Articles tagged with Kidney
Researchers found that SGLT2 inhibitors are associated with a two-fold increased risk of lower limb amputation and diabetic ketoacidosis compared to GLP1 receptor agonists. However, the use of these drugs was not linked to other serious adverse events.
A new method for treating and preventing acute kidney injury (AKI) has been developed using tiny, self-assembling forms of DNA origami nanostructures. These nanostructures were shown to protect the kidneys from harm as effectively as the leading drug therapy and alleviate symptoms of AKI.
Researchers have developed a mouse model that closely replicates human diabetic nephropathy, revealing a key role for immune and inflammatory responses in promoting kidney damage. This finding suggests targeting these pathways may be useful for preventing or slowing the development of diabetic nephropathy.
Researchers analyzed data from 28 papers involving over 1,300 participants and found no evidence linking high protein diets to kidney disease in healthy individuals or those at risk of kidney disease. A high-protein diet can actually increase kidney function, making it a safe and important tool for muscle health across the lifespan.
Researchers at Drexel University developed a wearable artificial kidney using MXene materials that can filter out urea from blood with high efficiency. The material has shown better ability to adsorb urea molecules compared to other known sorbents, paving the way for a more portable dialysis machine.
Researchers have successfully developed kidney tissue that exhibits the early stages of congenital kidney disease using iPS cells from a patient with a nephrin mutation. The study found that repairing the nephrin mutation can normalize abnormalities and may lead to the development of effective drugs for kidney disease.
Frailty in kidney failure patients is associated with lower likelihoods of being placed on the transplant waitlist and receiving a transplant. Frail participants had nearly twofold increased risk of dying while on the transplant waitlist and underwent transplantation at a 35% lower rate than nonfrail participants.
A study comparing transplant data from the US and France reveals that approximately 2,000 donated kidneys are discarded annually in the US, despite a shortage of organs. Adopting greater willingness to accept higher-risk donor groups could provide an additional 132,445 allograft life-years.
Recent clinical trials have shown promising results in reducing progression of kidney disease and improving cardiovascular outcomes in patients with type 2 diabetes. These trials investigated the effects of linagliptin, a DPP inhibitor, on kidney outcomes, as well as high-dose versus low-dose intravenous iron therapy for hemodialysis p...
A recent study has found that nephrologists often lack confidence in managing various women's health issues, including menstrual disorders and menopause. The survey of 154 nephrologists revealed inconsistent documentation of obstetric history, highlighting the need for improved patient-centered care.
A new study has found that frequent home hemodialysis is associated with a lower mortality risk compared to traditional hemodialysis. The study analyzed data from over 1,700 patients and found that HHD patients were 23% less likely to die during follow-up than IHD patients.
A national sample of 1,084 adults with chronic kidney disease (CKD) found that pro-inflammatory diets increased the risk of developing kidney failure. The study suggests that nutritional interventions focusing on reducing inflammation may help halt CKD progression.
A new study has linked physical disabilities in kidney transplant recipients to poor outcomes, including a higher risk of organ failure for those with visual disabilities and early death for those with walking disabilities. The study suggests that these patients may benefit from additional supportive care and monitoring post-transplant.
A clinical trial showed that low-phosphorus diets and medication can decrease FGF23 levels in hemodialysis patients. This reduction decreases the risk of cardiovascular problems and increases life expectancy.
A study of over 10,000 participants with type 2 diabetes found that intensive blood sugar control and targeting low blood pressure reduced the risk of macroalbuminuria, but had no impact on more significant kidney outcomes. The use of fenofibrate to lower cholesterol increased the risk for doubling of serum creatinine.
A recent study published by the American Society of Nephrology found a strong link between acute kidney injury and an increased risk of developing dementia. Patients with acute kidney injury had a 7.0% vs. 2.3% chance of developing dementia, highlighting the potential long-term cognitive consequences of AKI.
Pediatric kidney transplant recipients face worsening long-term survival disparities, despite overall improvement in patient survival from 1995 to 2014. Racial/ethnic differences persist, with Black children at highest risk of death compared to White and Hispanic counterparts.
A phase II clinical trial found that sparsentan significantly reduces proteinuria by 45% in patients with focal segmental glomerulosclerosis (FSGS), a rare kidney disorder. The study also suggests potential implications for other kidney diseases characterized by proteinuria.
A new study published in American Society of Nephrology found that ideal BMI (18-25) recipients had the best organ survival rates, while there was no difference in patient survival across different BMI groups. Obesity may not be a significant barrier to kidney transplantation for obese patients.
A recent study found that procurement biopsies taken when kidneys are procured from donors were not reliable for determining suitability for transplantation. This lack of reliability may result in unnecessary kidney discard and reduced organ utilization, prompting a need to re-examine the role of such biopsies in organ allocation.
Scientists have discovered a way to increase NAD+ levels in the kidney and liver by blocking an enzyme, ACMSD, which limits its production. This breakthrough has shown promise for treating liver and kidney diseases, with enhanced mitochondrial function and improved health outcomes.
Researchers found that aggressive blood pressure treatment does not damage the kidneys themselves, but rather leads to decreased blood flow. This discovery challenges previous beliefs and offers new hope for patients with hypertension.
Researchers have found that intensive blood pressure lowering does not necessarily lead to true kidney disease, but rather benign reductions in kidney blood flow. This major advancement challenges current clinical standards for diagnosing and monitoring chronic kidney disease.
A new study shows that stereotactic ablative radiotherapy (SABR) is as safe and effective for patients with one kidney as it is for those with two. The treatment provided high local control and cancer-specific survival rates, with minimal impact on renal function.
Researchers have created a nanomaterial called MXene that can capture urea from dialysis waste, paving the way for a more comfortable and effective artificial kidney. The material is lightweight, safe, and can hold onto urea even at body temperature.
Researchers have gained fresh insights into how kidney stones form using cryo-electron microscopy to capture the 3D structure of an ion channel protein called TRPV5. The study reveals a unique mechanism of TRPV5 inhibition that could be useful for finding novel binding partners and drug discovery.
A large multi-ethnic study found that high circulating levels of an inflammatory marker are linked to long-term decline in kidney function. The study suggests a novel marker, soluble TNFR-1, is strongly related to kidney function decline over time.
Researchers found that lixisenatide slowed the progression of kidney damage in patients with macro-albuminuria and type 2 diabetes. The study showed a statistically significant reduction in urinary albumin-to-creatinine ratio and a borderline significant reduction in risk of incidence of macroalbuminuria.
A stage four sarcomatoid kidney cancer patient has achieved complete response to immunotherapy treatment, marking a significant breakthrough in the fight against this aggressive form of cancer. Researchers are now recruiting patients with sarcomatoid kidney cancer in clinical trials with checkpoint inhibitors.
Researchers identified specific genes and cells associated with CKD, including the adaptor protein DAB2 in the TGF-β pathway. Further experiments confirmed that reducing DAB2 expression protected mice from CKD. The findings could inform treatment options for this complex disease.
A study by Mohammad Asghar seeks to understand age-related kidney function impairment and identify targets for drug interventions. The researcher believes that mitochondrial respiration plays a critical role in maintaining normal kidney function.
A Mayo Clinic study found that premenopausal women who have their ovaries surgically removed face an increased risk of developing chronic kidney disease. The risk is highest for those younger than 46, with a 7.5% increased risk.
Despite changes to the US kidney allocation system, low-income and minority patients still face significant barriers to timely diagnosis and transplant. Early disease diagnosis and preemptive waitlisting are critical strategies to improve survival chances, but many vulnerable populations lack access to these essential care pathways.
Exposure to PFAS has been linked to worse kidney function and other signs of kidney damage in studies analyzing all relevant research. The analysis points to the need for further research on the effects of PFAS on kidney health.
A new study reveals that kidney stones are built up in calcium-rich layers resembling mineralizations in nature. The research found that the stones partially dissolve and regrow again and again as they form, contradicting the widely held notion that they never dissolve.
Researchers from University of Otago identify genetic variant that controls urate levels and gout risk in the gut as well as kidney. This discovery has significant implications for developing new medical interventions in gout and kidney disease.
A study by Gemma Scholes and colleagues found that newborn babies with congenital heart disease tend to have significantly enlarged kidneys. This contradicts previous assumptions about organ development in these infants. The type of congenital abnormality also influences kidney size, with some having larger or smaller than normal kidneys.
Using fMRI scans, University of Pennsylvania researchers found that people who donated a kidney to an anonymous recipient were more sensitive to a stranger's fear and pain, with activation in the anterior insula brain region. This study provides the first clear link between real-world altruism and empathy for the pain of strangers.
A study published in Canadian Medical Association Journal found that patients with acute critical illness without pre-existing kidney disease are at increased risk of developing chronic kidney disease and end-stage renal disease. The study also shows that these patients have a higher risk of death.
A new study has introduced a 'failure-aware' algorithmic matching approach to improve the success rate of kidney transplants. The method takes pre-transplant compatibility failures into account probabilistically and can roughly double the number of successful transplants, depending on the setting.
The NIH grant will aid research in understanding how to prevent kidney damage and failure caused by type 2 diabetes. Tubular epithelial cells play a crucial role in kidney function and require high amounts of lipids and fatty acids to work correctly, but people with type 2 diabetes have lipid metabolism derailments.
A new study published in PLOS ONE suggests that polluted air may be a threat to your kidneys, increasing the risk of chronic kidney disease. Air pollution contains fine particulate matter (PM2.5), which can cause serious health effects when inhaled regularly.
Researchers found high levels of toxic metals in drinking water, including nickel, copper, cadmium, and lead, leading to increased morbidity rates. The study also revealed a significant link between the accumulation of these metals in kidneys and livers, increasing the risk of malignant neoplasms.
Researchers at Loma Linda University Health found that kidney transplantation can be safely performed using organs testing positive for hepatitis C virus antibody but negative for active viral infection. The study expanded the number of kidneys available for those in need, addressing a shortage in organ donations.
Researchers have developed a new nanoparticle that can target kidney cells and deliver medication directly to the site of the disease, potentially reducing side effects. This innovation may prove critical in addressing chronic kidney disease, which affects one in three Americans.
A $5.67 million federal grant will extend and expand research into acute kidney injury, affecting 1.2 million hospitalized patients yearly, with the goal of improving prevention and treatment strategies.
A multidisciplinary research team found a form of vitamin B3 has the potential to prevent acute kidney injury by boosting NAD+ levels in high-risk patients. The study suggests a non-invasive test and therapy for patients at risk for acute kidney injury.
Researchers found that higher oxidative stress in males reduces the production of nitric oxide, a powerful blood vessel dilator. An antioxidant treatment restored similar production levels of protective nitric oxide between males and females.
Researchers found that autophagy efficiency declines with age, leading to accumulation of damaged biological structures in the kidneys. They discovered that nutrition restrictions and pharmacological drugs like rapamycin may help tackle this issue.
A UBC study found that prioritizing kidney transplant chains over exchanges can increase the total number of transplants and save more lives. This is particularly beneficial for hard-to-match patients with end-stage renal disease. The research could lead to longer kidney transplant chains through improved matching algorithms.
Researchers identified specific gene activity in each cell, revealing that Wilms' tumour cells have the same characteristics as normal developing kidney cells. Adult renal carcinoma cells were found to be a version of rare healthy adult kidney cells called PT1.
A new study found that rates of Acute Kidney Injury (AKI) among Irish patients have more than doubled in the past decade. The study highlights the importance of targeting 'minor' AKI events to prevent severe forms and reduce risk of kidney failure.
Researchers found that transplantation followed by antiviral therapy cured hepatitis C in all 20 patients who received kidneys from infected donors. The treatment resulted in excellent renal function and stable to improved quality of life.
A clinical trial at Penn Medicine has successfully cured 20 patients of the Hepatitis C virus (HCV) after receiving kidney transplants from infected donors who were treated with an antiviral therapy. The results show that the quality and function of the transplanted kidneys are similar to those from non-HCV infected donors.
Gene expression analysis of blood samples from 15 kidney transplant recipients revealed that the most robust gene expression changes occurred in the first day following transplantation. A comparison between living donors and deceased donor groups identified 11 genes that may play a key role in kidney repair and regeneration.
Researchers have developed a new treatment that delivers an inflammation inhibitor directly to the kidneys, reversing the course of destructive nephritis. The treatment restores mitochondrial function and reduces cell death, offering hope for patients with chronic kidney disease.
A recent study by KU Leuven researchers reveals that the lifespan of transplanted kidneys has stagnated despite improvements in the past. The study analyzed data from over 100,000 recipients across Europe and found that the average lifespan of a transplanted kidney is now around 15-20 years.
A study found that tolvaptan treatment slowed the rate of kidney function decline in individuals with autosomal dominant polycystic kidney disease (ADPKD) for up to 11 years. The therapy also showed a lower risk of a 33% reduction in eGFR from baseline.
A new procedure harnessing ultrasound technology to reposition kidney stones is being tested in emergency patients at UW Medicine's Harborview Medical Center and University Center. The approach could benefit astronauts as well as Earth-side patients, providing quick relief and avoiding unnecessary pain medications.
Researchers have developed a new protocol to produce mature human podocytes from induced pluripotent stem cells, offering a robust source for scientific studies and potential cell therapies for kidney diseases. The method has been confirmed to exhibit transcriptomic and protein expression profiles matching those of mature podocytes.