Articles tagged with Kidney
A study found that most donors and recipients support sharing health information, but not social details. The transplant team should be involved in the discussion, according to both parties.
Janos Peti-Peterdi, a USC kidney researcher, has made significant advances in visualizing the function of the living kidney's filter and studying kidney stem cells. He aims to find new treatments and therapies for patients with chronic kidney disease.
A study found that only about one in four patients with end-stage renal disease in Georgia were referred for kidney transplant evaluation within a year of starting dialysis. The study suggests that standardized guidelines are needed to improve access to kidney transplantation.
Research reveals a strong link between kidney impairment and decreased blood flow to the brain, increasing the risk of stroke and dementia. Poor kidney function was strongly related to decreased blood flow to the brain, with the strongest association seen in participants with decreased blood flow.
Scientists at University of Texas MD Anderson Cancer Center identified EMT as a potential therapeutic target for reversing kidney disease and fibrosis. The study showed that inhibiting EMT in tubular epithelial cells can restore their health and function.
Researchers found that TMAO levels increase with advancing severity of kidney disease and are linked to atherosclerosis and premature death. Targeting TMAO generation by intestinal bacteria may be a novel strategy for safeguarding heart health in patients with CKD.
A licensed technology measures anti-HLA antibody secretion from memory B cells, improving kidney transplant efficiency and preventing rejection. Researchers found high-risk patients using this technique, which complements existing antibody measurement methods.
Researchers found that mild hypothermia in deceased organ donors significantly reduces delayed graft function in kidney transplant recipients by nearly 40%. This intervention could lead to an increase in the availability of kidneys for transplant and improve patient outcomes.
Proteins in the Wnt signaling pathway play a critical role in driving kidney scarring, which can lead to chronic kidney disease. Boosting expression of Wnt proteins in healthy kidneys may be an effective strategy for treating chronic kidney disease.
A new study by Houston Methodist researchers finds that artificially added phosphates in dairy and cereal products cause bigger spikes in blood phosphorus levels than natural phosphates. This can lead to increased kidney function problems and heart damage, especially for people with healthy kidneys.
Researchers used iPSC-derived renal progenitors to treat acute kidney injury in mice, showing improved recovery with reduced fibrosis and necrosis. The study's findings suggest that paracrine actions of the cells, rather than integration, led to therapeutic effects.
A new clinical trial found that tamsulosin improves the passage of larger kidney stones, with 83.3% of patients treated with the medication passing their stones compared to 61% on placebo. However, for small kidney stones, time remains the best cure, according to lead author Jeremy Furyk.
Researchers found that postmenopausal women with kidney or bladder stones were not at increased risk for osteoporosis, contrary to previous findings in men. Women with a urinary tract stone were more likely to develop a second stone, however.
Researchers identified a cellular signal causing kidney cells to die, leading to increased risk of acute kidney injuries. The study found that lack of alpha(E)-catenin protein contributes to this process.
Researchers developed targeted therapy using immunoglobulin-A antibodies to neutralize specific receptors in polycystic kidneys. The strategy enables repurposing of existing monoclonal antibodies for PKD therapy, opening up new class of therapeutics.
A new US study reveals that end-stage kidney disease patients who receive specialized care have significantly improved survival rates and access to life-saving treatment. The research highlights the importance of timely referrals to nephrologists in reducing mortality risks, particularly in low-performing regions.
Inflamed kidney cells produce an enzyme that consumes tryptophan, activating a stress response and inducing autophagy to clear damaged protein. The IDO-GCN2 pathway provides natural protection against inflammation-induced kidney damage, offering new potential treatment targets.
Researchers found that mortality rates vary significantly according to kidney disease subtype, suggesting that treatment plans should be tailored towards disease-specific risks. The study analyzed data from 84,301 patients and showed significant differences in survival rates among those with different subtypes of glomerulonephritis.
A new study found that people allocate medical resources equally across groups, but make more efficient decisions when presented with individual patient information. This bias towards equality can lead to suboptimal allocation decisions, but may also have positive outcomes in certain contexts.
Children with lower vitamin D levels had higher blood markers related to kidney dysfunction and greater kidney function loss over time. Maintaining normal vitamin D levels helps preserve kidney function in children with CKD.
A Phase II clinical trial presented promising results for baricitinib in people with diabetic kidney disease, reducing a key sign of kidney damage and inflammation. The trial's success demonstrates the potential of precision medicine in treating this common yet devastating condition affecting millions of Americans.
Researchers have discovered a new treatment approach targeting tiny blood and lymphatic vessels inside the kidneys, which improves renal function and slows disease progression in mice. This innovative therapy may offer hope for patients with polycystic kidney disease, particularly those with rare forms of the condition.
New research reveals zinc may be the core of stone formation in kidneys, with changes in oxalate levels tracking dietary zinc intake. The findings suggest that understanding zinc's role in preventing kidney stones could lead to new preventive and therapeutic approaches.
Researchers at Wake Forest Baptist Medical Center have made progress in recycling human kidneys for transplantation. The team successfully preserved the micro-vessels and growth factors within discarded kidneys, paving the way for tailor-made replacement kidneys.
Simple measures of kidney function and damage may be better than traditional tests in predicting heart failure, death from heart attack, and stroke. Researchers found that indicators of kidney function and damage outperformed cholesterol levels and systolic blood pressure as risk factors for cardiovascular disease.
Researchers have developed a new, non-invasive method to diagnose kidney disease using an optical probe and Raman spectroscopy. The technique allows for the detection of subtle molecular changes in kidney tissue, enabling accurate differentiation between healthy and diseased kidneys.
Researchers have discovered a key driver of kidney growth in response to losing a single organ, highlighting the importance of protein synthesis and mTORC1 activation. By understanding this mechanism, they hope to develop new strategies for preserving kidney function in patients with a single functioning kidney.
A new study published in The Lancet reveals that ACE inhibitors and angiotensin-receptor blockers (ARBs) are the most effective treatments for preventing end-stage kidney disease in adults with diabetes. These medications, used alone or in combination, have been shown to protect kidney function in the long term.
Duke University researchers identified physiological changes affecting patients with acute kidney injury during sepsis treatment, potentially improving patient survival rates after kidney failure. The study showed that kidney function is a critical determinant of how patients respond to treatment.
A new study reveals that severe kidney injury during pregnancy is rare, but affects otherwise healthy women who acquire a major complication. Babies born to mothers with severe kidney injury are at increased risk of low birth weight or premature birth.
A study explores the quality of organs from HIV-positive donors for potential transplant use in the US, finding that donor kidneys may be of reduced quality. The study suggests nearly 400 potential organ donors might be available annually, but long-term viability and hepatitis C virus infection could impact organ health.
A study published in the American Journal of Transplantation found that there are nearly 400 HIV-positive potential organ donors in the US who could provide life-saving organs for HIV-positive patients. The study estimates that these donors could reduce the waiting time for transplants, but the quality of their organs is a concern.
Researchers analyzed over 1.3 million patient records to find that mildly abnormal results on kidney function tests are the strongest risk factor for acute kidney injury. Physicians can identify high-risk patients by paying close attention to common blood and urine tests for kidney function, potentially preventing the devastating injury.
A recent study found that dexamethasone can reduce the risk of severe acute kidney injury after cardiac surgery by 2.5 times compared to a placebo. Patients with pre-existing advanced chronic kidney disease showed the greatest benefits from the drug.
Research suggests that nitrofurantoin is less effective at treating bladder infections in older women with low kidney function compared to other antibiotics. The study found that patients taking nitrofurantoin were more likely to experience treatment failure and require a second antibiotic prescription or hospital visit.
A study in Australia found that the public generally favors eliminating disincentives for living kidney donors, but is opposed to providing financial incentives. Many participants believed reimbursement and justifiable recompensation were acceptable ways to support living donors.
Scientists at the University of Manchester have made a groundbreaking discovery that could lead to an early test for kidney disease. They found significant differences in protein composition and structure between mice with different genetic backgrounds and sexes, which may contribute to susceptibility to kidney disease.
A study at Columbia University Medical Center found significant DNA anomalies in 31% of children with CKD, linked to neurocognitive disorders. Routine genetic screening could lead to personalized care and earlier detection of complications like diabetes and seizures.
A new assay developed by researchers can identify novel drug candidates that protect kidney cells from damage, which could lead to the development of new treatments for chronic kidney disease. The system has already identified a small molecule called pyrintegrin that effectively protected rodent kidney cells.
A recent study published in Kidney International found that HIV-positive kidney transplant patients have superior outcomes compared to those with Hepatitis C. The three-year survival rates for HIV patients were similar to those of uninfected patients (90%), while Hepatitis C patients had a lower rate (84%).
Researchers found that transplant outcomes using kidneys from deceased donors with AKI were no different between the AKI and non-AKI groups at both 1 and 3 years post-transplant. The study results suggest that acutely injured kidneys can be considered for transplantation, potentially alleviating the US kidney shortage.
A new study reveals that kidneys from older donors provide a lifetime of kidney function for older patients with shorter life expectancy, while younger patients do not benefit. Rapid transplantation from older donors is superior to delayed transplantation, increasing access to these organs.
A new study found that kidneys from deceased African-American donors with two APOL1 gene renal risk variants failed more rapidly after transplantation. The study suggests that rapid genotyping of these donors at the time of organ recovery may improve transplant outcomes.
Researchers found that a blood test immediately after heart surgery can predict postoperative stroke risk, with elevated BUN levels being the most powerful predictor. This study aims to better assess stroke risk and reduce incidents, disabilities, and expenses.
At least 30 dogs in England have died from a mysterious kidney disease, with evidence found in 15 breeds including English springer spaniel, Labrador retriever and cocker spaniel. The disease is believed to be Alabama rot, which causes skin lesions and kidney failure.
Researchers from MDC have discovered a novel molecular signaling pathway in the kidney that regulates epithelial barrier function and lumen expansion. The Grhl2 transcription factor teams up with Ovol2 to control genes essential for forming an impermeable barrier.
HIV+ kidney transplant recipients who are not infected with HCV have similar 5-year and 10-year kidney survival rates as uninfected recipients. Patient survival among mono-infected HIV+ recipients is also comparable to uninfected recipients, while co-infected patients experience inferior outcomes.
Researchers identified high blood pressure, protein loss, and anemia as predictors of disease worsening in children with mild to moderate CKD. Intervening on these modifiable risk factors may change the long-term course of the disease, preventing kidney failure and delaying dialysis or transplantation.
A protein called MG53 is necessary for the repair of injured kidney cells, according to a study published in Science Translational Medicine. The discovery could lead to new preventive or therapeutic treatments for acute kidney failure, which affects over 30 million Americans.
A team of UK researchers has designed Arterio-Venous Fistulae with reduced failure rates using computational simulation software from the aerospace industry. The new design aims to decrease blockages in dialysis connections, improving clinical outcomes for patients with end-stage renal disease.
Columbia University researchers have identified a unique set of patient-specific T cells that react to donor tissue, increasing in number before rejection but decreasing after acceptance. The study supports combining kidney and bone marrow transplants to reduce organ rejection and potentially eliminate lifelong immunosuppression.
Acute kidney injury affects 13 million people annually and contributes to 1.7 million deaths. Experts believe it can be nearly eliminated in 10 years with current treatments costing $150 per patient. The Lancet Commission proposes a three-pronged strategy to raise awareness, improve diagnosis, and invest in sustainable infrastructure.
A new study reveals that at least 2.3 million people may have died prematurely from kidney failure in 2010 due to lack of access to life-saving treatment. The researchers predict that the number of patients needing dialysis or transplantation will more than double to 5.4 million by 2030.
A recent study published in the Journal of the American Society of Nephrology found that even mild stages of chronic kidney disease during pregnancy can increase risks of preterm delivery, neonatal intensive care, and hypertension. In contrast, risks of intrauterine death or fetal malformations were not significantly higher in women wi...
A Yale-led study found that donated kidneys with acute injury are associated with delayed graft function but not poor long-term transplant outcomes. The research suggests that injured kidneys could be used for transplants, potentially increasing the number of available organs and improving survival rates for patients on dialysis.
A urine test can predict the risk of kidney injury in heart failure patients, allowing clinicians to identify those at high risk and take preventive measures. The study found that urinary angiotensinogen levels can accurately predict acute kidney injury and patient rehospitalization or death within one year.
A Yale University study found that electronic alerts for acute kidney injury did not improve outcomes, despite increasing interventions such as dialysis. The study suggests that the tool was ineffective due to inadequate training of clinicians on its proper use.
A study published in the Journal of the American Society of Nephrology suggests that a diet high in animal proteins, especially red meat, can increase the risk of developing kidney failure in people with chronic kidney disease. Conversely, consuming diets rich in fruits and vegetables may protect kidney function.
A recent study found that patients with advanced kidney disease have been initiating dialysis progressively earlier over time. Despite no measurable differences in patient sickness or reasons for dialysis, the trend suggests a shift towards embracing higher levels of kidney function as acceptable for dialysis initiation.
As of January 1, 2016, Elsevier will publish the flagship journals Kidney International and Kidney International Supplements from the International Society of Nephrology. These journals are highly regarded for their original research in nephrology and kidney disease.