Articles tagged with Kidney
Researchers developed a method to extract information from soil surrounding bodies, allowing for insight into the day before death. High mercury concentrations in soil suggest exposure occurred within hours or days prior to death.
Researchers found that a non-invasive ultrasound treatment can prevent acute kidney injury in mice by stimulating an anti-inflammatory response. The therapy, which uses sound waves to activate the immune system, showed promise as a potential prevention method for patients at risk of kidney damage after surgery.
GP Margaret McCartney argues that NHS patient information leaflets are inadequate, providing inconsistent guidance and conflicting advice. The problem persists despite previous studies and a planned major project to standardize information, highlighting the need for high standards in updating and accessibility.
Researchers at the National Human Genome Research Institute identified biomarkers of kidney damage and demonstrated that antioxidant therapy protected kidney function in mice. These findings offer new tools for monitoring disease progression and may pave the way for clinical trials for patients with methylmalonic acidemia.
A recent URMC study questions the assumption that saving kidney tissue during surgery improves patient outcomes and survival rates, suggesting radical nephrectomy may be a viable option for certain patients with small kidney cancers.
A study of over 240,000 participants found that women with a history of kidney stones had an increased risk of coronary heart disease, while no association was seen in men. The researchers suggest further research is needed to determine the underlying cause of this sex-specific association.
A study analyzing data from 1000 black and white patients with kidney disease found that black patients experienced a faster progression to kidney failure. The disparity was predominantly present in patients with diabetes and those who excreted greater amounts of protein, indicating more advanced kidney dysfunction.
A new drug called Bendavia has been shown to prevent acute kidney injury (AKI) in animal models and is currently being studied for kidney disease. By protecting the unique fatty compound cardiolipin, Bendavia helps preserve mitochondrial structure and function, leading to accelerated ATP recovery and reduced cell death.
A new noninvasive urine test can diagnose and predict kidney transplant rejection with high accuracy, offering an alternative to the standard kidney biopsy. The test uses biomarkers in the urine of kidney transplant recipients to detect rejection, allowing doctors to intervene early and prevent kidney injury.
A non-invasive urine test using a three-gene signature can diagnose acute rejection and predict kidney transplant patients at risk weeks to months before symptoms appear. The test helps tailor immunosuppressive drug doses for optimal organ care.
A new technique called 'renal denervation' has shown significant reductions in blood pressure and improved long-term stability. The procedure involves removing nerves connecting the kidney to the brain using radio-frequency energy, with minimal side effects and no need for tablets.
A single systemic dose of dendritic cells prevented rejection for almost four months in a preclinical animal model of kidney transplantation. The treatment successfully regulated the immune system without side effects, allowing for longer organ survival.
A study by researchers at Wake Forest Baptist Medical Center found that African-Americans with Medicaid are significantly less likely to receive living kidney transplants compared to those with private insurance. This disparity is attributed to various factors, including limited access to living donors and resources.
Researchers analyzed data from two large clinical trials to investigate the impact of high-dose statins on kidney function. The findings suggest that higher-strength statins do not increase the risk of hospitalizations with kidney injury when compared to low-dose statins.
A recent study published in the Canadian Medical Association Journal found that current use of fluoroquinolone antibiotics increases the risk of acute kidney injury by two-fold. The risk was highest with ciprofloxacin and moxifloxacin, and concurrent use with renin-angiotensin-system blockers further increased the risk.
Research found that low birth weight and prematurity are linked to low nephron numbers, increasing the risk of high blood pressure and chronic kidney disease. The study suggests clinicians use birth weight as a parameter for screening patients.
Chronic kidney disease (CKD) is now a global epidemic with prevalence exceeding 10% in most countries and as high as 50% in certain populations. CKD increases with age and is more common among black people, those with diabetes or cardiovascular disease.
A 10-minute test for frailty can predict increased risk of death and frequent hospitalization among kidney dialysis patients. The test measures physiological reserve and suggests that dialysis patients are undergoing premature aging, leading to higher mortality rates.
A new study presented at Heart Failure 2013 found that ambulatory levosimendan improved event-free survival by 50% compared to placebo in patients with end-stage heart failure. However, it failed to show significant improvements in functional capacity and quality of life.
Researchers discovered human kidneys discarded for transplant can serve as a natural scaffold material for manufacturing replacement organs in the lab. The study suggests that these organs could potentially be used to help solve the critical shortage of donor organs.
A study published in the Journal of the American Society of Nephrology found that LDL cholesterol is not a reliable indicator of heart disease risk in patients with kidney disease. Patients with very low kidney function were more likely to have a heart attack, regardless of their LDL levels.
A study by Brigham and Women's Hospital found that consuming sugar-sweetened drinks increases the risk of developing kidney stones. On the other hand, beverages like coffee, tea, and orange juice are associated with a lower risk of stone formation.
A study of over 1,100 adults who had a stroke found that those living closest to major roads had lower kidney function and increased cardiovascular death rates. Exposure to air pollution from traffic was linked to reduced renal function and an increased risk of cardiovascular events.
African Americans receive more kidney transplants than other minority groups, but they have fewer live donors, according to a new study. The disparity in live donation may be due to lower numbers of potential donors among African Americans due to higher rates of obesity and diabetes.
A recent study found that women are more likely to undergo percutaneous nephrolithotomy (PCNL), a minimally invasive procedure to remove medium to large kidney stones. The study also discovered an increase in blood infection and overall complications, with sepsis incidence doubling from 1.2% to 2.4%.
A new study found that patients with severe acute kidney injury who see a nephrologist within 90 days of discharge have a 24% lower risk of dying. The benefit was most pronounced in individuals without prior specialist care, suggesting earlier follow-up may mitigate adverse events and improve outcomes.
The BIOMARGIN project aims to develop reliable, non-invasive methods to diagnose lesions in transplanted kidneys using integrated 'omics' technologies. The study will consist of four phases, including a retrospective analysis of existing samples to identify biomarkers and validate diagnostic performance.
A new Mayo Clinic survey reveals that support for living and deceased organ donation is increasing. Eighty-four percent would consider donating a kidney to a close friend or family member, while 49% would donate to someone they've never met.
A multicenter study found that administering sodium bicarbonate during and after open heart surgery does not reduce the incidence of acute kidney injury, but may increase mortality. The authors recommend against using this treatment to prevent AKI in patients undergoing open heart surgery.
Researchers at Massachusetts General Hospital successfully developed implantable, bioengineered rat kidneys that produced urine and functioned in living animals. The approach uses donor organs stripped of cells, repopulated with human or animal cells, and cultured to mimic native organ structure and function.
People with apple-shaped bodies are more likely to develop kidney disease due to lower kidney function, lower kidney blood flow, and higher blood pressure within the kidneys. Treatments that reduce kidney blood pressure may be beneficial for these individuals.
Research suggests that individuals with an apple-shaped body distribution may experience lower kidney function and higher blood pressure within the kidneys, increasing their risk of developing kidney disease. Treatments that reduce kidney blood pressure could be beneficial for these individuals.
The Johns Hopkins researchers developed a Web-based mathematical model to predict which patients would benefit from taking a possibly infected organ. The tool considers factors such as waiting list duration, previous transplants, age, and diabetes status.
A study found that low vitamin D levels at three months post-transplantation were associated with lower kidney function and increased scarring at one year. Vitamin D deficiency is common in patients with kidney failure. Maintaining normal vitamin D levels may prevent renal function deterioration after transplantation.
A recent study by Henry Ford Hospital reveals that the rise in minimally invasive kidney stone surgery has led to a higher incidence of blood infections and overall complications among female patients. The procedure's use has increased by 47% since 1999, with women making up a larger share of those undergoing the treatment.
A recent study published in BJU International found that despite growing trends towards kidney-preservation treatments, patients with chronic kidney insufficiency are more likely to undergo total nephrectomy. The researchers emphasize the need for further investigation into treatment selection factors.
A recent study found that suboptimal kidney response to the hormone FGF-23 may increase risks for kidney disease patients, particularly those with lower urinary phosphorus levels. The study suggests that resistance to FGF-23's hormonal actions in the kidney may identify novel aspects of kidney dysfunction.
A study found that patients with greater knowledge and motivation about transplantation are more likely to receive a living donor transplant. This suggests that improving patient education may help reduce disparities in transplantation outcomes.
A multicenter analysis found patients taking high potency statins for high blood pressure are at a 34% higher risk of hospitalisation for acute kidney injury (AKI) compared to those taking low potency statins. This risk remains elevated for two years after initiation, highlighting the need for clinicians to consider alternative options.
A study of over 404,000 dialysis patients found significant racial and geographic disparities in kidney care. Black patients received less pre-end-stage renal disease (ESRD) care than their white counterparts, particularly in rural and large-metro counties.
Researchers identify semaphorin 3A as a sensitive biomarker for early detection of acute kidney injury, which can help minimize damage and potentially reverse it with rapid intervention. High levels of the protein in urine are accurate at identifying injured kidneys within two hours after cardiopulmonary bypass surgery.
A Johns Hopkins study suggests that paired kidney exchanges, also known as 'kidney chains,' could increase by an additional 1,099 transplants annually if more hospitals perform these transplants. The growth in the use of these exchanges stalled since 2010 due to financial barriers related to logistics and administrative costs.
A recent study presented at the American College of Cardiology's Annual Scientific Session found that high doses of rosuvastatin significantly reduced the rate of acute kidney injury caused by contrast agents used in imaging tests. The statin group had lower rates of kidney damage and adverse events compared to the control group.
Pediatric kidney transplant recipients with antibodies are more likely to experience kidney injury and rejection. Steroids do not prevent this antibody-mediated injury, but monitoring recipients for antibodies and customizing immunosuppressive treatments can help.
A team led by Dr. Marie-Josée Hébert discovered a new class of antibodies - anti-LG3 - which can trigger severe rejection episodes and high organ loss rates in kidney transplant patients. This breakthrough holds promise for developing new therapies to prevent or limit organ rejection.
Researchers believe blocking the sodium transporter HVI may stop the vicious cycle of excessive sodium, free radicals, and hypertension. If successful, targeted treatment could help reduce cardiovascular disease risk.
A specialized receptor in blood vessels senses molecules created by gut microbes, increasing blood pressure. The finding suggests a complex system involving gut bacteria and blood vessel regulation.
A study found that certain gene mutations increase the risk of developing aHUS and affect patient prognosis after diagnosis. Screening for these mutations may help diagnose and treat affected individuals.
IBN researchers successfully generated human kidney cells from human embryonic stem cells in vitro, providing a potentially unlimited source of cells for in vitro toxicology testing and regenerative medicine applications. The cells displayed similar gene and protein expression patterns to those isolated from fresh human kidney samples.
Researchers at the University of Manchester have identified a molecular basis for tissue-specific immune regulation in eye and kidney diseases. A common genetic alteration in complement factor H (CFH) is associated with AMD, while a different mutation is linked to rare kidney disease aHUS.
A study found that certain gut microbes convert melamine into toxic cyanuric acid, accelerating kidney stone formation. This conversion process is key to understanding melamine-induced kidney failure in humans.
Adding fruits and vegetables to the diet has been shown to reduce metabolic acidosis and kidney injury in late-stage chronic kidney disease patients. One-year plasma total carbon dioxide levels increased in both groups, indicating a lessening of metabolic acidosis.
A Mayo Clinic-led study has identified two biomarkers, IGFBP-7 and TIMP-2, that can detect acute kidney injury in urine, allowing for early intervention and improved patient outcomes. The study's findings have the potential to revolutionize the diagnosis and management of this deadly condition.
A recent study published in Kidney International found that higher levels of omega-3 fatty acids in the blood of patients starting hemodialysis were associated with a lower risk of sudden cardiac death. The five-year survival rate for dialysis patients is 35%, with sudden cardiac death being a major cause of mortality.
A large population-based study of men found that those taking vitamin C supplements are twice as likely to develop kidney stones as non-supplement users. The risk increased with the frequency of supplement use. Conversely, multivitamin use was not associated with an increased risk of kidney stones.
A recent study published in the Clinical Journal of the American Society of Nephrology found that African Americans and individuals without private insurance are less likely to receive a kidney transplant before needing dialysis. The study examined data from over 11,000 adult first-time deceased donor kidney transplant recipients in th...
A new study from the Johns Hopkins Bloomberg School of Public Health found chronic kidney disease is associated with a higher risk of death and end-stage renal disease for both women and men. The study analyzed data from over 2 million participants worldwide, including a diverse population of women making up 54% of the cohort.
Researchers developed an efficient method to induce human induced pluripotent stem (iPS) cells into intermediate mesoderm, the precursor of kidney cells. The protocol achieved a high success rate of 90% or more and successfully generated renal tubule structures.
Researchers found that nearly 3% of pediatric acute kidney injury cases can be directly linked to the use of common nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen. The study identified four young patients who needed dialysis and at least seven who may have suffered permanent kidney damage.
A new study reports that non-steroidal anti-inflammatory drugs (NSAIDs) cause acute kidney injury (AKI) in children, with younger patients more seriously affected and at higher risk of chronic kidney disease. The study found that 30% of patients experienced mild chronic kidney damage after recovery from AKI.