Articles tagged with Kidney
A Mayo Clinic-led study has found that two commonly used drugs, low-dose dopamine and low-dose nesiritide, do not improve kidney function in hospitalized acute heart failure patients. The study analyzed data from 360 patients with kidney dysfunction and showed no significant improvement in urine volume or serum cystatin-C levels.
Research suggests that damage to small blood vessels in the retina and kidneys increases the risk of developing atrial fibrillation, a common type of abnormal heart rhythm. The study found that those with signs of vessel damage were more likely to develop atrial fibrillation than those without.
Researchers at Salk Institute create three-dimensional kidney structures from human stem cells, offering new avenues for studying kidney development and diseases. The breakthrough may lead to the discovery of new drugs targeting human kidney cells.
A recent study identified TRPC5, a molecule that plays a key role in the breakdown of the kidney filter, as a potential therapeutic target for stopping damage. The researchers found that blocking TRPC5 channels can prevent cytoskeletal collapse and subsequent kidney damage.
Recent studies highlight the effects of combination therapy with ACE inhibitors and ARBs on kidney function decline and cardiovascular events. Additionally, genetic variants of the APOL1 gene are found to increase CKD progression in African Americans.
Two clinical trials present new hope for treating patients with kidney disease: a phase 2 trial of ZS-9 shows significant reductions in blood potassium levels, while another trial of abatacept plus cyclophosphamide fails to improve renal response in lupus nephritis. Researchers explore these findings at Kidney Week 2013.
Two studies present findings that consuming at least two soft drinks per day may increase excretion of protein in the urine, a hallmark of kidney dysfunction. Moderate fructose intake also increases salt reabsorption by the kidneys, which could contribute to diabetes, obesity, and hypertension.
A significant link has been found between high levels of exposure to particulate matter by first responders at Ground Zero and the development of kidney damage. Albuminuria, a sign of kidney disease, was significantly higher in those with high exposure levels.
First responders at Ground Zero experienced significant kidney damage after exposure to particulate matter. The study found a linear trend between level of exposure and measures of poor kidney function.
A study published in JAMA found that coprescribing calcium-channel blockers with clarithromycin increases the risk of hospitalization with acute kidney injury and hypotension. The risk was highest among patients taking nifedipine, suggesting a need for quality improvement initiatives to mitigate this largely preventable drug-drug inter...
A new study links preeclampsia during pregnancy to a higher risk of developing kidney failure. Researchers analyzed data from Olmsted County, MN and found that individuals with preeclampsia were more likely to develop kidney failure later in life, but this association was attenuated when diabetes and hypertension were considered.
A new study found that kidney failure patients who experienced discrimination and mistrust in healthcare had poorer quality of life. Patients who reported greater medical mistrust and lower trust in their physicians also showed decreased quality of life.
A recent study has found that the APOL1 gene variant is independently associated with a more aggressive course of disease, particularly in African-Americans. The variant is linked to twice the rate of CKD progression and loss of kidney function in those with chronic kidney disease.
Studies suggest that consuming more fruits and vegetables can counteract the negative effects of dietary acid on kidney health. Research found that individuals with hypertensive nephropathy who received extra fruits and vegetables or an oral alkaline medication experienced preserved kidney health, while those with high dietary acid lev...
Triferic effectively delivers iron to the body's bone marrow, maintaining hemoglobin levels without rapid flux, a safer alternative to current intravenous injection methods. The study demonstrated its effectiveness in preventing iron overload and iron deficiency in 300 patients with chronic kidney disease undergoing dialysis.
A new study finds that treatment with abatacept appears to halt the course of focal segmental glomerulosclerosis (FSGS) in patients, preventing proteinuria and promoting remission. Abatacept has been shown to be effective in treating patients with recurrent disease and those at high risk for kidney failure.
Researchers at Massachusetts General Hospital found that mice lacking TRPC5 were protected from losing kidney filter function following kidney injury. Pharmacological inhibition of TRPC5 also protected animals from protein loss in the urine.
Researchers found that inhibiting ion channel TRPC5 limits kidney filtration loss after injury, suggesting a new therapeutic target. The study demonstrates the protective effects of TRPC5 inhibition on kidney function and provides hope for treating kidney failure.
A study of 264 kidney transplant recipients found that vitamin D supplementation was associated with improved patient outcomes, including lower risk of organ rejection and death. The research suggests that maintaining adequate vitamin D levels may be crucial for optimal health in kidney transplant patients.
A study published by UC researchers found that patients with acute kidney injury (AKI) before starting dialysis are 1.5 times more likely to die in their first year compared to those without AKI. This discovery may help improve dialysis outcomes and quality of life for millions of patients.
A randomized trial found that lowering salt intake reduces excess fluid volume, blood pressure, and protein excretion in the urine of people with CKD. This could lead to a 30% reduction in risk of progressing to end-stage kidney disease.
A new study found that consuming more vegetable protein is associated with a 14% lower risk of death in kidney disease patients. The study, which analyzed data from 1,104 CKD patients, suggests that increasing vegetable protein intake may help prolong survival among those with chronic kidney disease.
The global prevalence of kidney failure treatment is skyrocketing, with a 165% increase in dialysis treatments over the past two decades. Dialysis therapy has seen significant growth, particularly in countries with universal access, where adjusted prevalence increased by 134%.
A study of US nephrologists reveals that hospitalized patients with acute kidney injury (AKI) often do not receive sufficient follow-up care, despite being critically ill. The survey found that only one in five patients seen in clinics for AKI follow-up received reliable transition of care services after hospital discharge.
A Northwestern Medicine study using stem cells has shown promise in improving organ transplant outcomes by enabling patients to stop taking anti-rejection medicines. The research, which began in 2009, uses specially engineered stem cells to make the recipient's immune system recognize the new kidney as its own.
Researchers developed a saliva test for diagnosing acute kidney injury, found Mediterranean diet linked to reduced risk of chronic kidney disease, and explored mindfulness meditation's benefits on blood pressure in patients with kidney disease. Initiating dialysis can cause significant burdens and loss of independence in elderly patients.
Levels of bisphenol A (BPA) in dialysis machine components have been found to be toxic to the immune cells circulating in kidney failure patients' blood. Researchers analyzed the effects of BPA on immune cells and found that alternative polymers for dialyzers' components may reduce BPA elution during dialysis.
New research reveals a clear association between ACE inhibitors and acute kidney injury, with a potential increase of 1636 avoidable hospital admissions. The study estimates that one in seven cases may be linked to increased prescriptions for these drugs.
Researchers at Harvard University have identified a novel mechanism of kidney repair, where mature cells reprogram themselves after injury. This finding challenges the long-held theory that kidney stem cell populations respond to damage.
A large observational study found that only 43% of patients with gout achieved the recommended serum uric acid level after taking allopurinol. The study showed no new safety signals with the commonly used treatment.
Researchers found that diabetic mice showed reduced reactive oxygen species production in their kidneys, linked to lower AMPK activity. This decrease was associated with lowered kidney damage and improved symptoms.
Research suggests that many high-risk organs are safe and should not be labeled as such. After a median of 2.4 years, 86.5% of transplants from these donors were functioning without evidence of infections. The study challenges the CDC's current classification system.
A study suggests that paying living kidney donors $10,000 could increase the number of transplants by 5% or more, resulting in incremental cost savings and improved patient outcomes. This approach could also improve quality and quantity of life for patients with end-stage renal disease.
Kidney transplant recipients who discontinue immunosuppressive drugs before conception have a higher rate of live births and a lower rate of birth defects without an increased risk of kidney problems, according to research published by the American Society of Nephrology.
A new study found that overnight dialysis boosts kidney health and reduces the risk of heart disease by improving artery function. This treatment method allows for more frequent and longer dialysis sessions at home, leading to reduced toxin buildup in the blood.
A recent study of 2,012 participants found no association between vitamin D levels and kidney stone incidence, contradicting earlier concerns about supplementation. However, the study did identify older age, male gender, and higher BMI as risk factors for developing kidney stones.
A study found that Hispanics are less likely to receive a kidney transplant, despite being equally likely to be placed on the waitlist as non-Hispanic whites. The disparity is largely attributed to differences in patient blood type and regional variability of organ supply.
A study finds that African Americans and individuals with less education are more likely to receive lower-quality kidneys, highlighting racial and social disparities in the allocation of transplanted organs. The findings suggest that addressing these inequalities is crucial for improving patient outcomes.
A study published in the Journal of the American Society of Nephrology found that obesity increases the risk of developing chronic kidney disease by suppressing an important cellular process called autophagy. Restoring this process may help protect kidney health in obese individuals.
Researchers developed an in silico nano-dissection method to isolate and identify genes from specific cell types in human tissues. The technique successfully identified genes expressed in podocytes, which malfunction in kidney disease, correlating with the severity of impairment.
A study published in British Journal of Pharmacology found that naringenin from citrus fruits successfully blocks the formation of kidney cysts, a common disorder leading to loss of kidney function. The component was shown to regulate the PKD2 protein responsible for polycystic kidney disease.
A new study from Japan found that individuals with a history of kidney stones have significantly increased levels of inflammatory chemokines GRO and CXCL1, while those without kidney stones have higher levels of anti-inflammatory cytokine IL-4. This research may lead to the development of new therapeutic drugs for kidney stone formation.
The Joslin Diabetes Center will conduct a clinical trial to evaluate the benefits of allopurinol in reducing kidney function loss among people with type 1 diabetes. The five-year trial aims to determine if high serum uric acid levels are the cause of diabetic kidney disease.
A recent study examining the health of kidney donors has found that complications and hospital length-of-stay have declined since 1998. The researchers studied over 69,000 living kidney donors between 1998 and 2010, finding that rates of complications and length-of-stay for donors were comparable with other low-risk abdominal surgeries.
A recent study found a rise in the prevalence of chronic kidney disease (CKD) among adults aged 80 and older, with significant increases in those with reduced kidney function. The study suggests that targeted efforts to address CKD are necessary for this age group.
Adult childhood cancer survivors who underwent nephrotoxic therapies or kidney surgery had worse kidney function that did not recover over time. The study found a significant decline in glomerular function after treatment and a higher risk of premature chronic renal failure.
Researchers found that genetic loss of a proton pump in beta-intercalated cells leads to increased prostaglandin E2 production, promoting hypokalemia and hypercalcemia. Pharmacologic inactivation also results in dRTA-like symptom development.
Dr. David Pollock emphasizes the importance of considering the endothelin system in hypertension research, particularly in salt-sensitive patients. His studies have shown that the kidney's endothelin B receptor plays a critical role in eliminating both acute and chronic salt loads by activating nitric oxide.
A biomarker test has been shown to accurately detect acute kidney injury (AKI) in a diverse group of patients admitted from the emergency department. The test measures neutrophil gelatinase-associated lipocalin (NGAL) and can provide results within 15 minutes, allowing for timely treatment.
Researchers tracked changes in gene expression to predict kidney damage severity in children with urinary tract obstruction. The study identified specific genes associated with the degree of obstruction, which could help identify children at risk of chronic kidney disease and permanent organ damage.
The use of blood levels of cystatin C strengthens the association between kidney function and risks of death and end-stage renal disease. Cystatin C allows for better staging and risk classification of chronic kidney disease, potentially leading to targeted management and improved patient outcomes.
The study found that measuring cystatin C in the blood strengthens the association between kidney function and risks of death and end-stage renal disease. Kidney function stages categorized by cystatin C were better at reflecting future risk than those based on creatinine estimates.
A study published in the Journal of the American Society of Nephrology found that African Americans with lower incomes have lower rates of living kidney donation compared to White Americans. However, among high-income African Americans, they actually have higher rates of donation. The findings highlight the importance of targeting soci...
A recent study has found a link between kidney transplant patients and an increased risk of invasive skin cancer. The research suggests that tumor cells from the donated kidney can lead to cancer formation in recipient tissues.
Researchers at Henry Ford Hospital developed a new technique using ice slush and robotic surgery to remove large kidney stones. The ICE procedure provides kidney protection during blood flow stoppage, allowing for complex surgeries. Three patients were successfully treated without complications.
Researchers have identified a link between the tight junction protein TRIC and cochlear hair cell preservation, as well as a potential mechanism for combatting drug-resistant cancers. Additionally, studies have found that donor tissue can lead to cancer formation in transplant recipients, highlighting the importance of careful screening.
The study found a significant increase in women's risk of developing kidney stones, with more cases being seen in emergency departments over a four-year period. The rate of hospitalization remained stable, but the use of CT scans to diagnose kidney stones may contribute to the rise in emergency department charges.
Researchers identified gene variants associated with an increased risk of kidney problems in lupus patients, which could lead to better treatments to protect kidney health. The study found that variants in the ABIN1 gene were linked to an increased risk of lupus nephritis, a common complication of the disease.
Researchers developed a noninvasive protein-based urine test that accurately monitors kidney transplant risk and detects rejection before clinical signs appear. The study found low levels of CXCL9 protein can rule out rejection as a cause of kidney injury, offering a promising diagnostic tool for managing transplant patients.
Researchers found that patients who are retired and/or disabled, working part time, or working full time are more likely to be placed on a transplant waiting list than unemployed patients. Transplant centers may restrict access due to concerns about post-transplant medical care costs and noncompliance with treatment.