Articles tagged with Kidney
A new study found that preterm infants with acute kidney injury (AKI) have higher levels of certain proteins in their urine compared to healthy infants. This could lead to better diagnostics and treatment for AKI in newborns, which is a common complication in premature infants and can predict poor clinical outcomes.
A study published in Clinical Journal of the American Society of Nephrology found that preterm infants with acute kidney injury have distinct protein profiles in their urine compared to those with healthy kidneys. This discovery could help physicians diagnose kidney health in newborns and improve treatment outcomes.
Researchers have identified a panel of genes that can help predict whether a transplanted kidney will develop fibrosis, leading to organ failure. The study's findings have the potential to change how doctors monitor and manage renal transplant patients.
Researchers have discovered a link between cellular stress and multiple types of birth defects, including heart defects. A study led by Professor Sally Dunwoodie found that reduced oxygen levels triggered a stress response in embryonic cells, leading to heart development problems.
Researchers have detected high levels of KIM-1, a biomarker for kidney injury, as well as arsenic and chromium in children's urine in a region of Mexico with high incidence of chronic kidney disease. The findings suggest that early exposure to environmental toxins may lead to irreversible harm if not addressed.
A new study found a strong association between red meat intake and increased risk of end-stage renal disease (ESRD), with soy and legumes appearing slightly protective. Substituting one serving of red meat with other protein sources can significantly reduce the risk of ESRD by up to 62%.
A study found that regions in China with high levels of fine particulate air pollution have elevated rates of membranous nephropathy, an immune disorder of the kidneys. The likelihood of developing membranous nephropathy increased by 13% annually over 11 years.
Researchers at the University of Nottingham have discovered a genetic link between an immune system gene and an increased risk of kidney disease, specifically IgA nephropathy. The study found that variations in the number of copies of the alpha-defensin genes were strongly correlated with the condition.
The study reveals that errors in cell adhesion and inhibition cause two types of kidney cyst formation, which can lead to a significant increase in kidney size. The researchers used advanced computer simulations to identify the potential new drug target and confirmed its accuracy using real human cells.
A new study published in CardioRenal Medicine suggests that patients with more inflammation prior to kidney transplantation are at higher risk of developing diabetes after surgery. The researchers also found that a patient's fat stores play a role in this process, and that reducing inflammation before transplant may help prevent diabetes.
A study by University of Illinois researchers suggests that protein S supplementation can inhibit beta-cell death and improve blood glucose levels, insulin sensitivity, and kidney damage in mice with type 1 and type 2 diabetes. The findings offer a potential new approach to treating the disease.
Researchers have identified a new therapeutic approach to prevent renal damage in cardiorenal syndrome type 2 (CRS2), a condition that causes chronic kidney disease secondary to heart failure. By inhibiting G protein-coupled receptors, the study found that renal function can be protected.
Researchers aim to develop strategies to protect the kidneys from permanent damage caused by cisplatin, a common chemotherapy agent used to treat various cancers. They investigate two pathways: p53 and PKCδ, which contribute to kidney cell death during treatment.
Researchers found that faster intestinal calcium absorption and increased urinary excretion of calcium may predispose hypercalciuric patients to developing kidney stones. Measuring these factors could help identify individuals at risk, allowing for early prevention and treatment.
A mathematical model of open-heart surgery simulates oxygen levels in rat kidneys, revealing vulnerability to hypoxia during surgery. The study sheds light on the causes of kidney injury and suggests potential strategies for prevention.
Researchers have developed a culture method that significantly increases kidney progenitor cell proliferation while maintaining their ability to form glomeruli and tubules. This breakthrough finding has major implications for regenerative medicine, potentially aiding in the search for causes of kidney disease and new drug development.
Researchers found that kidney-specific deletion of the D2 dopamine receptor increased inflammation and hypertension, while restoration of DRD2 expression decreased these effects. The study suggests that targeting DRD2 may be a useful approach for treating renal injury.
A genetic variant in the HO-1 gene is highly associated with development of AKI following cardiac surgery, leading to decreased expression and iron toxicity. Testing for this variant may help identify patients at risk, enabling therapeutic strategies to mitigate kidney damage.
Researchers are examining DNA samples from 20,000 people with diabetes to identify genetic factors in diabetic kidney disease. The study aims to develop new tests and treatments to prevent kidney complications and improve patient outcomes.
A wearable artificial kidney has been shown to effectively clear waste products from the blood while maintaining electrolyte balance. The device, still requiring redesign for technical issues, offers an alternative to conventional hemodialysis, providing greater patient satisfaction and mobility.
A 55-year-old man underwent a combined VCA and double-organ transplant procedure, combining a scalp and skull flap with a kidney and pancreas transplant from the same donor. The patient experienced excellent outcomes, including good cosmetic appearance of the transplanted scalp.
Research found that smoking increases kidney function decline by 83% in current smokers compared to non-smokers. Smoking also worsens inflammation levels, suggesting a possible mechanism between smoking and kidney function decline.
A simple public health intervention helped prevent many cases of chronic kidney disease (CKD) in Pakistan by training community health workers and general practitioners on healthy lifestyle advice. After 7 years, individuals with the combined intervention had preserved kidney function, while those who received usual care experienced a ...
A targeted screening program in Canada identified a high proportion of individuals with risk factors for chronic kidney disease and many with unrecognized CKD. The See Kidney Disease (SeeKD) program successfully promoted good kidney health and provided early detection of CKD, emphasizing the importance of targeted screening.
Researchers found a sustained high prevalence of urinary tract stones, with an increased trend to treat patients with surgery. Surgical intervention for ureter or kidney stones rose from 12,062 to 18,055 cases over the study period.
Researchers have identified a 'weekend effect' contributing to the decline in donor kidney availability in the US. Organs procured on Fridays and Saturdays were more likely to be discarded than those during weekdays, with higher quality kidneys also being thrown away at a greater rate.
A recent study found that junk food diets can cause significant damage to the kidneys, similar to type 2 diabetes. The research used animal models and found that certain glucose transporters were present in higher numbers in rats with type 2 diabetes, but also increased after consuming high-fat or junk food diets.
A new study from Intermountain Medical Center Heart Institute found that atrial fibrillation patients taking warfarin require proper management to prevent kidney failure. The study showed that patients with low anticoagulation levels were at risk of developing kidney dysfunction and failure.
A new device called AVERT significantly reduced the volume of radiographic dye used in patients at risk of developing acute kidney injury (AKI) during coronary angiography and PCI, but did not reduce contrast-induced AKI. The study found a 15.5% relative reduction in CMV for all patients and a 22.8% reduction for PCI patients.
Research analyzed newspaper articles from 2010 to 2015, finding that social embarrassment due to gout was reported in 23.7% of articles and jokes about gout were featured in 26.3%. Effective medication was underemphasized compared to dietary solutions. The study highlights the potential consequences of stigmatizing people with gout.
The new technique could lead to more precise dosing of drugs in intensive care units, where up to two-thirds of patients experience serious kidney injury. By simulating the flow of medication through human kidneys, researchers can test medications and determine safe doses more accurately.
Ricardo Sosa, a University of Houston student, has been awarded a National Science Foundation Graduate Research Fellowship to continue his research on kidney stones. He will study how organic modifiers affect kidney stone growth, potentially leading to new treatments or prevention methods.
Researchers found that female reproductive hormone cycles are associated with transient increases in enzymes indicative of kidney health. This suggests that women may have an increased resistance to kidney damage due to cyclical changes in sex hormone levels.
Research in female mice reveals estrogen's protective effects against renal ischemia, leading to improved survival rates and lower kidney injury. Human kidney transplant outcomes also show greater failure rates in male recipients compared to females.
A new study by Penn researchers found that female mice experience less renal ischemia reperfusion injury compared to male mice, suggesting a potential benefit of estrogen treatment. Human data also supports this finding, with female recipients experiencing less delayed graft function after kidney transplantation.
A new study from Mayo Clinic found that patients with high and low levels of donor-specific alloantibodies who received simultaneous liver-kidney transplants showed a lower incidence of cellular and antibody-mediated rejection, chronic injury to the kidney, and better overall kidney function compared to those who received a kidney tran...
Research finds that proton pump inhibitors, widely used for heartburn and ulcers, can lead to kidney function decline, chronic kidney disease, and kidney failure. Long-term use of these medications significantly increases the risk of developing kidney problems.
Patients with severe kidney stones admitted on weekends are 26% less likely to receive timely treatment, with nearly three times higher mortality rates compared to those treated early.
A multi-disciplinary team of researchers has identified a pivotal role for sphingomyelin in driving inflammatory mechanisms underlying type 1 diabetes and obesity-related kidney dysfunction. This study provides new insights into the underlying mechanisms of diabetic kidney disease and may lead to the development of novel treatments.
A study found that kidneys possess an innate circadian clock regulating various functions, including urine formation and excretion, which adapt to daily light-dark cycles. This internal clock also influences the levels of amino acids and lipids in the blood and affects drug elimination in individuals taking medications.
A new study found that achieving ideal cardiovascular health factors, such as healthy blood pressure and cholesterol, is associated with a reduced risk of new-onset kidney disease. The study included 14,832 adults aged 45-64 and followed them for an average of 22 years to develop chronic kidney disease.
A study published in the Journal of the American College of Cardiology found that US prediction models for kidney injury after angioplasty performed well in Japan, predicting acute kidney injury and dialysis with high accuracy. The models have potential for clinical decision-making worldwide.
A recent study found that an investigational drug called CMX-2043 showed no improved protection for the kidneys of patients undergoing angiograms. The trial, which recruited over 300 patients, tested four different doses of the drug to prevent contrast-induced kidney injury.
A new thematic issue of The Open Urology & Nephrology Journal reports on the association between hyperuricemia and kidney disease. Chronic inflammation is a common link between the two conditions, with research exploring its role in uric acid excretion and progression of renal disease.
Researchers found that inhibiting Wnt secretion can prevent the build-up of scar tissue in kidneys and protect against renal fibrosis. This suggests a novel therapeutic approach to treating kidney disease.
A study of 10,533 kidney transplant recipients found that nearly half visited an emergency department within 2 years, with younger age, female patients, and public insurance being significant risk factors. The findings highlight the need for coordinated care for this vulnerable patient population.
A survey of US citizens found that many are willing to donate a kidney, with 68% open to donating to anyone and 59% motivated by $50,000 payment. The study suggests compensating living kidney donors could alleviate the organ shortage.
Researchers found that SIX1 plays a more substantial role in human kidney development than previously thought, remaining present beyond the initial branching of the kidney. This discovery may help better understand normal development and pediatric kidney cancer, Wilms' tumor.
Researchers at MUSC report findings on the mechanisms underlying impaired ciliogenesis and abnormal kidney development characteristic of PKD. Depletion of dynamin-binding protein or Tuba disrupts renal ciliogenesis, leading to uncontrolled production of cysts.
Researchers at The University of Nottingham are developing Sodium MRI technology to provide more detailed tissue health and disease information. The technique uses naturally occurring sodium ions, which can offer greater clarity than current hydrogen-based MRI scans.
A recent study published in Nature has discovered that mitochondria play a key role in kidney injury, with the gene PGC1 alpha providing protection through NAD. The study suggests that manipulating NAD levels could lead to new therapies for acute kidney injury.
Researchers found that a lower-than-standard dose of calcineurin inhibitors (CNIs) results in better clinical outcomes for kidney transplant recipients. The study analyzed 88 randomized controlled trials and found that CNI minimization had the best long-term impact on renal function.
Researchers found that acute and chronic kidney rejection are different parts of the same immune rejection process, making it a single entity at the molecular level. They identified interstitial fibrosis and tubular atrophy as an early warning sign of active but 'silent' rejection.
A new study published in Antimicrobial Agents and Chemotherapy found that patients taking oxacillin had lower rates of potassium imbalances and kidney damage compared to those on nafcillin. Oxacillin was also associated with fewer treatment discontinuations, highlighting its potential as a safer alternative.
A new survey found significant country-to-country differences in kidney transplant donation rates, varying by up to 35 donors per million population. The variation is attributed to different legal and social standards across Europe, with some countries having more generous organ donation schemes than others.
Researchers have discovered cells in the urine of preterm infants that can differentiate into mature kidney cells and provide protection against cell death. These cells could potentially be used as a treatment to regenerate damaged kidneys and improve outcomes for patients with kidney disease.
A study published in JAMA found that high-dose statin treatment before and after cardiac surgery did not reduce the risk of acute kidney injury, contradicting previous studies. The research suggests that patients undergoing cardiac surgery may be at increased risk of AKI if taking statins.
A study of 1492 patients with chronic kidney disease found that nearly 28% had masked hypertension, which increases the risk of kidney, heart, and vascular damage. Measuring blood pressure outside the clinic is recommended to assess patients' risks for hypertension-related health problems.
A new study by Mayo Clinic reveals that only one-third of patients receive preemptive or early living donor kidney transplants, despite research suggesting improved patient outcomes. The study highlights the need for education and access to information about living donor kidney transplantation to improve long-term outcomes.
A new study reveals reduced racial disparities in kidney transplant outcomes between black and white recipients over the past 2 decades. The findings show improved organ survival rates for black patients, including those who received live donor or deceased donor kidney transplants.