Articles tagged with Kidney
Researchers identified microRNA-668 as a key player in protecting kidney cells from damage caused by acute kidney injury. By upregulating this microRNA, the protective pathway can prevent most of the damage and allow cells to function ideally until blood and oxygen are restored.
Researchers found that men with chronic kidney disease experience faster disease progression and higher death rates compared to women. The study analyzed over 4,000 participants and discovered a 17% lower risk of end-stage renal disease in women.
Researchers at Charité - Universitätsmedizin Berlin aim to develop new treatment strategies for chronic and acute kidney diseases through a €10.5 million funded Collaborative Research Center. The project focuses on identifying common pathways of kidney injury and developing tailored treatments.
Researchers discovered a new pathway to enhance kidney self-repair by reprogramming the body's metabolism. The 'lift and push' process involves shifting glucose from energy production to repair damaged cells, resulting in improved lifespan for injured animals.
Researchers from Kanazawa University investigated gut microbiota effects on kidney function and discovered that the gut microbiota produces D-serine, a substance protective for the kidney. Administering D-serine to normal mice mitigated kidney injury, suggesting its potential as a biomarker or medication for acute kidney injury.
An international study has discovered 35 kidney genes linked to chronic kidney disease risk, bringing a step closer to understanding, diagnosing, and preventing the disease. The study used next-generation RNA sequencing on one of the largest collections of human kidneys.
Scientists at Newcastle University have identified a gene editing method to stop kidney damage in patients with Joubert syndrome, a genetic condition causing brain and kidney issues. The 'exon-skipping' technique may lead to personalized therapies for inherited kidney diseases.
A recent study published in Clinical Kidney Journal found that marijuana use by live kidney donors had no measurable impact on the outcomes of kidney transplants. The study, which reviewed over 290 living donor medical records, also showed no long-term differences in kidney function between marijuana users and non-users.
Researchers discovered that lab-grown kidney cells can contain rogue brain and muscle cells, making them imperfect models for human kidneys. However, they found a way to prevent most of these off-target cells from forming, which could accelerate progress in developing better treatments for kidney disease.
Researchers found that SGLT2 inhibitors are associated with a two-fold increased risk of lower limb amputation and diabetic ketoacidosis compared to GLP1 receptor agonists. However, the use of these drugs was not linked to other serious adverse events.
Researchers have developed a mouse model that closely replicates human diabetic nephropathy, revealing a key role for immune and inflammatory responses in promoting kidney damage. This finding suggests targeting these pathways may be useful for preventing or slowing the development of diabetic nephropathy.
A new method for treating and preventing acute kidney injury (AKI) has been developed using tiny, self-assembling forms of DNA origami nanostructures. These nanostructures were shown to protect the kidneys from harm as effectively as the leading drug therapy and alleviate symptoms of AKI.
Researchers at Drexel University developed a wearable artificial kidney using MXene materials that can filter out urea from blood with high efficiency. The material has shown better ability to adsorb urea molecules compared to other known sorbents, paving the way for a more portable dialysis machine.
Researchers analyzed data from 28 papers involving over 1,300 participants and found no evidence linking high protein diets to kidney disease in healthy individuals or those at risk of kidney disease. A high-protein diet can actually increase kidney function, making it a safe and important tool for muscle health across the lifespan.
Researchers have successfully developed kidney tissue that exhibits the early stages of congenital kidney disease using iPS cells from a patient with a nephrin mutation. The study found that repairing the nephrin mutation can normalize abnormalities and may lead to the development of effective drugs for kidney disease.
A study comparing transplant data from the US and France reveals that approximately 2,000 donated kidneys are discarded annually in the US, despite a shortage of organs. Adopting greater willingness to accept higher-risk donor groups could provide an additional 132,445 allograft life-years.
Frailty in kidney failure patients is associated with lower likelihoods of being placed on the transplant waitlist and receiving a transplant. Frail participants had nearly twofold increased risk of dying while on the transplant waitlist and underwent transplantation at a 35% lower rate than nonfrail participants.
A new study has found that frequent home hemodialysis is associated with a lower mortality risk compared to traditional hemodialysis. The study analyzed data from over 1,700 patients and found that HHD patients were 23% less likely to die during follow-up than IHD patients.
A national sample of 1,084 adults with chronic kidney disease (CKD) found that pro-inflammatory diets increased the risk of developing kidney failure. The study suggests that nutritional interventions focusing on reducing inflammation may help halt CKD progression.
Recent clinical trials have shown promising results in reducing progression of kidney disease and improving cardiovascular outcomes in patients with type 2 diabetes. These trials investigated the effects of linagliptin, a DPP inhibitor, on kidney outcomes, as well as high-dose versus low-dose intravenous iron therapy for hemodialysis p...
A recent study has found that nephrologists often lack confidence in managing various women's health issues, including menstrual disorders and menopause. The survey of 154 nephrologists revealed inconsistent documentation of obstetric history, highlighting the need for improved patient-centered care.
A phase II clinical trial found that sparsentan significantly reduces proteinuria by 45% in patients with focal segmental glomerulosclerosis (FSGS), a rare kidney disorder. The study also suggests potential implications for other kidney diseases characterized by proteinuria.
A new study published in American Society of Nephrology found that ideal BMI (18-25) recipients had the best organ survival rates, while there was no difference in patient survival across different BMI groups. Obesity may not be a significant barrier to kidney transplantation for obese patients.
A recent study found that procurement biopsies taken when kidneys are procured from donors were not reliable for determining suitability for transplantation. This lack of reliability may result in unnecessary kidney discard and reduced organ utilization, prompting a need to re-examine the role of such biopsies in organ allocation.
A new study has linked physical disabilities in kidney transplant recipients to poor outcomes, including a higher risk of organ failure for those with visual disabilities and early death for those with walking disabilities. The study suggests that these patients may benefit from additional supportive care and monitoring post-transplant.
A clinical trial showed that low-phosphorus diets and medication can decrease FGF23 levels in hemodialysis patients. This reduction decreases the risk of cardiovascular problems and increases life expectancy.
A study of over 10,000 participants with type 2 diabetes found that intensive blood sugar control and targeting low blood pressure reduced the risk of macroalbuminuria, but had no impact on more significant kidney outcomes. The use of fenofibrate to lower cholesterol increased the risk for doubling of serum creatinine.
A recent study published by the American Society of Nephrology found a strong link between acute kidney injury and an increased risk of developing dementia. Patients with acute kidney injury had a 7.0% vs. 2.3% chance of developing dementia, highlighting the potential long-term cognitive consequences of AKI.
Pediatric kidney transplant recipients face worsening long-term survival disparities, despite overall improvement in patient survival from 1995 to 2014. Racial/ethnic differences persist, with Black children at highest risk of death compared to White and Hispanic counterparts.
Scientists have discovered a way to increase NAD+ levels in the kidney and liver by blocking an enzyme, ACMSD, which limits its production. This breakthrough has shown promise for treating liver and kidney diseases, with enhanced mitochondrial function and improved health outcomes.
Researchers found that aggressive blood pressure treatment does not damage the kidneys themselves, but rather leads to decreased blood flow. This discovery challenges previous beliefs and offers new hope for patients with hypertension.
Researchers have found that intensive blood pressure lowering does not necessarily lead to true kidney disease, but rather benign reductions in kidney blood flow. This major advancement challenges current clinical standards for diagnosing and monitoring chronic kidney disease.
A new study shows that stereotactic ablative radiotherapy (SABR) is as safe and effective for patients with one kidney as it is for those with two. The treatment provided high local control and cancer-specific survival rates, with minimal impact on renal function.
Researchers have created a nanomaterial called MXene that can capture urea from dialysis waste, paving the way for a more comfortable and effective artificial kidney. The material is lightweight, safe, and can hold onto urea even at body temperature.
Researchers have gained fresh insights into how kidney stones form using cryo-electron microscopy to capture the 3D structure of an ion channel protein called TRPV5. The study reveals a unique mechanism of TRPV5 inhibition that could be useful for finding novel binding partners and drug discovery.
A large multi-ethnic study found that high circulating levels of an inflammatory marker are linked to long-term decline in kidney function. The study suggests a novel marker, soluble TNFR-1, is strongly related to kidney function decline over time.
Researchers found that lixisenatide slowed the progression of kidney damage in patients with macro-albuminuria and type 2 diabetes. The study showed a statistically significant reduction in urinary albumin-to-creatinine ratio and a borderline significant reduction in risk of incidence of macroalbuminuria.
A stage four sarcomatoid kidney cancer patient has achieved complete response to immunotherapy treatment, marking a significant breakthrough in the fight against this aggressive form of cancer. Researchers are now recruiting patients with sarcomatoid kidney cancer in clinical trials with checkpoint inhibitors.
Researchers identified specific genes and cells associated with CKD, including the adaptor protein DAB2 in the TGF-β pathway. Further experiments confirmed that reducing DAB2 expression protected mice from CKD. The findings could inform treatment options for this complex disease.
A study by Mohammad Asghar seeks to understand age-related kidney function impairment and identify targets for drug interventions. The researcher believes that mitochondrial respiration plays a critical role in maintaining normal kidney function.
A Mayo Clinic study found that premenopausal women who have their ovaries surgically removed face an increased risk of developing chronic kidney disease. The risk is highest for those younger than 46, with a 7.5% increased risk.
Despite changes to the US kidney allocation system, low-income and minority patients still face significant barriers to timely diagnosis and transplant. Early disease diagnosis and preemptive waitlisting are critical strategies to improve survival chances, but many vulnerable populations lack access to these essential care pathways.
A new study reveals that kidney stones are built up in calcium-rich layers resembling mineralizations in nature. The research found that the stones partially dissolve and regrow again and again as they form, contradicting the widely held notion that they never dissolve.
Exposure to PFAS has been linked to worse kidney function and other signs of kidney damage in studies analyzing all relevant research. The analysis points to the need for further research on the effects of PFAS on kidney health.
Researchers from University of Otago identify genetic variant that controls urate levels and gout risk in the gut as well as kidney. This discovery has significant implications for developing new medical interventions in gout and kidney disease.
Using fMRI scans, University of Pennsylvania researchers found that people who donated a kidney to an anonymous recipient were more sensitive to a stranger's fear and pain, with activation in the anterior insula brain region. This study provides the first clear link between real-world altruism and empathy for the pain of strangers.
A study by Gemma Scholes and colleagues found that newborn babies with congenital heart disease tend to have significantly enlarged kidneys. This contradicts previous assumptions about organ development in these infants. The type of congenital abnormality also influences kidney size, with some having larger or smaller than normal kidneys.
A study published in Canadian Medical Association Journal found that patients with acute critical illness without pre-existing kidney disease are at increased risk of developing chronic kidney disease and end-stage renal disease. The study also shows that these patients have a higher risk of death.
The NIH grant will aid research in understanding how to prevent kidney damage and failure caused by type 2 diabetes. Tubular epithelial cells play a crucial role in kidney function and require high amounts of lipids and fatty acids to work correctly, but people with type 2 diabetes have lipid metabolism derailments.
A new study has introduced a 'failure-aware' algorithmic matching approach to improve the success rate of kidney transplants. The method takes pre-transplant compatibility failures into account probabilistically and can roughly double the number of successful transplants, depending on the setting.
A new study published in PLOS ONE suggests that polluted air may be a threat to your kidneys, increasing the risk of chronic kidney disease. Air pollution contains fine particulate matter (PM2.5), which can cause serious health effects when inhaled regularly.
Researchers found high levels of toxic metals in drinking water, including nickel, copper, cadmium, and lead, leading to increased morbidity rates. The study also revealed a significant link between the accumulation of these metals in kidneys and livers, increasing the risk of malignant neoplasms.
Researchers at Loma Linda University Health found that kidney transplantation can be safely performed using organs testing positive for hepatitis C virus antibody but negative for active viral infection. The study expanded the number of kidneys available for those in need, addressing a shortage in organ donations.
Researchers have developed a new nanoparticle that can target kidney cells and deliver medication directly to the site of the disease, potentially reducing side effects. This innovation may prove critical in addressing chronic kidney disease, which affects one in three Americans.
A $5.67 million federal grant will extend and expand research into acute kidney injury, affecting 1.2 million hospitalized patients yearly, with the goal of improving prevention and treatment strategies.
A multidisciplinary research team found a form of vitamin B3 has the potential to prevent acute kidney injury by boosting NAD+ levels in high-risk patients. The study suggests a non-invasive test and therapy for patients at risk for acute kidney injury.
Researchers found that higher oxidative stress in males reduces the production of nitric oxide, a powerful blood vessel dilator. An antioxidant treatment restored similar production levels of protective nitric oxide between males and females.
Researchers found that autophagy efficiency declines with age, leading to accumulation of damaged biological structures in the kidneys. They discovered that nutrition restrictions and pharmacological drugs like rapamycin may help tackle this issue.
Researchers identified specific gene activity in each cell, revealing that Wilms' tumour cells have the same characteristics as normal developing kidney cells. Adult renal carcinoma cells were found to be a version of rare healthy adult kidney cells called PT1.
A UBC study found that prioritizing kidney transplant chains over exchanges can increase the total number of transplants and save more lives. This is particularly beneficial for hard-to-match patients with end-stage renal disease. The research could lead to longer kidney transplant chains through improved matching algorithms.