Articles tagged with Kidney
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A US policy giving priority to prior organ donors has been shown to significantly reduce waiting times and improve the quality of organs received. Living donors who later need a transplant experience much shorter waits and receive higher-quality kidneys compared to those on the waiting list without donation history.
A study found that living kidney donors are at a higher risk of gestational hypertension and preeclampsia during pregnancy. Despite this, most women who become pregnant after donating a kidney have healthy pregnancies.
A study found that 80% of kidney dialysis patients were not adequately prepared for emergencies or natural disasters. However, after receiving individualized education from a multidisciplinary team, 78% of these patients became adequately prepared, according to a Loyola University Medical Center study. The educational sessions made a s...
Researchers developed a genetic test that can predict acute rejection up to three months in advance. The non-invasive test measures gene expression levels and can identify patients at high risk of rejection, allowing for tailored immunosuppressive therapy.
Researchers have identified a second protein, THSD7A, associated with membranous nephropathy, a common cause of kidney failure. This finding allows for the development of a new blood test to diagnose and monitor the disease, providing additional tools for clinicians to follow treatment response.
Researchers at the University of Cincinnati have discovered a gene in the kidneys that may contribute to high blood pressure in males. The study, led by Manoocher Soleimani, found that mice with a deficiency in this gene had significantly reduced blood pressure, suggesting its role in regulating salt absorption in the kidney tubule.
Researchers have identified a new protein, THSD7A, that turns the immune system against itself in kidney disease called membranous nephropathy (MN). This discovery enables the development of a blood test to diagnose MN, which can reduce the need for kidney biopsies by up to 85%.
Researchers discovered that fondaparinux, an anticoagulant, can protect transplanted kidneys from damage. Improved kidney function was observed both immediately after transplantation and months later, suggesting this strategy could augment the pool of available organs.
A study found that perceived racial discrimination may contribute to disparities in kidney disease by increasing stress-related pathways. Among African Americans and whites, those who experienced 'a lot' of discrimination had higher systolic blood pressure but a lower prevalence of diabetes.
A recent study published in JAMA found that taking aspirin or clonidine before and after surgery did not lower the risk of acute kidney injury. The study involved over 6,900 patients and showed that major bleeding with aspirin increased AKI risk, while low blood pressure with clonidine had a similar effect.
Researchers found that peritoneal dialysis and high-frequency home hemodialysis can significantly reduce mortality risks. Patients receiving these treatments had 10-26% lower mortality rates than those with standard in-center hemodialysis.
Studies found significant disparities in access to pre-ESRD kidney care across the US, with certain geographic areas and racial groups receiving lower quality care. Disparities were more pronounced among black patients, who had a 10% to 54% lower odds of receiving care from a kidney specialist.
Studies found that a higher-quality diet reduces the risk of needing dialysis or dying from kidney problems by 16-23%. High potassium intake also shows promise in reducing future risk. Dietary modifications are considered a low-cost and simple intervention to reduce chronic kidney disease burden.
Researchers found that using two drugs was no more effective than a single drug in slowing disease progression in people with autosomal dominant polycystic kidney disease (ADPKD). However, rigorous blood pressure treatment did slow the growth of kidney cysts and preserve kidney function.
Recent high-impact clinical trials have yielded promising results in the fight against kidney disease, with several treatments showing significant benefits in reducing the risk of end-stage kidney disease. For example, intensive glucose control has been shown to lead to long-term reductions in the risk of developing end-stage kidney di...
A recent study has found a strong association between air pollution and the development of chronic kidney disease. The research, which analyzed data from over 1.1 million people in the US, revealed that even low levels of particulate matter can increase the risk of CKD.
A study found that sodium-reduced meat and poultry products contain significantly higher levels of potassium due to additives. This can pose a risk for patients with kidney disease who require low phosphorus and potassium diets.
A 3-month course of levofloxacin following kidney transplantation did not prevent BK virus from appearing in the urine, according to a study. The intervention was associated with increased risk of adverse events like bacterial resistance.
Late-breaking clinical studies presented at ASN Kidney Week 2014 highlight significant advances in kidney care, including the reduction of disparities in transplant referrals through a community-based intervention. Additionally, new treatments for End-Stage Renal Disease (ESRD) have shown promising results, such as ferric citrate's abi...
Exercise training slows kidney function decline and improves cardio-respiratory fitness in patients with progressive stages 3–4 CKD. A personalized, low-intensity home exercise program also improves physical performance in dialysis patients.
For the first time, clinicians have successfully provided hemodialysis to a patient with Ebola virus disease, resulting in recovery of kidney function. The protocol involved careful measures to maximize safety and minimize risk of secondary transmission, demonstrating that renal replacement therapies can be provided safely.
A study found that sleep apnea is associated with more rapid loss of renal function in patients with diabetic nephropathy. Researchers identified high-risk scores for obstructive sleep apnea, which were common in non-dialysis CKD patients and linked to decreased kidney function.
Two new studies suggest that smartphones can be a key tool in improving medication adherence among teens and young adults with chronic conditions. Researchers found that patients who used cell phones for reminders were more likely to have 100% self-reported medication adherence, while those involved in a dedicated Young Adult Service h...
A new study from the University of East Anglia finds that a single high level of lithium can cause significant decrease in kidney function, which remains affected for up to nine months. The research emphasizes the importance of regular monitoring, supporting current UK guidelines.
A study found that 55% of the US population is not eligible to donate a kidney due to preventable health conditions such as hypertension, obesity, and diabetes. The majority of individuals with lower incomes are less likely to donate due to financial difficulties and immigration status.
A study found that weight loss after bariatric surgery is associated with increased kidney function and decreased albuminuria, a marker of kidney dysfunction. This suggests a beneficial impact on kidney health for patients with and without baseline kidney disease.
A study of 699 African American adults found that those with severe periodontal disease developed chronic kidney disease at a rate 4 times higher than those without. Targeting periodontal disease may be an important path towards reducing disparities in chronic and end-stage kidney disease.
A new multi-center study has confirmed that specific gene variants in African American kidney donors are associated with a higher risk of organ failure after transplantation. The findings suggest that rapidly genotyping deceased donors for these variants could help inform organ allocation and consent processes.
A study found that 26.3% of dialysis patients missed sessions after Hurricane Sandy, while 95% were interested in learning about emergency preparedness. Another study showed a positive effect of distributing an 'emergency information packet' to patients.
A new study published in PLOS Medicine has developed a 17-gene set to analyze peripheral blood samples and determine which patients are at risk of acute rejection after kidney transplantation. The test, called kSORT, was found to be highly accurate and clinically applicable, with an area under the curve of 0.93.
Lori O'Brien, a USC postdoctoral research associate, has received the first Broad Fellowship to investigate how epigenetic regulation affects kidney stem cells. The fellowship will support her research on Phf19, an epigenetic regulator that encourages embryonic stem cell self-renewal.
A study found that an endothelin-A antagonist can enhance renal recovery in patients with renovascular disease. The medication, already used for pulmonary hypertension, promotes kidney function and improves responses after renal angioplasty.
A study found that maternal obesity increases the risk of congenital abnormalities of the kidney and urinary tract in children. Being overweight was not linked with an increased risk. The research highlights the importance of addressing obesity as a public health concern.
The American College of Physicians recommends increasing fluid intake to at least two liters per day to prevent kidney stone recurrence. A new guideline also suggests dietary changes, including reducing oxalate and animal protein consumption, to help prevent stone formation. Sofosbuvir plus ledipasvir has shown promise in re-treating H...
The American College of Physicians recommends increasing daily fluid intake to at least two liters to reduce kidney stone recurrence. Additionally, medication with a thiazide diuretic, citrate, or allopurinol can effectively reduce stone recurrence in patients with calcium stones.
A new study published in the American Journal of Transplantation found that frailty significantly increases the risk of premature death in kidney transplant recipients. The study analyzed data from 537 patients and found that those who were classified as frail had a mortality rate twice that of non-frail patients.
A Mediterranean-style diet is associated with a 17% decreased likelihood of developing chronic kidney disease, while dietary patterns resembling the diet reduce risk by 50%. More than 20 million US adults have chronic kidney disease.
A recent study found that home blood pressure monitors can be inaccurate, with systolic readings off by as much as 5mm Hg and diastolic readings off by as much as 10mm Hg in up to 30% of patients. The American Society of Nephrology recommends that all patients with home monitors get them validated with their healthcare providers.
A study of 51,785 individuals with kidney stones found a significant link between the condition and an increased risk of bone fractures. The excess risk was greatest in males during adolescence and women during middle age.
A blood test can help doctors predict which patients with an autoimmune disease are at risk of relapse, potentially preventing kidney failure. Researchers found that autoantibody increases were linked to an 11-fold increased risk of relapse in patients with kidney involvement.
A new blood test has been identified as a potential predictor for focal segmental glomerulosclerosis (FSGS), a devastating form of kidney disease. The test, called FAST, uses high-density protein tests to detect antibodies against specific antigens that are significantly increased in patients at risk for FSGS.
A study of over 600 patients with acute kidney injury after cardiac surgery found that fenoldopam did not decrease the need for dialysis or mortality rates. Instead, it was associated with a higher incidence of low blood pressure.
Kidney transplant recipients infected with BK virus are more likely to develop donor-specific antibodies, which can lead to organ rejection. The study found a significant association between persistent BK infections and the development of these detrimental antibodies.
A new study published in the New England Journal of Medicine found that CT scans are no more accurate than ultrasound exams in diagnosing painful kidney stones. The study suggests that ultrasound should be used as the first step in diagnosis, avoiding unnecessary radiation exposure.
Researchers developed a math model that can predict the progression from nephritis to interstitial fibrosis in lupus patients. The model can also gauge the effectiveness of experimental treatments for inflammation and fibrosis, reducing the need for invasive biopsies.
Researchers at Wake Forest Baptist Medical Center developed a new method to coat blood vessels in lab-grown kidneys, allowing them to remain open for four hours. The breakthrough could potentially be applied to other complex organs, such as the liver and pancreas.
A study finds that older adults, women, and less educated individuals have more concerns about kidney transplantation. These concerns can lead to lower chances of getting listed for a transplant. The study aims to address these barriers to improve access to transplantation.
A large-scale study found that iodine-based contrast material used in CT scans is not linked to kidney damage or death in most patients. The research, conducted at the Mayo Clinic, analyzed data from over 21,000 patients and showed no significant difference in adverse events between those who received contrast and those who did not.
Researchers at Wake Forest Baptist Medical Center have developed a successful method to keep blood vessels in lab-built kidneys open and flowing, overcoming a major challenge in the quest for human transplants. The new approach has shown promise in keeping vessels open for four hours, paving the way for longer-term studies.
A recent study published in Journal of the American Society of Nephrology found that CKD patients who experience multiple heart failure hospitalizations are at a higher risk of developing kidney failure. The study's findings suggest that coordinated care between specialists is crucial in managing these patients.
A study of dialysis patients found that clinicians' reported discussions about transplantation did not increase patients' likelihood of being listed, despite patient-reported discussions being associated with a nearly 3-fold increased chance. The findings suggest the need for improved patient communication and informed consent.
Renal artery stenting may benefit patients with kidney artery blockages who were excluded from clinical trials. Expert panel recommendations suggest patients with cardiac disturbance or severe high blood pressure are good candidates for the procedure, while others may not be suitable due to mild or moderate blockages.
Using Extracorporeal Membrane Oxygenation (ECMO) has increased the number of organs available for transplant after circulatory death by 20%. This technology improves organ viability, particularly for kidneys, livers, and pancreases, making more life-saving organs available for patients waiting for transplants.
Researchers at Washington University School of Medicine have identified a potential new class of drugs, histone deacetylase inhibitors, that can dissolve kidney stones by reducing calcium and magnesium levels in the urine. The study shows promising results using small doses of two specific drugs, Vorinostat and trichostatin A.
A recent study found that black women are less likely to want to receive kidney transplants from living donors, despite receiving more unsolicited offers from family and friends. Women were also less likely to be evaluated for a transplant, highlighting the need for targeted interventions to alleviate existing disparities.
Ashley Anh Vo, a transplant pharmacist at Cedars-Sinai, received the 2014 Clinician of Distinction award for her work on anti-rejection drugs. Her research identified IVIG as an effective therapy to reduce HLA antibody levels and prolong patient survival.
A new nomogram tool uses 11 questions to accurately calculate the probability of developing another symptomatic kidney stone at various time points. The tool helps determine whether preventive measures are needed, and can help patients avoid burdensome dietary restrictions or medications.
Researchers seek to reduce inflammation in kidney transplants by increasing regulatory T cells, either through infusions or pharmacologically. The goal is to maximize long-term organ survival and improve graft success rates, which have remained unchanged at 4% loss annually.
A meta-analysis of nine cohort studies found that children with fever over 102 degrees, infection with organisms other than E.coli, or abnormal kidney ultrasonography findings are at high risk for renal scarring. The study developed a clinical prediction model to identify nearly 45% of children who scar.
Scientists are developing 3D printing technology to create working tissues and organs on-demand, addressing the organ shortage. They discovered that adding more cells in bioinks reduces droplet size and dispensing rate, advancing the technology.