Articles tagged with Kidney
A Canadian study found that kidney transplant recipients lived longer and had better treatment success rates than patients on intensive home hemodialysis. However, these patients were also at a higher risk of hospitalization within the first year after transplantation.
Research suggests that patients with polycystic kidney disease (PKD) who undergo a kidney transplant may be less likely to develop cancer compared to those without PKD. The study found that PKD patients were 16% less likely to develop cancer than others who received a kidney transplant, and their overall cancer risk was 48% lower than ...
Italian scientists developed a continuous renal replacement therapy (CRRT) machine to treat smallest babies and have successfully used it to treat a newborn with multiple organ failure. The CARPEDIEM device overcomes technical challenges of existing machines, allowing for accurate fluid management and treatment delivery.
A new study finds that kidney transplantation offers better treatment outcomes and increased survival rates compared to intensive home hemodialysis. However, patients on home dialysis still have good health outcomes, highlighting the need for further research.
A study published in JAMA Surgery found that patients who underwent ureteroscopy had fewer repeat treatments and lower costs compared to those who received shock wave lithotripsy. The researchers suggest that the decision to choose one procedure over the other should be carefully considered by both doctors and patients.
A new kidney allocation policy is expected to improve patient and transplant survival rates, with median organ survival increasing by 2.8%, according to a study published in the Journal of the American Society of Nephrology. The policy prioritizes highly sensitized patients while potentially reducing access for older candidates.
Excessive phosphate consumption stimulates the production of FGF23, leading to negative effects on the cardiovascular system, including high blood pressure and vascular calcification. The study provides new insights into the connection between renal disease, FGF23 levels, and cardiovascular disease.
A biomedical engineer at UH is studying a potential treatment for lupus nephritis by targeting the interaction between three specific molecules. The goal is to determine if blocking this pathway can prevent kidney inflammation and failure.
A new study shows that children with vesicoureteral reflux who receive antimicrobial prophylaxis have a substantially reduced risk of UTI recurrences compared to those receiving a placebo. The study found that prophylaxis was most effective in children with fever and bladder/bowel dysfunction at baseline.
A two-year clinical trial found that long-term use of a drug combination reduces the risk of recurrent urinary tract infection by up to 80% in children with vesicoureteral reflux. Children with bladder and bowel dysfunction saw the greatest reduction, up to an 80% lower risk of recurrent infections.
Researchers investigated the role of atrogin-1 in cardiac homeostasis and found that its deficiency promotes cardiomyopathy and premature death via impaired autophagy. Additionally, endothelial HIF-2 was shown to protect kidney from hypoxia-induced damage. These findings highlight the importance of protein turnover regulation and HIF-2...
A study of over 93,000 patients found that complications from kidney stone treatments require hospitalization or emergency care for one in seven patients. The procedures were shock wave lithotripsy, ureteroscopy, or percutaneous nephrolithotomy, with costs ranging from $32,000 to $47,000.
A study of 67 transplant patients found those with naturally high levels of HLA-G dimer, a powerful immune molecule package, had the lowest risk of rejecting their transplanted kidney. High HLA-G levels also correlated with lower inflammation and higher expression of HLA-G receptors.
Researchers have developed a novel method to help doctors diagnose and treat kidney stones more effectively. By analyzing the behavior of nanocrystals and crystallites under different chemical conditions, they found that certain methods can reduce stone size and change its shape, improving treatment outcomes.
Researchers found that nearly one-third of pediatric kidney cancer cases are linked to the Lin28 gene, which holds promise for regenerating damaged kidneys. The study's findings suggest that controlled expression of Lin28 can promote kidney development and may lead to new therapeutic targets for treating Wilms tumors.
Atrasentan has been shown to lower albuminuria by 36% without major side effects in patients with type 2 diabetes and kidney disease. The drug also lowers blood pressure and cholesterol levels, suggesting a potential benefit for patients at high risk of serious medical problems.
Researchers found that rheumatoid arthritis patients have a 1 in 4 chance of developing chronic kidney disease over a 20-year period, compared to the general population's 1-in-5 risk. Patients should work to keep blood pressure under control and avoid medications damaging to the kidneys.
Henry Ford Hospital has implemented a kidney transplant technique using new patient safety standards coordinated by the University of Oxford. The IDEAL framework was used to develop and test the minimally-invasive procedure, which successfully transplanted kidneys in 50 recipients.
Dr. Ira Kurtz's research aims to understand the molecular processes affecting kidney function, with a focus on designing specific drugs targeting disease-causing proteins. The goal is to reduce side effects and costs associated with current treatments, which affect millions of people worldwide.
A recent study found that individuals with diabetes who experience major depressive symptoms are at a significantly higher risk of developing kidney failure. In contrast, minor depressive symptoms were not found to have a significant association with kidney disease development.
A new project, ATHENA, is developing four human organ constructs that mimic the response of actual human organs. The system, which includes a liver, heart, lung, and kidney, aims to provide a realistic and cost-effective way to screen new drugs and toxic agents.
Researchers discovered that stem cells from a fatty fold of tissue, called the omentum, can help heal diseased kidneys when fused to the organs. This innovative approach uses the patient's own stem cells to treat chronic kidney disease, potentially alleviating the need for external cell sources.
A new study from researchers at the University of Pennsylvania found that dialysis for acute kidney injury (AKI) is potentially hazardous for frail patients with lower creatinine concentration levels. In contrast, more robust patients experience increased survival and reduced mortality when receiving dialysis. These findings highlight ...
Duke University engineers developed a modified lens for shock wave machines, improving lithotripsy efficiency by 89% while reducing tissue damage. The new design uses a groove near the lens's perimeter to optimize pressure distribution and cavitation bubble formation.
A new noninvasive urine test can distinguish among different causes of acute kidney dysfunction in transplant recipients. The test measures messenger RNAs related to disease processes and may allow patients to avoid invasive kidney biopsies.
Researchers have identified two new biomarkers for acute kidney injury (AKI) in urine, allowing for earlier detection and treatment. The markers, TIMP-2 and IGFBP7, were validated using clinical adjudication and tested in independent labs.
Dr. Richard Glassock, a member of LA BioMed's Board of Directors, has been awarded the 2014 Medal of Excellence for his exceptional contributions to patient care. He is recognized for his extensive research and clinical expertise in glomerular diseases and clinical nephrology.
Researchers discovered abnormal molecular signaling pathways that promote chronic kidney disease progression, targeting endothelial mitochondrial oxidative stress and glomerular filtration barrier. New therapeutic targets may prevent or reverse disease, providing hope for millions of Americans affected by kidney disease.
Research from Oregon State University finds that low birth weight individuals have impaired kidney function, affecting drug excretion and metabolism. This may lead to reduced effectiveness of medications in treating diseases such as diabetes and hypertension.
Researchers created a synthetic version of low-molecular-weight heparin that can be counteracted by an existing drug and cleared by the liver, not the kidneys. This new form of heparin is safer for patients with poor kidney function, reducing the risk of uncontrolled bleeding.
Researchers have developed a groundbreaking MRI technique that can visualize metabolic changes in the body's cells. This breakthrough could lead to earlier diagnoses of diseases such as diabetes and cancer. The hyperpolarization method provides a fingerprint of cellular activity, allowing for real-time monitoring of disease progression.
Studies found that biopsied kidney injuries were modestly associated with delay in organ function, but only for donor kidneys already at high risk. However, there was a large degree of overlap between discarded and transplanted kidneys, suggesting low-quality biopsies may be used to make acceptance decisions.
A mathematical model simulates and optimizes donor kidney distribution to ease regional inequities and potentially save hundreds of lives. The model identifies areas for policy changes, including sharing within states and transplanting lower-quality kidneys.
A 4-year follow-up study found that patients with acute kidney injury (AKI) in intensive care units who require renal replacement therapy do not benefit from higher-intensity treatment. Albuminuria was common among survivors, indicating ongoing risk of chronic kidney disease and mortality.
A study of nearly 100,000 kidney donors found a small increased lifetime risk of developing end-stage renal disease following donation compared to healthy nondonors. The estimated cumulative incidence of ESRD at 15 years after donation was higher in donors than healthy nondonors, with blacks having the highest absolute risk.
A new Johns Hopkins research reveals that kidney failure is much less prevalent in living kidney donors than in the general population. The study found a lifetime rate of kidney failure in donors to be 90 per 10,000, compared to 326 per 10,000 in non-donors.
Scientists at the University of Nottingham are developing non-invasive measurements using magnetic resonance imaging (MRI) to assess blood flow and oxygenation in the human kidney. The goal is to improve monitoring and treatment for chronic kidney disease, which can be caused by health conditions like diabetes and high blood pressure.
A study by American Society of Nephrology reveals domoic acid, a neurotoxin found in seafood, can harm kidneys even at levels considered safe for consumption. The toxin damages kidneys at concentrations 100 times lower than what causes neurological effects, raising concerns about potential kidney failure and dialysis.
Patients who experience acute kidney injury following surgery have a higher risk of developing heart problems, including coronary events and mortality. The study found that properly treating AKI can help protect heart health.
A new study suggests that subjective well-being may 'nudge' adults into altruistic acts like kidney donation. States with higher per capita donation rates tend to have higher levels of well-being, and the link holds even after accounting for regional variation in other factors.
A high-protein diet may increase the risk of developing kidney stones and renal diseases in rats. The study found that a high-protein diet can lead to a decrease in urinary citrate and an increase in urinary calcium, which can promote pathologies like nephrolithiasis.
Researchers successfully transplanted kidneys into 50 recipients using a robot-assisted procedure that cools the organ with sterile ice during operation. This innovative method reduces post-operative pain and complications compared to traditional open surgery.
A new study reveals substantial geographic variation in waiting times for children needing kidney transplants, with local organ supply and demand affecting outcomes. The findings suggest that a broader geographic sharing of kidneys is necessary to address these disparities.
A recent study by Joslin Diabetes Center researchers has identified key metabolic factors that may contribute to diabetic kidney failure. The study found increased levels of uremic solutes and myo-inositol in patients who developed end-stage renal disease, suggesting a potential link between tubular injury and kidney failure.
A new study, funded by the NIH, will investigate whether reducing uric acid levels can slow down kidney function decline in people with type 1 diabetes. The research aims to find an additional safe and inexpensive way to prevent or delay kidney failure.
Patients with pre-existing chronic kidney disease who underwent robot-assisted partial nephrectomy for kidney cancer experienced minimal loss of kidney function compared to those with normal kidney function. The procedure also showed no cases of end-stage kidney disease requiring long-term dialysis.
A new device developed at the University of Washington is testing the use of low-power ultrasound to move small kidney stones, potentially reducing pain and treatment times. The technology has been tested on artificial kidneys and pigs before moving to human trials, with promising results.
Researchers have found that certain cells contribute to kidney function decline by causing destructive scarring, making them attractive targets for treatments. An additional but limited reserve of mature and functional filter cells is present at birth, which can be preserved and protected through pharmacological strategies.
A single low dose of lithium helped restore kidney function in mice with acute kidney injury, suggesting a potential therapeutic application for the mood stabilizer. Acute kidney injury is a serious complication affecting hospitalized patients, with limited treatment options.
Scientists have successfully differentiated human pluripotent stem cells into kidney tubular cells using a specific cocktail of chemicals. The resulting cells expressed key markers and could form functional tubules when transplanted into adult mouse kidneys.
A new UCSF-led study reveals that body mass index significantly increases the risk of developing chronic kidney disease, even before other obesity-related diseases emerge. Healthy kidneys play a vital role in various bodily functions, and the research emphasizes the importance of intervening early in life with obese patients.
A recent study published in the Journal of the American Society of Nephrology found that increased physical activity can slow the progression of kidney disease in patients. The researchers discovered that each 60-minute increment in weekly physical activity was linked with a 0.5% slower decline per year in kidney function.
A recent study published in the Journal of the American Society of Nephrology found that even small amounts of physical activity can significantly decrease the risk of developing kidney stones. The research also discovered that consuming more than 2200 calories per day may increase the risk of developing kidney stones by up to 42%.
A study found that HIV infection occurred in 68% of HIV-positive transplant recipients' new organs despite undetectable blood levels. Researchers developed a new, simple urine test to diagnose kidney infections in these patients, which could improve diagnosis and treatment.
A recent study published in Clinical Journal of the American Society of Nephrology found that acute kidney injury is associated with higher mortality rates compared to heart attacks. Patients who experienced both conditions had a significantly higher risk of death.
Recent study published in Neural Regeneration Research shows that Chinese medicines used for tonifying the kidney can protect nerve cells by regulating apoptosis-related factors and neurotrophic factors. Herba Epimedii and Herba Cistanches were found to be effective in inhibiting dopaminergic neuron apoptosis.
A study by researchers at Henry Ford Hospital found that while minimally invasive nephrectomy is gaining popularity, it still accounts for less than 10% of pediatric kidney surgeries. The majority of procedures are performed on children under age one and those with benign conditions.
Researchers found significant differences in DNA chemical modifications on genes related to kidney fibrosis, suggesting an early role in development. The study provides new insights into the molecular roots of chronic kidney disease and potential targets for new drugs.
Children and adolescents with chronic kidney disease from lower-income families were less likely to grow to normal height ranges. Researchers found that more aggressive intervention or programs to support treatment adherence could help improve outcomes.
A University of Colorado Cancer Center study found that crizotinib treatment reduces kidney function in ALK positive non-small cell lung cancer patients. Kidney function recovered after treatment, but additional tests are recommended if concerns arise.