Articles tagged with Bone Marrow
Researchers develop bone marrow models to study hematological and musculoskeletal disorders, focusing on regeneration and disease disturbance. The project aims to understand the relationship between blood and bone, leading to new regenerative therapies.
Researchers at the Francis Crick Institute found that acute myeloid leukemia causes bone marrow to 'leak' blood, preventing chemotherapy from working. Drugs that reversed this leakiness boosted chemotherapy's effect in mice and human tissue.
A new study has identified Del-1, a bone marrow protein, as a potential regulator of hematopoiesis, the process by which blood cells are created. Targeting Del-1 may enhance immune cell production and improve stem cell transplants for both donors and recipients.
Increases in bone marrow fat are associated with a decline in bone density after gastric bypass surgery, while improvements in blood sugar control are linked to reduced marrow fat levels. The study suggests that weight loss and blood sugar metabolism may influence bone health through changes in bone marrow fat.
Researchers used CRISPR to study dyskeratosis congenita, a rare condition that causes progressive DNA damage leading to blood cell failure. The study reveals new ways to potentially treat the disease by blocking signaling pathways involved in blood cell formation.
Researchers developed a two-pronged approach to treat multiple blood cancers by targeting cancer cells directly and driving them out of the bone marrow environment. The new antibody PF-06747143 has been shown to eradicate more cancer cells compared to standard care in preclinical studies.
Researchers at the University of California San Diego have developed biomimetic bone tissues that provide a safe space for donor cells to grow without competition from host cells. This breakthrough technology has shown promising results in mice, with donor cells surviving for up to six months and supplying new blood cells.
Researchers identified a key mutation in a tumor suppressor gene as the cause of a rare genetic disorder that leads to myelodysplastic syndrome. Children with this condition develop a shortage of normal blood cells due to disrupted bone marrow function.
Scientists have developed biomaterials that can mimic the characteristics of bone marrow, allowing them to alter blood cell development. The study's findings hold promise for treating hematopoietic cancers such as leukemia and improving our understanding of bone marrow failure.
Research reveals that regulatory T cells interact with and support the survival of plasma cells, a crucial component of the immune system. The interaction is essential for maintaining plasma cells, which produce antibodies against previously encountered pathogens or vaccines.
Researchers discovered lipocalin-2 and prolactin proteins regulate mesenchymal stem cell activity in the lab and in mice with calvarial defects. This discovery aims to improve culture conditions for growing bone cells and develop therapies for bone repair.
Research highlights the role of myeloid-derived suppressor cells in regulating immune responses to viral infections. These cells have been shown to directly alter the viral infectious process, posing challenges for developing antiviral therapies.
A study published in Nature Medicine identifies bone marrow-derived immature myeloid cells as the source of suPAR, a reliable marker for chronic kidney disease. Elevated suPAR levels have been linked to future chronic kidney disease, potentially enabling early intervention and prevention of recurrence after transplant.
A noninvasive Magnetic Resonance Imaging (MRI) method has been proposed to detect bone marrow cancer, potentially changing the way this disease is diagnosed. The researchers used T2-weighted MRI to identify a pre-fibrotic state of the disease with a clear bright signal.
Researchers have identified a molecular key that allows breast cancer cells to invade bone marrow in mice, where they may be protected from chemotherapy or hormonal therapies. The study found ways to outmaneuver this tactic by preventing cancer cells from entering the bone marrow and flushing them into the bloodstream for destruction.
A new study found that the dose of transplanted bone marrow affects hematopoietic stem cell behavior, impacting their ability to produce specialized blood cells. Only 20-30% of these cells took on a generalist role, producing most abundant types of white blood cells.
A new bone marrow-on-a-chip device mimics living bone marrow's response to radiation exposure and treatment, enabling the testing of experimental drugs. This innovation holds promise for improving radiation countermeasures.
The study reveals that the source of stem cells used for hematopoietic stem cell transplantation in patients with bone marrow failure varies worldwide. Bone marrow is predominantly used in the Americas and Europe, while cord blood and peripheral blood stem cells are more commonly used in other regions.
Researchers from University Health Network have found a specific cell type plays a key role in maintaining healthy arteries after inflammation. A group of tissue macrophages can self-replicate and help to heal the vessel after inflammation. This discovery could provide new treatment options for cardiovascular disease.
Researchers have found that bone marrow stem cells can produce fat cells that contribute to chronic illnesses like diabetes and cardiovascular disease. The discovery highlights the possibility of genetically modifying fat-storing cells to prevent or reverse fat-related diseases.
Researchers identified abnormal miRNA levels in patients with myeloma, detectable in peripheral blood, suggesting a potential biomarker for disease progression. Analysis revealed unique miRNA signatures indicative of myeloma, including the let-7 family members.
Imetelstat, a novel telomerase targeting drug, demonstrates potential value in treating patients with myelofibrosis by inducing morphologic and molecular remissions in some patients. The study shows selective anti-clonal activity, inhibiting the growth of cancer cells.
Researchers tested the novel next-generation small molecule drug SGI-110 in MDS and AML patients, revealing it is well-tolerated and biologically active. The study found potent dose-related DNA demethylation associated with clinical response, showing promise for treating leukemia patients.
Researchers at Duke University have discovered that stem cells from bone marrow can alleviate neuropathic pain in mice by increasing levels of the anti-inflammatory protein TGF-β1. The treatment remained effective for several weeks, outlasting traditional painkillers and offering new hope for chronic pain conditions.
Researchers identified a protein called Myb that creates long-term immunity by preserving antibody-producing plasma cells in the bone marrow. The discovery could lead to developing lasting immunity against diseases like malaria.
Researchers have identified specific genetic mutations in patients with aplastic anemia that can help doctors optimize treatment. The study, which analyzed over 400 patient genomes, found that certain mutations are associated with poorer long-term outcomes and increased risk of blood cancers.
A new study reveals that Mycobacterium tuberculosis hijack protective hypoxic zones in bone marrow stem cells to hide and survive. The research found that these stem cells exhibit strong binding to pimonidazole, indicating hypoxia localization, and express a key gene involved in regulating oxygen levels.
Scientists have identified a key role for gut tissue in programming immune cells, known as monocytes, to either repair or protect the body. The discovery has implications for treating conditions such as inflammatory bowel diseases and certain cancers.
A study found that injecting stem cells during rotator cuff surgery improved healing and durability of tendons. After 10 years, 87% of patients who received stem cell injections had intact rotator cuffs, compared to 44% without treatment.
The TSRI team found that a specific enzyme called ItpkB is crucial in maintaining healthy periods of inactivity in blood stem cells. Without this enzyme, HSCs become hyperactive, leading to anemia and other diseases. Researchers are now exploring the potential of targeting ItpkB to develop new therapies for these conditions.
A study at MD Anderson Cancer Center found PRM-151 to be well-tolerated in patients with advanced myelofibrosis, showing encouraging trends in clinical and histologic aspects of the disease. The therapy demonstrated reduced bone marrow fibrosis and improved hematologic parameters, suggesting potential for further development.
Researchers report successful stem cell transplants in patients with dyskeratosis congenita using immunosuppressive drugs only, avoiding radiation and conventional chemotherapy. All four participants are alive and well after transplant, with no significant toxicities or infections.
B cells use a unique migration strategy in the bone marrow that allows them to exit slowly and be passively swept out by blood flow. The researchers found that the absence of CXCR4 significantly slows down B cell movement, highlighting the importance of this protein in regulating immune cell egress.
Research published in the Journal of Leukocyte Biology suggests that poor eating habits alter gene expression, leading to persistent effects on the immune system and increased risk of cardiovascular disorders. Even after successful treatment of atherosclerosis, the immune system's function remains altered.
Researchers found that beneficial immune cells originate in the embryonic heart and can promote regeneration, while harmful macrophages come from the bone marrow. Blocking the influx of bone marrow-derived macrophages protects the resident macrophages, allowing them to promote repair and reduce inflammation.
Researchers established a standardized model of radial nerve injury in rhesus monkeys to evaluate peripheral nerve repair. The study found that bone marrow stem cell-laden allografts achieved comparable nerve regeneration to autografts, suggesting potential for improved treatments.
Researchers discovered that a biochemical cascade in the bone marrow microenvironment leads to inflammation and disruption of normal blood formation, resulting in potentially deadly disorders. By targeting this inflammatory reaction, potential new strategies for treating these diseases may be developed.
Researchers found that bone marrow fat tissue is a significant source of the hormone adiponectin, which maintains insulin sensitivity and reduces risk of diseases like diabetes and cardiovascular disease. With calorie restriction, bone marrow fat tissue releases adiponectin, indicating potential benefits for overall health.
A UCLA research team has discovered a new hormone called erythroferrone, which regulates the iron supply needed for red blood-cell production. Erythroferrone suppresses hepcidin, allowing more iron to be made available for red blood-cell production and potentially treating iron disorders.
Researchers found that patients with tumor cells in their blood after surgery had a higher risk of relapse and poorer survival rates. The presence and count of tumor cells also predicted disease-free survival, with those having 5 or more CTCs at higher risk of recurrent disease.
Scientists at Harvard's Wyss Institute have created a bone marrow-on-a-chip device that replicates the complex structure and function of living bone marrow. The device has passed initial tests, including a drug-testing capability that protected the engineered marrow from radiation.
The study found that 660 nm red light promotes the migration of bone marrow mesenchymal stem cells, enhancing their contribution to treating hypoxic-ischemic brain damage. After phototherapy and cell transplantation, rats showed a significantly increased active avoidance response rate.
Scientists have identified perivascular stem cells as a reservoir of HCMV, suggesting a potential treatment target. The discovery could lead to the development of novel targeted therapies to prevent HCMV re-activation and its associated complications.
A new disease gene ERCC6L2 has been identified as the underlying cause of bone marrow failure, allowing for reliable genetic testing. The discovery could lead to the development of new treatments for this specific gene defect.
Researchers have created an artificial bone marrow that can reproduce hematopoietic stem cells, which could facilitate the treatment of leukemia. The new technology uses synthetic polymers and protein building blocks to mimic the natural environment of bone marrow, allowing for more efficient stem cell reproduction.
Researchers discovered imetelstat, a telomerase inhibitor, induces morphologic, molecular and clinical remissions in some patients with myelofibrosis. The study showed five patients achieved complete or partial remissions, including reversal of bone marrow fibrosis.
A study found that transendocardial stem cell injection with autologous mesenchymal stem cells and bone marrow mononuclear cells is safe for patients with ischemic cardiomyopathy. The treatment also showed promise in improving quality of life and walking distance.
A study found that PET/CT is more sensitive and accurate than bone marrow biopsy in detecting bone marrow involvement in DLBCL patients. The imaging modality also predicted progression-free survival and changed treatment plans for 42% of patients with bone marrow involvement.
Researchers have discovered a new leukemia model, showing that cancer stem cells actively remodel the bone marrow environment to favor diseased cells. This finding could influence the effectiveness of bone marrow transplants and lead to the development of new therapies.
Researchers found that cancer cells are putting healthy stem cells to sleep, preventing them from forming new blood cells. This discovery offers a potential new approach to treating Acute Myeloid Leukaemia (AML), which affects around 2,500 people in the UK each year.
A new study published in the journal Radiology found that excess liver and muscle fat can increase the risk of osteoporosis by affecting bone marrow quality. Higher levels of bone marrow fat were linked to increased fracture risk, suggesting that obesity can weaken bones.
A new technique developed by Stanford researchers allows for the tracking of mesenchymal stem cells after transplantation, giving surgeons a better sense of whether the procedure was successful. The approach uses an FDA-approved iron supplement to label the cells, alleviating risks associated with standard labeling methods.
Researchers have discovered four biomarkers that characterize the non-genetic form of amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease. These biomarkers could lead to earlier and more accurate diagnostics, as well as new directions for therapeutic research.
Researchers have found a way to eliminate a gene that causes cells in the bone marrow microenvironment to die, allowing donor cells to replace them. This breakthrough could lead to improved bone marrow transplant therapy for patients with blood diseases such as leukemia and multiple myeloma.
Researchers discovered that discarded immune cells stimulate the release of hematopoietic stem cells from the bone marrow into the bloodstream. This process is regulated by the daily elimination of neutrophils and follows a circadian cycle, which could have implications for cardiovascular health.
Cancer chemotherapy can cause peripheral neuropathy and delay recovery after bone marrow transplantation. Researchers at Albert Einstein College of Medicine discovered that nerve damage in the bone marrow also causes anemia by impairing hematopoietic stem cell regeneration.
A new study identifies osteopontin as a potential new leukemia treatment target. The protein helps leukemia cells avoid the effects of chemotherapy by appearing dormant in the bone marrow environment.
A new study suggests that bone-marrow grafts may be effective in treating low-back pain, with patients experiencing significant improvements in pain relief and activity tolerance. The procedure involves injecting a concentrated form of bone-marrow cellular aspirate into affected discs.
Researchers at Weill Cornell Medicine developed a new method to expand adult hematopoietic stem cells outside the human body, overcoming a major technical hurdle. This breakthrough could lead to fewer donor cells being needed for transplantation and make bone marrow banking possible.
Researchers have found that macrophages help produce and eliminate red blood cells, which could lead to novel therapies for diseases affecting red blood cell balance. The study also showed that eliminating certain macrophages can normalize abnormal red blood cell counts in conditions like polycythemia vera.