Articles tagged with Bone Marrow
Researchers at Eindhoven University of Technology developed a 'nanobiologic' immunotherapy that trains the innate immune system to eliminate tumorous cells. The approach has shown promising results in mouse melanoma models and non-human primates, offering a new anti-cancer therapy.
An international team led by George Hajishengallis showed that training the innate immune system with β-glucan can inspire neutrophils to target tumors. The study found that trained immunity can be transferred through bone marrow transplants, leading to improved tumor-fighting ability.
Researchers at University of Helsinki identified mechanism behind bone marrow failure in Fanconi anaemia by finding MYC gene overexpression. This led to stem cell detachment from the bone marrow and development of bone marrow failure.
Researchers create nanoparticles that can target specific genes in bone marrow cells, showing promise for treating heart disease by reducing inflammation. The approach could also enhance stem cell yields for patients undergoing transplants.
MarrowQuant, a new digital pathology software, can quantify bone marrow components in histological images without bias. The tool builds maps based on values to complement images, potentially re-examining historical sample collections and old clinical trials.
Researchers found that seasonal flu vaccination boosts antibody-producing cells, but most are lost within a year. The study suggests longer-lasting 'universal' flu vaccines and improved vaccine design could address this issue.
Researchers found that flu vaccines induce short-lived bone marrow plasma cells, which decline to pre-vaccination levels within a year. The study suggests that the longevity of flu vaccines can be improved by enhancing the persistence of these cells.
A study published in Advanced Science has revealed that joint implants can release metals into the surrounding bone tissue, leading to osteolysis and premature loosening. The researchers used a unique synchrotron-based X-ray fluorescence imaging setup to determine the concentration and distribution of metallic degradation products.
Researchers found that bisphosphonates can reduce bone marrow lesions in people with knee osteoarthritis, which could lead to improved pain management and halted disease progression.
Researchers at Ohio State University found that spinal cord injuries in mice cause an acquired bone marrow failure syndrome contributing to chronic immune dysfunction. The study also discovered a potential treatment using the FDA-approved drug Plerixafor to mobilize cells from the bone marrow niche and restore immune function.
Researchers at Hackensack Meridian Health's CDI laboratory have made a breakthrough in treating blood cancers, specifically leukemia. They identified a novel protein called Stem Cell Growth Factor Alpha (SCGFa), which has shown promise in preserving vascular function and promoting hematopoietic recovery following chemotherapy.
Researchers have developed a new tool to study Shwachman-Diamond Syndrome, a disease that affects bone marrow production. The bone marrow-on-a chip mimics the behavior of diseased bone marrow and has shown impaired blood cell production in patients. This discovery provides new research directions for developing treatments for SDS.
A new organ-on-a-chip technology advance from Harvard University enables scientists to effectively replicate drug- and radiation-induced toxicity responses observed in human patients. The chip also replicated blood cell formation defects seen in patients with a rare genetic disorder, accurately predicting previously unknown abnormalities.
New study finds liver mesenchymal stromal cells have immunoregulatory qualities making them more effective than similar cells derived from bone marrow and fat tissue. The discovery could lead to better treatment options for diseases like organ rejection, inflammatory bowel disease, and autoimmune disorders.
Researchers have developed a new method to characterise the complex organ of bone marrow, revealing previously unknown cell types and their spatial organisation. The study identifies niche cells that regulate blood stem cells and provides insights into leukaemia treatments.
Researchers have developed a new approach to study the bone marrow in unprecedented resolution, revealing previously unknown cell types and their local environments. The study provides a novel basis for studying blood diseases such as leukemias and has made its dataset publicly accessible for further research.
Researchers have found that cytomegalovirus (CMV) causes reduced blood cell production in bone marrow, increasing the risk of life-threatening infections. The study identified a specific genetic material called microRNA US5-2, which leads to the suppression of TGF-? expression.
Researchers at Pohang University of Science & Technology discovered a mechanism by which microbiota signals are transmitted to the entire body, controlling hematopoiesis in the bone marrow. This process involves CX3CR1+ mononuclear cells recognizing microbiota signals and releasing cytokines that stimulate the immune system.
A transient wave of hematopoietic stem cell production occurs in the bone marrow of late fetuses and young adults, produced from resident hemogenic endothelial cells. This discovery fills a gap in our understanding of hematopoiesis and has implications for regenerative medicine and the development of innovative stem cell therapies.
A study has developed a method to determine activity in bone marrow, enabling personalized dosimetry. This approach can predict the effectiveness of treatment and prevent bone marrow toxicity.
Researchers discovered a way to stop the process that allows TB bacillus to infect and hijack blood stem cells using an anti-arthritis drug, Tocilizumab. The study found that this transformation can be halted by administering the drug.
Scientists have found evidence of prehistoric humans storing and consuming animal bone marrow at Qesem Cave, dating back to around 400,000 years ago. The discovery suggests that early Paleolithic people had a sophisticated understanding of food preservation, allowing them to store bone marrow for up to nine weeks before feasting on it.
Researchers have discovered a new drug target for Myelodysplastic Syndrome (MDS) by targeting an earlier stage of progenitor cells. Blocking the CHRM4 protein receptor significantly improves blood cell production in MDS patients. Preclinical tests in mice show sustained therapeutic efficacy.
Researchers at Yale University have discovered that a woman's bone marrow plays a crucial role in determining her ability to start and sustain a pregnancy. Bone marrow-derived stem cells travel to the uterus, where they help transform the uterine lining for implantation, essential for embryo implantation and pregnancy maintenance.
A recent study published in the Journal of Bone and Mineral Research found that calorie restriction can have negative effects on bone health, even when paired with regular exercise. Mice subjected to calorie restriction experienced an increase in bone marrow fat and a decrease in overall bone density.
Researchers discovered that megakaryocytes influence the migration of hematopoietic stem cells and neutrophils in the bone marrow. The study found that large megakaryocytes act as passive obstacles, reducing neutrophil mobility. This new understanding highlights the importance of biomechanical properties in regulating cell motility.
A novel marker for non-classical monocytes has identified their direct regulatory role in the adaptive immune response. Monocytes can infiltrate specific tissues, modulating immune cell activities.
A new nanotechnology treatment using exosomes extracted from bone marrow stem cells has reversed MS symptoms in mice by rejuvenating lost motor skills and decreasing nerve damage. The treatment will be tested on humans in early 2020, initially on people with Type 1 diabetes.
Researchers have found that modulating blood-forming stem cells' stiffness could help drive them out of the bone marrow and into the blood, but they need to be stiff to stay put. The study, published in Cell Stem Cell, suggests that altering cell biomechanics can improve mobilization regimens for stem cell-based therapy.
Researchers discovered that exosomes carry heart-specific microRNAs from the bloodstream to progenitor cells in the bone marrow, triggering a repair response. This signals can improve cell-based cardiovascular repair after heart attacks.
A study at Cedars-Sinai Medical Center found that transplanting young bone marrow into old mice preserved their memory and learning abilities. The research suggests that specific properties of youthful blood cells may be responsible for this effect.
Researchers have identified CDK6 as a significant factor in the development of JAK2V617F-initiated MPNs. The absence of CDK6 reduces proliferation of affected stem cells and increases life expectancy for patients.
Researchers have identified a previously unknown blood vessel system in bones, which supplies bones with oxygen and nutrients. The 'trans-cortical vessels' connect bone marrow to the bloodstream, allowing immune cells to quickly reach the source of inflammation.
Researchers at Duke University Medical Center have identified a key player in bone healing - young macrophage cells and their secreted proteins. Introducing these factors into old mice improves fracture repair, providing a potential new treatment for delayed healing.
Researchers at Baker Heart and Diabetes Institute found that specific brain signaling promotes heart disease by altering bone marrow stem cells, leading to atherosclerosis. The study highlights the importance of managing stress, anxiety, and pain in controlling this form of hypertension.
A new delivery system combines blood platelets with stem cells to guide drugs into the bone marrow, where leukemia begins. In mice with acute myeloid leukemia, this therapy halted disease progression and achieved a cure rate of 87.5%.
A new method developed by MIT researchers helps blood cells regenerate faster after radiation therapy, which can help leukemia and lymphoma patients recover from bone marrow irradiation. The technique involves stimulating stem cells to secrete growth factors that aid in the differentiation of precursor cells into mature blood cells.
Researchers at Cincinnati Children's Hospital Medical Center describe a new method to improve the bone marrow transplant process, utilizing CASIN to mobilize higher quality donor HSCs and condition transplant recipients. This approach has potential to reduce toxicity and increase engraftment efficiency for vulnerable patients.
Researchers from Massachusetts General Hospital found that immune cells responding to a stroke or brain injury in an animal model are more likely to come from the skull's bone marrow. Microscopic channels were discovered in the skull's inner layer, allowing inflammatory cells to migrate directly to the brain surface.
Researchers discovered tiny tunnels in the skull that connect bone marrow to the lining of the brain, enabling immune cells to quickly reach injured tissue. The study found that these channels play a crucial role in inflammation and may be important in various brain disorders.
Researchers found that brain tumors can sequester immune cells in the bone marrow, preventing them from attacking the tumor. This trapping mechanism is mediated by a protein called S1P1, and releasing it may help unlock the immune cells' potential to target cancer.
Researchers found that the PGC-1α gene controls the equilibrium of bone and fat in bone marrow and affects how stem cells differentiate into bone or fat cells. Increasing PGC-1α expression may slow down bone loss and decrease bone marrow fat, suggesting a protective role in maintaining the bone-to-fat balance.
Researchers measured manual pressures during stone tool behaviors to understand the impact on human hand anatomy. The study found that accessing bone marrow required the greatest pressure, suggesting it may have played a key role in the evolution of human dexterity.
Patients taking JAK inhibitors for myelofibrosis are at increased risk of developing aggressive B-cell lymphomas. Screening for a preexisting B-cell clone before treatment may help prevent this side effect.
Scientists from the University of Basel and ETH Zurich have developed an artificial bone marrow niche that mimics natural biological properties, allowing hematopoietic stem cells to multiply for several days. This breakthrough could lead to personalized research models for blood diseases like leukemia and drug screening.
Researchers reveal malaria parasite's hidden reservoir in bone marrow, where it can remain undetectable by blood tests. The findings may help explain why many malaria infections go undetected and inform new diagnostic tools.
Researchers have found that blood biopsies provide highly detailed genetic information that agrees well with bone marrow tests. This breakthrough could lead to more personalized treatment plans for patients with multiple myeloma, as the disease's progression can vary over time.
Japanese researchers at Osaka University have identified a key cellular protein, Ebf3, involved in maintaining the bone marrow niche. The study found that Ebf3-deficient CAR cells take on bone-synthesizing properties, which has significant clinical implications for regenerative therapies.
Young recreational and elite athletes often accumulate excess fluid in bone marrow around joint connecting spine to pelvis. Magnetic resonance imaging detects this excess fluid in healthy individuals, raising debate about diagnostic thresholds for axial spondyloarthropathy.
A new telomere length test has been shown to alter treatment decisions for patients with certain types of bone marrow failure. The test can help identify people at increased risk for developing diseases associated with short telomeres, such as lung scarring and other cancers.
The development of freezing techniques for bone marrow, pioneered by NASA engineer Tom Williams, has revolutionized transplant medicine. The technique allows donor marrow to be transported over long distances without cell death.
A recent study by KAUST researchers reveals that CD34, a protein used to identify blood-forming cells, also binds adhesion molecules in the bone marrow. This binding aids in proper engraftment of blood-forming stem and progenitor cells following transplantation.
Researchers have identified a distinct subset of hematopoietic stem cells capable of fully repopulating the bone marrow after transplantation. These cells, marked by specific surface markers, were found to be essential for successful bone marrow transplantation in nonhuman primates and show promise for human applications.
A large NIH-funded clinical trial will determine if bone marrow transplantation can be part of standard care for patients with severe sickle cell disease. The study aims to balance health risks with the promise of being cured, and participants will be followed for two years.
Researchers develop bone marrow models to study hematological and musculoskeletal disorders, focusing on regeneration and disease disturbance. The project aims to understand the relationship between blood and bone, leading to new regenerative therapies.
Researchers at the Francis Crick Institute found that acute myeloid leukemia causes bone marrow to 'leak' blood, preventing chemotherapy from working. Drugs that reversed this leakiness boosted chemotherapy's effect in mice and human tissue.
A new study has identified Del-1, a bone marrow protein, as a potential regulator of hematopoiesis, the process by which blood cells are created. Targeting Del-1 may enhance immune cell production and improve stem cell transplants for both donors and recipients.
Increases in bone marrow fat are associated with a decline in bone density after gastric bypass surgery, while improvements in blood sugar control are linked to reduced marrow fat levels. The study suggests that weight loss and blood sugar metabolism may influence bone health through changes in bone marrow fat.
Researchers used CRISPR to study dyskeratosis congenita, a rare condition that causes progressive DNA damage leading to blood cell failure. The study reveals new ways to potentially treat the disease by blocking signaling pathways involved in blood cell formation.
Researchers developed a two-pronged approach to treat multiple blood cancers by targeting cancer cells directly and driving them out of the bone marrow environment. The new antibody PF-06747143 has been shown to eradicate more cancer cells compared to standard care in preclinical studies.