A breakthrough treatment targeting bone marrow cancer cells destroyed 90% of multiple myeloma cells in laboratory tests and 60% in human tissue samples. Researchers developed lipid-based nanoparticles containing RNA molecules that silence the CKAP5 gene, inhibiting cancer cell division.
SourceTel-Aviv University·JournalAdvanced Science·TypeRandomized controlled/clinical trial·DateJul 27, 2023
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A Swiss patient has achieved 20 months of HIV remission after a bone marrow transplant performed as part of cancer treatment. The patient's cells remained HIV-permissive despite the absence of a protective mutation, yet the virus was still undetectable after antiretroviral therapy was discontinued.
Patients with GATA2 deficiency have impaired ability to produce immune cells, leading to increased risk of recurrent infections and blood cancers. The study's findings suggest that a zebrafish model may help develop new treatments to slow or reverse the disease.
SourceUniversity of Birmingham·JournalCell Reports·DateJun 22, 2023
A study published in Radiology found that weight-loss surgery, specifically sleeve gastrectomy, has negative effects on bone health in adolescents and young adults. The procedure led to an increase in bone marrow fat and a decrease in bone density, suggesting potential long-term consequences for bone health and fracture risk.
SourceRadiological Society of North America·JournalRadiology·DateJun 13, 2023
A team from the University of Tsukuba has discovered that the enzyme ELOVL6 plays a significant role in the development of acute myeloid leukemia, a type of blood cancer. The study found that high levels of ELOVL6 are linked to shorter survival rates for leukemia patients.
SourceUniversity of Tsukuba·JournalLeukemia·DateMay 24, 2023
Increased expression of Musashi 1 on breast cancer cells has significant implications for understanding dormancy and survival in bone marrow. Msi 1 knockdown led to a reduction in cancer stem cells with undetectable PD-L1, suggesting a potential therapeutic target.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateMay 16, 2023
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Researchers at ETH Zurich have developed a new method called pharmacoscopy to test treatment options for multiple myeloma patients. This high-throughput screening platform analyzes the reactions of cancer cells to various treatments, offering personalized therapeutic strategies.
SourceETH Zurich·JournalNature Cancer·TypeObservational study·DateApr 27, 2023
Acute myeloid leukemia is a cancer that affects blood cells and can lead to infection, anemia, and easy bleeding. The Georgia Cancer Center has received a $2.3 million grant to study how cancer cells resist treatment and propose new options to improve patient survival.
SourceMedical College of Georgia at Augusta University·DateApr 17, 2023
A study by Linköping University researchers found that blood stem cells from leukemia patients remain in the bone marrow, but become defective over time, leading to long-term effects on blood formation. This discovery may explain why many leukemia survivors experience blood cell function disorders later in life.
SourceLinköping University·JournalHaematologica·TypeExperimental study·DateApr 5, 2023
Researchers at Mayo Clinic have made significant progress in treating multiple myeloma using chimeric antigen receptor therapy (CAR-T cell therapy), which has shown a median progression-free survival of 13.3 months compared to 4.4 months for standard treatment regimens.
SourceMayo Clinic·JournalNew England Journal of Medicine·DateMar 20, 2023
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Children with Down syndrome are highly vulnerable to developing aggressive leukaemia due to a defect in the RUNX1 gene, which regulates blood cell formation. Researchers have identified a specific variant of the gene that promotes leukaemia development and discovered potential therapeutic approaches to correct this malfunction.
SourceGoethe University Frankfurt·JournalBlood·TypeExperimental study·DateMar 10, 2023
A new study from WashU Medicine identified a possible treatment strategy for poikiloderma with neutropenia, a rare bone marrow failure syndrome. Researchers found that inhibiting an enzyme called PAPD5 can restore normal blood cell formation by stabilizing microRNA molecules.
A recent study published in Immunity found that skipping breakfast can lead to a decline in immune cells and an increased risk of heart disease. The research showed that fasting triggers a stress response in the brain, which negatively affects immune cells.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalImmunity·TypeExperimental study·DateFeb 23, 2023
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A new study found that long-term voluntary wheel running improved skeletal muscle and bone parameters in female mice, but the effects varied depending on body weight. High body weight was more beneficial for muscle and bone health with aging, especially when combined with exercise.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateFeb 8, 2023
Leif Ludwig's analytical method allows for easier disentanglement of blood cell trajectories, enabling identification of leukemia cell development or degenerative changes. This breakthrough opens up possibility for human medicine to conduct studies in clinical practice and derive therapeutic interventions.
Researchers found that female patients with diffuse large B-cell lymphoma treated in the afternoon had reduced mortality rates and cancer recurrence compared to those treated in the morning. The study suggests that timing chemotherapy delivery according to an individual's circadian clock may improve treatment outcomes.
SourceInstitute for Basic Science·JournalJCI Insight·TypeRandomized controlled/clinical trial·DateJan 24, 2023
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Researchers at Children's Hospital of Philadelphia have developed a custom-built application to automate the determination of engraftment after hematopoietic stem cell transplant. The tool has been shown to improve accuracy of reported engraftments, reducing errors in neutrophil and platelet engraftment reporting.
SourceChildren's Hospital of Philadelphia·JournalTransplantation and Cellular Therapy·DateJan 23, 2023
A new study found that the antibody-drug conjugate STRO-001 showed nanomolar cytotoxicity in 88% of cancer cell lines tested, with potent efficacy against proliferating B cells. The research supports ongoing clinical studies for patients with B-cell non-Hodgkin lymphoma.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateJan 17, 2023
A study by Osaka University tracked the survival of antibody-producing plasma cells, finding that most die shortly after immune response, but a small population can survive for months or years. The researchers identified molecular markers distinguishing these long-lived plasma cells from short-lived ones.
SourceOsaka University·JournalJournal of Experimental Medicine·TypeExperimental study·DateDec 14, 2022
Researchers from The Mount Sinai Hospital found that talquetamab, a bispecific antibody, was successful in killing multiple myeloma cells in over 70% of patients. This therapy directs the immune system to target cancer cells and has shown promise even for those who have resisted all other treatments.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalNew England Journal of Medicine·DateDec 10, 2022
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A team of researchers discovered that the gut microbiome plays a critical role in driving granulopoiesis, a process formation of granulocytes, in mice models. The study found that alterations in the gut microbiome composition induced by neutropenia stimulate reactive granulopoiesis via interleukin 17A secreted by T cells, promoting neu...
SourceHokkaido University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateNov 21, 2022
Opaganib, an oral small molecule pill, shows potential as a nuclear radiation injury therapeutic for homeland security medical countermeasures and antitumor radiotherapy. The compound protects normal tissue from radiation damage and improves antitumor activity and response to chemoradiation.
SourceRedHill Biopharma·JournalInternational Journal of Molecular Sciences·TypeExperimental study·DateNov 14, 2022
Researchers at UVA Cancer Center have identified interleukin-1 as a crucial contributor to the development of myelofibrosis, a potentially deadly bone marrow cancer. Targeting this cytokine could prevent myelofibrosis from progressing and spare bone marrow scarring.
SourceUniversity of Virginia Health System·JournalNature Communications·DateNov 9, 2022
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A study found that impairing mitochondria in two different ways can cause severe anemia. Researchers used mouse models to investigate the role of mitochondria in blood cell differentiation and found that disrupting mitochondrial function and dynamics causes anemia through distinct mechanisms.
SourceUniversity of Tsukuba·JournalPharmacological Research·DateOct 17, 2022
A study found that high-fat diets fuel the creation of inflammatory immune cells in mouse bone marrow. These cells can later invade fat tissue, leading to insulin resistance and other complications associated with obesity. The bone marrow's sensitivity to environmental changes plays a crucial role in this process.
A KAUST-led research team identified two drug treatments that boost the activity of molecules involved in cell adhesion, enhancing the ability of blood-forming stem cells to enter the bloodstream and produce new blood. This breakthrough could lead to improved bone marrow transplant success for leukemia patients.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalBlood Advances·DateAug 25, 2022
A new study reveals a previously unrecognized level of heterogeneity and specialization of endothelial and mesenchymal cells in the bone marrow. By integrating single-cell gene expression data, researchers identified 14 endothelial and 11 mesenchymal subclusters, providing insights into blood stem cell self-renewal and differentiation
SourceKing Abdullah University of Science & Technology (KAUST)·JournaliScience·DateAug 16, 2022
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The study found that mice lacking both Runx1 and Runx2 in CAR cells showed a significant reduction of HSPCs and immune cells, along with an increase in fibrosis. The researchers suggest that Runx1 and Runx2 may be potential targets for the diagnosis and treatment of myelofibrosis.
SourceOsaka University·JournalNature Communications·TypeExperimental study·DateJun 9, 2022
A phase 3 randomized study showed that momelotinib significantly improved outcomes for patients with myelofibrosis, a rare and fatal bone marrow cancer. The oral pill met all primary and secondary endpoints, showing a trend toward overall survival benefit within six months.
SourceUniversity of Texas Health Science Center at San Antonio·DateJun 7, 2022
This study shows how specific brain regions control the immune response during acute stress, highlighting the detrimental effect on fighting off infection. Researchers found that acute stress prompts a major migration of immune cells, diminishing an immune response to viruses like COVID-19 and influenza.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalNature·TypeExperimental study·DateMay 30, 2022
A study published in Cell reveals that individuals with gum disease are more susceptible to developing arthritis due to alterations in immune cell precursors in the bone marrow. The researchers also found that this association may prompt a reconsideration of how bone marrow donors are selected.
SourceUniversity of Pennsylvania·JournalCell·TypeExperimental study·DateApr 27, 2022
Researchers have discovered that a new type of solid bone marrow aspirate concentrate exhibits enhanced migratory potential and promotes greater cell growth compared to traditional platelet-rich fibrin. This breakthrough may lead to the development of novel therapeutics for promoting wound healing and bone regeneration.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalTissue Engineering Part A·TypeCase study·DateApr 18, 2022
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A new study published in Nature Immunology finds that B cells produce the neurotransmitter acetylcholine, which blocks white blood cell production and reduces cardiovascular inflammation. This discovery may lead to new treatments for conditions such as atherosclerosis and heart failure.
SourceMassachusetts General Hospital·JournalNature Immunology·DateMar 29, 2022
Researchers at CNIC discover that bone marrow activation is an early event in the development of atherosclerosis, leading to inflammation and plaque formation. The study identifies metabolic syndrome as a key trigger for this process.
SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalEuropean Heart Journal·TypeRandomized controlled/clinical trial·DateMar 22, 2022
A recent study found that a subset of immune cells within the alveolar bone marrow were activated by the presence of commensal oral microbes, leading to increased osteoclast-mediated bone resorption and bone loss. Reducing the burden of commensal microbes through oral antiseptic rinses can help protect against alveolar bone loss.
SourceMedical University of South Carolina·JournalJCI Insight·DateFeb 16, 2022
Researchers tracked antibody response to COVID-19 vaccination and found that antibodies improve in quality for months after vaccination. Even low levels of antibodies provide some protection as long as the virus doesn't change.
SourceWashU Medicine·JournalNature·TypeObservational study·DateFeb 15, 2022
Paczesny will explore biomarkers and a new type of immune cell to identify and regulate acute lung injury after BMT. She aims to improve understanding of signaling mechanisms in lung injury after BMT, particularly as they relate to idiopathic pneumonia syndrome.
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Researchers discovered a protein, syndecan-2, that helps identify and deploy blood stem cells for treatments. Transplanting only cells expressing syndecan-2 could make blood stem cell transplants more efficient and less toxic.
SourceCedars-Sinai Medical Center·JournalBlood·DateJan 25, 2022
Researchers have found that blocking mineralocorticoid receptors, a key factor in bone health, may help protect against bone loss and osteoporosis. This new target is thought to be more effective than previously believed logical targets, such as reducing glucocorticoid receptor activity.
SourceMedical College of Georgia at Augusta University·JournalJournal of Bone and Mineral Research·DateJan 5, 2022
Research in mice suggests that first-responder cells launching repair after a heart attack promote more inflammation than necessary, threatening optimum healing of the heart.
SourceOhio State University·JournalCirculation·DateJan 5, 2022
Researchers found a novel therapy called AVID200 safe and well-tolerated, with modest improvements in symptom burden, anemia, and spleen enlargement. The therapy needs to be combined with other drugs to optimize impact in patients.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·DateDec 11, 2021
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Researchers discovered that blood stem cells use high-energy fatty acids from the body's fat stores to power up their response to infection. This finding could lead to new approaches in treating bacterial infections, particularly in vulnerable and older individuals.
SourceUniversity of East Anglia·JournalNature Communications·TypeExperimental study·DateDec 8, 2021
Researchers at the University of Oklahoma have discovered a new protein fragment that could improve cartilage regeneration and reduce the need for osteoarthritis treatments. The protein fragment, developed by Handan Acar and Amgad Haleem, aims to help the body heal itself by elicititing a response from stem cells.
Research suggests that obesity triggers inflammation, leading to an increase in myeloid-derived suppressor cells, which break down bone tissue. This can result in gum disease and tooth loss. The study found a significant link between high-fat diets and increased osteoclasts and alveolar bone destruction.
SourceUniversity at Buffalo·JournalJournal of Dental Research·DateNov 12, 2021
A new study by USC researchers uses a genetic technology to analyze gene expression signatures of individual cancer cells from patients with leukemia. The findings show that cancer cells with distinct gene expression profiles tend to grow in different organs, while those with specific genes are more resistant to chemotherapy.
SourceKeck School of Medicine of USC·JournalNature Communications·TypeExperimental study·DateNov 11, 2021
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Dendritic cells, crucial in detecting infectious agents, need boosting when they are scarce in healthy tissue. A new process, dubbed 'emergency' dendritic cell response, rapidly replenishes these cells from bone marrow upon infection.
SourceThe Francis Crick Institute·JournalScience Immunology·TypeExperimental study·DateNov 5, 2021
A subpopulation of mesenchymal stem cells expressing CD73 has been identified as crucial for bone regeneration, displaying enhanced proliferation and differentiation capabilities. This subgroup promotes fracture healing by forming new cartilage and bone cells, contributing to the remodeling process.
SourceUniversity of Tsukuba·JournalBone Reports·DateOct 7, 2021
Aging stem cells in bone marrow lose function due to epigenetic changes that affect bone production. Researchers reverse these changes by adding acetate, rejuvenating the epigenome and improving stem cell activity. This finding holds promise for treating diseases like osteoporosis.
SourceMax-Planck-Gesellschaft·JournalNature Aging·TypeExperimental study·DateSep 14, 2021
Researchers found that remnant cholesterol levels above 24 micrograms per deciliter were associated with a 40-50% higher risk of major heart disease or stroke. The study suggests using remnant cholesterol as an additional metric for predicting cardiovascular disease and stroke risk, in addition to LDL cholesterol levels.
SourceJohns Hopkins Medicine·JournalEuropean Heart Journal·DateSep 7, 2021
Researchers discovered that cancer-associated mutations in blood progenitor cells lead to distinct changes in both cancer and non-cancer immune cells in Waldenstrom macroglobulinemia. This finding has potential implications for origins and therapy of the disease, suggesting a new approach to immune therapies.
SourceEmory Health Sciences·JournalBlood Cancer Discovery·TypeObservational study·DateSep 1, 2021
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Scientists at University of California San Diego School of Medicine have developed a method to keep cultured hematopoietic stem cells healthy, positive news for patients seeking stem cell transplants. The findings also hint at a new way to ward off aging by super-activating the heat shock pathway.
SourceUniversity of California - San Diego·JournalCell Stem Cell·DateAug 12, 2021
Researchers at UVA Health System discovered that combining drug palbociclib with ruxolitinib could effectively treat myelofibrosis by preventing bone marrow scarring and improving blood cell counts. This potential new treatment offers a promising approach to devastating blood disorder.
SourceUniversity of Virginia Health System·JournalCancer Research·DateAug 11, 2021
Researchers have identified a gene variant that contributes to unnecessary bone marrow biopsies in African Americans. The study found that 63% of African Americans carry the variant, which lowers white blood cell levels and is associated with Benign Ethnic Neutropenia.
SourceVanderbilt University Medical Center·JournalJAMA Internal Medicine·DateJun 28, 2021
A new study reveals that a hormone in fat cells inside bone marrow helps regulate bone and fat production. The findings suggest potential new approaches to treating conditions like osteoporosis.
Researchers found that autologous bone marrow stromal stem cells can lower blood glucose levels and reduce medication doses in non-obese Type 2 diabetes patients with a short disease duration. The study's results are promising for the potential treatment of this chronic disease.
SourceAlphaMed Press·JournalStem Cells Translational Medicine·DateJun 3, 2021
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Researchers found that people who had mild COVID-19 developed antibody-producing cells that can last a lifetime. These cells will continue to produce antibodies against the virus even after infection has resolved.
A new method makes it possible to accurately show whether the number of cancerous cells in the bone marrow is increasing in a patient with multiple myeloma. This blood test could potentially replace the current bone marrow puncture, enabling quicker treatment initiation.
SourceRadboud University Medical Center·JournalClinical Chemistry·DateMar 26, 2021
Research found heightened brain activity in the amygdala region of stressed individuals, increasing risk of TTS, a temporary weakening of heart muscles. Stress reduction interventions may help prevent TTS, which is more common in women.
SourceEuropean Society of Cardiology·JournalEuropean Heart Journal·DateMar 25, 2021
Researchers at Boston University School of Medicine have found that PXS-LOX_1 and PXS-LOX_2 can slow primary myelofibrosis's disease progression in experimental models by inhibiting lysyl oxidase. These findings represent a possible novel avenue for treatment, potentially slowing cancer progression and easing symptoms.
SourceBoston University School of Medicine·JournalArchives of Stem Cell and Therapy·DateMar 22, 2021
A study at the University of Helsinki uses machine learning to analyze bone marrow samples and identify genetic mutations associated with myelodysplastic syndrome (MDS). The technique provides new insights into disease progression and can help assess and diagnose hematological malignancies.
SourceUniversity of Helsinki·JournalBlood Cancer Discovery·DateMar 22, 2021
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