Articles tagged with Gene Transfer
A research team led by Bingyu Zhao from Virginia Tech has developed a strategy to introduce rust fungus resistance in switchgrass. The team plans to use genetic engineering and molecular biologists to transfer disease-resistant genes into the grass.
A new data-driven statistical model incorporating the surrounding landscape, pollinating insects, and human seed dispersal accurately predicts gene flow between crop plants. The study finds that human farming activity has a significant impact on gene transfer rates, while the influence of pollinators is relatively small.
Researchers have successfully transferred green pepper genes into African bananas, giving them resistance to the deadly Banana Xanthomonas Wilt disease. The banana varieties exhibit strong resistance to the disease and could potentially save millions of farmers' livelihoods.
Italian scientists have successfully completed preclinical trials for a gene transfer treatment that can correct the lack of beta-globin in patients' blood cells, a major step towards treating beta-thalassemia. The treatment uses genetically corrected stem cells to restore haemoglobin production and overcome the disorder.
New gene transfer agents have been developed to overcome the limitations of viral vectors and chemical agents, showing promise for treating hereditary diseases and cancer. The agents are more effective at delivering DNA into cell nuclei, increasing the chances of successful treatment.
Researchers discovered an identical gene for antibiotic resistance in human and animal samples, suggesting its transfer between bacteria species. This finding poses a risk to the treatment of common human infections like UTIs, which are increasingly difficult to treat due to rising antibiotic resistance.
Researchers found a 'longevity gene' associated with slower cognitive decline and reduced risk of dementia and Alzheimer's disease. The CETP gene variant alters protein function, leading to higher HDL cholesterol levels and increased protection against age-related illnesses.
Researchers at Boston University School of Medicine have developed an approach to sustainably express normal human alpha-1 antitrypsin in the mouse lung, reducing emphysema symptoms. This breakthrough could provide a therapeutic approach for overcoming lung diseases caused by single-gene defects.
A University of Michigan study found that color differences in fruit flies have a common genetic basis with those in humans and chimps. Genetic analysis revealed the tan gene as responsible for part of the color variation within and between species.
A study identified a genetic variation in humans that allows some people to require less sleep. Researchers created 'insomniac' mice with the same gene variation, which appeared to function normally despite less sleep. The discovery sheds light on two aspects of sleep: biological clocks and body homeostasis.
A researcher at Virginia Tech has identified a disease-resistant gene in corn that can be transferred to other plants, offering new hope for disease-free crops. The gene, Rxo1, defies traditional plant pathology rules and could revolutionize crop breeding.
Researchers successfully delivered functional genes to patients with alpha-1 antitrypsin deficiency, triggering the production of a protective protein. The study shows promise for gene therapy as a potential treatment option for this genetic disorder.
Researchers at University of Florida have safely given new genes to patients with alpha-1 antitrypsin deficiency, enabling them to produce trace amounts of the protective protein for up to one year. This potential step toward a gene therapy could benefit approximately 100,000 Americans with the condition.
Researchers from Cold Spring Harbor Laboratory present a method for targeting hematopoietic stem cells using engineered lentiviral vectors. An alternative approach using DNA transposons offers a safer and effective way for non-viral gene transfer.
A recent study found that nearly all human embryos produced through IVF have chromosomal problems, rendering current preimplantation genetic screening techniques useless. Chromosomal instability is likely responsible for low fertility rates and high abortion rates, and could impact spontaneous pregnancies as well.
Scientists developed a method to measure the transport of therapeutic genes through the body using magnetic nanoparticles. The technology significantly increases gene transfer efficiency compared to non-magnetic methods, with potential for targeted cell delivery.
Researchers found that a novel mutated variant of a gene in dogs is responsible for the black coat color in wolves, transferred through matings. The discovery suggests that natural selection has increased the frequency of black coat color in wolf populations across North America.
A new study found a link between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and risk for post-treatment relapse among alcohol-dependent patients. The findings suggest that genetic markers may be used to predict treatment outcomes and inform personalized therapy approaches.
Researchers identified the structure of a key component facilitating the exchange of antibiotic resistance genes between bacteria. This discovery sheds light on how type IV secretion systems, which also transport toxins, contribute to disease-causing properties and public health concerns.
NYU researchers found that Staphylococcus aureus can co-opt bacteriophages to transfer toxic genes to unrelated bacteria, including Listeria monocytogenes. This discovery raises concerns about the potential for bacterial toxin exchange and antibiotic resistance.
Researchers identify key gene transferred from Sicilian plant to British Groundsel weed, allowing for natural genetic exchanges and evolution. This discovery challenges traditional views of evolution as a one-way process.
Researchers have developed a new grape called Improved Chancellor that is resistant to the popular herbicide 2,4-D. The discovery of the gene that makes this grape resistant came about by accident, and it has the potential to help salvage the wine and grape industry in the Midwest.
A new study demonstrates that transferring human insulin genes to the gastrointestinal tract using a non-viral vector called chitosan nanoparticles can successfully treat type 1 diabetes in rats. The study found that this method is safe and efficient, without any wound or infection.
Research highlights the importance of diet, statins, and genetic factors in cholesterol regulation and cardiovascular health. Studies have shown that low HDL-C levels are strongly associated with an increased risk of CAD, and genetic mutations can affect HDL-C production.
Embryos with hereditary disorders should not always be transferred without unaffected ones, experts say. Doctors should discuss decision-making processes and policy before PGD, prioritizing the child's welfare.
Researchers presented findings on Maxi-K gene therapy, showing it to be safe and restoring erectile function in men with moderate to severe ED. The treatment has been shown to enhance sexual behavior, including increases in partial and full erections and a two-fold increase in erection duration.
Researchers have developed a tool to rapidly silence specific genes in rice, enabling faster breeding and improved crop performance. This breakthrough uses artificial miRNAs to target and disable genes of interest, with potential applications in hybrid seed production and enhanced resistance to pathogens and insects.
Researchers are conducting a phase 1 clinical trial using gene therapy to treat LCA2, aiming to restore vision in individuals with inherited blindness. The treatment involves injecting trillions of replacement genes into the retina, using an adeno-associated virus to deliver the therapeutic gene.
Scientists have discovered a way to transfer genes into diseased tissue of the human inner ear, aiming to restore hearing. The breakthrough could lead to the development of gene therapy compounds that produce new hair cells and restore hearing function in humans.
Scientists created a mathematical model of bacterial gene transfer rates, taking into account natural subsurface environments. The new model suggests that bacterial transport and colonization are crucial factors in controlling gene spread, potentially impacting bioremediation and antibiotic resistance.
Researchers found that mitochondrial genes transfer to the nucleus in clonally reproducing plants and those capable of self-pollination. This contradicts the expectation that such migration is driven by sexual recombination.
A clinical trial of gene transfer therapy for erectile dysfunction found significant and sustained improvements in patients who received a transfer gene called hMaxi-K. The therapy works by creating additional potassium channels in smooth muscle cells, relaxing the muscle and allowing blood flow required for an erection.
A new gene transfer therapy has shown promising results in treating erectile dysfunction (ED) and may also have potential benefits for overactive bladder, irritable bowel syndrome, and asthma. The therapy, which targets smooth muscle cells, was well-tolerated and safe in a small pilot study of 11 men.
Researchers developed a gene transfer method using the mutant form of apolipoprotein A-I (Apo A-I Milano) to treat vascular inflammation and plaque buildup. The study found that Apo A-I Milano gene transfer resulted in a 65% reduction in plaque buildup, compared to a 25% decrease with the normal HDL gene.
Researchers at Einstein College of Medicine have observed a phenomenon where a gene plays a major role in organism development, displaying pulses of transcription that turn on and off at irregular intervals. This discovery could enable precise regulation of development by allowing genes to be turned on and off as needed, similar to a t...
A new protocol allows for efficient transformation of strawberry plants using Agrobacterium's circular DNA molecule, enabling researchers to study the function of thousands of genes in this economically important crop. This breakthrough could lead to improved nutritional value and antioxidant content in strawberries.
Researchers at Florida State University have identified a gene called BDNF as playing a key role in social aversion, leading to the development of a potential new treatment for depression. Long-term use of antidepressants was successful in reversing social withdrawal, but a gene therapy approach showed promise with fewer side effects.
Researchers have developed a novel approach to prevent and treat atherosclerosis by transferring the apo A-I Milano gene or using antibody therapy to reduce plaque buildup. The studies show that these methods can significantly shrink existing plaques and even remove bad cholesterol.
Gene flow researchers found that separation distances between GM and conventional crops can meet most impurity thresholds, reducing the risk of genetic material transfer. The study also estimated that around 32,000 oil seed/B. rapa hybrids are produced in the UK every year.
Researchers have successfully applied a novel PET/CT technique to characterize the effects of a gene therapy intervention in animal models, demonstrating its potential for improving cardiac health. The study showed that successful transfer of a VEGF gene resulted in increased tissue perfusion without impairing cardiac function.
Gene targeting allows scientists to alter specific genes in cultured cells and transfer them to laboratory mice, enabling the study of human diseases. The technique has revolutionized biomedical research and is now practiced by thousands of scientists worldwide.
The BIOS Initiative provides a new licensing mechanism that encourages sharing of core tools of innovation, empowering researchers worldwide. The launch of BioForge, an online collaborative research platform, enables scientists to work together to craft new technologies within a protected commons.
Researchers at Rush University Medical Center are exploring a new gene transfer technique that uses CERE-110 to deliver nerve growth factor to specific areas of the brain affected by Alzheimer's disease. The goal is to prevent cell death and reverse cell atrophy, which may have a widespread effect on the entire brain.
A groundbreaking study reveals a comprehensive genetic map of important tree genes, enabling scientists to unlock the secrets of tree biology. The database contains over 102,000 gene sequences from the Populus genus, allowing researchers to explore the genetic functions of trees and their responses to environmental stresses.
Researchers successfully delivered a phosphorescent green protein from jellyfish to the eyes of laboratory cats, producing a permanent effect. The study demonstrates a potential gene therapy approach to treat glaucoma, a chronic disease affecting 70 million people worldwide.
Researchers have successfully engineered plant-dwelling bacteria to break down toxic pollutants, enabling plants to thrive in contaminated environments. The technique uses naturally occurring bacteria and natural gene-transfer methods, offering a promising solution for environmental cleanup.
Amanda Rudisin, a Virginia Tech undergraduate, has developed polymers that can transport DNA across cell membranes. Her research found that linear and branched molecules have varying effects on complexation with DNA.
A team of biologists has discovered that the parasite relies on salvage enzymes to steal nutrients from its host to survive. This discovery provides new targets for drugs designed to treat victims of this parasitic disease, which causes chronic severe diarrhea and life-threatening complications in AIDS patients.
Scientists have discovered a key role for lipid metabolism in the regulation of the immune system. The study reveals that natural killer T cells can recognize lipids on the surface of bacteria, triggering an immune response. By understanding this process, researchers hope to develop new treatments for autoimmune diseases and cancer.
Bacteriophage, or phage, previously thought not to be infectious to humans, may be a new target for fighting certain bacteria that produce toxins. Scientists found that phage can transfer toxins and genes between bacteria, transforming harmless microbes into virulent bugs.
Researchers at North Carolina State University have successfully created a line of transgenic chickens carrying a reporter gene that can be easily tracked. This innovation provides a valuable tool for studying embryo development and potentially leads to new insights into birth defects and improvements in human and animal health.
A breakthrough in genetic engineering has enabled scientists to transform loblolly pine trees with improved drought tolerance and disease resistance. The study demonstrates the use of a shoot-based transformation method, which can accelerate the improvement of this important species.
Scientists have successfully genetically altered human blood stem cells to selectively activate genes in developing immune cells, providing a potential breakthrough for gene therapy. The research uses a lentivirus to transfer a fluorescent protein gene into stem cells, which then express the gene only in specific immune cells called an...
The UNC-Chapel Hill Gene Therapy Center will use the funds to translate basic research knowledge into safe human clinical trials, with a focus on cystic fibrosis and hemophilia. The center aims to provide new treatments for diseases caused by single-gene defects.
Researchers at Women's and Children's Hospital in Adelaide have developed a way to safely use Human Immunodeficiency Virus Type 1 (HIV-1) to transfer therapeutic genes into human cells. This method has wide applicability for various human genetic diseases and is currently being tested on animal models before moving to human trials.
The National Center for Advancing Translational Sciences (NCATS) has established a network to provide clinical researchers with access to human gene vectors and toxicology studies. Seven NIH components will participate in the network, which aims to eliminate barriers to gene transfer research.
Researchers used gene transfer to increase vasopressin receptor density in the ventral pallidum of prairie voles, leading to increased pair bonding. The study shows that higher levels of vasopressin receptor expression are associated with more affiliative behavior and stronger pair bonds.
Researchers at the University of Wisconsin-Madison have made a breakthrough in gene transfer technology by inserting a jellyfish gene into rhesus monkey embryos, resulting in transgenic placentas that produce the desired protein. The study promises new insights into pathologies of pregnancy and has implications for human gene therapy.
Researchers at Virginia Tech have discovered a way to stimulate the production of Vitamin C in lettuce and other plants using rat genes. This breakthrough could lead to longer shelf life and improved nutrition, particularly in developing countries where access to fresh produce is limited.
A new study sequenced the gene of a deadly type of Escherichia coli, revealing that it frequently picks up new DNA from other bacteria and viral genes. These newly acquired genes may contribute to the organism's virulence and make infections difficult to treat.