Articles tagged with Kidney
A study of 3725 participants with chronic kidney disease found that depressive symptoms were associated with a higher risk of early death in white individuals, but not in black individuals. Treatment of depressive symptoms may help lower this risk.
A recent analysis has linked proton pump inhibitors (PPIs) to a 33% increased relative risk of chronic kidney disease or kidney failure. The study, published at ASN Kidney Week 2017, suggests that providers should consider the potential risks of PPI therapy in patients.
New treatments for kidney disease, such as tolvaptan for autosomal dominant polycystic kidney disease (ADPKD), have shown promising results in slowing kidney function decline. Bardoxolone methyl has also improved renal function in patients with diabetic kidney disease. Meanwhile, QPI-1002 has reduced the incidence and severity of acute...
A study found VA patients had significantly lower rates of kidney transplantation compared to those with private insurance, Medicare, or Medicaid. The researchers suggest that distance from transplant centers and other factors may contribute to these disparities.
A history of kidney stones may increase the risk of metabolic and hypertensive complications during pregnancy. Research found that women with pre-existing kidney stones were more likely to experience gestational diabetes and hypertension.
A study of over 900,000 US veterans found chronic insomnia to be associated with increased risks of early death, rapid kidney function decline, and kidney failure. The study suggests that attention to proper management of chronic insomnia could have long-ranging positive effects on overall health.
New research suggests that greater reductions in mean blood pressure may harm the kidneys, rather than benefiting them. In hypertensive patients, intensive blood pressure treatment was found to be associated with an increased risk of kidney function decline.
A dose-dependent inverse association was found between caffeine consumption and early death in patients with chronic kidney disease. The study, presented at ASN Kidney Week 2017, suggests that advising patients to drink more caffeine may reduce mortality.
A recent study found that African American patients were less likely to be wait-listed for a kidney transplant than White patients. Non-medical factors such as comorbidities, socio-economic status and social support played a significant role in the disparities.
A recent study found that children with high blood pressure at night experienced a faster time to kidney failure than those with normal blood pressure. The study also showed that patients with high blood pressure during both day and night had an even more rapid decline, highlighting the importance of nighttime blood pressure control in...
A new computer program has been developed to help doctors detect acute kidney injury earlier, reducing its severity and improving survival rates. The program, which was tested in over half a million patients, showed a significant reduction in hospital mortality, length of stay, and dialysis rates.
Longtime advocates Paul T. Conway and Richard Knight received the ASN's President's Medal for their significant contributions to the fight against kidney diseases, including improving access to treatment and increasing funding for research and treatment innovations.
A particular protein, DNAJB9, is found in abundance in the kidneys of patients with fibrillary glomerulonephritis, an aggressive kidney disease. The discovery may improve diagnosis and treatment options for this disease, which affects nearly half of patients who become dependent on dialysis.
The US Renal Data System report highlights the high burden of kidney disease in the US, with over 30 million adults affected, and a significant cost to healthcare. However, there is low awareness about the condition among patients, especially those with early stages of CKD.
A recent analysis found that kidney transplant recipients lived longer than those who stayed on dialysis for at least 10 years. The benefit was observed after 657 days post-transplant, with a 40% lower risk of death compared to patients on dialysis.
A study published in The Clinical Journal of the American Society of Nephrology found that left ventricular assist device (LVAD) therapy can affect kidney function, particularly in patients with chronic kidney disease. Researchers identified interventions to improve outcomes, including nephrologist involvement and enhanced dialysis tra...
A team of engineers is creating a smartphone-based test kit to detect kidney inflammation in patients with Systemic Lupus Erythematosus. The test uses glow-in-the-dark nanoparticles to measure protein levels in urine, offering a non-invasive and quantitative solution for patients.
Researchers found that robot-assisted laparoscopic surgery for kidney removal had comparable patient outcomes but higher costs, with a 46.3% chance of prolonged operative time compared to traditional procedures.
A study found that young adults with kidney failure have lower quality of life, worse employment prospects, and are less likely to be married or have a partner. Higher education, alcohol abstinence, and smoking status did not differ significantly between those on dialysis and transplantation.
Scientists have discovered a key protein controlling ferroptosis, a highly regulated cell death process that plays a role in health and disease. The research links ferroptosis to diseases such as asthma, kidney injury, and brain trauma, suggesting potential drug targets for treatment.
A new study found that acute kidney injury (AKI) is associated with significant healthcare costs, with the mildest forms of AKI resulting in 1.2 to 1.3 times greater costs than patients without AKI. The study estimates the incremental cost of AKI in Canada to be over $200 million per year.
A team of researchers has identified a region of the genome that regulates vitamin D activation in the kidneys, which could lead to new treatments for diseases involving vitamin D. The discovery also sheds light on the role of calcitriol in inflammatory diseases and its potential use as a treatment.
A study found that Canadian nephrologists generally recommend follow-up kidney evaluations for most patients with acute kidney injury but only a minority receive these evaluations. The disparity between recommendations and actual practices may be attributed to various factors, including patient age and pre-existing conditions.
A study found that many discarded kidney organs can be suitable for transplantation if certain steps are taken to limit damage following donation. The use of these organs could be increased by limiting cold ischemia times.
Researchers at UW Medicine have developed mini-kidney organoids that can track the early stages of polycystic kidney disease. By manipulating the micro-environment, they found that cyst formation can be increased or decreased.
A new $5 million NIH grant will investigate the effects of a genetic variation on kidney transplant outcomes in African American donors. The study aims to improve matching of donor kidneys with recipients and extend post-transplant kidney function.
Researchers found that adding healthy bacteria like Lactobacillus can reduce disease symptoms in female mice with lupus. The study suggests that a 'leaky gut' condition may contribute to the disease, and testosterone suppression may affect probiotic effects.
A study found a linear relationship between air pollution levels and the risk of experiencing kidney function decline and developing kidney disease or failure. The results suggest that particulate matter above the EPA's recommended limit is associated with new cases of chronic kidney disease (CKD) and end-stage renal disease (ESRD).
A new study from Washington University School of Medicine and VA St. Louis Health Care System found that breathing dirty air may harm kidneys. The research analyzed data on nearly 2.5 million people over 8.5 years, concluding that high levels of particulate matter increase the risk of chronic kidney disease and failure.
The UCLA-led study highlights the success of the kidney voucher program, which enables individuals to donate a kidney now and prioritize family members for future transplants. The program has led to 25 lifesaving transplants across the US, thanks to the altruistic donations of living donors.
Researchers discovered the GREB1L gene associated with renal agenesis, a hereditary condition causing one or no kidneys. The finding enables early detection of the disorder, providing relief to families.
A study found that individuals with chronic kidney disease who experienced high sleep fragmentation were at elevated risk of developing kidney failure. Higher sleep fragmentation and shorter sleep duration were also linked to steeper declines in kidney function over time. Subjectively measured daytime sleepiness was associated with an ...
A new research network, led by CHOP and Penn Medicine, aims to identify strategies to prevent kidney stone recurrence. The PUSH study tests personalized fluid goals, financial incentives, and health coaching to reduce stone recurrence over a two-year period.
A new study finds that sofosbuvir-based direct-acting antiviral therapy is safe and effective in patients with chronic kidney disease (CKD) and Hepatitis C virus (HCV) infection. The treatment improved kidney function in stage 3 patients after cure, suggesting a potential therapeutic option for CKD patients with HCV.
Researchers found that high levels of suPAR are a reliable predictor of kidney damage in children, similar to adults. The protein is associated with increased risk of kidney loss and progression in children with mild to moderate kidney disease.
Researchers discovered that a particular receptor in kidney cells plays a crucial role in obesity-induced kidney damage. Targeting this receptor or its associated signaling pathway may help protect the kidneys of individuals with obesity from structural and functional changes, thereby reducing the risk of chronic kidney disease.
Researchers use MRI elastogram to measure kidney scarring and predict future kidney function within one year. The test detects high variability in scarring throughout the entire organ and is comparable to traditional needle biopsies.
A recent study of healthy young adults found no association between marijuana use and change in kidney function over time or albumin in the urine. Further research is needed to assess the effects of marijuana on older adults and patients with kidney disease.
A cancer drug called bosutinib showed promise in slowing cyst growth in patients with autosomal dominant polycystic kidney disease (ADPKD). The study found a 66% reduction in kidney enlargement for those receiving bosutinib compared to placebo.
A study found that individuals with poor kidney function had a higher risk of developing lower respiratory tract infections, urinary tract infections, and sepsis. The relative proportion of these infections increased as kidney function decreased.
A new analysis suggests that targeted educational interventions can improve living kidney donation rates. The study found significant benefits from educating both the potential recipient and their close social network, highlighting a promising approach to increase living donor kidney transplantation.
A research team at Lund University has discovered that gene expression in normal tissue varies depending on the location within the kidney. This variation affects the accuracy of comparisons between tumour cells and healthy tissue, leading to a better understanding of kidney cancer subtypes.
The study found that individuals with kidney disease have a higher risk of developing atrial fibrillation. The risk increased step-wise with decreasing kidney function, and the link held even after accounting for other factors such as cardiovascular health.
A new approach to assess renal function in term newborns with hypoxic ischemic encephalopathy identifies early stages of AKI. Approximately 69% of infants did not develop kidney failure, while 19% showed a slower serum creatinine decline rate matching those with established AKI.
Researchers at Osaka University developed a non-invasive imaging technique to detect kidney damage and predict chronic kidney disease in diabetic patients. The method uses diffusion tensor MRI (DTI) to identify specific regions of the kidney with abnormal fluid dynamics, offering a promising approach to prevent kidney disease progression.
Researchers found that treating patients with IdeS drug before transplantation significantly reduced donor-specific antibodies, allowing successful kidney transplants. The enzyme, produced by Streptococcus pyogenes, can remove organ-rejecting antibodies, making kidney transplantation possible.
Charuhas Thakar, a leading expert on acute kidney injury (AKI), has addressed the treatment challenges of AKI as a guest editor for the Advances in Chronic Kidney Disease Journal. Thakar emphasizes the need to view AKI not only as a patient-centric issue but also as a systems quality issue that affects the entire healthcare system.
A study found that steroid treatment for IgA nephropathy was associated with a significantly higher risk of serious adverse events, primarily infections. The trial was stopped early due to an unexpectedly high rate of serious infections and two deaths.
A study published in BMC Nephrology found that patients receiving non-renal solid organ transplants are at a higher risk of death due to acute kidney injury. The research suggests that reducing AKI-D diagnoses can improve health outcomes and reduce the financial burden on the healthcare system.
A study found that US transplant centers rejected donated kidneys a median of 7 times before accepting them for transplantation. The rejections varied by patient and donor characteristics, contributing to racial and ethnic disparities in access to kidney transplants.
A new study reveals that patients discharged home from the emergency department with acute kidney injury (AKI) are at an increased risk of dying within 30 days. Patients with moderate-to-severe AKI have a higher risk of death, emphasizing the need for close follow-up and repeat kidney function testing.
Researchers have developed a method to quickly diagnose preeclampsia, which affects 5% of pregnancies and is linked to elevated fetal hemoglobin levels. The findings may lead to better diagnostics and treatments for affected women.
Researchers identified potential kidney damage from aggressive blood pressure treatments in mice and patients with high blood pressure. The study found that blocking renin cells, which are sometimes targeted in treating high blood pressure, can cause obstructive vascular lesions in the kidneys.
Researchers at the University of Cambridge have developed a new statistical model to estimate kidney function in cancer patients, improving chemotherapy dosing accuracy. The model reduces errors from over 20% to 11.7% compared to existing methods.
A recent study found that biopsy tests had no impact on kidney function after transplantation from living donors, but did influence outcomes with deceased donor kidneys. Despite this, nearly 20% of organs are still being discarded in the US due to suboptimal biopsy results.
The DYNAMO study aims to identify genes and processes involved in diabetic kidney disease, with the goal of reducing DKD by 30% in Singapore within five years. The research collaboration will utilize multiple experimental approaches to develop new treatments for kidney complications from diabetes.
Patients with acute heart failure and diabetes show unique signs of kidney health and inflammation compared to those without diabetes. Different treatment strategies may be needed for diabetic patients with acute heart failure due to these differences.
Researchers found that high suPAR protein levels combine with common genetic mutation to trigger disease onset and define rate of progression. The study used large cohorts of black patients with genetic risk factors for chronic kidney disease and found that plasma suPAR levels predict renal function decline.
Targeting a systolic blood pressure of <120 mm Hg reduced cardiovascular events and premature death in CKD patients, but slightly accelerated kidney function decline. The benefits were observed across all age groups within the CKD subgroup.
Researchers developed a calculator estimating graft survival after kidney transplant from living donors, accounting for mismatches in age, sex, HLA, and body size. The tool is particularly useful for kidney paired donation, allowing candidates to compare estimated graft survival with different potential donors.