Articles tagged with Bone Marrow
Researchers at Stanford University School of Medicine have discovered a protein called p53 that responds to disruptions in the cell's protein factories, leading to changes in skin color and causing anemia in mice. The findings may lead to new treatments for bone marrow failure in humans by modulating the levels of p53.
Researchers at St. Jude Children's Research Hospital found that the loss of NEU1 triggers a catastrophic fall in biochemical dominos leading to disrupted hematopoietic stem cell formation and enlarged spleens. The study sheds new light on the cause of sialidosis and its link to bone marrow transplantation failure.
Researchers found adult stem cells can improve fracture healing by increasing bone and cartilage formation at the fracture site. This approach may lead to a new treatment for people suffering from non-healing fractures, which can cause pain, deformities, and even death.
Researchers found that transplanted bone marrow stromal cells can differentiate into liver cells and may be used for cell replacement therapy. The study also suggests that these cells are not the origin of liver cancer in mice.
Researchers discovered that watery pools of osteoclast precursors in the bone marrow near affected joints may be responsible for the erosion of bones in psoriatic arthritis. This finding provides clues on how to prevent this process and offers a promising direction for developing new treatments with fewer side effects.
A new technique developed at Yale School of Medicine promotes rapid bone formation by removing bone marrow and injecting a hormone, offering a promising alternative to current treatments for weakened or fractured bones. The study, conducted in mice, shows that this procedure creates new bone tissue with improved biomechanical properties.
A new experimental protocol successfully induced immune tolerance to HLA-mismatched kidney transplants in four out of five patients. The treatment involved a combined organ and bone marrow transplant, followed by immunosuppressive drug withdrawal, resulting in normal kidney function for all patients.
Researchers will inject selected stem cells from patients' own bone marrow into their hearts during coronary bypass surgery. The goal is to prevent late scar formation and improve heart contraction, reducing the risk of congestive heart failure.
Researchers at the University of Pittsburgh successfully isolated and cultured human hematopoietic stem cells from fat tissue, suggesting an alternate source for life-saving bone marrow transplants. The study's findings indicate that these stem cells are integral to normal adipose tissue and may provide a safer alternative for patients...
Two studies show that defects in the bone marrow microenvironment can lead to pre-cancerous conditions in mice, contradicting previous assumptions about the root cause of myeloproliferative syndromes. The findings highlight the importance of environmental considerations for stem cell therapies.
A recent study published in The Lancet found that mismatched cord blood transplants performed as well as matched bone marrow transplants in terms of leukemia-free survival rates. Additionally, patients receiving matched cord blood had a 20% higher survival rate than those with matched bone marrow.
Researchers at University of Cincinnati have found that bone marrow stem cells can differentiate into keratocan-producing cells, potentially treating abnormal corneal cell growth. The study showed that injected stem cells altered the shape and healed abnormal corneas in animal models within a week
A new study finds that exposure to phenanthraquinone, a chemical component of diesel exhaust particles, can impair the ability of resistance arteries to regulate blood flow to bone marrow. The study, conducted on animal models, reveals that post-menopausal females and elderly males are most likely to be impacted.
A new study found that lung-derived mesenchymal stem cells reside in transplanted lungs, challenging the assumption that they originate from bone marrow. These cells have been shown to differentiate into multiple connective tissue cell types and may hold the key to understanding therapeutic options using MSCs that reside in adult organs.
A new study reveals a molecular mechanism underlying bone marrow failure in X-linked human disease, dyskeratosis congenita. Telomere maintenance defects are caused by reduced telomerase RNA, contradicting previous hypotheses about ribosome biogenesis.
A study found that higher levels of specialized blood cells from bone marrow are associated with liver cancer prognosis. Elevated endothelial progenitor cells were linked to poorer outcomes in patients with inoperable hepatocellular carcinoma.
A recent study published in Arthritis Research & Therapy reveals a strong genetic link between hereditary knee bone marrow lesions and osteoarthritis. The research, conducted on 115 siblings from 48 families, found that the prevalence of these lesions was significantly influenced by genetics.
Researchers developed gene therapy using manganese superoxide dismutase to protect mice from radiation damage. The treatment showed no changes in body weight, little bone-marrow damage, and longer lifespan in mice exposed to varying doses of whole-body radiation.
Researchers discovered that bone marrow stromal cells can improve brain receptor function in patients with cerebral stroke, showing potential for neural tissue regeneration. The study may provide a 'missing link' needed in understanding receptor function, possibly leading to safe and ethical cell transplantation therapy.
Researchers have identified individual, isolated hematopoietic stem cells at the edge of bone marrow using a novel gene expression technique. This breakthrough allows for the study of these rare cells in their natural environment, shedding light on how they maintain their pluripotency and function.
Researchers discovered that PrP protein plays a crucial role in maintaining healthy human stem cells, particularly in the brain. The findings suggest that PrP's positive function is essential for preventing prion-related neurodegenerative diseases.
The study reveals that the calcium-sensing receptor is crucial for the proper localization of blood stem cells in the bone marrow. Without this receptor, stem cells are unable to adhere to essential bone proteins and have limited regenerative capabilities.
A Phase I study will test the safety of injecting bone marrow stem cells into coronary arteries of patients with chronic ischemic coronary artery disease. The trial aims to determine if this method can help patients with this heart condition in the future.
A new stem cell technology allows HLA-mismatched and haploidentical donors into the donor pool, improving stem cell transplantation outcomes. Researchers identified genetic risk factors for acquired aplastic anemia affecting immune response and hematopoietic cell number and function.
A recent study at the University of Bonn found that bone marrow-derived adult stem cells do not take on tissue-specific functions, meaning they cannot replace defective muscle cells. The researchers discovered that the cells migrate into muscle fibers but are unable to produce functioning dystrophin, a key muscle protein.
Researchers found that stem cells in the bone marrow of female mice can produce new egg cells, contradicting long-standing theories on mammalian reproductive physiology. This discovery could lead to new treatments based on regenerative medicine.
A new study suggests that stem cells in bone marrow and blood can regenerate egg cells in adult mice, potentially leading to new fertility treatments and alternatives to hormone replacement therapy. The findings also provide evidence for the existence of germ cell progenitors outside of the ovary.
Researchers at University of Cincinnati have developed a new chemical compound that can accelerate adult stem cell mobilization, enabling easier harvesting. The findings reveal the RAC GTPase family plays a crucial role in regulating stem cells' movement into bone marrow and blood stream.
Researchers at Duke University Medical Center have developed a life-saving treatment for newborns with Krabbe Disease using umbilical cord blood stem cells. The study shows that 11 asymptomatic newborns and 14 symptomatic infants were successfully treated, with all asymptomatic babies surviving and 43% of symptomatic babies surviving.
Researchers found that high-dose gamma radiation and bone marrow transfer prevented glaucoma in mice by blocking neurodegeneration. The treatment, which is already used for human cancers, may also offer protection against other neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers at Johns Hopkins Medicine have developed a new method to educate T-cells in the bone marrow, increasing their ability to recognize and kill cancer cells. The approach shows promise for treating myeloma and potentially other blood and solid tumors.
A new reduced-intensity stem cell transplant regimen has shown superior results in pediatric patients, allowing early recovery of immune function and nearly eliminating transplant rejection. The procedure, which uses a shorter and lower-dose treatment of Campath-1H, also reduces the incidence and severity of graft vs. host disease.
A study published in the American Journal of Roentgenology found that increased bone marrow fat is an independent marker of bone weakening. The ratio of bone marrow fat to bone mineral density was higher in healthy individuals and lower in those with signs of bone weakening.
Researchers found that PBSC transplants were associated with higher rates of mortality and chronic graft-versus-host disease compared to bone marrow transplants. This suggests a potential need for re-evaluation of transplant approaches in pediatric patients.
A new study published in Science suggests that enhancing the homing of hematopoietic stem cells to bone marrow could increase transplant success rates. By inhibiting or deleting CD26, researchers were able to boost short-term homing and long-term engraftment of these precursor blood cells.
A study found that patients who received bone marrow stem-cell transfer showed a 7% improvement in left-ventricular function, compared to a 0.7% increase for those given medical therapy. Larger trials are needed to confirm the effectiveness of this approach in treating cardiovascular disease.
Researchers at Duke University Medical Center found that cord blood stem cells can halt disease progression and aid repair in organs and tissues, improving survival rates and reducing complications. Children treated with cord blood transplants showed significant cognitive gains and improvements in organ function.
Researchers at the University of Pittsburgh Medical Center have discovered a molecular mechanism that enhances the ability of stem cells to fight disease. By blocking the function of p18, a molecule critical for cell cycle control, scientists found improved long-term engraftment of stem cells in bone marrow tissue.
Researchers at Northwestern University successfully induced embryonic stem cells to develop into precursor bone marrow and blood cells in genetically mismatched mice. The technique could lead to a renewable alternative to donor bone marrow transplantation, reducing the risk of graft-versus-host disease.
USF researchers identify bone marrow-derived BNP as a potential candidate for treating stroke, spinal cord injury and neurological damage. Bone marrow stromal cells release levels of BNP far exceeding the amounts normally found in circulating blood and spinal fluid.
Rockefeller University scientists have discovered that natural killer cells, a crucial part of the immune system, need to be 'nurtured' before they can effectively destroy tumor and infected cells. This new understanding paves the way for potential changes in bone marrow and stem cell transplant procedures.
Researchers have discovered that bone marrow-derived stem cells are present in the lungs of mice with pulmonary fibrosis. This finding suggests a new approach to treating the disease using stem cell therapy. Understanding how these stem cells engraft and interact with the lung tissue could lead to improved treatment outcomes.
Researchers have identified late-life anemia as a risk factor for mortality and hospitalization in elderly adults. A new drug, CC5013, shows unprecedented activity in treating myelodysplastic syndrome, offering hope to patients.
The Tulane center will prepare and distribute a continuous supply of marrow stromal cells (MSCs) using standardized protocols, addressing the need for standard MSC preparations. The center's availability will allow scientists to better understand the capabilities of these cells for potential therapeutic uses.
The study found that intracoronary infusion of progenitor cells after acute myocardial infarction (AMI) significantly increased mean signal intensity (MSI) in areas with AMI damage, regardless of the type of progenitor cells used. The treatment showed a positive effect on myocardial viability.
A pilot study found that intrathymic bone marrow injections during heart transplantation reduce acute cellular rejection rates and require fewer anti-rejection drugs, improving patient outcomes. The approach may also lower the risk of chronic rejection.
Researchers found that progenitor cells from the bone marrow contribute to atherosclerosis by seeding into plaque formations, and that these cells can also help stabilize vulnerable plaques. The study opens up new possibilities for preventing heart attacks.
Researchers have identified bone marrow stem cells with the ability to produce functional insulin-producing cells, offering a new potential avenue for treating diabetes. The study used a molecular biology technique called CRE-loxP to isolate and study these cells, which were found to exhibit characteristics of pancreatic beta cells.
Researchers successfully treated patients with scar tissue and impaired heart function after heart attacks by injecting their own bone marrow into the affected area. The treatment showed significant improvement in heart wall motion, persisting for at least 10 months in some patients.
Researchers found that ATG significantly improved the ability of patients to produce healthy blood cells, allowing them to stop blood transfusions. The treatment has also shown potential in preventing progression to leukemia and improving quality of life for patients with myelodysplastic syndromes.
Researchers discovered that degradation of SDF-1 protein is crucial for stem cell mobilization in bone marrow transplants. G-CSF growth factor triggers this process by reducing SDF-1 levels, allowing stem cells to flow into the bloodstream. The findings may lead to improved collection of stem cells for clinical transplantations.
Researchers found that bone marrow stem cells naturally migrate to injured brain regions after a stroke to aid in tissue repair. These cells can form new neurons and blood vessels, potentially enhancing recovery from stroke-related damage.
The Office of Naval Research developed an inexpensive and effective HLA test to screen potential bone marrow donors, increasing compatibility by 30%. New research aims to slow down tissue rejection response, allowing near matches.
Researchers at the University of Pittsburgh found that infusing donor bone marrow into the thymus significantly reduces rejection rates, especially with multiple doses. The study also showed promise in pediatric heart transplantation, where the procedure is both safe and feasible.
Bone marrow stem cells have been shown to form liver cells, suggesting a potential new approach for treating cirrhosis. Researchers at McGill University in Quebec discovered that cells from bone marrow can differentiate into hepatocytes, oval cells and bile duct cells.
Researchers at the University of Pittsburgh Medical Center found that simultaneous bone marrow infusions at lung transplantation significantly reduced obliterative bronchiolitis, a marker for chronic rejection. The study showed a 25% reduction in chronic rejection incidence among recipients who received bone marrow infusions.