Articles tagged with Kidney
The new UNOS system reduced disparities in national kidney transplant rates for blacks and Hispanics, with significant increases in transplant rates for these groups after implementation. However, disparities may return if the most disadvantaged patients are cleared from the list.
A study by Loyola Medicine found that 0.09% of patients who underwent urologic surgery were diagnosed with opioid dependence or overdose (ODO) within a year. Patients at highest risk for ODO were younger, had longer hospital stays, and were on Medicaid or Medicare.
Receiving donor kidneys from individuals with diabetes offers a greater survival benefit than remaining on the waitlist for many transplant candidates. Patients at high risk of dying while on the waitlist and those at centers with long wait times may benefit the most from transplantation with kidneys from diabetic donors.
A new study finds that accepting a kidney from a deceased diabetic donor can improve survival rates for sicker patients, with a nearly 10% improvement in long-term survival. Patients over 40 or with existing diabetes may benefit most from transplantation with diabetic donor kidneys.
A new study has identified various medical diagnoses that may elevate an individual's risk of developing acute kidney injury (AKI) while in the hospital. AKI is often associated with medical or surgical conditions that deprive the kidneys of normal blood flow, and previous studies have only identified certain risk factors.
A team of researchers at Harvard's Wyss Institute has successfully engineered human induced pluripotent stem cells into mature podocytes with over 90% efficiency, paving the way for modeling patient-specific kidney diseases and guiding therapeutic discovery. The development of a functional human kidney glomerulus chip opens up new expe...
Researchers at UVA Health System discover that a single type of stem cell turns into both blood and heart tissue, shedding light on cause of ventricular non-compaction cardiomyopathy. The S1P1 gene is vital for proper heart formation.
A new study analyzed 21,380 nephrectomies and found the 30-day mortality rate to be only 0.5%. Established risk factors were confirmed, with old age, co-morbidities, significant blood loss, and advanced stage of disease identified as major contributors.
Researchers developed a technique using multimodal autofluorescence and light scattering to evaluate kidney function after ischemic injury. The study suggests that variations in tissue microstructure, fluorophore emission, and blood absorption spectral characteristics contribute to the behavior of recorded signals.
A novel treatment has been successfully used to treat patients with a rare disorder that causes kidney failure, allowing targeted elimination of abnormal proteins and improving kidney function. The treatment, Daratumumab, targets plasma cell clones in the bone marrow, offering a new way to specifically treat the problem.
The University of Alabama at Birmingham has been awarded a five-year, $11.2 million Program Project Grant to study the renal control of sodium and salt balance. The research aims to understand how the body regulates salt intake and its impact on blood pressure regulation.
Researchers have developed a novel fruit fly model of kidney cysts, enabling the deciphering of biochemical pathways in polycystic kidney disease and cancer. The findings will help identify new treatment targets and methods for certain kidney diseases and cancers.
Researchers at Indiana University identified a therapy that rapidly restores blood flow in the organ, reduces inflammation and improves overall kidney function after acute kidney injury. The therapy has the potential to eliminate the need for dialysis treatment.
Ten patients at Penn Medicine have been cured of Hepatitis C following kidney transplants from HCV-infected donors. The study demonstrates the potential for increasing organ supply and may open up new transplant options for hundreds more patients.
Researchers developed a risk calculator to estimate long-term risks of developing kidney failure in living kidney donors. The study found that black donors and older male donors were at higher risk, while younger black candidates should be carefully evaluated.
A new study published in Oncoimmunology suggests that kidney dysfunction in cancer patients can be triggered by the immune system's response to the tumor. Researchers identified neutrophils as a key player in this process, which can lead to impaired blood flow and inflammation in organs like the kidneys.
Scientists at Joslin Diabetes Center have found that healthy individuals with diabetes develop protective enzymes against damage from high blood sugar levels. The researchers identified an enzyme called PKM2 and showed that activating it can stop abnormalities in mouse podocytes and delay diabetic kidney disease progression.
Researchers discovered a protein cocktail in urine that can distinguish between viral infection and organ rejection. The new test may enable early detection of transplant failure, improving outcomes for patients.
Chronic kidney disease (CKD) affects one-third of the population, with 9 out of 10 people unaware of their condition. The Global Kidney Health Atlas highlights gaps in care and prevention worldwide, with many countries not prioritizing kidney health.
A recent study examines how new kidney specialists feel their training has prepared them to care for patients, highlighting areas for improvement in nephrology fellowship structure and content. The findings suggest that fellows may be underprepared for home dialysis modalities and emphasize the need for more education in core nephrolog...
A novel dietary supplement has been shown to reverse cellular damage caused by specific genetic mutations in the kidneys of transgenic fruit flies. The study provides a personalized model for testing novel therapies for rare diseases such as focal segmental glomerulosclerosis (FSGS), which currently lack treatment options.
A new study published in JCI Insights reveals that increasing SMOC2 levels in the kidney can initiate and continue kidney fibrosis, while reducing SMOC2 levels prevents it. Detecting SMOC2 in urine may help diagnose fibrosis, making it a potential biomarker for early intervention.
A new noninvasive imaging test, sestamibi SPECT/CT, has been shown to accurately rule out kidney cancers. The test adds diagnostic information to conventional CT and MRI scans, improving physicians' ability to differentiate between benign and malignant tumors.
A new analysis reveals that by 2013, cardiovascular deaths due to reduced kidney function surpassed kidney failure deaths globally. Maintaining kidney health may help prevent cardiovascular diseases and deaths. The study found that reduced kidney function increases the risk of congestive heart failure, heart attacks, and strokes.
A study by Maastricht University Medical Center found that up to 10% of patients undergoing euthanasia in Belgium could be potential organ donors. This estimate suggests that donation after euthanasia could significantly ease the organ shortage, potentially increasing available organs from 684 to over 1,400.
A new study found that a type of vaginal bacteria, Gardnerella vaginalis, can trigger recurrent urinary tract infections (UTIs) by damaging bladder cells and allowing E. coli to multiply. The researchers suggest that this may be why some women experience UTIs after having sex.
A new study reveals that a higher risk of transplant failure is associated with a 28% increase in weight compared to the donor, as well as a 35-50% relative risk for opposite-sex kidney transplants. This highlights the importance of considering donor and recipient matching beyond current immunology-based protocols.
Researchers found that certain white blood cells, known as BK virus-specific CD8 killer T lymphocytes, significantly increase in patients who can control the virus. These cells can be propagated in cell cultures and may contribute to developing vaccines and adoptive T-cell therapy.
Researchers developed a new method to track perfluorinated and polyfluorinated alkyl substances (PFASs) from fast-food wrappers in the body, linking them to various health issues. The study found PFASs were detected in all tested organs, including liver, stomach, lungs, kidney, heart, skin, muscle, brain, and others.
A recent Yale-led study found that marathon running can cause short-term kidney injury in runners, with 82% of participants showing signs of Stage 1 Acute Kidney Injury after the event. The researchers attribute this to sustained rises in core body temperature, dehydration, and decreased blood flow to the kidneys.
A meta-analysis of three randomized trials found that vitamin E supplementation reduced the risk of contrast medium-induced acute kidney injury (CIAKI) by up to 62%. This may be due to its antioxidant activity, with a pooled effect indicating significant protection against CIAKI.
Scientists discovered that 'bad' mitochondria accumulate in old kidneys, leading to permanent damage and renal failure. Preliminary training may not be effective in older animals due to impaired quality control mechanisms.
The Special Issue highlights the exciting applications of organoid research in the medical field, including drug screening and modeling human diseases. Organoid technology also offers insight into developmental biology, enabling scientists to study human development in a developing embryo.
A new study reveals that patients with pre-existing donor-specific antibodies experience better kidney survival rates compared to those with de novo antibodies. Understanding the timing of antibody responses can guide matching and prevent rejection.
A preclinical study has established a link between gene variants in African American populations and kidney disease risk. The G1 and G2 APOL1 variants, found almost exclusively in West African descent individuals, cause human-like kidney disease when expressed in filtering cells.
A new study reports improved kidney transplant success rates in children and infants over the past 53 years. The study found that young children now experience better long-term transplant success than adults, with almost 100 percent patient survival rate.
A new study found that HIV-infected individuals with kidney failure are less likely to receive a transplant, especially from living donors. The study highlights the need for expanded access to organs for HIV+ patients to address disparities in transplantation.
Researchers found that an initial diagnosis of acute kidney injury may have been inaccurate for many patients, as the current method of assessing kidney function may be misleading during the initial evaluation. The study identified sets of biomarkers in mouse models that could potentially detect kidney damage more reliably.
A research team at Mount Sinai has identified biological pathways involved in diabetic kidney disease, providing a potential diagnostic test and therapeutic strategy. The study found that blocking a cellular receptor can prevent kidney damage in mice with diabetic kidney failure.
A study of 125,000 patients found that more than half with chronic kidney damage took PPIs without acute problems, highlighting the need for vigilance in monitoring kidney function. Doctors advise caution and only prescribe when necessary due to significant risks of kidney deterioration.
Researchers found that acute kidney injury causes a buildup of indoxyl sulfate in the blood and lungs, leading to damage. Oral treatment with AST-120 decreases IS levels and improves lung function in animal models.
Researchers at UT Southwestern Medical Center have developed a potential drug, RGLS4326, to treat polycystic kidney disease, an incurable genetic disorder. The drug has shown promise in slowing cyst growth and delaying ADPKD progression in preclinical animal testing.
Researchers have discovered a new pathway that likely plays an important role in rejection following kidney transplantation. The findings suggest that targeting specific immune cells or signaling pathways may help prevent tissue scarring.
A novel microfluidic device models human kidney function, exhibiting more natural cell behaviors than traditional culturing methods. The device's glomerular filtration system is crucial for healthy cell function and accurately predicting renal drug toxicity in humans.
Patients with primary non-English language fluency face disparities in completing kidney transplant evaluations, ultimately affecting their access to a transplant. Researchers found that linguistically isolated households were linked to lower likelihoods of transitioning to active waitlist status and incomplete evaluations.
The new method can pinpoint kidney damage in under three-quarters of an hour, using blood/urine with the help of fumarase. Researchers expect the method to be transferable to patients soon, and are currently testing it on patient blood samples.
Scientists are investigating how increased cell death from high blood pressure leads to inflammation and further increases blood pressure. They aim to identify targets that could block unintended results without suppressing the natural immune response.
Researchers at Buck Institute for Research on Aging found that alpha-lipoic acid prevented stone formation in a mouse model of cystinuria, a rare inherited disease. The supplement increased the solubility of cystine crystals, providing a new function for alpha-lipoic acid.
Researchers at Queen Mary University London have discovered a genetic defect causing kidney and adrenal disease in patients from around the world. The study found that defects in the SGPL1 gene can lead to progressive diseases with neurological involvement.
A study found that patients with renal dysfunction upon admission are more likely to die while hospitalized and have lower chances of being discharged home. Those with normal kidney function have better short-term outcomes, according to the estimated glomerular filtration rate (eGFR) test.
Patients with kidney failure receiving chronic hemodialysis often have depressive symptoms but refuse treatment. When willing, doctors commonly don't prescribe anti-depressant therapy, citing underlying reasons including physiological and psychological changes associated with kidney failure.
A recent study published in Annals of Emergency Medicine found no association between intravenous contrast media and acute kidney injury. The research, which analyzed five years of records, showed that the probability of developing acute kidney injury was higher for patients receiving unenhanced CT scans.
A study at Columbia University Medical Center found that a missing CRKL gene causes kidney and urinary tract defects in people with DiGeorge syndrome. The team analyzed genomic data from over 2,600 children with congenital anomalies of the kidney and urinary tract.
A randomized trial will investigate canagliflozin's effects on kidney function decline and provide benefits to diabetic patients. The study aims to slow kidney damage and inform treatment decisions.
A study found that decreased blood levels of soluble klotho were linked to an increased likelihood of experiencing kidney function decline in elderly adults. Higher klotho levels may help preserve kidney function.
A combination of steroids and sirolimus with immune checkpoint inhibitors may help prevent organ rejection in kidney transplant patients undergoing cancer treatment. This discovery shows promise for people with cancer who have also had a kidney transplant, potentially allowing them to receive full benefits from immunotherapy.
Researchers at Massachusetts General Hospital developed a new monoclonal antibody that binds to CD11b/CD18 receptor molecules, preventing ischemia/reperfusion injury and halting fibrotic kidney failure. The treatment has shown promise in cynomolgus monkeys and may also be useful in treating heart attack, stroke, and organ transplants.
Dutch clinicians have developed a personalized dosing strategy for treating multidrug-resistant tuberculosis, reducing hearing loss from 40% to 10%. By monitoring drug concentrations and effectiveness, they were able to decrease doses without compromising efficacy.
A new study from Intermountain Medical Center found that using longitudinal data improves predictive accuracy for kidney transplant patients. Four predictive models were developed by layering available data, achieving accuracy improvements of nearly 16% and up to 83.8% in predicting kidney loss or death.
A study analyzing data from over 12,000 children reveals racial disparities in kidney transplant survival rates, with black children at higher risk due to reduced access to transplantation. Hispanic children, despite lower access, had a lower risk of death compared to non-Hispanic white children.