Articles tagged with Kidney
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Children with lower vitamin D levels had higher blood markers related to kidney dysfunction and greater kidney function loss over time. Maintaining normal vitamin D levels helps preserve kidney function in children with CKD.
A Phase II clinical trial presented promising results for baricitinib in people with diabetic kidney disease, reducing a key sign of kidney damage and inflammation. The trial's success demonstrates the potential of precision medicine in treating this common yet devastating condition affecting millions of Americans.
Researchers have discovered a new treatment approach targeting tiny blood and lymphatic vessels inside the kidneys, which improves renal function and slows disease progression in mice. This innovative therapy may offer hope for patients with polycystic kidney disease, particularly those with rare forms of the condition.
Researchers at Wake Forest Baptist Medical Center have made progress in recycling human kidneys for transplantation. The team successfully preserved the micro-vessels and growth factors within discarded kidneys, paving the way for tailor-made replacement kidneys.
New research reveals zinc may be the core of stone formation in kidneys, with changes in oxalate levels tracking dietary zinc intake. The findings suggest that understanding zinc's role in preventing kidney stones could lead to new preventive and therapeutic approaches.
Simple measures of kidney function and damage may be better than traditional tests in predicting heart failure, death from heart attack, and stroke. Researchers found that indicators of kidney function and damage outperformed cholesterol levels and systolic blood pressure as risk factors for cardiovascular disease.
Researchers have developed a new, non-invasive method to diagnose kidney disease using an optical probe and Raman spectroscopy. The technique allows for the detection of subtle molecular changes in kidney tissue, enabling accurate differentiation between healthy and diseased kidneys.
Researchers have discovered a key driver of kidney growth in response to losing a single organ, highlighting the importance of protein synthesis and mTORC1 activation. By understanding this mechanism, they hope to develop new strategies for preserving kidney function in patients with a single functioning kidney.
A new study published in The Lancet reveals that ACE inhibitors and angiotensin-receptor blockers (ARBs) are the most effective treatments for preventing end-stage kidney disease in adults with diabetes. These medications, used alone or in combination, have been shown to protect kidney function in the long term.
Duke University researchers identified physiological changes affecting patients with acute kidney injury during sepsis treatment, potentially improving patient survival rates after kidney failure. The study showed that kidney function is a critical determinant of how patients respond to treatment.
A study explores the quality of organs from HIV-positive donors for potential transplant use in the US, finding that donor kidneys may be of reduced quality. The study suggests nearly 400 potential organ donors might be available annually, but long-term viability and hepatitis C virus infection could impact organ health.
A study published in the American Journal of Transplantation found that there are nearly 400 HIV-positive potential organ donors in the US who could provide life-saving organs for HIV-positive patients. The study estimates that these donors could reduce the waiting time for transplants, but the quality of their organs is a concern.
A new study reveals that severe kidney injury during pregnancy is rare, but affects otherwise healthy women who acquire a major complication. Babies born to mothers with severe kidney injury are at increased risk of low birth weight or premature birth.
Researchers analyzed over 1.3 million patient records to find that mildly abnormal results on kidney function tests are the strongest risk factor for acute kidney injury. Physicians can identify high-risk patients by paying close attention to common blood and urine tests for kidney function, potentially preventing the devastating injury.
A recent study found that dexamethasone can reduce the risk of severe acute kidney injury after cardiac surgery by 2.5 times compared to a placebo. Patients with pre-existing advanced chronic kidney disease showed the greatest benefits from the drug.
Research suggests that nitrofurantoin is less effective at treating bladder infections in older women with low kidney function compared to other antibiotics. The study found that patients taking nitrofurantoin were more likely to experience treatment failure and require a second antibiotic prescription or hospital visit.
A study in Australia found that the public generally favors eliminating disincentives for living kidney donors, but is opposed to providing financial incentives. Many participants believed reimbursement and justifiable recompensation were acceptable ways to support living donors.
Scientists at the University of Manchester have made a groundbreaking discovery that could lead to an early test for kidney disease. They found significant differences in protein composition and structure between mice with different genetic backgrounds and sexes, which may contribute to susceptibility to kidney disease.
A study at Columbia University Medical Center found significant DNA anomalies in 31% of children with CKD, linked to neurocognitive disorders. Routine genetic screening could lead to personalized care and earlier detection of complications like diabetes and seizures.
A new assay developed by researchers can identify novel drug candidates that protect kidney cells from damage, which could lead to the development of new treatments for chronic kidney disease. The system has already identified a small molecule called pyrintegrin that effectively protected rodent kidney cells.
Researchers found that transplant outcomes using kidneys from deceased donors with AKI were no different between the AKI and non-AKI groups at both 1 and 3 years post-transplant. The study results suggest that acutely injured kidneys can be considered for transplantation, potentially alleviating the US kidney shortage.
A recent study published in Kidney International found that HIV-positive kidney transplant patients have superior outcomes compared to those with Hepatitis C. The three-year survival rates for HIV patients were similar to those of uninfected patients (90%), while Hepatitis C patients had a lower rate (84%).
A new study reveals that kidneys from older donors provide a lifetime of kidney function for older patients with shorter life expectancy, while younger patients do not benefit. Rapid transplantation from older donors is superior to delayed transplantation, increasing access to these organs.
A new study found that kidneys from deceased African-American donors with two APOL1 gene renal risk variants failed more rapidly after transplantation. The study suggests that rapid genotyping of these donors at the time of organ recovery may improve transplant outcomes.
At least 30 dogs in England have died from a mysterious kidney disease, with evidence found in 15 breeds including English springer spaniel, Labrador retriever and cocker spaniel. The disease is believed to be Alabama rot, which causes skin lesions and kidney failure.
Researchers found that a blood test immediately after heart surgery can predict postoperative stroke risk, with elevated BUN levels being the most powerful predictor. This study aims to better assess stroke risk and reduce incidents, disabilities, and expenses.
Researchers identified high blood pressure, protein loss, and anemia as predictors of disease worsening in children with mild to moderate CKD. Intervening on these modifiable risk factors may change the long-term course of the disease, preventing kidney failure and delaying dialysis or transplantation.
Researchers from MDC have discovered a novel molecular signaling pathway in the kidney that regulates epithelial barrier function and lumen expansion. The Grhl2 transcription factor teams up with Ovol2 to control genes essential for forming an impermeable barrier.
HIV+ kidney transplant recipients who are not infected with HCV have similar 5-year and 10-year kidney survival rates as uninfected recipients. Patient survival among mono-infected HIV+ recipients is also comparable to uninfected recipients, while co-infected patients experience inferior outcomes.
A protein called MG53 is necessary for the repair of injured kidney cells, according to a study published in Science Translational Medicine. The discovery could lead to new preventive or therapeutic treatments for acute kidney failure, which affects over 30 million Americans.
A team of UK researchers has designed Arterio-Venous Fistulae with reduced failure rates using computational simulation software from the aerospace industry. The new design aims to decrease blockages in dialysis connections, improving clinical outcomes for patients with end-stage renal disease.
Columbia University researchers have identified a unique set of patient-specific T cells that react to donor tissue, increasing in number before rejection but decreasing after acceptance. The study supports combining kidney and bone marrow transplants to reduce organ rejection and potentially eliminate lifelong immunosuppression.
Acute kidney injury affects 13 million people annually and contributes to 1.7 million deaths. Experts believe it can be nearly eliminated in 10 years with current treatments costing $150 per patient. The Lancet Commission proposes a three-pronged strategy to raise awareness, improve diagnosis, and invest in sustainable infrastructure.
A new study reveals that at least 2.3 million people may have died prematurely from kidney failure in 2010 due to lack of access to life-saving treatment. The researchers predict that the number of patients needing dialysis or transplantation will more than double to 5.4 million by 2030.
A recent study published in the Journal of the American Society of Nephrology found that even mild stages of chronic kidney disease during pregnancy can increase risks of preterm delivery, neonatal intensive care, and hypertension. In contrast, risks of intrauterine death or fetal malformations were not significantly higher in women wi...
A Yale-led study found that donated kidneys with acute injury are associated with delayed graft function but not poor long-term transplant outcomes. The research suggests that injured kidneys could be used for transplants, potentially increasing the number of available organs and improving survival rates for patients on dialysis.
A urine test can predict the risk of kidney injury in heart failure patients, allowing clinicians to identify those at high risk and take preventive measures. The study found that urinary angiotensinogen levels can accurately predict acute kidney injury and patient rehospitalization or death within one year.
A Yale University study found that electronic alerts for acute kidney injury did not improve outcomes, despite increasing interventions such as dialysis. The study suggests that the tool was ineffective due to inadequate training of clinicians on its proper use.
A study published in the Journal of the American Society of Nephrology suggests that a diet high in animal proteins, especially red meat, can increase the risk of developing kidney failure in people with chronic kidney disease. Conversely, consuming diets rich in fruits and vegetables may protect kidney function.
A recent study found that patients with advanced kidney disease have been initiating dialysis progressively earlier over time. Despite no measurable differences in patient sickness or reasons for dialysis, the trend suggests a shift towards embracing higher levels of kidney function as acceptable for dialysis initiation.
As of January 1, 2016, Elsevier will publish the flagship journals Kidney International and Kidney International Supplements from the International Society of Nephrology. These journals are highly regarded for their original research in nephrology and kidney disease.
A new study has discovered how the enzyme heme oxygenase-1 (HO-1) regulates immune cells in response to kidney injury. The research found that HO-1 directs a specific subset of myeloid cells to and from the kidney, which helps protect against poor recovery after acute kidney injury.
Patients with chronic kidney disease who consume high acid diets are 3-times more likely to develop kidney failure than those on low acid diets. A diet rich in fruits and vegetables can help protect kidneys.
A simple test using furosemide and urine output can predict which patients with acute kidney injury (AKI) are at risk of developing serious kidney problems. The Furosemide Stress Test (FST) improved predictions of outcomes in patients with early AKI, paving the way for robust clinical diagnostic tools.
A new BU study finds a decline in kidney function among Nicaraguan sugarcane workers, suggesting heat stress and dehydration may play a role in the high rates of chronic kidney disease. The research team recruited 284 workers performing different tasks and found that those with longer employment duration had worse kidney function.
A recent study found that women with kidney transplants in childhood and adulthood have comparable live birth rates, premature birth rates, and small-for-gestational-age babies. The findings suggest that early onset of kidney failure and longer periods of immunosuppression do not negatively impact pregnancy outcomes.
A new review highlights techniques to provide optimal dosing recommendations for patients with kidney disease. Mathematical modeling tools can help analyze clinical program level data to inform dosing decisions.
A study found that people with recurrent kidney stones have more calcification in their arteries, increasing their risk for heart disease. Additionally, kidney stone formers tend to have less dense bones, elevating their risk for osteoporosis.
A study found that high-salt intake accelerates kidney scarring in rats with chronic kidney disease by activating the brain-kidney connection called the renin-angiotensin axis. Targeting this nerve reduced salt-induced kidney scarring, providing new strategies for protecting patients' kidney health.
Researchers discovered that babies born with smaller kidneys are more likely to develop chronic kidney disease and high blood pressure as adults. The study found enhanced nerve activity and an inability to respond to nitric oxide promote kidney injury.
High-dose atorvastatin therapy has been linked to reduced blood levels of creatinine and lower incidence of acute kidney injury in heart surgery patients. This finding comes from an analysis of 14 randomized controlled clinical trials involving 1689 patients.
A UK hospital performed the world's first successful organ donation from a newborn, involving kidney and liver cell transplants. The donor was just over 3 kg at birth and had poor brain oxygenation, leading to her death; however, her parents agreed to donate her organs for other patients in need.
A Pitt study links biomarkers to long-term kidney damage and death in critically ill, highlighting the importance of early intervention. Researchers found that tissue inhibitor metalloproteinase-2 (TIMP-2) and IGF-binding protein-7 (IGFBP7) can identify patients at increased risk for adverse outcomes.
A study by Penn Medicine found that many patients with type 2 diabetes are being discouraged from taking metformin due to an overly conservative FDA label. The authors recommend amending the label to reflect more modern guidelines, which could extend the drug's use to nearly 1 million additional patients.
Researchers at University of Cincinnati discover a new drug therapy that effectively lowers antibodies in kidney patients, paving the way for more successful kidney transplants. The study suggests this approach could benefit up to 10-20% of heart and pancreas transplant candidates who are currently ineligible due to high antibody levels.
A systematic review of the literature suggests that metformin is safe for patients with mild to moderate kidney disease, contrary to FDA guidelines. The risk of lactic acidosis is extremely low and comparable to those who do not take metformin.
A Johns Hopkins Children's Center study found that high-dose IV infusions of the antibiotic vancomycin to treat drug-resistant bacterial infections can cause an increased risk for kidney damage in hospitalized children. The researchers emphasize the need for careful dosing and monitoring of kidney function in pediatric patients.
A recent study published in the Journal of the American Society of Nephrology found that older kidney donors with hypertension had good kidney health after donation. After 6 months, hypertensive and non-hypertensive donors both maintained excellent blood pressure control and robust compensatory kidney responses.
A study by University of Houston researchers suggests that activating intrinsic antioxidant pathways, such as Nrf2, could protect the kidney dopamine system and maintain normal blood pressure. The study's findings have significant implications for understanding and treating hypertension and other diseases related to oxidative stress.
A genetic marker in the SHROOM3 gene has been found to be associated with increased fibrosis and function loss in kidney transplants. Researchers hope this discovery will lead to improved screening of potential donors and development of new drugs to prevent disease progression.