Articles tagged with Kidney
A recent study found that women are more likely to undergo percutaneous nephrolithotomy (PCNL), a minimally invasive procedure to remove medium to large kidney stones. The study also discovered an increase in blood infection and overall complications, with sepsis incidence doubling from 1.2% to 2.4%.
A new study found that patients with severe acute kidney injury who see a nephrologist within 90 days of discharge have a 24% lower risk of dying. The benefit was most pronounced in individuals without prior specialist care, suggesting earlier follow-up may mitigate adverse events and improve outcomes.
The BIOMARGIN project aims to develop reliable, non-invasive methods to diagnose lesions in transplanted kidneys using integrated 'omics' technologies. The study will consist of four phases, including a retrospective analysis of existing samples to identify biomarkers and validate diagnostic performance.
A new Mayo Clinic survey reveals that support for living and deceased organ donation is increasing. Eighty-four percent would consider donating a kidney to a close friend or family member, while 49% would donate to someone they've never met.
A multicenter study found that administering sodium bicarbonate during and after open heart surgery does not reduce the incidence of acute kidney injury, but may increase mortality. The authors recommend against using this treatment to prevent AKI in patients undergoing open heart surgery.
Researchers at Massachusetts General Hospital successfully developed implantable, bioengineered rat kidneys that produced urine and functioned in living animals. The approach uses donor organs stripped of cells, repopulated with human or animal cells, and cultured to mimic native organ structure and function.
Research suggests that individuals with an apple-shaped body distribution may experience lower kidney function and higher blood pressure within the kidneys, increasing their risk of developing kidney disease. Treatments that reduce kidney blood pressure could be beneficial for these individuals.
People with apple-shaped bodies are more likely to develop kidney disease due to lower kidney function, lower kidney blood flow, and higher blood pressure within the kidneys. Treatments that reduce kidney blood pressure may be beneficial for these individuals.
The Johns Hopkins researchers developed a Web-based mathematical model to predict which patients would benefit from taking a possibly infected organ. The tool considers factors such as waiting list duration, previous transplants, age, and diabetes status.
A study found that low vitamin D levels at three months post-transplantation were associated with lower kidney function and increased scarring at one year. Vitamin D deficiency is common in patients with kidney failure. Maintaining normal vitamin D levels may prevent renal function deterioration after transplantation.
A recent study by Henry Ford Hospital reveals that the rise in minimally invasive kidney stone surgery has led to a higher incidence of blood infections and overall complications among female patients. The procedure's use has increased by 47% since 1999, with women making up a larger share of those undergoing the treatment.
A recent study published in BJU International found that despite growing trends towards kidney-preservation treatments, patients with chronic kidney insufficiency are more likely to undergo total nephrectomy. The researchers emphasize the need for further investigation into treatment selection factors.
A recent study found that suboptimal kidney response to the hormone FGF-23 may increase risks for kidney disease patients, particularly those with lower urinary phosphorus levels. The study suggests that resistance to FGF-23's hormonal actions in the kidney may identify novel aspects of kidney dysfunction.
A study found that patients with greater knowledge and motivation about transplantation are more likely to receive a living donor transplant. This suggests that improving patient education may help reduce disparities in transplantation outcomes.
A multicenter analysis found patients taking high potency statins for high blood pressure are at a 34% higher risk of hospitalisation for acute kidney injury (AKI) compared to those taking low potency statins. This risk remains elevated for two years after initiation, highlighting the need for clinicians to consider alternative options.
A study of over 404,000 dialysis patients found significant racial and geographic disparities in kidney care. Black patients received less pre-end-stage renal disease (ESRD) care than their white counterparts, particularly in rural and large-metro counties.
Researchers identify semaphorin 3A as a sensitive biomarker for early detection of acute kidney injury, which can help minimize damage and potentially reverse it with rapid intervention. High levels of the protein in urine are accurate at identifying injured kidneys within two hours after cardiopulmonary bypass surgery.
A Johns Hopkins study suggests that paired kidney exchanges, also known as 'kidney chains,' could increase by an additional 1,099 transplants annually if more hospitals perform these transplants. The growth in the use of these exchanges stalled since 2010 due to financial barriers related to logistics and administrative costs.
A recent study presented at the American College of Cardiology's Annual Scientific Session found that high doses of rosuvastatin significantly reduced the rate of acute kidney injury caused by contrast agents used in imaging tests. The statin group had lower rates of kidney damage and adverse events compared to the control group.
Pediatric kidney transplant recipients with antibodies are more likely to experience kidney injury and rejection. Steroids do not prevent this antibody-mediated injury, but monitoring recipients for antibodies and customizing immunosuppressive treatments can help.
A team led by Dr. Marie-Josée Hébert discovered a new class of antibodies - anti-LG3 - which can trigger severe rejection episodes and high organ loss rates in kidney transplant patients. This breakthrough holds promise for developing new therapies to prevent or limit organ rejection.
Researchers believe blocking the sodium transporter HVI may stop the vicious cycle of excessive sodium, free radicals, and hypertension. If successful, targeted treatment could help reduce cardiovascular disease risk.
A specialized receptor in blood vessels senses molecules created by gut microbes, increasing blood pressure. The finding suggests a complex system involving gut bacteria and blood vessel regulation.
A study found that certain gene mutations increase the risk of developing aHUS and affect patient prognosis after diagnosis. Screening for these mutations may help diagnose and treat affected individuals.
IBN researchers successfully generated human kidney cells from human embryonic stem cells in vitro, providing a potentially unlimited source of cells for in vitro toxicology testing and regenerative medicine applications. The cells displayed similar gene and protein expression patterns to those isolated from fresh human kidney samples.
Researchers at the University of Manchester have identified a molecular basis for tissue-specific immune regulation in eye and kidney diseases. A common genetic alteration in complement factor H (CFH) is associated with AMD, while a different mutation is linked to rare kidney disease aHUS.
A study found that certain gut microbes convert melamine into toxic cyanuric acid, accelerating kidney stone formation. This conversion process is key to understanding melamine-induced kidney failure in humans.
Adding fruits and vegetables to the diet has been shown to reduce metabolic acidosis and kidney injury in late-stage chronic kidney disease patients. One-year plasma total carbon dioxide levels increased in both groups, indicating a lessening of metabolic acidosis.
A recent study published in Kidney International found that higher levels of omega-3 fatty acids in the blood of patients starting hemodialysis were associated with a lower risk of sudden cardiac death. The five-year survival rate for dialysis patients is 35%, with sudden cardiac death being a major cause of mortality.
A Mayo Clinic-led study has identified two biomarkers, IGFBP-7 and TIMP-2, that can detect acute kidney injury in urine, allowing for early intervention and improved patient outcomes. The study's findings have the potential to revolutionize the diagnosis and management of this deadly condition.
A large population-based study of men found that those taking vitamin C supplements are twice as likely to develop kidney stones as non-supplement users. The risk increased with the frequency of supplement use. Conversely, multivitamin use was not associated with an increased risk of kidney stones.
A recent study published in the Clinical Journal of the American Society of Nephrology found that African Americans and individuals without private insurance are less likely to receive a kidney transplant before needing dialysis. The study examined data from over 11,000 adult first-time deceased donor kidney transplant recipients in th...
A new study from the Johns Hopkins Bloomberg School of Public Health found chronic kidney disease is associated with a higher risk of death and end-stage renal disease for both women and men. The study analyzed data from over 2 million participants worldwide, including a diverse population of women making up 54% of the cohort.
Researchers found that nearly 3% of pediatric acute kidney injury cases can be directly linked to the use of common nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen. The study identified four young patients who needed dialysis and at least seven who may have suffered permanent kidney damage.
A new study reports that non-steroidal anti-inflammatory drugs (NSAIDs) cause acute kidney injury (AKI) in children, with younger patients more seriously affected and at higher risk of chronic kidney disease. The study found that 30% of patients experienced mild chronic kidney damage after recovery from AKI.
Researchers developed an efficient method to induce human induced pluripotent stem (iPS) cells into intermediate mesoderm, the precursor of kidney cells. The protocol achieved a high success rate of 90% or more and successfully generated renal tubule structures.
Researchers at UCSF and Kaiser Permanente have found that atrial fibrillation significantly increases the risk of end-stage renal disease among patients with chronic kidney disease. The study involved over 206,000 adults and showed that those who developed atrial fibrillation were 67% more likely to progress to kidney failure.
Research examines data from multiple studies to better understand how obesity impacts kidney transplant patients. Obese patients experience more adverse outcomes, including wound infections and cardiac disease, leading to poorer health outcomes after surgery.
A study published in The Lancet found that approximately one of every five individuals with kidney tumors common in patients with tuberous sclerosis complex has had a kidney removed unnecessarily due to misdiagnosis. Everolimus successfully shrinks these tumors, offering an alternative to surgery.
A large, randomized trial found that angiotensin II blockade did not lessen tissue scarring or prevent kidney failure in kidney transplant recipients. The treatment was safe and well-tolerated but showed no benefit in slowing disease progression.
A UK-wide clinical trial has identified a treatment approach that significantly reduces the risk of kidney failure in patients with membranous nephropathy. The study, published in The Lancet, recommends alternating monthly cycles of prednisolone and chlorambucil as the most effective treatment for this common type of kidney disease.
A new study found that directing short bursts of radio waves at nerves surrounding the kidneys lowered blood pressure for at least six months and up to one year. The procedure, called renal denervation, has significant public health implications in treating resistant hypertension.
Researchers at Monash University used advanced microscopy techniques to visualize the movements of white blood cells in healthy and diseased kidneys. They found that leukocytes are constantly circulating through and patrolling blood vessels within healthy kidneys, but become agitated during disease, causing inflammation and kidney damage.
Researchers at Henry Ford Hospital have developed a new technique for minimally invasive robotic partial nephrectomy procedures, sparing the kidney and eliminating long hospital stays. The technique, called ICE, provides better outcomes by giving surgeons more time to perform the procedure and allows for better tumor removal and analysis.
The 'Smart stethoscope' assesses the effectiveness of shock wave lithotripsy treatment for kidney stones by analyzing echoes after each shock wave hits the stone. This device has been shown to achieve high accuracy (94.7%) in clinical trials, reducing the need for repeat therapy and x-ray monitoring.
A study published by UCSF found that acute kidney injuries have doubled over the last decade, from 222 to 533 cases per million people. The total number of deaths associated with acute kidney injury also more than doubled during this time, from 18,000 in 2000 to nearly 39,000 in 2009.
The most severe form of acute kidney injury has seen a significant increase in incidence rates, with deaths associated with the condition also rising. The study highlights the need for further research into the causes behind this trend and potential interventions to reduce its impact.
The Belatacept Early Steroid withdrawal Trial (BEST) seeks to determine if a belatacept-based regimen can prevent organ rejection in post-transplant patients. Led by the University of Cincinnati, the trial will enroll 315 new kidney transplant patients and evaluate the safety and efficacy of steroid-free immunosuppression.
A study by Temple University found a significant association between decreased kidney function and reduced global cognitive ability, abstract reasoning, and verbal memory. Researchers tracked 590 individuals over five years to examine the longitudinal impact of renal decline on cognitive functioning.
A new study reveals that even low levels of preformed donor-specific antibodies can nearly double the risk of antibody-mediated rejection and increase kidney failure by 76%. This finding could help clinicians provide better donor-recipient matches and tailor immunosuppressive therapy.
A recent study published by Columbia University Medical Center has found a surprising genetic link between kidney defects and neurodevelopmental disorders in children. The research identified large genomic alterations in 10% of kids born with kidney defects, which are known to cause neurodevelopmental delay or mental illness.
A GW researcher has received a grant to study the effectiveness of Tamsulosin as an alternative treatment for kidney stones, with the goal of reducing complications and speeding up stone passage. The four-year study will enroll patients in three Emergency Departments and randomize them to receive either Tamsulosin or a placebo.
A study by UCSF analyzed emergency department visits and found that many minor genital injuries can be prevented through educational and product safety approaches. The research identified specific age groups and consumer products as risk factors, offering insights into preventing such injuries.
Recent studies suggest that hypertension and diabetes are more prevalent in black versus white donors, but the risk attributable to donation remains unknown. Individuals with prediabetes can safely donate kidneys without increasing their risk of developing diabetes or kidney failure.
A new study published in JAMA found that chronic kidney disease and its complications are associated with a higher risk of death regardless of age. Both low kidney function and high albuminuria were independently linked to mortality and end-stage renal disease, according to the findings.
A novel hydration protocol guided by left ventricular end-diastolic pressure reduced kidney damage by 59% in patients undergoing cardiac catheterization, according to the POSEIDON trial. The study found that this technique can be easily implemented and adapted for both inpatient and outpatient settings.
LncRNAs have been found to regulate gene expression in various diseases, including brachydactyly and HELLP syndrome. Additionally, research on obesity has shown that early genetic intervention can rescue mice from obesity-induced metabolic disorders. Furthermore, editing mistakes in miR-376 cluster have been linked to invasive brain tu...
Researchers have successfully created functional 'organoids' that can carry out kidney functions when implanted into rats. The breakthrough could lead to more options for individuals with kidney failure and better tools for understanding and treating complex kidney diseases.
Researchers have identified a new therapeutic target for diabetic nephropathy, the leading cause of kidney failure, by activating liver x receptor (LXR) to inhibit osteopontin expression. Activation of LXR with a drug named T0901317 improves kidney health and function in diabetic mice.
A recent study suggests that active surveillance is a viable alternative to surgery for small kidney masses, offering similar cancer outcomes in the short and intermediate term. Researchers found that patients under active surveillance had a growth rate of 0.21cm per month, with 53% showing no growth.