Articles tagged with Kidney
Researchers at UCSF and Kaiser Permanente have found that atrial fibrillation significantly increases the risk of end-stage renal disease among patients with chronic kidney disease. The study involved over 206,000 adults and showed that those who developed atrial fibrillation were 67% more likely to progress to kidney failure.
Research examines data from multiple studies to better understand how obesity impacts kidney transplant patients. Obese patients experience more adverse outcomes, including wound infections and cardiac disease, leading to poorer health outcomes after surgery.
A large, randomized trial found that angiotensin II blockade did not lessen tissue scarring or prevent kidney failure in kidney transplant recipients. The treatment was safe and well-tolerated but showed no benefit in slowing disease progression.
A study published in The Lancet found that approximately one of every five individuals with kidney tumors common in patients with tuberous sclerosis complex has had a kidney removed unnecessarily due to misdiagnosis. Everolimus successfully shrinks these tumors, offering an alternative to surgery.
A UK-wide clinical trial has identified a treatment approach that significantly reduces the risk of kidney failure in patients with membranous nephropathy. The study, published in The Lancet, recommends alternating monthly cycles of prednisolone and chlorambucil as the most effective treatment for this common type of kidney disease.
A new study found that directing short bursts of radio waves at nerves surrounding the kidneys lowered blood pressure for at least six months and up to one year. The procedure, called renal denervation, has significant public health implications in treating resistant hypertension.
Researchers at Monash University used advanced microscopy techniques to visualize the movements of white blood cells in healthy and diseased kidneys. They found that leukocytes are constantly circulating through and patrolling blood vessels within healthy kidneys, but become agitated during disease, causing inflammation and kidney damage.
Researchers at Henry Ford Hospital have developed a new technique for minimally invasive robotic partial nephrectomy procedures, sparing the kidney and eliminating long hospital stays. The technique, called ICE, provides better outcomes by giving surgeons more time to perform the procedure and allows for better tumor removal and analysis.
The 'Smart stethoscope' assesses the effectiveness of shock wave lithotripsy treatment for kidney stones by analyzing echoes after each shock wave hits the stone. This device has been shown to achieve high accuracy (94.7%) in clinical trials, reducing the need for repeat therapy and x-ray monitoring.
The most severe form of acute kidney injury has seen a significant increase in incidence rates, with deaths associated with the condition also rising. The study highlights the need for further research into the causes behind this trend and potential interventions to reduce its impact.
A study published by UCSF found that acute kidney injuries have doubled over the last decade, from 222 to 533 cases per million people. The total number of deaths associated with acute kidney injury also more than doubled during this time, from 18,000 in 2000 to nearly 39,000 in 2009.
The Belatacept Early Steroid withdrawal Trial (BEST) seeks to determine if a belatacept-based regimen can prevent organ rejection in post-transplant patients. Led by the University of Cincinnati, the trial will enroll 315 new kidney transplant patients and evaluate the safety and efficacy of steroid-free immunosuppression.
A study by Temple University found a significant association between decreased kidney function and reduced global cognitive ability, abstract reasoning, and verbal memory. Researchers tracked 590 individuals over five years to examine the longitudinal impact of renal decline on cognitive functioning.
A recent study published by Columbia University Medical Center has found a surprising genetic link between kidney defects and neurodevelopmental disorders in children. The research identified large genomic alterations in 10% of kids born with kidney defects, which are known to cause neurodevelopmental delay or mental illness.
A new study reveals that even low levels of preformed donor-specific antibodies can nearly double the risk of antibody-mediated rejection and increase kidney failure by 76%. This finding could help clinicians provide better donor-recipient matches and tailor immunosuppressive therapy.
A GW researcher has received a grant to study the effectiveness of Tamsulosin as an alternative treatment for kidney stones, with the goal of reducing complications and speeding up stone passage. The four-year study will enroll patients in three Emergency Departments and randomize them to receive either Tamsulosin or a placebo.
A study by UCSF analyzed emergency department visits and found that many minor genital injuries can be prevented through educational and product safety approaches. The research identified specific age groups and consumer products as risk factors, offering insights into preventing such injuries.
Recent studies suggest that hypertension and diabetes are more prevalent in black versus white donors, but the risk attributable to donation remains unknown. Individuals with prediabetes can safely donate kidneys without increasing their risk of developing diabetes or kidney failure.
A new study published in JAMA found that chronic kidney disease and its complications are associated with a higher risk of death regardless of age. Both low kidney function and high albuminuria were independently linked to mortality and end-stage renal disease, according to the findings.
A novel hydration protocol guided by left ventricular end-diastolic pressure reduced kidney damage by 59% in patients undergoing cardiac catheterization, according to the POSEIDON trial. The study found that this technique can be easily implemented and adapted for both inpatient and outpatient settings.
LncRNAs have been found to regulate gene expression in various diseases, including brachydactyly and HELLP syndrome. Additionally, research on obesity has shown that early genetic intervention can rescue mice from obesity-induced metabolic disorders. Furthermore, editing mistakes in miR-376 cluster have been linked to invasive brain tu...
Researchers have identified a new therapeutic target for diabetic nephropathy, the leading cause of kidney failure, by activating liver x receptor (LXR) to inhibit osteopontin expression. Activation of LXR with a drug named T0901317 improves kidney health and function in diabetic mice.
Researchers have successfully created functional 'organoids' that can carry out kidney functions when implanted into rats. The breakthrough could lead to more options for individuals with kidney failure and better tools for understanding and treating complex kidney diseases.
A recent study suggests that active surveillance is a viable alternative to surgery for small kidney masses, offering similar cancer outcomes in the short and intermediate term. Researchers found that patients under active surveillance had a growth rate of 0.21cm per month, with 53% showing no growth.
A Johns Hopkins analysis found that three in 10 kidney transplant recipients require hospital readmission within 30 days. The study highlights the need for better outpatient management systems to prevent costly and potentially preventable return visits.
A simple six-question quiz can identify kidney dialysis patients at high risk of death, with those needing assistance with basic activities being more than three times more likely to die. The study, published in the Journal of the American Geriatrics Society, found that over 600,000 people in the US are on dialysis due to kidney failure.
A study found that kidney transplants performed in Europe have higher survival rates after 5 and 10 years compared to those in the United States. The disparity may be attributed to the lack of cost reimbursement for anti-rejection drugs in the US, leading to poorer outcomes among certain demographics.
A single gene variant in donors has been linked to a 69% increased risk for long-term failure of transplanted kidneys. The variant affects the expression of the protein that pumps drugs out of cells, which can be toxic to the kidneys.
A study found that variations in the APOL1 gene are associated with non-diabetic kidney disease in African-Americans, but not all carriers develop the disease. Researchers suggest that environmental or viral infections may play a role in triggering the disease.
A study found that nearly half of Canadians view financial incentives for deceased kidney donation as acceptable. Lower-income individuals were not more likely to donate for financial gain, according to the researchers. The study suggests that financial incentives may increase donations from both living and deceased donors.
A recent study by Henry Ford Health found that women are more than twice as likely to suffer infections related to kidney stones and other urinary blockages. The study also showed significantly higher rates of complications following urgent treatments for the condition.
Two new studies found that chronic kidney disease is a strong indicator of death and end-stage renal disease in patients without hypertension or diabetes. Chronic kidney disease affects 10-16% of adults globally and is associated with increased mortality risk regardless of the presence of diabetes.
A US multicenter study showed that 46% of kidney transplant recipients in living donor chains were minorities, contradicting previous fears. The study highlights the potential for expanding donor chains to increase diversity and accessibility for minority patients.
Researchers at Sahlgrenska Academy, University of Gothenburg, have found that metformin is effective in reducing the risk of cardiovascular disease, serious infection, and death in patients with mild kidney impairment. The study suggests that metformin can be prescribed for many more patients with diabetes than previously thought.
A University of Maryland study found that single-port kidney removal through the belly button resulted in higher satisfaction rates among living donors, with fewer limitations after surgery. The new technique also showed slightly less pain and no increased risks or complications compared to traditional multi-port laparoscopic removal.
A new study found that patients with common kidney disease IgA nephropathy who have normal kidney function and only minor urinary abnormalities at diagnosis experience remission without special treatments. No patients developed kidney failure over a 20-year follow-up, indicating an excellent prognosis.
Researchers found that individuals with a history of kidney stones are more susceptible to developing serious kidney problems and kidney failure, particularly women under 50. The study's results highlight the importance of screening for risk factors in patients with a history of kidney stones.
The study discovered that the claudin-10 gene plays a crucial role in reabsorbing sodium chloride in the kidney. In its absence, mice exhibit elevated magnesium levels and excess calcium deposition in the kidneys, highlighting the importance of this gene in maintaining salt balance.
A recent study found that waiting to treat cytomegalovirus infections in transplant recipients until they reach a certain threshold is more beneficial than prophylactically treating all recipients. This approach led to less kidney scaring and better long-term organ survival among patients.
A study estimates that approximately 1 in 93 men and 1 in 133 women of middle age may develop kidney failure in their lifetime. People with reduced kidney function face a higher risk, with men facing a 7.51% chance and women a 3.21%.
Researchers found that abnormal proteins and antibodies in blood levels increase according to disease severity. High antibody levels are associated with higher risk of kidney failure and premature death.
Scientists at UCSB have demonstrated a new drug, folate-conjugated rapamycin (FC-rapa), effective in preventing kidney cyst growth in mice with ADPKD. The research builds on earlier findings by Thomas Weimbs, who identified mTOR as driving cyst growth in the disease.
A multi-center study found that patients who undergo complete kidney removal are 3.5 times more likely to develop erectile dysfunction compared to those with kidney reconstruction. Researchers suggest that total kidney removal may also increase the risk of metabolic diseases and decrease quality of life.
Patients under 35 years old and those without private health insurance are more likely to be overlooked when starting dialysis, according to a recent study. The findings highlight the need to address racial and socioeconomic disparities in kidney transplantation.
Researchers at the University of Alberta discovered a link between sodium and calcium regulation in the body. Excessive sodium intake can lead to calcium depletion, causing thin bones and osteoporosis, while high urine calcium levels increase the risk of kidney stones.
Scientists at Joslin Diabetes Center have identified the biological mechanisms by which glucagon-like peptide-1 (GLP-1) protects against kidney disease, including its ability to inhibit the signaling pathway of angiotensin II. The study suggests that effective therapeutic agents could be developed to enhance GLP-1R on the endothelium, ...
A study found that rituximab, an immune drug, helped patients with serious kidney disorder idiopathic membranous nephropathy experience remission, even when standard therapies failed. The treatment was safe and well-tolerated, with all patients achieving complete or partial remission over time.
The American Heart Association has released a scientific statement addressing varied cardiac evaluation policies in transplant patients. The guidelines aim to standardize cardiac evaluation practices before kidney and liver transplantation, reducing unnecessary testing and improving patient outcomes.
Researchers at TGen developed a method to isolate protein-rich urinary exosomes, which can help discover biomarkers for better CKD diagnosis and treatment. The study found that the new method produces high yields of miRNA and mRNA, making it suitable for downstream genetic profiling experiments.
A new study published in the Canadian Medical Association Journal found that uncircumcised boys are at a higher risk of urinary tract infections. The researchers did not find a significant association between the degree of urethral visibility and infection risk.
A new equation that combines creatinine and cystatin C levels provides a more accurate measurement of kidney function, reducing over-diagnosis of chronic kidney disease (CKD). The study suggests that this approach could be used as a confirmatory test for CKD in patients with estimated GFR near 60.
A recent Vanderbilt University Medical Center study has found that obesity is associated with a higher risk of acute kidney injury (AKI) following cardiac surgery. The study, which followed 455 cardiac surgery patients, found that a higher body mass index (BMI) was linked to a greater risk of AKI, with patients weighing more than avera...
A new study suggests long-term calcium and vitamin D supplement use is linked to high urinary levels of calcium, potentially increasing the risk of kidney stones. The researchers found that approximately 33% of participants developed hypercalciuria, which was unrelated to vitamin D dosage.
Researchers studied 552,672 patients and found a three-fold increase in acute dialysis after cardiac and vascular surgeries. The incidence of acute dialysis increased from 0.2% to 0.6% over the 15-year study period.
A new study found a significant increase in acute kidney injury requiring dialysis after major elective surgery, with the number of patients tripling since 1995. The study suggests that developing interventions to prevent severe AKI could lead to improved outcomes for patients.
Scientists successfully created 'scaffolds' from pig kidneys to potentially build replacement kidneys for humans. The structure of the nephron was maintained, and blood vessels were able to maintain normal pressure when re-filled with blood in animal models.
Stem cells in the developing embryo give rise to adult nephrons, but unlike skin and gut, kidneys can't build new ones. FGF9 and FGF20 proteins maintain the embryonic kidney's stem cell niche, which is crucial for future research on growing kidney stem cells in the lab.
The NIH has awarded $400,000 to Arizona State University's Kevin Bennett to develop a non-invasive method for detecting nephritis, a common form of kidney disease. The new technology uses magnetic resonance imaging and magnetic nanoparticles to extract information about the kidney's function and location.
Researchers found that fresh islet cells are superior to cultured islet cells in terms of success rate and blood glucose levels after transplantation. However, the results of islet isolation did not correlate with clinical outcomes for kidney transplantations from non-heart-beating donors.
A low-carbohydrate high-protein diet has been found to be safe for healthy obese patients' kidney function and fluid balance, unlike a low-fat diet. However, additional studies are needed to evaluate its effects in individuals with pre-existing kidney disease or other health conditions.