Articles tagged with Kidney
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A study of nearly 100,000 kidney donors found a small increased lifetime risk of developing end-stage renal disease following donation compared to healthy nondonors. The estimated cumulative incidence of ESRD at 15 years after donation was higher in donors than healthy nondonors, with blacks having the highest absolute risk.
A new Johns Hopkins research reveals that kidney failure is much less prevalent in living kidney donors than in the general population. The study found a lifetime rate of kidney failure in donors to be 90 per 10,000, compared to 326 per 10,000 in non-donors.
Scientists at the University of Nottingham are developing non-invasive measurements using magnetic resonance imaging (MRI) to assess blood flow and oxygenation in the human kidney. The goal is to improve monitoring and treatment for chronic kidney disease, which can be caused by health conditions like diabetes and high blood pressure.
A study by American Society of Nephrology reveals domoic acid, a neurotoxin found in seafood, can harm kidneys even at levels considered safe for consumption. The toxin damages kidneys at concentrations 100 times lower than what causes neurological effects, raising concerns about potential kidney failure and dialysis.
Patients who experience acute kidney injury following surgery have a higher risk of developing heart problems, including coronary events and mortality. The study found that properly treating AKI can help protect heart health.
A new study suggests that subjective well-being may 'nudge' adults into altruistic acts like kidney donation. States with higher per capita donation rates tend to have higher levels of well-being, and the link holds even after accounting for regional variation in other factors.
A high-protein diet may increase the risk of developing kidney stones and renal diseases in rats. The study found that a high-protein diet can lead to a decrease in urinary citrate and an increase in urinary calcium, which can promote pathologies like nephrolithiasis.
Researchers successfully transplanted kidneys into 50 recipients using a robot-assisted procedure that cools the organ with sterile ice during operation. This innovative method reduces post-operative pain and complications compared to traditional open surgery.
A new study reveals substantial geographic variation in waiting times for children needing kidney transplants, with local organ supply and demand affecting outcomes. The findings suggest that a broader geographic sharing of kidneys is necessary to address these disparities.
A recent study by Joslin Diabetes Center researchers has identified key metabolic factors that may contribute to diabetic kidney failure. The study found increased levels of uremic solutes and myo-inositol in patients who developed end-stage renal disease, suggesting a potential link between tubular injury and kidney failure.
A new study, funded by the NIH, will investigate whether reducing uric acid levels can slow down kidney function decline in people with type 1 diabetes. The research aims to find an additional safe and inexpensive way to prevent or delay kidney failure.
Patients with pre-existing chronic kidney disease who underwent robot-assisted partial nephrectomy for kidney cancer experienced minimal loss of kidney function compared to those with normal kidney function. The procedure also showed no cases of end-stage kidney disease requiring long-term dialysis.
A new device developed at the University of Washington is testing the use of low-power ultrasound to move small kidney stones, potentially reducing pain and treatment times. The technology has been tested on artificial kidneys and pigs before moving to human trials, with promising results.
Researchers have found that certain cells contribute to kidney function decline by causing destructive scarring, making them attractive targets for treatments. An additional but limited reserve of mature and functional filter cells is present at birth, which can be preserved and protected through pharmacological strategies.
A single low dose of lithium helped restore kidney function in mice with acute kidney injury, suggesting a potential therapeutic application for the mood stabilizer. Acute kidney injury is a serious complication affecting hospitalized patients, with limited treatment options.
Scientists have successfully differentiated human pluripotent stem cells into kidney tubular cells using a specific cocktail of chemicals. The resulting cells expressed key markers and could form functional tubules when transplanted into adult mouse kidneys.
A new UCSF-led study reveals that body mass index significantly increases the risk of developing chronic kidney disease, even before other obesity-related diseases emerge. Healthy kidneys play a vital role in various bodily functions, and the research emphasizes the importance of intervening early in life with obese patients.
A recent study published in the Journal of the American Society of Nephrology found that increased physical activity can slow the progression of kidney disease in patients. The researchers discovered that each 60-minute increment in weekly physical activity was linked with a 0.5% slower decline per year in kidney function.
A recent study published in the Journal of the American Society of Nephrology found that even small amounts of physical activity can significantly decrease the risk of developing kidney stones. The research also discovered that consuming more than 2200 calories per day may increase the risk of developing kidney stones by up to 42%.
A study found that HIV infection occurred in 68% of HIV-positive transplant recipients' new organs despite undetectable blood levels. Researchers developed a new, simple urine test to diagnose kidney infections in these patients, which could improve diagnosis and treatment.
A recent study published in Clinical Journal of the American Society of Nephrology found that acute kidney injury is associated with higher mortality rates compared to heart attacks. Patients who experienced both conditions had a significantly higher risk of death.
Recent study published in Neural Regeneration Research shows that Chinese medicines used for tonifying the kidney can protect nerve cells by regulating apoptosis-related factors and neurotrophic factors. Herba Epimedii and Herba Cistanches were found to be effective in inhibiting dopaminergic neuron apoptosis.
A study by researchers at Henry Ford Hospital found that while minimally invasive nephrectomy is gaining popularity, it still accounts for less than 10% of pediatric kidney surgeries. The majority of procedures are performed on children under age one and those with benign conditions.
Researchers found significant differences in DNA chemical modifications on genes related to kidney fibrosis, suggesting an early role in development. The study provides new insights into the molecular roots of chronic kidney disease and potential targets for new drugs.
Children and adolescents with chronic kidney disease from lower-income families were less likely to grow to normal height ranges. Researchers found that more aggressive intervention or programs to support treatment adherence could help improve outcomes.
A University of Colorado Cancer Center study found that crizotinib treatment reduces kidney function in ALK positive non-small cell lung cancer patients. Kidney function recovered after treatment, but additional tests are recommended if concerns arise.
A Mayo Clinic-led study has found that two commonly used drugs, low-dose dopamine and low-dose nesiritide, do not improve kidney function in hospitalized acute heart failure patients. The study analyzed data from 360 patients with kidney dysfunction and showed no significant improvement in urine volume or serum cystatin-C levels.
Research suggests that damage to small blood vessels in the retina and kidneys increases the risk of developing atrial fibrillation, a common type of abnormal heart rhythm. The study found that those with signs of vessel damage were more likely to develop atrial fibrillation than those without.
Researchers at Salk Institute create three-dimensional kidney structures from human stem cells, offering new avenues for studying kidney development and diseases. The breakthrough may lead to the discovery of new drugs targeting human kidney cells.
A recent study identified TRPC5, a molecule that plays a key role in the breakdown of the kidney filter, as a potential therapeutic target for stopping damage. The researchers found that blocking TRPC5 channels can prevent cytoskeletal collapse and subsequent kidney damage.
Recent studies highlight the effects of combination therapy with ACE inhibitors and ARBs on kidney function decline and cardiovascular events. Additionally, genetic variants of the APOL1 gene are found to increase CKD progression in African Americans.
Two clinical trials present new hope for treating patients with kidney disease: a phase 2 trial of ZS-9 shows significant reductions in blood potassium levels, while another trial of abatacept plus cyclophosphamide fails to improve renal response in lupus nephritis. Researchers explore these findings at Kidney Week 2013.
Two studies present findings that consuming at least two soft drinks per day may increase excretion of protein in the urine, a hallmark of kidney dysfunction. Moderate fructose intake also increases salt reabsorption by the kidneys, which could contribute to diabetes, obesity, and hypertension.
A significant link has been found between high levels of exposure to particulate matter by first responders at Ground Zero and the development of kidney damage. Albuminuria, a sign of kidney disease, was significantly higher in those with high exposure levels.
First responders at Ground Zero experienced significant kidney damage after exposure to particulate matter. The study found a linear trend between level of exposure and measures of poor kidney function.
A study published in JAMA found that coprescribing calcium-channel blockers with clarithromycin increases the risk of hospitalization with acute kidney injury and hypotension. The risk was highest among patients taking nifedipine, suggesting a need for quality improvement initiatives to mitigate this largely preventable drug-drug inter...
A new study links preeclampsia during pregnancy to a higher risk of developing kidney failure. Researchers analyzed data from Olmsted County, MN and found that individuals with preeclampsia were more likely to develop kidney failure later in life, but this association was attenuated when diabetes and hypertension were considered.
A new study found that kidney failure patients who experienced discrimination and mistrust in healthcare had poorer quality of life. Patients who reported greater medical mistrust and lower trust in their physicians also showed decreased quality of life.
A recent study has found that the APOL1 gene variant is independently associated with a more aggressive course of disease, particularly in African-Americans. The variant is linked to twice the rate of CKD progression and loss of kidney function in those with chronic kidney disease.
Studies suggest that consuming more fruits and vegetables can counteract the negative effects of dietary acid on kidney health. Research found that individuals with hypertensive nephropathy who received extra fruits and vegetables or an oral alkaline medication experienced preserved kidney health, while those with high dietary acid lev...
Triferic effectively delivers iron to the body's bone marrow, maintaining hemoglobin levels without rapid flux, a safer alternative to current intravenous injection methods. The study demonstrated its effectiveness in preventing iron overload and iron deficiency in 300 patients with chronic kidney disease undergoing dialysis.
A new study finds that treatment with abatacept appears to halt the course of focal segmental glomerulosclerosis (FSGS) in patients, preventing proteinuria and promoting remission. Abatacept has been shown to be effective in treating patients with recurrent disease and those at high risk for kidney failure.
Researchers at Massachusetts General Hospital found that mice lacking TRPC5 were protected from losing kidney filter function following kidney injury. Pharmacological inhibition of TRPC5 also protected animals from protein loss in the urine.
Researchers found that inhibiting ion channel TRPC5 limits kidney filtration loss after injury, suggesting a new therapeutic target. The study demonstrates the protective effects of TRPC5 inhibition on kidney function and provides hope for treating kidney failure.
A study of 264 kidney transplant recipients found that vitamin D supplementation was associated with improved patient outcomes, including lower risk of organ rejection and death. The research suggests that maintaining adequate vitamin D levels may be crucial for optimal health in kidney transplant patients.
A study published by UC researchers found that patients with acute kidney injury (AKI) before starting dialysis are 1.5 times more likely to die in their first year compared to those without AKI. This discovery may help improve dialysis outcomes and quality of life for millions of patients.
A randomized trial found that lowering salt intake reduces excess fluid volume, blood pressure, and protein excretion in the urine of people with CKD. This could lead to a 30% reduction in risk of progressing to end-stage kidney disease.
A new study found that consuming more vegetable protein is associated with a 14% lower risk of death in kidney disease patients. The study, which analyzed data from 1,104 CKD patients, suggests that increasing vegetable protein intake may help prolong survival among those with chronic kidney disease.
The global prevalence of kidney failure treatment is skyrocketing, with a 165% increase in dialysis treatments over the past two decades. Dialysis therapy has seen significant growth, particularly in countries with universal access, where adjusted prevalence increased by 134%.
A study of US nephrologists reveals that hospitalized patients with acute kidney injury (AKI) often do not receive sufficient follow-up care, despite being critically ill. The survey found that only one in five patients seen in clinics for AKI follow-up received reliable transition of care services after hospital discharge.
A Northwestern Medicine study using stem cells has shown promise in improving organ transplant outcomes by enabling patients to stop taking anti-rejection medicines. The research, which began in 2009, uses specially engineered stem cells to make the recipient's immune system recognize the new kidney as its own.
Researchers developed a saliva test for diagnosing acute kidney injury, found Mediterranean diet linked to reduced risk of chronic kidney disease, and explored mindfulness meditation's benefits on blood pressure in patients with kidney disease. Initiating dialysis can cause significant burdens and loss of independence in elderly patients.
Levels of bisphenol A (BPA) in dialysis machine components have been found to be toxic to the immune cells circulating in kidney failure patients' blood. Researchers analyzed the effects of BPA on immune cells and found that alternative polymers for dialyzers' components may reduce BPA elution during dialysis.
New research reveals a clear association between ACE inhibitors and acute kidney injury, with a potential increase of 1636 avoidable hospital admissions. The study estimates that one in seven cases may be linked to increased prescriptions for these drugs.
Researchers at Harvard University have identified a novel mechanism of kidney repair, where mature cells reprogram themselves after injury. This finding challenges the long-held theory that kidney stem cell populations respond to damage.
A large observational study found that only 43% of patients with gout achieved the recommended serum uric acid level after taking allopurinol. The study showed no new safety signals with the commonly used treatment.
Researchers found that diabetic mice showed reduced reactive oxygen species production in their kidneys, linked to lower AMPK activity. This decrease was associated with lowered kidney damage and improved symptoms.
Research suggests that many high-risk organs are safe and should not be labeled as such. After a median of 2.4 years, 86.5% of transplants from these donors were functioning without evidence of infections. The study challenges the CDC's current classification system.
A study suggests that paying living kidney donors $10,000 could increase the number of transplants by 5% or more, resulting in incremental cost savings and improved patient outcomes. This approach could also improve quality and quantity of life for patients with end-stage renal disease.
Kidney transplant recipients who discontinue immunosuppressive drugs before conception have a higher rate of live births and a lower rate of birth defects without an increased risk of kidney problems, according to research published by the American Society of Nephrology.