Articles tagged with Kidney
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Elderly individuals living in UK care homes are at high risk of dehydration due to conditions like dementia, diabetes, and kidney problems. Research finds dehydration is associated with poor health outcomes, including disability and death.
Researchers have made significant breakthroughs in nanopore technology that could pave the way for a surgically implantable artificial kidney. The new device is designed to remove toxins and waste from the blood without a pump or electrical power, offering a promising alternative to dialysis for patients with end-stage renal disease.
Researchers have created a new 'progenitor cell' capable of unlimited expansion and differentiation into mature kidney cells without the risk of forming tumors. This breakthrough presents several advantages over using undifferentiated human stem cells, including reduced tumor growth potential and easier manipulation for therapeutic use.
New equations predict lifetime risk of kidney failure in living kidney donors, with those developing diabetes or hypertension facing higher risks. The findings highlight the need for revised kidney transplant policies and emphasize the importance of monitoring donor health.
Recent high-impact clinical trials have explored various treatments for kidney-related medical care. Researchers found that statins may increase risk of acute kidney injury in patients with chronic kidney disease, while methylprednisolone did not alter the risk of acute kidney injury in patients undergoing cardiac surgery. Additionally...
Recent studies focus on hypertension in overweight and obese adolescents, revealing under-diagnosis despite risk factors. Lead exposure in pregnancy is linked to higher blood pressure in young children. Microparticles released from cells cause fetal death, preeclampsia, and embryonic growth restriction in mice.
A study finds that advanced stages of chronic kidney disease significantly increase the risk of falling into poverty. Black ethnicity, low educational attainment, single adult households, and low income are also linked to a higher likelihood of financial hardship.
A study found that African American and Native American dialysis patients were 43-44% less likely to use hospice before dying compared to white patients. The research highlights the need for high-quality research into the benefits of dialysis therapy in older and sicker segments of society.
A new study reveals that deceased donor kidneys are more likely to be discarded on weekends than weekdays. Organs procured during the weekend were also more likely to be discarded and of higher quality than those procured on other days.
A study found that adults who received kidneys from deceased pediatric donors aged 0 to 5 years experienced no surgical complications, organ failure, or rejection. The results showed excellent outcomes with no adverse effects from younger donor age or low weight.
A new study reveals racial disparities in living kidney donation rates and complications after donation. African Americans have the lowest rates of living donation, while also experiencing higher risks of complications, including gastrointestinal issues, bleeding, and respiratory problems. The findings suggest that socioeconomic factor...
Researchers warn that thiazide diuretics may cause low blood pressure in congestive heart failure patients, leading to dizziness and reduced blood flow to the brain and kidneys. The study suggests that these patients should exercise caution when taking thiazides or consider alternative medications.
A study found that three commonly used kidney function equations yield discordant results for transplant waitlist qualification, potentially leading to significant differences in qualification time and disadvantage patients. The Cockroft-Gault equation most often disadvantaged patients compared to the MDRD and CKD-EPI equations.
A new study comparing kidney transplantation and home hemodialysis found that transplant recipients outlived their hemodialysis counterparts by 4 times over 5 years. Elderly patients on hemodialysis had nearly a 5 times higher risk of dying compared to those with transplants, highlighting racial disparities in mortality rates.
A study evaluating patients who purchased organs internationally found higher rates of hepatitis C, B, and cytomegalovirus, as well as increased risk of acute and recurrent rejections. Survival rates were also lower compared to living related donor transplants.
A new treatment using vascular endothelial growth factor fused to a bioengineered carrier promotes the recovery of kidney function in pigs with chronic renovascular disease. The study shows that this treatment can improve kidney function, potentially leading to substantial implications for the management of renovascular disease.
A new study suggests that shorter sleep duration is significantly linked with a more rapid decline in kidney function. Women who slept less than 5 hours per night had a 65% increased likelihood of experiencing a rapid decline in kidney function compared to those sleeping 7-8 hours.
A University of Cincinnati researcher found that acute kidney injury doubles the rate of renal function loss in diabetic patients. The study suggests that AKI increases the risk of chronic kidney disease and accelerates the progression to end-stage renal disease.
A study in New England Journal of Medicine found that suPAR, a circulating protein, can reliably predict chronic kidney disease up to five years before symptoms appear. High suPAR levels are associated with an increased risk of developing the disease, which affects over 15% of people in the US.
A recent study presented at ASN Kidney Week 2015 found that hormone replacement therapy was associated with lower levels of microalbuminuria and decreased estimated glomerular filtration rate in postmenopausal women. This suggests that hormone replacement therapy may help protect kidney health in these women.
Researchers aim to conduct clinical trials on implantable, engineered organs in this decade. The device mimics human kidney functions and has shown encouraging early studies.
Researchers aim to create a permanent solution for organ transplantation scarcity using bio-hybrid devices combining silicon filters with living human kidney cells. The device, if successful, could run on the body's normal blood pressure without power source, eliminating organ rejection issues.
Two new studies show that increased use of proton pump inhibitors (PPIs) may contribute to the CKD epidemic. PPI users were between 20% and 50% more likely to develop CKD than non-PPI users, even after accounting for baseline differences.
The American Society of Nephrology (ASN) has released a report outlining current and future challenges to the specialty of nephrology. Key findings include the increasing fragmentation of kidney care, uneven distribution of nephrologists across the US, and declining interest among residents choosing nephrology fellowships.
Researchers have grown mini-kidney organoids in a laboratory by combining stem cell biology with leading-edge gene-editing techniques. These engineered mini-kidneys contain tubules, filtering cells and blood vessel cells, and can mimic both healthy and diseased kidneys.
Three new studies led by The Ottawa Hospital researchers show that ramipril, levofloxacin, and sirolimus are not nearly as effective as previously thought, with potential serious side effects.
A recent study found that each 80 minutes/day increase in sedentary duration was linked with a 20% increased likelihood of having chronic kidney disease. The association was independent of moderate/vigorous physical activity and other factors.
A consultant nephrologist criticizes Wales' upcoming opt-out organ donation system, citing concerns over a lack of commitment among potential donors. He believes that more radical solutions are needed to increase organ donation and argues that the current system may not be effective in addressing these issues.
Researchers found that patients taking calcium supplements had lower urine calcium and oxalate levels but faster kidney stone growth rates. Vitamin D supplementation decreased urinary calcium excretion and stone growth rates, potentially preventing stone formation.
Scientists at Brigham and Women's Hospital have developed a method to create kidney structures from adult stem cells, which could be used to study diseases such as chronic kidney disease and test new therapies. These kidney structures can model the development of kidney abnormalities and susceptibility to drug toxicity.
Researchers discovered that statins can help prevent acute kidney injury by suppressing inflammation and regulating blood vessel thickness, thanks to the presence of KLF4 protein in endothelial cells. The study found that treating mice with statins protects against AKI, and loss of KLF4 exacerbates the condition.
A new project at the University of Michigan aims to educate patients and healthcare professionals on how to make dialysis sessions safer, reducing instability and its associated risks. The study will use a combination of peer mentoring and provider education to support behavior change.
Researchers have discovered a gene called Sox9 that enables kidney cells to switch on and repair damaged tissue after acute injury, offering new hope for treating this serious condition. The study found that the Sox9 gene promotes timely repair of the nephron's cellular lining and repairs the kidney after AKI.
A study discovered six metabolites in the blood that strongly correlate with kidney function. Two of these metabolites, pseudouridine and C-mannosyltryptophan, are equally effective measures of kidney function as creatinine, offering potential improvements in diagnosing chronic kidney disease.
A new study suggests that chronic dehydration caused by global climate change may be responsible for the Mesoamerican Nephropathy epidemic, which has killed over 20,000 people. The disease is most prevalent among manual laborers on sugar cane plantations in Central America.
Albert D. Kim, a postdoctoral fellow at the Keck School of Medicine of USC, has received the first Hearst Fellowship for his work on turning stem cells into nephrons, the functional units of the kidney. He aims to isolate and generate kidney progenitor cells to repair damaged adult kidneys.
A recent study identified a significant association between childhood kidney stones and thickened arteries, a precursor to cardiovascular diseases. The research found that children with kidney stones showed increased thickness of key arteries, potentially leading to future cardiovascular complications.
A new study published in Diabetologia shows that high protein diets from both animal and plant sources improve blood sugar control and reduce liver fat in patients with type 2 diabetes. Insulin sensitivity improved only in the animal protein group, while the plant protein group showed significant reductions in kidney function parameters.
Among 51 military service members who experienced severe acute kidney injury, 88% were due to blasts or projectiles, and 22% died within 60 days. Most survivors regained normal kidney function, but some developed chronic kidney disease or proteinuria, highlighting the need for long-term monitoring.
Researchers at Boston University School of Medicine have discovered a new protein, TMIGD1, that protects kidney epithelial cells from injury. Increasing expression of this protein can reduce cell death and potentially prevent kidney failure. The findings could lead to the development of therapeutic agents that target these cells.
A Rutgers study found that people tend to allocate scarce transplant organs across groups instead of prioritizing individuals with the best chance of a successful transplant. When presented with individual-level information, participants were more likely to make efficient decisions, but when grouped, they allocated resources based on p...
Janos Peti-Peterdi, a USC kidney researcher, has made significant advances in visualizing the function of the living kidney's filter and studying kidney stem cells. He aims to find new treatments and therapies for patients with chronic kidney disease.
A study found that most donors and recipients support sharing health information, but not social details. The transplant team should be involved in the discussion, according to both parties.
A study found that only about one in four patients with end-stage renal disease in Georgia were referred for kidney transplant evaluation within a year of starting dialysis. The study suggests that standardized guidelines are needed to improve access to kidney transplantation.
Research reveals a strong link between kidney impairment and decreased blood flow to the brain, increasing the risk of stroke and dementia. Poor kidney function was strongly related to decreased blood flow to the brain, with the strongest association seen in participants with decreased blood flow.
Scientists at University of Texas MD Anderson Cancer Center identified EMT as a potential therapeutic target for reversing kidney disease and fibrosis. The study showed that inhibiting EMT in tubular epithelial cells can restore their health and function.
A licensed technology measures anti-HLA antibody secretion from memory B cells, improving kidney transplant efficiency and preventing rejection. Researchers found high-risk patients using this technique, which complements existing antibody measurement methods.
Researchers found that TMAO levels increase with advancing severity of kidney disease and are linked to atherosclerosis and premature death. Targeting TMAO generation by intestinal bacteria may be a novel strategy for safeguarding heart health in patients with CKD.
Researchers found that mild hypothermia in deceased organ donors significantly reduces delayed graft function in kidney transplant recipients by nearly 40%. This intervention could lead to an increase in the availability of kidneys for transplant and improve patient outcomes.
Proteins in the Wnt signaling pathway play a critical role in driving kidney scarring, which can lead to chronic kidney disease. Boosting expression of Wnt proteins in healthy kidneys may be an effective strategy for treating chronic kidney disease.
A new clinical trial found that tamsulosin improves the passage of larger kidney stones, with 83.3% of patients treated with the medication passing their stones compared to 61% on placebo. However, for small kidney stones, time remains the best cure, according to lead author Jeremy Furyk.
A new study by Houston Methodist researchers finds that artificially added phosphates in dairy and cereal products cause bigger spikes in blood phosphorus levels than natural phosphates. This can lead to increased kidney function problems and heart damage, especially for people with healthy kidneys.
Researchers used iPSC-derived renal progenitors to treat acute kidney injury in mice, showing improved recovery with reduced fibrosis and necrosis. The study's findings suggest that paracrine actions of the cells, rather than integration, led to therapeutic effects.
Researchers found that postmenopausal women with kidney or bladder stones were not at increased risk for osteoporosis, contrary to previous findings in men. Women with a urinary tract stone were more likely to develop a second stone, however.
Researchers identified a cellular signal causing kidney cells to die, leading to increased risk of acute kidney injuries. The study found that lack of alpha(E)-catenin protein contributes to this process.
Researchers developed targeted therapy using immunoglobulin-A antibodies to neutralize specific receptors in polycystic kidneys. The strategy enables repurposing of existing monoclonal antibodies for PKD therapy, opening up new class of therapeutics.
A new US study reveals that end-stage kidney disease patients who receive specialized care have significantly improved survival rates and access to life-saving treatment. The research highlights the importance of timely referrals to nephrologists in reducing mortality risks, particularly in low-performing regions.
Inflamed kidney cells produce an enzyme that consumes tryptophan, activating a stress response and inducing autophagy to clear damaged protein. The IDO-GCN2 pathway provides natural protection against inflammation-induced kidney damage, offering new potential treatment targets.
Researchers found that mortality rates vary significantly according to kidney disease subtype, suggesting that treatment plans should be tailored towards disease-specific risks. The study analyzed data from 84,301 patients and showed significant differences in survival rates among those with different subtypes of glomerulonephritis.
A new study found that people allocate medical resources equally across groups, but make more efficient decisions when presented with individual patient information. This bias towards equality can lead to suboptimal allocation decisions, but may also have positive outcomes in certain contexts.