Articles tagged with Gene Transfer
Researchers at King Abdullah University of Science & Technology (KAUST) have identified a stem rust resistance gene in Aegilops sharonensis and transferred it to common wheat. The new transgenic wheat lines show high levels of resistance to the stem rust pathogen, providing hope for mitigating the devastating effects of climate change.
Researchers discovered MRSA in 10% of hedgehogs in Helsinki, including a successful clone with global spread potential. The study suggests spillover of antimicrobial resistance from anthropogenic sources to urban wildlife, posing a risk for human patients.
Scientists at UC San Diego are working on next-generation gene drive systems based on CRISPR technology to combat malaria and reduce mosquito populations. The $1.4 million grant will support the development of new technologies, including a neutralizing system called ERACR, to mitigate risks associated with gene editing in mosquitoes.
A team of researchers identified a stem rust resistance gene from wild goat grass species Aegilops sharonensis, which can be cross-bred into wheat for immunity against deadly crop pathogens. The genetic potential of this hardy relative has been largely unexplored and holds promise for reducing the threat of the stem rust disease.
A novel surgical approach and synthetic viral vector Anc80L65 successfully delivered genetic cargo to the inner ear of nonhuman primates, paving the way for a potential treatment for hearing loss and vestibular disorders. The study's findings suggest that this method could be translated to humans.
Researchers at Toyohashi University of Technology have developed DNA stamper injections using nanoscale-tipped wire arrays to deliver biomolecules into live neuronal cells within brain tissues ex vivo and in vivo. This technique allows for the efficient genetic modification of brain cells, making it a powerful tool for neuronal research.
Researchers have identified a key gene that confers stripe rust resistance in bread wheat, providing hope for improving crop yields and ensuring global food security. The discovery was made possible by the assembly of the highest-quality genome to date for bread wheat using advanced DNA sequencing techniques.
A new Michigan Medicine study suggests that genes from oceanic bacteria have entered the human gut microbiome, enabling digestion of seaweed polysaccharides. The research found that these genes are more common than previously recognized and are linked to the ability to process certain seaweed-derived sugars.
A research team led by University of Adelaide found tangible evidence that Australian elapids arrived by sea rather than land. The study analyzed genomes of two Australian elapids and compared them to marine and semi-marine elapid sea snakes, finding similarities with marine life genes.
Researchers at the University of Copenhagen have discovered that resistant bacteria can hide resistance genes in inactive bacteria within biofilms, creating a reservoir of resistance that can be drawn upon when antibiotics are not present. This new understanding challenges the long-held assumption that resistant bacteria lose their res...
A novel gene therapy has shown sustained expression of clotting factor VIII, leading to a reduction or complete elimination of bleeding events in patients with hemophilia A. The trial demonstrated improved production of coagulation factor VIII over prolonged periods.
A new study reveals that multiple pathways regulate poly(A) tail lengths in yeast, involving poly(A) binding proteins and a self-regulating pathway. This discovery sheds light on the complex control of mRNA tails and their impact on protein production.
A team of researchers from HKU has developed a transferrable and integrative type I CRISPR-based platform that can efficiently edit Pseudomonas aeruginosa, a superbug capable of infecting various tissues and organs. The technique enables rapid identification of resistance determinants and development of novel anti-resistance strategies.
Researchers from Hiroshima University have discovered mutant genes that facilitate genetic transfer between bacteria and other organisms across different kingdoms, including fungi and protists. The study suggests that these genes work together to activate or repress the conjugation mechanism, enabling cross-kingdom transfer.
Computational research reveals that genetic transfer between bacteria may be more widespread than expected, with plasmids containing resistance genes found in various environments and species. This could lead to rapid development of resistance in human pathogens.
Researchers at University of Queensland have discovered how bacteria share antibiotic-resistance genes, shedding light on the rapid spread of 'superbugs'. The study reveals a mechanism through which plasmids are mobilized and transferred between bacteria, offering potential solutions to combat antibiotic resistance.
Researchers from the University of Bonn successfully transferred a moss protein into a flowering plant, demonstrating its ability to correct genetic errors. This breakthrough could contribute to the development of more efficient crops and provide insights into plant energy metabolism.
Researchers found that genetic makeup of mice can influence transfer of antibiotic-resistant plasmids, suggesting new ways to stop resistance. The study analyzed how plasmids spread in genetically different groups of mice, leading to discovery of potential host factors triggering or reducing plasmid transfer.
A new study shows that a commonly used vector for large gene transfer can deliver genes to retinal cells, but provokes an acute inflammatory response when injected subretinally into rats. The researchers conclude that further work is needed to understand the inflammatory pathways involved and modulate the immune response.
A study explores the genetic mechanisms by which alterations in colon-associated microbes might promote colorectal cancer. Alterations in gut microbes have been linked to increased DNA methylation changes and CRC risk.
Studies of autism spectrum disorder have identified new features of the condition in the brain, including the role of placental hormones and gene editing technologies. These findings may contribute to the development of therapeutic treatments for individuals with ASD.
Researchers defined the dynamics of mitochondrial DNA transfer from mothers to offspring, revealing control mechanisms to prevent heteroplasmy. The study helps devise strategies to prevent mitochondrial disease and unwanted results in medical interventions.
Children's Hospital of Philadelphia researchers have developed a new AAV vector screening method that captures the full range of gene expression patterns caused by AAV vectors. This innovative technique is expected to significantly advance the field of gene therapy by providing a more sensitive approach to detecting gene transfer sites.
Researchers have shown that gene transfer therapy can improve left ventricle function and glucose disposal in mice with diabetes. A single injection of a hormone called urocortin 2 increased heart function and reduced blood sugar levels, offering a potential new treatment for cardiovascular disease.
Researchers have discovered a novel glycocin, a small antimicrobial peptide with a sugar group attached, produced by the thermophilic bacterium Aeribacillus palladius. The compound has been successfully expressed in E. coli bacteria, making it easier to produce and investigate. This breakthrough could lead to new alternatives for biofu...
A recent study found that grasses can acquire genes from at least nine donor species, including those involved in photosynthesis and disease resistance. This mechanism allows certain plants to adapt quickly to environmental changes.
A global alliance of researchers has pioneered a new method to rapidly recruit disease-resistance genes from wild plants for transfer into domestic crops. The technique, called AgRenSeq, promises to transform the development of disease-resistant varieties for the global food supply.
Researchers at Kiel University will develop next-generation gene therapies for cardiovascular disease using AAV vectors, aiming to improve treatment approaches and reduce vascular inflammation in conditions like atherosclerosis. The project aims to translate experimental treatments into clinical applications.
Researchers found that supermarket produce is a reservoir for transferable antibiotic resistance genes, which can evade traditional detection methods. The study highlights the importance of characterizing the resistome in produce and emphasizes the need for improved detection methods.
Researchers at Tokyo Medical and Dental University developed a method to increase lentiviral particle production, enabling safe and efficient gene introduction into cells. The discovery utilizes the SPSB1 protein to activate transcription factors, leading to up to 12-fold boosted virus production.
The RAC's elimination would shift review responsibility to local Institutional Biosafety Committees. The new approach aims to reduce redundancies between FDA and RAC roles in human gene therapy.
Researchers found gene cassettes transfer across generations in strawberry plants, leading to sex chromosome changes and homomorphic female heterogametic inheritance. The discovery sheds light on the mechanisms behind sex chromosome evolution and has implications for creating new crop varieties.
A study by the University of Helsinki found that IVF can alter embryonic growth, particularly in relation to genetic variation. Children born from frozen embryo transfer had significantly higher birth weights than those born from fresh embryo transfer.
Researchers compared six adeno-associated viral (AAV) vectors for efficiency of gene transfer to both retinal pigment epithelial and photoreceptor cells. Human pluripotent stem cell-derived organoids were used as an in vitro test system for AAV vector development.
Researchers at UCR discover how plants package and deliver small RNAs to fight plant pathogens. The study found that plants transfer sRNAs into fungi, inhibiting their ability to cause disease, through a process called cross-kingdom RNA interference.
Two independent studies found that mistletoe lacks key components of the cellular machinery to convert glucose into ATP. This loss is associated with a remodeled respiratory chain and reduced ATP generation by mitochondria.
Researchers have found that ocean acidification impairs phytoplankton's access to iron, a crucial nutrient for growth. This discovery highlights the critical impact of rising CO2 levels on marine food webs and global carbon cycling.
A team of investigators found the mcr-1 drug resistance gene in Shigella flexneri, a common cause of diarrhea globally. The gene was detected on a transferable plasmid and can jump to other bacteria, raising concerns about its potential spread.
Researchers found a shift in cytokine profiles of mice with FVIII inhibitor development, including increased levels of pro-inflammatory cytokines. A negative correlation was also observed between risk factors for FVIII inhibitor development and age at gene therapy administration.
A team of scientists at Université de Montréal developed a novel strategy to block the transfer of antibiotic-resistant genes by binding molecules that target the TraE protein. This approach has the potential to reduce the spread of resistance genes, preserving the potency of antibiotics and improving human health.
Researchers have identified ten times more new genes on the Y chromosome than previously thought in fruit flies. These genes appear to have taken on important functions, raising questions about their durability and potential impact on species.
A study by Oregon State University and the Oregon Health Authority identified 21 cases of extensively drug-resistant Acinetobacter baumannii, a rare gene responsible for antibiotic resistance. Effective communication between facilities can prevent transmission and ensure appropriate contact precautions are taken.
A new study uses gene transfer to block the expression of an enzyme that breaks down alcohol, leading to increased acetaldehyde levels and potential treatment for alcoholism. The approach has strong proof-of-concept data and bodes well for future development of a genetic therapy.
Researchers found that thyroxine and metformin can repair memory and learning deficits caused by fetal alcohol exposure when given after birth. The study provides potential treatment for fetal alcohol spectrum disorder.
Researchers found that simultaneous genetic and chromosomal screening of a single biopsy improved pregnancy rates. The study used double genetic tests on cells taken from 1122 blastocysts, resulting in 99 pregnancies and 70 healthy births. This approach reduces the risk of implantation failure and miscarriage.
A new study found that oral prednisone reduced immune responses to AAV-based gene delivery, resulting in a 60% decrease in cytotoxic T cell infiltrates. The treatment also increased PD-L2 levels, which induce programmed T-cell death, suggesting a potential therapeutic benefit for gene therapy.
Recent clinical trials using different gene transfer approaches have shown acceptable risk and potential for treating heart failure with reduced ejection fraction. Despite mixed results in terms of efficacy, the data support further clinical development of this therapeutic strategy.
Researchers at Kyoto University identified a key gene that regulates iron uptake, revealing a functional defect in the duodenum and potentially leading to new treatment methods for anemia. The study found that Regnase-1 degrades iron-controlling genes, such as TfR1, which can help prevent debilitating disorders like hemochromatosis.
Researchers have created a new cellular model to test the efficacy of new gene therapies for Chronic Granulomatous Disease more efficiently, using Crispr/Cas9 technology. The improved method allows for faster and cheaper development of new treatments.
Researchers found a gene from the common fruit fly that can be expressed in plants to improve TNT removal from contaminated soil. The breakthrough has the potential to clean up millions of hectares of land contaminated by munitions.
Researchers have developed plants that can more effectively remove TNT from contaminated soil using the glutathione transferase DmGSTE6 gene. These plants show improved resistance to TNT and enhanced removal capabilities, offering a potential solution for land contamination
A Phase 1 clinical trial demonstrated the long-term safety of gene transfer in treating neovascular age-related macular degeneration. The therapy produced therapeutic proteins encoded by genes for at least 2.5 years in patients with advanced NVAMD.
Researchers developed a lentiviral vector-based gene therapy approach to deliver normal copies of the alpha-iduronidase gene to HSCs, indicating safety and efficacy in mice. The study sets the stage for a clinical trial to determine if MPS I patients can be successfully treated with this approach.
A new gene therapy approach successfully delivered a therapeutic gene to the brains of treated mice, restored enzyme function, and extended survival. The treatment holds promise for developing similar therapies for humans and targeting additional brain disorders.
A new study found no serious adverse events related to gene therapy in patients with advanced Parkinson's disease five years after treatment. The long-term safety profile of the therapy is promising, lending support to its potential as a treatment for this debilitating disease.
Researchers describe expanding scope of gene therapy targeting CNS diseases, including Alzheimer's and ALS. The article highlights rapid progress in viral vector development and delivery strategies for treating these conditions.
A transferrable gene for colistin resistance has been discovered in the United States, raising concerns about the emergence of truly pan-drug resistant bacteria. The finding is a significant public health concern, as it may render colistin, the last agent used to combat resistant bacteria, ineffective.
Promising results from clinical trials of globin gene transfer have eliminated the need for blood transfusions in some individuals with beta-thalassemias. Gene editing technologies hold promise to correct beta-globin deficiencies and reactivate fetal hemoglobin production, potentially leading to a cure for severe globin disorders.
Researchers have mapped the core set of genes that enable strep bacteria to acquire new genes for antibiotic resistance and escape the immune response. The study identifies 83 specific genes in 29 regions of the strep chromosome that are required for DNA uptake.
Researchers have discovered an enzyme that enables the production of fuel-grade oil from plants, a breakthrough that could lead to sustainable energy solutions. The enzyme, lycopaoctaene synthase (LOS), is capable of initiating the production of hydrocarbons, which can be used to make fuels such as gasoline and diesel.