Articles tagged with Kidney
Scientists led by George C. Tsokos discover that inhibiting CaMK4 can prevent podocyte damage in lupus-prone mice, reversing classical dogma on inflammation causing kidney damage. The finding opens doors to potential new therapies for autoimmune and non-autoimmune diseases impacting the kidneys.
A recent study published in Annals of Internal Medicine has found that cross-sex hormone therapy may increase the risk for certain vascular events among transgender women. The researchers compared the incidence rates of acute cardiovascular events in a large cohort of transgender persons with those observed in age-, race-, site-, and m...
Asymptomatic bacteriuria screening in pregnancy may reduce kidney infections and low birth weight, but evidence is low-quality. Women's values and preferences play a significant role in screening decisions.
A computer analysis predicts that transplanting HCV-infected dialysis patients with organs from HCV-positive donors and treating the infection after transplantation is more effective and less costly. This strategy shortens wait times for donated organs, saves $41,591 per patient, and increases quality-adjusted life years.
Researchers have successfully used viral vectors to deliver genetic material to kidney cells, paving the way for new treatments for chronic kidney disease. The discovery could lead to gene therapies that slow or reverse the growth of cells contributing to CKD.
Researchers at Washington University School of Medicine have developed a gene therapy method to target damaged kidney cells, which could lead to improved treatment for chronic kidney disease. The approach uses adeno-associated virus (AAV) to deliver genetic material to targeted cells, showing promise in slowing or reversing cell damage.
The endolymphatic sac acts as a pressure-relief valve for the inner ear, regulating fluid pressure and composition. The discovery may inform the study and treatment of disorders like Meniere's disease.
A randomized, controlled trial found that administration of nitric oxide gas during and for 24 hours following heart surgery decreased the risk of acute and chronic kidney problems. Nitric oxide reduced the risk of acute kidney injury by 50% and chronic kidney disease by 21%.
A new study found that Medicaid expansion increased the number of chronic kidney disease patients with Medicaid coverage who were placed on the kidney transplant waiting list. States that expanded Medicaid saw a significant boost in Medicaid-covered preemptive listings, especially among racial and ethnic minority patients.
Medicaid expansion has helped place many low-income individuals with chronic kidney disease on the kidney transplant waiting list before starting dialysis. The findings show larger gains in pre-emptive listing for minorities with Medicaid coverage than for whites.
A new study aims to clarify the role of the APOL1 gene in predicting kidney-transplant failure. By genotyping deceased and living African-American donors and recipients, researchers hope to determine if high-risk variants can replace race as a risk factor for discarded kidneys.
A recent study published in Clinical Transplantation found that carefully-selected older adults over 60 years old pose minimal risks for living kidney donation. The research suggests that accepting more older donors can expand the donor pool, making a previously perceived high-risk group accessible.
Researchers have discovered a glycoside called arbutin, extracted from the bearberry plant, that can break up kidney stones. The molecule has shown remarkable ability to dissolve kidney stones in pre-clinical studies, offering a potential new treatment option for patients.
A recent clinical trial has shown that tamsulosin is not effective in promoting the passage of ureteral stones, contradicting previous small studies. The study's findings suggest that the medication may be beneficial for specific subgroups of patients with larger or distal stones.
A recent study suggests that metformin is safe for most adults with diabetes and chronic kidney disease (CKD). The research, conducted by Johns Hopkins Medicine, found no association between metformin use and acidosis in patients with mild to moderate CKD. However, the risk of acidosis increased significantly among patients with severe...
USC researchers have discovered that the precise arrival of progenitor cells determines their form and function in the kidney. The study advances understanding of how to assemble building blocks to fashion kidney tissue, which can lead to breakthroughs in drug development and organ transplantation.
A study found that living kidney donors consider post-donation concerns such as kidney health and surgical impacts more important than hypothetical long-term risks. The research highlights the need to understand donors' priorities for informed decision-making and care.
A clinical trial found that comparable diabetes care eliminates racial disparities in kidney function decline and chronic kidney disease among patients with type 2 diabetes. The study suggests that delivering standardized care can reduce racial disparities in diabetes-related complications.
Research suggests that women who have had gestational diabetes may benefit from periodic checkups to detect early-stage kidney damage. The study found a link between high glomerular filtration rates and pre-diabetes, indicating a potential risk for chronic kidney disease.
A new study published in PNAS reveals that a protein called hamartin plays a central role in shutting down the nephron formation process in preterm infants. By reducing hamartin levels, researchers found that preterm babies could develop 25% more nephrons than control groups.
A new study reveals that acute kidney injury (AKI) is associated with a higher risk of cardiovascular events, particularly heart failure, in patients even after discharge from the hospital. Researchers found that AKI was linked to an 18% increased risk of composite outcomes including heart failure and atherosclerotic events.
A recent study by Kaiser Permanente found that hospitalized patients with acute kidney injury have a 44% higher relative risk of heart failure within one year of discharge compared to those without acute kidney injury. This increased risk highlights the importance of monitoring for signs of heart failure in these patients.
Researchers at the University of Washington School of Medicine developed a robotic system to rapidly produce human mini-organs derived from stem cells, expanding basic research and drug discovery capabilities. The new technology enables mass production of organoids, which resemble rudimentary organs and behave similarly.
Researchers discovered that elevated stress response protein levels are associated with reduced kidney damage after heart surgery. High MIF levels before surgery may help identify patients at risk for acute kidney injury.
Researchers found that poor functional status is associated with a higher incidence of initiating hemodialysis and increased risk of central venous catheter use. Elderly patients with poor functional status have an increased one-year mortality by 48 percent.
A new study reveals that oral antibiotics are associated with an increased risk of developing kidney stones, particularly among children. The risk remains elevated several years after antibiotic use, highlighting the importance of reducing unnecessary antibiotic exposure.
Researchers found a significant association between oral antibiotic use and an increased risk of developing kidney stones in children and adults. The study suggests that disruptions in the intestinal and urinary microbiome may contribute to the occurrence of kidney stones.
A new clinical trial found that coaching patients with Chronic Kidney Disease (CKD) to drink more water did not slow down the decline of their kidney function. However, increased water intake did suppress antidiuretic hormone release and may be beneficial for those who are low-intake drinkers.
The HOPE in Action Multicenter Kidney Study evaluates the safety and efficacy of kidney transplants between people with HIV, following the passage of the HOPE Act of 2013. Researchers track outcomes of 160 kidney transplants, comparing recipients who received organs from HIV-positive donors to those from uninfected donors.
A University of Houston researcher has activated a kidney cell that could prevent damage from inflammation caused by obesity. The targeted cells express the angiotensin type 2 receptor, which shows anti-inflammatory and reno-protective actions.
Researchers have identified kidney stem cells of human origin in amniotic fluid, a promising source for cell replacement therapies. The study shows an increase in these cells with gestational time, making amniotic fluid a valuable source of fetal stem cells with regenerative potential.
A study by Loyola Medicine researchers found a diverse mix of bacteria in the urine of kidney disease patients, including Staphylococcus and Streptococcus. This diversity is higher in patients experiencing urinary urgency and may lead to new approaches for treating lower urinary tract problems.
Scientists have created a detailed image of BKV, a virus affecting kidney and bone marrow transplant patients, which may aid in developing antiviral therapies. The new structures allow researchers to visualize potential targets for blocking the virus's entry into cells or preventing its assembly.
New research from two large international trials confirms that intracavitary and interstitial brachytherapy is safe and does not increase the risk of ureteral stricture in cervical cancer patients. The treatment is associated with better survival rates and fewer adverse side effects compared to other radiation therapies.
A substudy of the PRECISION trial found that adding aspirin to celecoxib reduced its cardiovascular safety advantage, while maintaining fewer GI problems and kidney issues compared to ibuprofen. Celecoxib remained associated with better overall outcomes in patients taking aspirin.
Diabetes impairs autophagy, a protective mechanism that filters blood waste, worsening prognosis and destroying kidneys. Researchers focus on restoring autophagy to find new therapies for acute kidney injury.
A new staging system for children with chronic kidney disease (CKD) predicts the length of time until a child will need a transplant or dialysis. The system takes into account three factors: glomerular filtration rate, proteinuria, and disease etiology.
Researchers from the University of Pennsylvania identified three novel cell populations and understood how kidney disease develops at a single-cell level. They found that specific cell types convert to each other, leading to conditions like chronic kidney disease, which affects about 14 percent of Americans.
A recent analysis found that the risk of death due to infectious causes after kidney transplantation has dropped significantly, with common bacterial infections remaining the most frequent cause. The study revealed a drop in infection-related mortality by half since the 1990s, indicating improved outcomes for transplant recipients.
A new study finds that kidney dysfunction is a contributing factor to severe malaria cases caused by Plasmodium vivax parasites. Elevated creatinine levels were associated with increased disease severity and mortality, while certain immune molecules could predict outcome in patients.
Researchers have identified two biomarkers, KIM-1 and NGAL, that can detect acute and chronic kidney damage in children with cystic fibrosis. The study found that these biomarkers increase during exposure to antibiotics, even before a decline in kidney function is detected by traditional methods.
A clinical trial, TAKE-IT, combines electronic medication monitoring and coaching to encourage adherence behavior in adolescent kidney transplant recipients. The study shows a 66% higher adherence rate among participants who used the digital health medication management solution with coaching.
Researchers have developed a microsensor that can monitor and adjust the composition of kidney dialysis fluid in real-time, potentially alleviating serious side effects. The microsensor, made by Eindhoven University of Technology, measures sodium concentrations accurately and live.
A trained navigator with a degree in social work helped increase access to the transplant waitlist among patients who needed a longer time to get through the transplant evaluation process. Nearly 70,000 US patients have end-stage renal disease and most benefit from kidney transplantation.
A recent study published in International Journal of Obesity found that patients who underwent weight-loss surgery had a significantly lower risk of developing severe chronic kidney disease and kidney failure. The Swedish Obese Subjects (SOS) study followed over 4,000 patients with obesity for more than 20 years and showed that surgica...
A new study by Brigham and Women's Hospital investigators explores the influence of biological sex on transplant outcomes. Researchers found that female donor sex is associated with increased transplant organ rejection rates in male recipients, while hormone receptors may play a role in these differences.
A study discovered that an experimental drug connected to fat regulation prevents the formation of kidney stones in mice. The researchers found that the β3-agonist reduced inflammation in kidneys by consuming free fatty acids, potentially preventing both obesity and kidney stones. Further studies are needed to confirm these findings.
A recent VA study found that over 30% of diabetic veterans had prior signs of chronic kidney disease. The results highlight the importance of early detection and screening for CKD in at-risk populations. Researchers propose broadening screening among patients with increased risk of CKD to prevent organ damage.
A new study reveals that changes in living kidney donation in the US over the last decade have varied by sex, resulting in a widened gap in donation between women and men. The incidence of donation was 44% higher in women after adjusting for differences in age, race, and geographic factors.
Research analysis of blood mediators in type 1 diabetes and kidney disease patients reveals 10 elevated proteins, with TNF-alpha family and IL-6 significantly impacting 40% of patients. This study suggests personalized medicine approach to target specific inflammatory mediators for effective treatment.
Research highlights the importance of preserving healthy kidney tissue and minimizing ischemia time in partial nephrectomy to prevent chronic kidney disease. Minimally invasive surgery is also shown to offer therapeutic scope without compromising oncological outcomes.
In a groundbreaking study, doctors at Johns Hopkins successfully transplanted hepatitis C-infected kidneys into patients without the virus. The recipients remained hepatitis C-free, and their kidneys functioned well, paving the way for more organs to be used in transplants.
The American College of Physicians (ACP) recommends less intensive blood sugar control targets for most patients with type 2 diabetes, aiming for an A1C range of 7-8% rather than 6.5-7%. This approach prioritizes symptom management over intensive treatment to balance benefits and harms.
Two landmark studies by Vanderbilt researchers show significant improvement in patient outcomes using balanced fluids instead of saline for intravenous therapy, leading to a decline in saline use at the hospital. The studies found a 1 percent lower incidence of serious kidney problems or death in patients receiving balanced fluids, res...
A new study by Queen Mary University of London aims to develop a 'beetroot pill' that could reduce the risk of kidney failure in patients undergoing coronary angiography. The research seeks to harness the antioxidant properties of dietary nitrate found in beetroot to prevent contrast-induced nephropathy, a common complication of the pr...
Research found that resolvin D-1 limits heart attack-induced kidney inflammation and promotes reparative macrophage change. This suggests potential application to clinical settings for treating cardiorenal syndrome.
Researchers created an open-source data atlas of human kidney development, providing detailed molecular and cellular information. The dataset will accelerate stem cell-based technologies for kidney replacement and regeneration therapies.
Recent studies have compared human and mouse kidney development, revealing deep conservation of certain processes but also significant differences in gene expression and cell structures. The findings provide new insights into the processes directing cells to form functional kidney structures and may help guide emerging stem cell techno...
A Mayo Clinic study found a steady increase in kidney stone formers, particularly among women aged 18-39. Improved imaging technology allowed for better diagnosis and classification of stones, leading to more symptomatic cases being detected.
Scientists at the University of Manchester successfully produced human kidney tissue within a living organism that is able to produce urine. The new structures contain most of the constituent parts present in human nephrons, including proximal tubules and Bowman's capsule, and have been linked to the vasculature of mice.