Articles tagged with Neural Inhibition
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Researchers discover that neurons in auditory cortex encode temporal patterns using excitatory and inhibitory inputs. This breakthrough could lead to the development of state-of-the-art neural prosthetic devices capable of mimicking brain coding patterns.
Researchers found that Yizhijiannao granule inhibits neuronal apoptosis, reducing tau phosphorylation and neuroinflammation in Alzheimer's disease. The study identified multiple proteins involved in regulating amyloid beta production, oxidative stress, and neuronal survival.
Researchers investigated how neurons in the inferior colliculus respond to paired sounds producing precedence-effect illusions. After local GABA application, responses to lagging stimuli were suppressed, providing a potential new approach for improving speech perception in patients with hearing aids under background noise.
Researchers successfully constructed an adenovirus that induces DHCR24 specifically in neuronal cells, leading to reduced apoptosis. The findings suggest potential for future studies on DHCR24 gene therapy and neuronal functional research.
A new study reveals that leptin acts directly on neurons in the preoptic region of the hypothalamus to regulate peripheral levels of leutinizing hormone, essential for reproduction. The study demonstrates that leptin communicates the status of peripheral energy stores to GnRH-releasing neurons via the preoptic hypothalamus.
Researchers investigated how neurons in the inferior colliculus respond to paired sounds producing precedence-effect illusions. Local gamma-aminobutyric acid application suppressed responses to lagging stimuli, providing a new approach for improving speech understanding in patients with hearing aids under background noise.
Researchers have found that gabapentin can decrease neuronal excitability in spinal trigeminal nuclei and inhibit the formation of central sensitization during migraine. The study published in Neural Regeneration Research suggests a potential therapeutic role for gabapentin in treating migraine-related central sensitization.
A study by Jiang et al. found that baicalin inhibited colistin sulfate-induced neuronal apoptosis in PC12 cells by suppressing free radical injury, reducing caspase-3 activity and lactate dehydrogenase activity. Cell viability increased, and cell morphology improved.
5-hydroxymethylfurfural, extracted from wine-processed Fructus corni, protects against H2O2-induced rat hippocampal neuron apoptosis by regulating apoptosis-related genes. This finding provides evidence for the clinical prevention and treatment of oxidative injury-related diseases in the brain.
The Perspectives in General Physiology series provides an in-depth look at the mechanisms of sensory information processing, including visual, auditory, olfactory, and tactile processes. The series reveals key strategies used by researchers to quantify and characterize sensory information across multiple systems.
A CU-Boulder study found that neural inhibition plays a crucial role in decision-making, particularly for people with anxiety disorders. The research suggests that increasing neural inhibition could help improve treatment options for individuals struggling with decision paralysis.
The Proceedings of the National Academy of Sciences has selected six papers for the 2009 Cozzarelli Prize, acknowledging originality and scientific excellence across physical and mathematical sciences, biological sciences, engineering, biomedical sciences, behavioral and social sciences, and applied biological sciences. The award recog...
Scientists have identified CD99 as a crucial marker in Ewing sarcoma development and suggest targeting it to develop new therapies. The protein's role is tied to preventing neural differentiation, a process that contributes to oncogenesis.
A new study by Georgetown University Medical Center researchers suggests that zolpidem, a powerful sedative, activates brain circuits when neural activity is silenced. This 'activation' occurs due to changes in inhibitory neurons responsible for stopping neural activity, allowing excitatory neurons to re-awaken.
Researchers discovered that mother mice exhibit increased call-evoked inhibition in response to pup isolation calls, allowing for more effective detection in noisy environments. This neural plasticity improves the contrast between high-ultrasonic and lower-frequency neural populations.
Researchers found that Viagra's inhibition of PDE6 enzyme causes transient losses in sensitivity to flicker, with severe cases showing almost doubled integration times. This unique effect enables scientists to study the role of PDE6 in vision and light adaptation.
Scientists have discovered Wnt as an inhibitory factor in vertebrate heart development, with low activity leading to cardiogenesis. The research reveals a crucial mechanism in determining heart position.
Researchers at Yale University have identified a gene and protein responsible for stopping axon regrowth in the brain and spinal cord after nervous system injury. This discovery offers hope for reversing the failure of functional recovery in many brain and spinal injuries, including human spinal cord injury.
Researchers at McGill University have developed a new vaccine approach to block molecules that prevent nerve regeneration in spinal cord injuries. The technique showed significant regrowth of nerve fibers, outperforming previous methods.
Research found that pollutants in house dust, such as PAHs, can enhance the inhibitory effect of chlorpyrifos on cholinesterase, a critical enzyme for nerve cell function. The study suggests that exposure to these pollutants may increase pesticide toxicity, posing health risks to humans.
Marie Filbin's research discovery reveals a way to overcome the inhibiting function of MAG and other molecules that prevent axon regrowth after injury. By priming neurons with neurotrophins, she reverses inhibition and enables regeneration.
Researchers at Washington University School of Medicine have shown that a compound called BAF protects newborn rats from brain damage. The findings suggest that administering BAF after the damaging procedure is just as effective as giving it ahead of time, and that it also protects when injected systemically.