Articles tagged with Bone Marrow
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Researchers have identified two related oncogenes, FAM83A and B, which enable breast cancer cells to survive treatment with EGFR TKIs. Expression of these genes in human tumors is correlated with decreased overall survival.
A new clinical study by the National Heart, Lung, and Blood Institute found that eltrombopag improved blood cell production in 11 out of 25 participants with severe aplastic anemia. The drug was well-tolerated, with few side effects, and six patients showed significant improvements in all three types of blood cells.
Researchers at Albert Einstein College of Medicine found that abnormal bone marrow stem cells drive the development of myelodysplastic syndromes (MDS), serious blood diseases. The study reveals genetic and epigenetic alterations in stem and progenitor cells, offering new hope for targeted therapies and improved cure rates.
The University of Kentucky Markey Cancer Center will conduct research on myelodysplastic syndrome, a deadly blood disorder often caused by chemotherapy or radiation treatments. The goal is to determine biomarkers for the disease and tailor cancer treatments to reduce the risk of developing MDS.
Researchers have discovered evidence of humans consuming elephant meat and bone marrow in the Middle Palaeolithic site of Preresa, Madrid. The findings, published in the Journal of Archaeological Science, suggest that the practice was not as common as previously thought due to the difficulty of extracting marrow from bones.
A study led by Mayo Clinic researchers found that bone marrow-derived stem cells improved ejection fraction, a measure of the left ventricle's pumping ability, by 2.7% in patients with chronic heart failure. The most significant improvements were seen in younger patients and those with enriched CD34+ and CD133+ type of stem cells.
Researchers at Cardiff University discovered a new group of cells with strong immunosuppressive properties derived from cheek tissue. These cells can completely inhibit lymphocyte action with small doses, offering promise for combating diseases like diabetes and organ rejection.
Researchers have found that a new drug called plerixafor can help drive leukemia cells out of the bone marrow and into the bloodstream, making them more vulnerable to chemotherapy. In a clinical trial, 46% of patients with acute myeloid leukemia achieved complete remission after treatment.
Researchers identify CCL5/CCR5 interaction as key to recruiting endothelial progenitor cells for wound healing. Mice with faulty CCR5 show delayed healing, suggesting similar issues in humans with CCR5 mutations.
A new study found no survival advantage with filgrastim-mobilized peripheral blood stem cells compared to bone marrow transplants from unrelated donors. PBSC transplants are associated with higher rates of chronic graft-versus-host disease (GVHD), particularly in patients receiving unrelated donor transplants.
Researchers found adult stem cells from bone marrow have potential to improve heart function after a heart attack. However, the original two-week timeframe was not favorable, but the concept still shows promise for recovering lost or damaged heart tissue.
Researchers created a novel 3D long-term bone marrow culture system to investigate stromal cell biological function. This system successfully maintained hematopoietic stem cells (HSCs) for extended periods, enabling the analysis of stromal-cell interactions and regulatory factors.
A new treatment developed at Tel Aviv University uses laser-treated bone marrow stem cells to help restore heart function and health. The procedure significantly reduces heart scarring after an ischemic event by up to 80 percent, offering a safer and quicker alternative to existing options.
A study found no association between occult metastases in lymph nodes and overall survival among women with early-stage breast cancer. Researchers detected micro-metastases using immunohistochemical staining but did not find significant impact on death or recurrence rates.
Researchers at Brigham and Women's Hospital developed a method to predict MDS patient survival by identifying specific gene mutations in their abnormal bone marrow. Nearly a third of patients had mutations in one or more prognostic genes, which could guide treatment decisions.
Researchers at Boston University School of Medicine have identified a possible new approach to treating myelofibrosis by inhibiting an enzyme that forms scar tissue in the bone marrow. The study found that inhibiting this enzyme resulted in a significant decrease in the burden of myelofibrosis, offering a potential new avenue for treat...
A study found that most patients experience a return to normal motor and memory function within five years after stem cell transplant. However, some patients continue to have measurable deficits in fine motor skills and verbal memory, highlighting the need for cognitive rehabilitation strategies.
A Phase I clinical trial at UTHealth demonstrates that bone marrow stem cells are safely used in treating severe traumatic brain injury in children. After six months of follow-up, all children showed significant improvement, with seven out of ten experiencing a good outcome.
A study published in Blood reveals a close relationship between pulmonary arterial hypertension and myeloid abnormalities in the bone marrow. The researchers found that blood progenitor cells are increased in patients with PAH, suggesting an abnormal feedback loop connecting blood and lung cell behavior.
Researchers at UC Santa Cruz identified a crucial molecule for blood stem cells' niche in the bone marrow, potentially improving transplant safety and efficiency. The study's findings may lead to safer and more effective treatment options for cancers like lymphoma and leukemia.
Studies reveal that stem cell transplantation is safe and effective in treating various hematologic malignancies, with no significant increase in overall cancer risk. Researchers found a promising new treatment to prevent chronic graft-versus-host disease, a serious complication of stem cell transplantation.
A study by Thomas Jefferson University found that bone marrow stromal stem cells can significantly recover motor behavior in laboratory rats after a simulated stroke. Early administration of the stem cells was more effective than late administration, with profound changes in brain structure and long-lasting motor function improvement.
A study presented at the Radiological Society of North America found that excessive internal abdominal fat may harm bone health in women. Research revealed that women with more visceral fat had increased bone marrow fat and decreased bone mineral density.
Researchers have developed a medical model for regenerating bladders using stem cells harvested from a patient's own bone marrow. The study demonstrates the feasibility of MSCs in partial bladder regeneration and provides valuable insight into the processes governing bladder regeneration.
Researchers have developed a medical model for regenerating bladders using stem cells, which could lead to new organ replacement therapies. The study used bone marrow mesenchymal stem cells, which have been shown to retain their ability to populate and function in a grafted area.
A study found that shorter biological marker length, specifically telomere length, was associated with a higher rate of relapse and lower overall survival in patients with severe aplastic anemia receiving immunosuppressive therapy. The results suggest that telomere length may be a risk factor for disease progression.
Researchers found that MSCs create a supportive niche for HSCs, allowing them to self-renew and develop into blood cells. Altering MSC numbers affects HSC population, suggesting a regulatory interaction between the two cell types.
A team led by Drs. Michael A. Matthay and Jae W. Lee found that bone marrow stem cells secreted a protein that restored the lung barrier, preventing fluid and other elements from entering the lungs. The study suggests that this therapy may be a viable option for preventing respiratory failure in critically ill patients.
Researchers at University of Colorado Anschutz Medical Campus discover bone marrow progenitor-derived adipocytes, a new type of fat cell that poses health threats. The discovery may help explain the link between obesity and heart disease.
Researchers have discovered a direct relationship between a psychiatric disorder and the immune system, specifically microglia cells derived from bone marrow. Bone marrow transplants cured mutant mice with compulsive hair-pulling behavior, suggesting potential new treatments for obsessive-compulsive disorder.
Researchers at Mount Sinai School of Medicine have discovered that bone marrow cells play a crucial role in fighting respiratory viruses. The study found that cells produced by the bone marrow migrate to the lungs to help fight infection and produce infection-fighting proteins.
Researchers found that high cholesterol levels affect bone marrow microenvironment, leading to increased exit of cells into peripheral blood. This study has implications for transplantation and understanding bone marrow malignancies.
A small trial of bone marrow stem cell therapy in patients with MS found the procedure to be well-tolerated and suggested potential benefits. The study's results, published in Clinical Pharmacology and Therapeutics, provide a promising lead for further research into this emerging treatment option.
Two scientific teams at Cincinnati Children's Hospital Medical Center are receiving a total of $2.3 million in research funding to continue studies on novel treatments for leukemia and bone marrow failure. The researchers aim to develop new therapeutic strategies targeting CDC42 and FA protein complexes to eliminate leukemia stem cells.
Immunologist Roberta Pelanda and her team found that immature B cells require a positive signal from the B-cell receptor to mature and enter the spleen. Protein Erk helps deliver this signal, enabling B cells to escape the bone marrow and contribute to immune defense.
A new model of the human body is being developed to improve radiation treatment accuracy for cancer patients, especially children. The research found that children have a greater percentage of total mineral bone in direct contact with sensitive bone marrow than do adults, leading to higher radiation doses and increased cancer risk.
Researchers at Baylor College of Medicine report that hematopoietic stem cell subtypes exist and act as previously thought, contradicting the idea of a single stem cell giving rise to all types of blood cells. The study reveals distinct populations of stem cells over time, with implications for treatment.
Researchers have found that bone marrow cell transplants can improve heart function and relieve symptoms of refractory angina. Apelin, a newly described peptide, was also shown to increase significantly in patients who received the transplants, leading to improved cardiac function.
Researchers at Boston Children's Hospital discovered that people with anorexia nervosa have high levels of fat within their bone marrow. This unexpected finding may help track the effectiveness of hormonal therapies aimed at improving bone mass in individuals with this condition, who often experience bone loss and osteoporosis.
Patients who underwent peripheral blood stem cell transplantation (PBSC) had similar overall survival rates as those given bone marrow transplants, with no significant differences in mortality or late effects. However, subgroup analyses revealed improved leukaemia-free survival and overall survival for patients with acute leukaemias
Researchers found evidence that fat tissue contains functional hematopoietic stem and progenitor cells, which can regenerate and develop into various cell types. The study suggests that adipose tissue may be a valuable alternative source of these cells, potentially replacing bone marrow transplantation in the future.
Researchers at the University of Utah discovered that platelets can reproduce themselves in the circulation, increasing their numbers. This finding has significant implications for treating low platelet counts and transfusion medicine.
Researchers discovered a link between diabetes and bone marrow nerve damage that may help treat retinopathy. The abnormal release of stem cells from damaged nerves affects the body's ability to repair blood vessels, leading to blindness.
Researchers discovered a key compound, PGE2, that quickly restores blood cell production and continues to do so for six to eight weeks after bone marrow injury. This treatment could represent a precise way to accelerate recovery from life-threatening blood cell shortages.
A team from IRIC has successfully produced a large quantity of laboratory stem cells from a small number of blood stem cells. This breakthrough could lead to major implications in fields with no current treatment, such as transplantation and organ rejection prevention.
A breakthrough study has revealed that blood stem cells produce chemical signals of their own that influence their attachment to the bone marrow or migration into the circulatory system. This discovery holds implications for improving leukemia treatment and artificially culturing infection-fighting immune cells.
Research suggests mice without AT1A protein have a significantly prolonged lifespan. This is attributed to reduced cellular oxidation, contributing to aging. Additionally, studies investigate the role of MT1-MMP in regulating hematopoietic progenitor cells' release from bone marrow.
A new study suggests that adult bone marrow stem cells can be used to construct artificial skin, advancing wound healing and potentially pioneering organ reconstruction. The engineered skin containing stem cells showed better healing, less wound contraction, and improved blood vessel development.
Researchers have developed a new technique to mobilize specific types of adult stem cells into the bloodstream using new drug combinations. This method aims to accelerate tissue regeneration and repair in cases of heart disease or sports injuries, potentially treating autoimmune diseases like rheumatoid arthritis.
Artificial human bone marrow can replicate blood stem cells and produce B cells, key immune cells, in a test tube. This development could lead to simpler drug testing and a continuous supply of blood for transfusions.
Researchers have identified a group of dormant stem cells in mouse bone marrow that divide only five times throughout their lifespan, equivalent to one cell division in 18 years. These 'sleeping' stem cells can rapidly self-renew and replace damaged bone marrow in emergency situations.
Researchers at Stanford University School of Medicine have discovered a protein called p53 that responds to disruptions in the cell's protein factories, leading to changes in skin color and causing anemia in mice. The findings may lead to new treatments for bone marrow failure in humans by modulating the levels of p53.
Researchers at St. Jude Children's Research Hospital found that the loss of NEU1 triggers a catastrophic fall in biochemical dominos leading to disrupted hematopoietic stem cell formation and enlarged spleens. The study sheds new light on the cause of sialidosis and its link to bone marrow transplantation failure.
Researchers found adult stem cells can improve fracture healing by increasing bone and cartilage formation at the fracture site. This approach may lead to a new treatment for people suffering from non-healing fractures, which can cause pain, deformities, and even death.
Researchers found that transplanted bone marrow stromal cells can differentiate into liver cells and may be used for cell replacement therapy. The study also suggests that these cells are not the origin of liver cancer in mice.
Researchers discovered that watery pools of osteoclast precursors in the bone marrow near affected joints may be responsible for the erosion of bones in psoriatic arthritis. This finding provides clues on how to prevent this process and offers a promising direction for developing new treatments with fewer side effects.
A new technique developed at Yale School of Medicine promotes rapid bone formation by removing bone marrow and injecting a hormone, offering a promising alternative to current treatments for weakened or fractured bones. The study, conducted in mice, shows that this procedure creates new bone tissue with improved biomechanical properties.
A new experimental protocol successfully induced immune tolerance to HLA-mismatched kidney transplants in four out of five patients. The treatment involved a combined organ and bone marrow transplant, followed by immunosuppressive drug withdrawal, resulting in normal kidney function for all patients.
Researchers will inject selected stem cells from patients' own bone marrow into their hearts during coronary bypass surgery. The goal is to prevent late scar formation and improve heart contraction, reducing the risk of congestive heart failure.
Two studies show that defects in the bone marrow microenvironment can lead to pre-cancerous conditions in mice, contradicting previous assumptions about the root cause of myeloproliferative syndromes. The findings highlight the importance of environmental considerations for stem cell therapies.