Articles tagged with Kidney
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A preclinical study has established a link between gene variants in African American populations and kidney disease risk. The G1 and G2 APOL1 variants, found almost exclusively in West African descent individuals, cause human-like kidney disease when expressed in filtering cells.
A new study reports improved kidney transplant success rates in children and infants over the past 53 years. The study found that young children now experience better long-term transplant success than adults, with almost 100 percent patient survival rate.
A research team at Mount Sinai has identified biological pathways involved in diabetic kidney disease, providing a potential diagnostic test and therapeutic strategy. The study found that blocking a cellular receptor can prevent kidney damage in mice with diabetic kidney failure.
A new study found that HIV-infected individuals with kidney failure are less likely to receive a transplant, especially from living donors. The study highlights the need for expanded access to organs for HIV+ patients to address disparities in transplantation.
Researchers found that an initial diagnosis of acute kidney injury may have been inaccurate for many patients, as the current method of assessing kidney function may be misleading during the initial evaluation. The study identified sets of biomarkers in mouse models that could potentially detect kidney damage more reliably.
A study of 125,000 patients found that more than half with chronic kidney damage took PPIs without acute problems, highlighting the need for vigilance in monitoring kidney function. Doctors advise caution and only prescribe when necessary due to significant risks of kidney deterioration.
Researchers found that acute kidney injury causes a buildup of indoxyl sulfate in the blood and lungs, leading to damage. Oral treatment with AST-120 decreases IS levels and improves lung function in animal models.
Researchers have discovered a new pathway that likely plays an important role in rejection following kidney transplantation. The findings suggest that targeting specific immune cells or signaling pathways may help prevent tissue scarring.
Researchers at UT Southwestern Medical Center have developed a potential drug, RGLS4326, to treat polycystic kidney disease, an incurable genetic disorder. The drug has shown promise in slowing cyst growth and delaying ADPKD progression in preclinical animal testing.
Patients with primary non-English language fluency face disparities in completing kidney transplant evaluations, ultimately affecting their access to a transplant. Researchers found that linguistically isolated households were linked to lower likelihoods of transitioning to active waitlist status and incomplete evaluations.
The new method can pinpoint kidney damage in under three-quarters of an hour, using blood/urine with the help of fumarase. Researchers expect the method to be transferable to patients soon, and are currently testing it on patient blood samples.
Scientists are investigating how increased cell death from high blood pressure leads to inflammation and further increases blood pressure. They aim to identify targets that could block unintended results without suppressing the natural immune response.
A novel microfluidic device models human kidney function, exhibiting more natural cell behaviors than traditional culturing methods. The device's glomerular filtration system is crucial for healthy cell function and accurately predicting renal drug toxicity in humans.
Researchers at Queen Mary University London have discovered a genetic defect causing kidney and adrenal disease in patients from around the world. The study found that defects in the SGPL1 gene can lead to progressive diseases with neurological involvement.
Researchers at Buck Institute for Research on Aging found that alpha-lipoic acid prevented stone formation in a mouse model of cystinuria, a rare inherited disease. The supplement increased the solubility of cystine crystals, providing a new function for alpha-lipoic acid.
A study found that patients with renal dysfunction upon admission are more likely to die while hospitalized and have lower chances of being discharged home. Those with normal kidney function have better short-term outcomes, according to the estimated glomerular filtration rate (eGFR) test.
A recent study published in Annals of Emergency Medicine found no association between intravenous contrast media and acute kidney injury. The research, which analyzed five years of records, showed that the probability of developing acute kidney injury was higher for patients receiving unenhanced CT scans.
Patients with kidney failure receiving chronic hemodialysis often have depressive symptoms but refuse treatment. When willing, doctors commonly don't prescribe anti-depressant therapy, citing underlying reasons including physiological and psychological changes associated with kidney failure.
A randomized trial will investigate canagliflozin's effects on kidney function decline and provide benefits to diabetic patients. The study aims to slow kidney damage and inform treatment decisions.
A study at Columbia University Medical Center found that a missing CRKL gene causes kidney and urinary tract defects in people with DiGeorge syndrome. The team analyzed genomic data from over 2,600 children with congenital anomalies of the kidney and urinary tract.
A study found that decreased blood levels of soluble klotho were linked to an increased likelihood of experiencing kidney function decline in elderly adults. Higher klotho levels may help preserve kidney function.
A combination of steroids and sirolimus with immune checkpoint inhibitors may help prevent organ rejection in kidney transplant patients undergoing cancer treatment. This discovery shows promise for people with cancer who have also had a kidney transplant, potentially allowing them to receive full benefits from immunotherapy.
Researchers at Massachusetts General Hospital developed a new monoclonal antibody that binds to CD11b/CD18 receptor molecules, preventing ischemia/reperfusion injury and halting fibrotic kidney failure. The treatment has shown promise in cynomolgus monkeys and may also be useful in treating heart attack, stroke, and organ transplants.
Dutch clinicians have developed a personalized dosing strategy for treating multidrug-resistant tuberculosis, reducing hearing loss from 40% to 10%. By monitoring drug concentrations and effectiveness, they were able to decrease doses without compromising efficacy.
A new study from Intermountain Medical Center found that using longitudinal data improves predictive accuracy for kidney transplant patients. Four predictive models were developed by layering available data, achieving accuracy improvements of nearly 16% and up to 83.8% in predicting kidney loss or death.
A study analyzing data from over 12,000 children reveals racial disparities in kidney transplant survival rates, with black children at higher risk due to reduced access to transplantation. Hispanic children, despite lower access, had a lower risk of death compared to non-Hispanic white children.
A study by Massachusetts General Hospital found that women with a history of acute kidney injury have a higher risk of adverse outcomes during pregnancy, including preeclampsia and preterm delivery. Despite normal kidney function before pregnancy, these women were more likely to develop complications.
Children whose mothers smoked during pregnancy are more likely to show signs of kidney damage. Maternal smoking is linked to an increased risk of childhood proteinuria, a sign of reduced kidney function that can lead to chronic kidney disease and end-stage renal disease in adulthood.
A study found that women with a history of recovered acute kidney injury had an increased rate of preeclampsia and delivered infants earlier than those with normal kidney function. Infants born to these women were also at higher risk for small-for-gestational-age births.
A new study found that urinary epidermal growth factor levels provided improved ability to distinguish between patients with kidney involvement and those without. The biomarker was also associated with overall lupus damage, suggesting its potential role in monitoring disease progression.
Rates of dementia and Alzheimer's disease are higher among older kidney transplant recipients than in the general population. Older patients with kidney failure who receive a kidney transplant are at increased risk of developing these conditions, which can threaten both their transplanted organ and survival.
A study found that patient and kidney survival rates are comparable among donor age groups, including those over 80. Kidneys from octogenarian donors have a higher discard rate, but the difference is not significant. The results support using extended criteria donors, including older adults.
A meta-analysis published in Neurology found that people with protein in their urine are 35% more likely to develop cognitive impairment or dementia. Chronic kidney disease shares many risk factors with dementia, including high blood pressure, diabetes, and high cholesterol.
A study published in Nature Medicine identifies bone marrow-derived immature myeloid cells as the source of suPAR, a reliable marker for chronic kidney disease. Elevated suPAR levels have been linked to future chronic kidney disease, potentially enabling early intervention and prevention of recurrence after transplant.
Researchers have discovered an experimental molecule that inhibits kidney function in mosquitoes, preventing resistance to conventional insecticides. The new compound, VU041, targets blood-feeding female mosquitoes and does not harm honeybees.
Researchers developed low-cost 3D printed organ models of varying size and shape to aid in determining optimal dosing for individual patients. The study demonstrates the potential of 3D printing technology for clinical prototyping, particularly in quantitative SPECT/CT imaging.
A new review of 55 kidney stone studies suggests alpha blockers may be useful in facilitating stone passage, particularly for patients with larger stones. The findings indicate a 57% higher risk of stone passage for larger stones with an alpha blocker, but no benefit for smaller stones.
The Journal of X-Ray Science and Technology has added embedded 3D image videos to its articles, enhancing the value of five papers on kidney injuries, tumor diagnoses, and dental medicine. The videos allow readers to examine rotating 3D images in detail, gaining a deeper understanding of diagnoses, prognoses, and treatments.
A recent study found that low-fat diets and regular exercise can reduce liver inflammation and scarring in patients with non-alcoholic steatohepatitis. Additionally, improved liver health was associated with enhanced kidney function in these individuals, independent of other factors such as diabetes or weight loss.
Researchers found that diabetes patients with all three risk factors (AKI, proteinuria, and poor blood sugar control) lose renal function at nearly 5% annually, accelerating dialysis need to within 12 years. Patients with two or one of these risk factors still face accelerated loss of renal function.
Recent studies have yielded promising results for patients with type 2 diabetes, including a 21% reduced risk of kidney dysfunction or death. Remote ischemic preconditioning has also shown sustained improvement in kidney function after transplantation. Meanwhile, trials examining dialysate sodium levels and voclosporin treatment have o...
A study found that intensive systolic blood pressure lowering can prolong life compared to standard levels, preventing approximately 107,500 deaths per year. Additionally, this approach is projected to save around 32,800 lives annually among adults with stage 3-4 chronic kidney disease.
Research found that short and poor quality sleep were associated with a lower risk of developing kidney failure, while higher sleep fragmentation increased the risk. Patients who experienced daytime sleepiness also had a higher risk of death during follow-up.
Researchers have developed a living membrane using conditionally immortalized human renal proximal tubular epithelial cells on polyethersulfone-based hollow fiber membranes. This breakthrough brings the development of a bioartificial kidney closer to reality, offering hope for millions of patients with kidney failure.
A study by Eugene Lin and colleagues found that multi-disciplinary care is a cost-effective intervention, costing $24,613 per quality-adjusted life year (QALY), compared to dialysis which costs $129,090 per QALY. This approach can improve the health of patients with kidney disease while reducing medical costs.
Amit X. Garg, a renowned nephrologist, is being honored by the American Society of Nephrology for his groundbreaking research on living kidney donation and kidney health analytics. His work has led to improved understanding and treatment of kidney diseases, including E. coli O157:H7 poisoning and acute kidney injury.
Studies found that proton pump inhibitors and histamine receptor-2 blockers increase the risk of developing kidney stones and chronic kidney disease. Long-term use of these medications was associated with a higher risk of kidney stone formation, particularly those made of calcium oxalate.
A multinational study found that nearly one-fourth of children admitted to pediatric intensive care units worldwide develop acute kidney injury (AKI), which increases the risk of death. The study also revealed that severe AKI is associated with an increased need for mechanical ventilation and renal replacement therapy, highlighting the...
A simple saliva test for salivary urea nitrogen showed high accuracy in diagnosing kidney disease in adults in Malawi. The test also predicted patients' risk of early death, highlighting its potential to improve treatment outcomes.
The ASN Foundation is launching a Securing the Future Campaign to raise critical funding for the Career Development Grants Program. The program aims to provide support for early career investigators in kidney research. With the campaign, the organization hopes to guarantee funding and attract top talent to the field.
A study found that cigarette smoking blocked the benefits of medications taken by patients with early chronic kidney disease. Nonsmokers and quitters had slower worsening of kidney function compared to those who continued to smoke, highlighting the importance of quitting smoking for kidney health.
A telemedicine program in partnership with a national dialysis provider and a rural hospital in Kentucky has successfully treated over a dozen patients with more than 20 dialysis treatments, achieving 67% success rate. The program also provides 24/7 nephrology care for patients with kidney and electrolyte disorders.
A new study found that reducing sodium intake significantly reduced albuminuria and blood pressure in patients with chronic kidney disease. The combination of paricalcitol and a low sodium diet resulted in the lowest albuminuria levels in patients, indicating a strong reduction in kidney function decline and heart benefits.
Scientists have developed a method to create functional kidney units from patient cells, allowing for the study of human kidney diseases and potential therapeutic agents. The research enables in vitro studies of kidney pathophysiology and nephrotoxicity, with the ultimate goal of developing bioengineered kidneys for regenerative medicine.
Research links kidney damage to impaired cognitive function, including memory and attention, as well as structural brain changes. Higher albumin in urine, indicative of poor kidney function, was associated with worse cognitive performance.
Boston University researchers discovered a novel molecular pathway needed to regulate kidney podocytes, critical in maintaining normal kidney function. This finding may help identify a new drug target for chronic kidney diseases associated with podocyte loss.
A new program, Live Donor Champion, has been shown to increase knowledge of live donation and comfort approaching others about live donation. The program boosted live donor referrals, with a 5.5-fold increase in having at least one donor referral compared to matched controls on the waiting list.
A retrospective cohort study found that chronic kidney disease patients who achieve target urate levels show improvement in kidney function. The study suggests that urate-lowering therapy may help stabilize or improve kidney function in patients with significantly elevated serum uric acid and moderate kidney failure.
Research found no association between allopurinol use and increased risk of chronic kidney disease (CKD) Stage 3 or higher in gout patients with normal kidney function. Allopurinol may be beneficial for preventing renal decline, suggesting its safe use in managing gout symptoms.
Researchers have discovered a link between constipation and poor kidney health, suggesting that diagnosis and management of constipation may help prevent or treat kidney disease. Individuals with constipation had a 13% higher likelihood of developing chronic kidney disease and a 9% higher likelihood of developing kidney failure compare...