Articles tagged with Kidney
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Research in female mice reveals estrogen's protective effects against renal ischemia, leading to improved survival rates and lower kidney injury. Human kidney transplant outcomes also show greater failure rates in male recipients compared to females.
A new study from Mayo Clinic found that patients with high and low levels of donor-specific alloantibodies who received simultaneous liver-kidney transplants showed a lower incidence of cellular and antibody-mediated rejection, chronic injury to the kidney, and better overall kidney function compared to those who received a kidney tran...
Research finds that proton pump inhibitors, widely used for heartburn and ulcers, can lead to kidney function decline, chronic kidney disease, and kidney failure. Long-term use of these medications significantly increases the risk of developing kidney problems.
Patients with severe kidney stones admitted on weekends are 26% less likely to receive timely treatment, with nearly three times higher mortality rates compared to those treated early.
A multi-disciplinary team of researchers has identified a pivotal role for sphingomyelin in driving inflammatory mechanisms underlying type 1 diabetes and obesity-related kidney dysfunction. This study provides new insights into the underlying mechanisms of diabetic kidney disease and may lead to the development of novel treatments.
A study found that kidneys possess an innate circadian clock regulating various functions, including urine formation and excretion, which adapt to daily light-dark cycles. This internal clock also influences the levels of amino acids and lipids in the blood and affects drug elimination in individuals taking medications.
A new study found that achieving ideal cardiovascular health factors, such as healthy blood pressure and cholesterol, is associated with a reduced risk of new-onset kidney disease. The study included 14,832 adults aged 45-64 and followed them for an average of 22 years to develop chronic kidney disease.
A study published in the Journal of the American College of Cardiology found that US prediction models for kidney injury after angioplasty performed well in Japan, predicting acute kidney injury and dialysis with high accuracy. The models have potential for clinical decision-making worldwide.
A recent study found that an investigational drug called CMX-2043 showed no improved protection for the kidneys of patients undergoing angiograms. The trial, which recruited over 300 patients, tested four different doses of the drug to prevent contrast-induced kidney injury.
A new thematic issue of The Open Urology & Nephrology Journal reports on the association between hyperuricemia and kidney disease. Chronic inflammation is a common link between the two conditions, with research exploring its role in uric acid excretion and progression of renal disease.
Researchers found that inhibiting Wnt secretion can prevent the build-up of scar tissue in kidneys and protect against renal fibrosis. This suggests a novel therapeutic approach to treating kidney disease.
A study of 10,533 kidney transplant recipients found that nearly half visited an emergency department within 2 years, with younger age, female patients, and public insurance being significant risk factors. The findings highlight the need for coordinated care for this vulnerable patient population.
A survey of US citizens found that many are willing to donate a kidney, with 68% open to donating to anyone and 59% motivated by $50,000 payment. The study suggests compensating living kidney donors could alleviate the organ shortage.
Researchers found that SIX1 plays a more substantial role in human kidney development than previously thought, remaining present beyond the initial branching of the kidney. This discovery may help better understand normal development and pediatric kidney cancer, Wilms' tumor.
Researchers at MUSC report findings on the mechanisms underlying impaired ciliogenesis and abnormal kidney development characteristic of PKD. Depletion of dynamin-binding protein or Tuba disrupts renal ciliogenesis, leading to uncontrolled production of cysts.
Researchers at The University of Nottingham are developing Sodium MRI technology to provide more detailed tissue health and disease information. The technique uses naturally occurring sodium ions, which can offer greater clarity than current hydrogen-based MRI scans.
A recent study published in Nature has discovered that mitochondria play a key role in kidney injury, with the gene PGC1 alpha providing protection through NAD. The study suggests that manipulating NAD levels could lead to new therapies for acute kidney injury.
Researchers found that a lower-than-standard dose of calcineurin inhibitors (CNIs) results in better clinical outcomes for kidney transplant recipients. The study analyzed 88 randomized controlled trials and found that CNI minimization had the best long-term impact on renal function.
Researchers found that acute and chronic kidney rejection are different parts of the same immune rejection process, making it a single entity at the molecular level. They identified interstitial fibrosis and tubular atrophy as an early warning sign of active but 'silent' rejection.
A new study published in Antimicrobial Agents and Chemotherapy found that patients taking oxacillin had lower rates of potassium imbalances and kidney damage compared to those on nafcillin. Oxacillin was also associated with fewer treatment discontinuations, highlighting its potential as a safer alternative.
A new survey found significant country-to-country differences in kidney transplant donation rates, varying by up to 35 donors per million population. The variation is attributed to different legal and social standards across Europe, with some countries having more generous organ donation schemes than others.
Researchers have discovered cells in the urine of preterm infants that can differentiate into mature kidney cells and provide protection against cell death. These cells could potentially be used as a treatment to regenerate damaged kidneys and improve outcomes for patients with kidney disease.
A study published in JAMA found that high-dose statin treatment before and after cardiac surgery did not reduce the risk of acute kidney injury, contradicting previous studies. The research suggests that patients undergoing cardiac surgery may be at increased risk of AKI if taking statins.
A study of 1492 patients with chronic kidney disease found that nearly 28% had masked hypertension, which increases the risk of kidney, heart, and vascular damage. Measuring blood pressure outside the clinic is recommended to assess patients' risks for hypertension-related health problems.
A new study by Mayo Clinic reveals that only one-third of patients receive preemptive or early living donor kidney transplants, despite research suggesting improved patient outcomes. The study highlights the need for education and access to information about living donor kidney transplantation to improve long-term outcomes.
A new study reveals reduced racial disparities in kidney transplant outcomes between black and white recipients over the past 2 decades. The findings show improved organ survival rates for black patients, including those who received live donor or deceased donor kidney transplants.
The International Radiosurgery Oncology Consortium has developed consensus guidelines for the safe implementation and practice of Stereotactic Body Radiation Therapy (SBRT) for primary renal cell carcinoma. SBRT is a non-invasive treatment option with favorable comparisons to existing treatments, offering a cost-effective and widely av...
A ketoanalogue-supplemented vegetarian very low-protein diet was found to slow disease progression in patients with advanced CKD. The study suggests that this type of nutritional intervention could be used to postpone dialysis initiation in compliant patients.
Researchers have developed a new mouse model that successfully suppresses NF-kappaB signaling, reducing tissue damage and inflammation in the kidneys. This breakthrough could lead to a tailored therapy for patients with ischemic renal failure.
A worldwide study led by UC San Francisco and Emory University investigators found belatacept to be a better option for kidney transplant recipients, with lower mortality and graft loss rates. The drug's long-term benefits are seen in preserving kidney function and suppressing antibodies that cause late graft loss.
A Canadian study shows that pharmacists can detect chronic kidney disease (CKD) in a significant proportion of high-risk patients. Using an online decision-making tool, pharmacists screened 720 patients and found CKD in 39%, including previously unrecognized cases.
IL-17A and Th17 cells contribute to renal injury, which can lead to permanent scarring in kidneys. Blocking IL-17A/F signaling shows promise as a novel therapy for immune-mediated renal diseases.
A study in JCI Insight identifies Dickkopf-3 as a driver of renal fibrosis in chronic kidney disease. DKK3 expression is elevated in stressed tubular epithelia and associates with profibrotic T cell responses, leading to interstitial fibrosis and impaired kidney function.
Researchers found mild fibrosis in biopsies taken a few months after transplant correlated with acute kidney injury gene expression, while advanced fibrosis reflected ongoing injury. Older transplants with fibrosis were associated with an increased risk of kidney failure.
A new study reveals that transplant centers receiving low performance evaluations remove 60% more patients from the transplant waiting list. This suggests these centers prioritize healthier candidates over those with multiple risk factors.
The USRDS annual data report reveals a decline in deaths among dialysis and transplant patients, while prevalence of end-stage kidney disease continues to rise. Home dialysis use has increased, offering improved quality of life, but awareness of kidney disease remains low.
A recent study found a significant increase in kidney stone cases among adolescents, particularly females, and African-Americans in the US. The incidence of kidney stones doubled during childhood for both boys and girls, while there was a 45% increase in lifetime risk for women.
A new online calculator accurately estimates the risk of kidney failure in people with chronic kidney disease using common medical tests. The tool provides reassurance for most patients, who are not at serious risk of kidney failure, and helps high-risk patients prepare for dialysis or transplant.
New research found that even very healthy individuals with reduced kidney function experience changes in the heart, including increased left ventricle mass and elevated troponin levels, indicating potential for heart disease. The study tracked living kidney donors to explore direct effects of diminished kidney function on the heart.
The new allocation system has boosted transplantation rates for black and Hispanic patients on waiting lists, reducing racial disparities. Younger adults have gained wider access to coveted organs, while older candidates have seen a decline in transplant rates.
A study using mobile health technology has shown that patients taking kidney transplants can improve their medication adherence and blood pressure levels, leading to better patient outcomes. The innovative approach aims to reduce premature graft loss by providing personalized computer-automated monitoring systems.
Researchers found that infusing a small amount of IL-17A can prevent or reverse diabetic nephropathy in animal models. The therapy also reduced high levels of fat in the blood and aided survival and regeneration of key kidney cells, including podocytes and epithelial cells.
Patients undergoing major vascular surgery experienced high rates of acute kidney injury and chronic kidney disease, increasing long-term cardiovascular-specific death. Preoperative risk stratification through estimated glomerular filtration rate and albuminuria can help prevent or mitigate further decline in kidney function.
Researchers have found that screening male kidney transplant candidates for prostate cancer does not prolong their survival and may even delay receiving a transplant. Elevated PSA levels detected through screening were associated with a reduced likelihood of receiving a transplant regardless of the patient's age or PSA level.
Researchers at the University of Virginia Health System have identified the stem cells that develop into the blood vessels within the kidney, a critical step toward growing replacement kidneys. By understanding how these vessels form and function, scientists may be able to create functional organs for patients in need.
A study of 30 patients found that surgery effectively controlled hypercalcemia, normalized parathyroid hormone levels, and improved bone density. In contrast, medication only controlled excess calcium in 67% of cases, with no effect on PTH or slowing the decline in bone density.
Researchers have found a class of drugs, histone deacetylase inhibitors, can eliminate kidney toxicity caused by cisplatin, a widely used chemotherapy agent. The combination therapy shows promise in reducing inflammation and cell death in the kidneys.
Researchers found that paying attention to results of a simple blood test can help predict the likelihood of patients experiencing kidney failure or death. The studies emphasize the importance of monitoring measures of kidney function over time to inform treatment decisions.
Researchers used CRISPR/Cas9 to guide human pluripotent stem cells into becoming a lab model for polycystic kidney disease (PKD), a common inherited disorder. The system produced stable, biologically accurate human models with cyst-like structures in kidney tubules.
Researchers have identified a simple, non-invasive test to identify patients at risk of chronic kidney disease progression by measuring epidermal growth factor levels in urine. Decreased epidermal growth factor protein is an early sign of diminishing kidney function and pinpoints the at-risk patient population.
A new study reveals that Native Americans have decreased access to kidney transplants, leading to higher mortality rates on the waiting list. The study found that while short-term outcomes were similar, Native Americans experienced worse long-term survival outcomes compared to whites.
A consensus report by Mayo Clinic researchers provides a standardized approach to diagnosing glomerulonephritis based on the underlying cause of the disease. This new method aims to improve personalized diagnosis and targeted treatment for patients with kidney disease.
The BK polyomavirus often causes complications after kidney transplantation due to immunosuppressive drugs like Tacrolimus. Researchers have found that Tacrolimus directly activates virus replication, while Sirolimus inhibits it, providing a rationale for clinical trials.
Researchers successfully transplanted human-induced pluripotent stem cell-derived kidney tissues into mouse kidneys, where the animal's blood vessels connected to the human tissue. The advance allows for the creation of urine-producing kidneys through regenerative medicine.
Researchers at Kumamoto University have successfully connected iPS-derived kidney cells to a capillary network, enabling the formation of a functional filtration membrane. This breakthrough has significant implications for regenerative medicine and organ transplantation, particularly for patients with renal failure.
A study found that after 6 months of hydroxyurea treatment, sickle cell disease patients' kidney function improved significantly. The urinary albumin/creatine ratio decreased, indicating a potential renal benefit of HU in sickle cell disease.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that Viagra improves insulin sensitivity in individuals with prediabetes. The medication also reduces a biological marker that signals heightened risk of kidney and heart disease.
Elevated serum phosphorus levels in African Americans with chronic kidney disease (CKD) are associated with faster progression to kidney failure, known as end-stage renal disease (ESRD). The study found that African Americans are more than 3 times as likely to progress to kidney failure as Caucasians.
A study found that kidney failure patients on dialysis were at high risk of kidney and thyroid cancers, while those post-transplant were at higher risk of non-Hodgkin lymphoma and melanoma. The findings highlight the importance of cancer screening and prevention in these patients.
Higher levels of urinary potassium excretion were linked with slower declines in kidney function and lower cardiovascular complications among patients with type 2 diabetes. A diet rich in potassium may help protect heart and kidney health, according to the study.