A recent study published in the Journal of the American College of Surgeons found that minority patients with blood type B can receive kidneys from donors with blood type A2 without compromising their health. The study showed comparable patient and graft survival rates for both groups, but higher costs for type B recipients who receive...
SourceAmerican College of Surgeons·JournalJournal of the American College of Surgeons·DateJan 30, 2019
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A new study identifies key factors involved in cell cycle arrest and illuminates a novel intracellular structure, paving the way for new therapeutic targets to treat kidney fibrosis. The research team found that blocking the formation of TASCCs reduced the severity of kidney fibrotic disease progression in preclinical models.
SourceBrigham and Women's Hospital·JournalScience Translational Medicine·DateJan 28, 2019
Researchers discovered that kidney-resident macrophages in mice undergo a developmental reprogramming after acute kidney injury, similar to those found in newborn mice. This reprogramming may aid in promoting healing and tissue regeneration, potentially leading to new therapeutic approaches for patients.
SourceUniversity of Alabama at Birmingham·JournalJCI Insight·DateJan 24, 2019
Scientists identified an enzyme that regulates kidney function and found that excessive suppression can trigger renal failure. This research has implications for the use of existing drugs like lithium and the development of new pharmaceuticals.
SourceUniversity of Bristol·JournalNature Communications·DateJan 24, 2019
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A recent study published in the Journal of the American Society of Nephrology found that frailty is associated with cognitive decline in adults undergoing kidney transplantation. Cognitive function improved after transplantation but declined in frail recipients over several years.
SourceAmerican Society of Nephrology·JournalJournal of the American Society of Nephrology·DateJan 24, 2019
A streamlined process for low-risk kidney transplant candidates has been developed to maximize the chance of pre-emptive transplantation. Younger patients with few comorbidities and not on dialysis for over five years can expect a significantly longer life expectancy after transplantation.
SourceERA – European Renal Association·JournalNephrology Dialysis Transplantation·DateJan 22, 2019
Scientists at Sechenov University have discovered a new highly sensitive and quick method for diagnosing kidney cancer using antibodies to a retina protein. The method measures the immune response to arrestin-1, which is synthesized in cancerous cells of kidneys, and has been shown to detect benign growths at early stages.
A study found that whole-exome sequencing revealed a genetic diagnosis of kidney disease in 32.7% of pediatric kidney transplant recipients. This technique may help individualize pre- and post-transplant care for these young patients, guiding the development of more personalized treatment plans.
SourceAmerican Society of Nephrology·JournalJournal of the American Society of Nephrology·DateJan 17, 2019
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A team of researchers has discovered a previously unknown disease that causes children to suffer from epileptic seizures, loss of magnesium in urine, and reduced intelligence. The disease is linked to a mutation in the sodium-potassium pump's Alpha-1 form, affecting both kidneys and the brain.
SourceAarhus University·JournalAmerican Journal of Human Genetics·DateJan 10, 2019
A team of scientists has located the body's largest cell receptor, a mysterious structure that plays a crucial role in vitamin B12 absorption. The discovery, published in Nature Communications, sheds light on why people with specific genetic changes struggle to absorb the essential nutrient.
SourceAarhus University·JournalNature Communications·DateJan 3, 2019
A new study found that genes cause about 1 in 10 cases of chronic kidney disease in adults, and identifying the responsible gene has a direct impact on treatment. DNA testing reclassified the cause of kidney disease in 1 out of 5 individuals with a genetic diagnosis.
SourceColumbia University Irving Medical Center·JournalNew England Journal of Medicine·DateDec 26, 2018
A study reveals that nephrologists treat the most complex patients, with kidney disease patients having the highest number of comorbidities and medication needs. The findings highlight the need for better financial funding and awareness for kidney diseases in European healthcare systems.
SourceERA – European Renal Association·JournalJAMA Network Open·DateDec 21, 2018
A recent study on Australian diabetics aged under 50 reveals an alarming rise in end-stage kidney disease, underscoring the need for aggressive risk factor treatment. The research highlights the importance of early intervention to mitigate this trend and alleviate pressure on Australia's kidney dialysis services.
SourceBaker Heart and Diabetes Institute·JournalAmerican Journal of Kidney Diseases·DateDec 19, 2018
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Chronic kidney disease (CKD) is characterized by progressive loss of kidney function, which can be attributed to faulty cellular energy sensing. Researchers have identified a link between decreased AMPK activity and CKD progression, highlighting a potential therapeutic target for treatment.
SourceTokyo Medical and Dental University·JournalKidney International·DateDec 7, 2018
A national study suggests that kidneys from deceased donors with acute kidney injury have the same success rates as non-injured kidneys, and may be a valuable resource for patients in need of transplantation. The study found no significant differences in organ rejection rates or recipient outcomes between AKI and non-AKI kidneys.
SourceJohns Hopkins Medicine·JournalKidney International·DateDec 6, 2018
Researchers identified microRNA-668 as a key player in protecting kidney cells from damage caused by acute kidney injury. By upregulating this microRNA, the protective pathway can prevent most of the damage and allow cells to function ideally until blood and oxygen are restored.
SourceMedical College of Georgia at Augusta University·JournalJournal of Clinical Investigation·DateDec 6, 2018
Researchers found that men with chronic kidney disease experience faster disease progression and higher death rates compared to women. The study analyzed over 4,000 participants and discovered a 17% lower risk of end-stage renal disease in women.
SourceUniversity of Illinois Chicago·JournalJournal of the American Society of Nephrology·DateDec 4, 2018
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Researchers at Charité - Universitätsmedizin Berlin aim to develop new treatment strategies for chronic and acute kidney diseases through a €10.5 million funded Collaborative Research Center. The project focuses on identifying common pathways of kidney injury and developing tailored treatments.
Researchers discovered a new pathway to enhance kidney self-repair by reprogramming the body's metabolism. The 'lift and push' process involves shifting glucose from energy production to repair damaged cells, resulting in improved lifespan for injured animals.
SourceCase Western Reserve University·JournalNature·DateNov 28, 2018
Researchers from Kanazawa University investigated gut microbiota effects on kidney function and discovered that the gut microbiota produces D-serine, a substance protective for the kidney. Administering D-serine to normal mice mitigated kidney injury, suggesting its potential as a biomarker or medication for acute kidney injury.
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An international study has discovered 35 kidney genes linked to chronic kidney disease risk, bringing a step closer to understanding, diagnosing, and preventing the disease. The study used next-generation RNA sequencing on one of the largest collections of human kidneys.
SourceUniversity of Manchester·JournalNature Communications·DateNov 22, 2018
Scientists at Newcastle University have identified a gene editing method to stop kidney damage in patients with Joubert syndrome, a genetic condition causing brain and kidney issues. The 'exon-skipping' technique may lead to personalized therapies for inherited kidney diseases.
SourceNewcastle University·JournalProceedings of the National Academy of Sciences·DateNov 16, 2018
Researchers discovered that lab-grown kidney cells can contain rogue brain and muscle cells, making them imperfect models for human kidneys. However, they found a way to prevent most of these off-target cells from forming, which could accelerate progress in developing better treatments for kidney disease.
A recent study published in Clinical Kidney Journal found that marijuana use by live kidney donors had no measurable impact on the outcomes of kidney transplants. The study, which reviewed over 290 living donor medical records, also showed no long-term differences in kidney function between marijuana users and non-users.
SourceOxford University Press USA·JournalClinical Kidney Journal·DateNov 15, 2018
Researchers found that SGLT2 inhibitors are associated with a two-fold increased risk of lower limb amputation and diabetic ketoacidosis compared to GLP1 receptor agonists. However, the use of these drugs was not linked to other serious adverse events.
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A new method for treating and preventing acute kidney injury (AKI) has been developed using tiny, self-assembling forms of DNA origami nanostructures. These nanostructures were shown to protect the kidneys from harm as effectively as the leading drug therapy and alleviate symptoms of AKI.
SourceArizona State University·JournalNature Biomedical Engineering·DateNov 8, 2018
Researchers have developed a mouse model that closely replicates human diabetic nephropathy, revealing a key role for immune and inflammatory responses in promoting kidney damage. This finding suggests targeting these pathways may be useful for preventing or slowing the development of diabetic nephropathy.
SourceDuke-NUS Medical School·JournalDiabetes·DateNov 8, 2018
Researchers at Drexel University developed a wearable artificial kidney using MXene materials that can filter out urea from blood with high efficiency. The material has shown better ability to adsorb urea molecules compared to other known sorbents, paving the way for a more portable dialysis machine.
SourceDrexel University·JournalACS Nano·DateNov 5, 2018
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Researchers analyzed data from 28 papers involving over 1,300 participants and found no evidence linking high protein diets to kidney disease in healthy individuals or those at risk of kidney disease. A high-protein diet can actually increase kidney function, making it a safe and important tool for muscle health across the lifespan.
SourceMcMaster University·JournalJournal of Nutrition·DateNov 5, 2018
Researchers have successfully developed kidney tissue that exhibits the early stages of congenital kidney disease using iPS cells from a patient with a nephrin mutation. The study found that repairing the nephrin mutation can normalize abnormalities and may lead to the development of effective drugs for kidney disease.
SourceKumamoto University·JournalStem Cell Reports·DateOct 31, 2018
A study comparing transplant data from the US and France reveals that approximately 2,000 donated kidneys are discarded annually in the US, despite a shortage of organs. Adopting greater willingness to accept higher-risk donor groups could provide an additional 132,445 allograft life-years.
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Frailty in kidney failure patients is associated with lower likelihoods of being placed on the transplant waitlist and receiving a transplant. Frail participants had nearly twofold increased risk of dying while on the transplant waitlist and underwent transplantation at a 35% lower rate than nonfrail participants.
Recent clinical trials have shown promising results in reducing progression of kidney disease and improving cardiovascular outcomes in patients with type 2 diabetes. These trials investigated the effects of linagliptin, a DPP inhibitor, on kidney outcomes, as well as high-dose versus low-dose intravenous iron therapy for hemodialysis p...
A recent study has found that nephrologists often lack confidence in managing various women's health issues, including menstrual disorders and menopause. The survey of 154 nephrologists revealed inconsistent documentation of obstetric history, highlighting the need for improved patient-centered care.
A new study has found that frequent home hemodialysis is associated with a lower mortality risk compared to traditional hemodialysis. The study analyzed data from over 1,700 patients and found that HHD patients were 23% less likely to die during follow-up than IHD patients.
A national sample of 1,084 adults with chronic kidney disease (CKD) found that pro-inflammatory diets increased the risk of developing kidney failure. The study suggests that nutritional interventions focusing on reducing inflammation may help halt CKD progression.
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A new study has linked physical disabilities in kidney transplant recipients to poor outcomes, including a higher risk of organ failure for those with visual disabilities and early death for those with walking disabilities. The study suggests that these patients may benefit from additional supportive care and monitoring post-transplant.
A clinical trial showed that low-phosphorus diets and medication can decrease FGF23 levels in hemodialysis patients. This reduction decreases the risk of cardiovascular problems and increases life expectancy.
SourceUniversity of Córdoba·JournalPLOS ONE·DateOct 25, 2018
A study of over 10,000 participants with type 2 diabetes found that intensive blood sugar control and targeting low blood pressure reduced the risk of macroalbuminuria, but had no impact on more significant kidney outcomes. The use of fenofibrate to lower cholesterol increased the risk for doubling of serum creatinine.
SourceAmerican Society of Nephrology·JournalClinical Journal of the American Society of Nephrology·DateOct 25, 2018
A recent study published by the American Society of Nephrology found a strong link between acute kidney injury and an increased risk of developing dementia. Patients with acute kidney injury had a 7.0% vs. 2.3% chance of developing dementia, highlighting the potential long-term cognitive consequences of AKI.
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Pediatric kidney transplant recipients face worsening long-term survival disparities, despite overall improvement in patient survival from 1995 to 2014. Racial/ethnic differences persist, with Black children at highest risk of death compared to White and Hispanic counterparts.
A phase II clinical trial found that sparsentan significantly reduces proteinuria by 45% in patients with focal segmental glomerulosclerosis (FSGS), a rare kidney disorder. The study also suggests potential implications for other kidney diseases characterized by proteinuria.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalJournal of the American Society of Nephrology·DateOct 25, 2018
A new study published in American Society of Nephrology found that ideal BMI (18-25) recipients had the best organ survival rates, while there was no difference in patient survival across different BMI groups. Obesity may not be a significant barrier to kidney transplantation for obese patients.
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A recent study found that procurement biopsies taken when kidneys are procured from donors were not reliable for determining suitability for transplantation. This lack of reliability may result in unnecessary kidney discard and reduced organ utilization, prompting a need to re-examine the role of such biopsies in organ allocation.
SourceAmerican Society of Nephrology·JournalClinical Journal of the American Society of Nephrology·DateOct 25, 2018
Scientists have discovered a way to increase NAD+ levels in the kidney and liver by blocking an enzyme, ACMSD, which limits its production. This breakthrough has shown promise for treating liver and kidney diseases, with enhanced mitochondrial function and improved health outcomes.
SourceEcole Polytechnique Fédérale de Lausanne·JournalNature·DateOct 24, 2018
Researchers found that aggressive blood pressure treatment does not damage the kidneys themselves, but rather leads to decreased blood flow. This discovery challenges previous beliefs and offers new hope for patients with hypertension.
SourceUniversity of California - San Diego·JournalAnnals of Internal Medicine·DateOct 23, 2018
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Researchers have found that intensive blood pressure lowering does not necessarily lead to true kidney disease, but rather benign reductions in kidney blood flow. This major advancement challenges current clinical standards for diagnosing and monitoring chronic kidney disease.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·DateOct 22, 2018
A new study shows that stereotactic ablative radiotherapy (SABR) is as safe and effective for patients with one kidney as it is for those with two. The treatment provided high local control and cancer-specific survival rates, with minimal impact on renal function.
SourceAmerican Society for Radiation Oncology·DateOct 22, 2018
Researchers have created a nanomaterial called MXene that can capture urea from dialysis waste, paving the way for a more comfortable and effective artificial kidney. The material is lightweight, safe, and can hold onto urea even at body temperature.
SourceAmerican Chemical Society·JournalACS Nano·DateOct 17, 2018
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Researchers have gained fresh insights into how kidney stones form using cryo-electron microscopy to capture the 3D structure of an ion channel protein called TRPV5. The study reveals a unique mechanism of TRPV5 inhibition that could be useful for finding novel binding partners and drug discovery.
SourceUniversity of Pennsylvania School of Medicine·JournalNature Communications·DateOct 10, 2018
A large multi-ethnic study found that high circulating levels of an inflammatory marker are linked to long-term decline in kidney function. The study suggests a novel marker, soluble TNFR-1, is strongly related to kidney function decline over time.
SourceAmerican Society of Nephrology·JournalJournal of the American Society of Nephrology·DateOct 4, 2018
Researchers found that lixisenatide slowed the progression of kidney damage in patients with macro-albuminuria and type 2 diabetes. The study showed a statistically significant reduction in urinary albumin-to-creatinine ratio and a borderline significant reduction in risk of incidence of macroalbuminuria.
SourceDiabetologia·JournalThe Lancet Diabetes & Endocrinology·DateOct 3, 2018
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A stage four sarcomatoid kidney cancer patient has achieved complete response to immunotherapy treatment, marking a significant breakthrough in the fight against this aggressive form of cancer. Researchers are now recruiting patients with sarcomatoid kidney cancer in clinical trials with checkpoint inhibitors.
SourceVirginia Commonwealth University·JournalJournal of Oncology Practice·DateOct 2, 2018
Researchers identified specific genes and cells associated with CKD, including the adaptor protein DAB2 in the TGF-β pathway. Further experiments confirmed that reducing DAB2 expression protected mice from CKD. The findings could inform treatment options for this complex disease.
SourceUniversity of Pennsylvania School of Medicine·JournalNature Medicine·DateOct 1, 2018
A study by Mohammad Asghar seeks to understand age-related kidney function impairment and identify targets for drug interventions. The researcher believes that mitochondrial respiration plays a critical role in maintaining normal kidney function.
A Mayo Clinic study found that premenopausal women who have their ovaries surgically removed face an increased risk of developing chronic kidney disease. The risk is highest for those younger than 46, with a 7.5% increased risk.
SourceMayo Clinic·JournalClinical Journal of the American Society of Nephrology·DateSep 19, 2018
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Despite changes to the US kidney allocation system, low-income and minority patients still face significant barriers to timely diagnosis and transplant. Early disease diagnosis and preemptive waitlisting are critical strategies to improve survival chances, but many vulnerable populations lack access to these essential care pathways.
SourceDrexel University·JournalClinical Transplantation·DateSep 17, 2018
Exposure to PFAS has been linked to worse kidney function and other signs of kidney damage in studies analyzing all relevant research. The analysis points to the need for further research on the effects of PFAS on kidney health.
SourceAmerican Society of Nephrology·JournalClinical Journal of the American Society of Nephrology·DateSep 13, 2018
A new study reveals that kidney stones are built up in calcium-rich layers resembling mineralizations in nature. The research found that the stones partially dissolve and regrow again and again as they form, contradicting the widely held notion that they never dissolve.
SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalScientific Reports·DateSep 13, 2018
Researchers from University of Otago identify genetic variant that controls urate levels and gout risk in the gut as well as kidney. This discovery has significant implications for developing new medical interventions in gout and kidney disease.
SourceUniversity of Otago·JournalHuman Molecular Genetics·DateSep 12, 2018