMD is not caused by a single genetic change but rather by many events that accumulate over time.
Researchers have discovered seven new genetic loci associated with increased risk of age-related macular degeneration (AMD), a condition that affects central vision and can lead to blindness. The study, supported by the National Eye Institute, represents the most comprehensive genome-wide analysis of AMD genetics.
The study identified seven new loci near genes that are associated with increased risk of age-related macular degeneration. The analysis included data from over 17,000 people with advanced AMD and 60,000 without, revealing a variety of biological functions implicated in the disease.
A University of Utah study found a significant genetic connection to surgical site infections (SSIs) in families, suggesting personalized health care through genome analysis could be available soon. Researchers analyzed 651 hospital patients with SSIs and matched controls using the Utah Population Database.
Researchers have found genetic variants linked to alcoholism in the Spanish population, including women. The study identified polymorphisms in genes related to metabolism and the dopaminergic system, which are associated with increased risk of hazardous drinking and dependence.
The novel TP PCR test yields accurate results without unnecessary additional testing, improving diagnosis and prognosis by accurately sizing the genetic abnormality characteristic of HD. The test correctly sized 240 of 246 samples, including those with a wide range of CAG repeats.