Articles tagged with Kidney
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A recent study found that very few smartphone apps related to chronic kidney disease (CKD) are highly rated by both patients and physicians. The study suggests that patient opinions on app quality correlated poorly with physician ratings and consumer ratings from iOS and Android app stores.
A study of Swedish adults found a U-shaped relationship between kidney function and cancer incidence, with lower eGFR associated with higher cancer risk. The research suggests that individuals with mild to severe chronic kidney disease may be at increased risk for skin (non-melanoma) and urogenital cancers.
A machine learning approach using high-quality animal model data sheds new light on the biology of the liver and kidneys after toxin exposure, revealing nine distinct patterns of response to chemical exposure that may be broadly relevant to studies of human disease. The analysis highlights defense mechanisms and novel biomarkers, provi...
Researchers analyzed 385 patients with transplant glomerulopathy to identify distinct features and outcomes, developing a tool for clinicians to predict health outcomes. The study may help individualize treatments for patients at high risk of transplant failure.
A new study finds that occupational heat exposure is linked to a decline in kidney function and chronic kidney disease (CKD) in artisanal brick makers in Nicaragua. The researchers found 12.1% of the sample had stage 3-5 CKD, with risk factors including operating ovens, less education, older age, and inadequate water intake.
A large-scale study published in the Journal of Hepatology found that antiviral therapy significantly improves survival rates for kidney transplant recipients infected with hepatitis B or C. The study analyzed records of over 30,000 patients and confirmed that antiviral therapy should be systematically offered to these patients.
Researchers at Wake Forest Institute for Regenerative Medicine have made breakthroughs in treating chronic kidney disease with cell therapy. Amniotic fluid-derived stem cells injected into diseased kidneys showed improvement in kidney function and structural recovery after 10 weeks, reducing damage to capillary clusters.
Researchers at Children's National Hospital will examine genetic mutations causing nephrotic syndrome using Drosophila. The goal is to develop targeted treatments for pediatric patients with steroid-resistant nephrotic syndrome.
New research suggests that moderate water intake can reduce kidney cyst growth and fibrosis in people with polycystic kidney disease (PKD). Increased water consumption was also found to have secondary benefits, including reducing high blood pressure and cardiovascular risks associated with PKD.
A new study found that losing Medicare coverage before the three-year post-transplant mark significantly increases the risk of kidney failure and decreases medication adherence. This has significant policy implications, highlighting the need for healthcare safety nets and access to immunosuppressive medications.
A randomized controlled trial conducted across 18 countries found that steroid use during cardiopulmonary bypass surgery did not reduce the risk of acute kidney injury in patients at high risk of death. The study included 7286 patients and found no significant difference between those receiving steroids and those on placebo.
Researchers created a 3D vascularized proximal tubule model to study renal reabsorption outside the human body. The model exhibited functional epithelial and endothelial cell morphologies and transported glucose effectively, allowing for the testing of drugs and modeling of diseases.
Researchers at Utrecht University have successfully created mini kidneys from urine cells, which can be used to study certain kidney diseases. These mini kidneys can also be infected with viruses to test potential treatments for patients who undergo a transplant.
Researchers have developed a blood test that can predict kidney transplant rejection up to two months in advance. By monitoring seven immune genes, doctors may be able to intervene before damage occurs, improving patient outcomes and organ lifespan.
Patients who receive a kidney transplant are at increased risk of skin cancer, with the rate rising after stopping anti-rejection medications, according to a study. The study found that skin cancer rates fell during periods of transplant failure but remained higher than pre-transplant patients on dialysis.
Researchers found that cognitive behavioral therapy and the drug sertraline effectively reduce depression among people undergoing maintenance hemodialysis. The study, published in Annals of Internal Medicine, suggests that physicians should select the treatment available to patients, considering each comes with its own burdens.
A new study found that evidence-based care can improve patient outcomes for acute kidney injury, reducing hospital stays by several days. The intervention also led to improved recognition of AKI, medication optimization, and fluid assessment, resulting in better patient care.
A multinational collaboration study on familial primary distal renal tubular acidosis found that patients with adequate treatment had better growth and kidney function compared to those with inadequate treatment. The study, which included data from 340 patients across 29 countries, also highlighted the importance of controlling acid-ba...
Researchers at Wyss Institute develop method to enhance kidney organoid vascularization and maturation, enabling accurate modeling of kidney diseases and drug toxicity testing. This breakthrough paves the way for new building blocks in renal replacement therapies.
A Brazilian project aims to assess how patients awaiting kidney transplants react to porcine blood, with the goal of reducing the country's transplant waiting list. The initiative uses gene-edited pigs and CRISPR-Cas9 technology to make organs compatible with human bodies.
Researchers found blocked newborn kidneys can repair themselves after obstruction removal, shedding light on how kidney damage occurs and potentially leading to regeneration methods. They identified precursor cells playing critical roles in this process.
Researchers found that NSAID carprofen triggered low-grade inflammation in the heart and kidneys, amplifying cardiorenal syndrome. Biomarkers of kidney injury increased, indicating compromised glomerular structure integrity.
Researchers have successfully grown functional mouse kidneys inside rats from just a few donor stem cells, offering a promising solution to the global kidney shortage. The study, published in Nature Communications, used the blastocyst complementation method to generate human stem cell-derived organs.
Researchers used data from Olmsted County, Minnesota to develop an online prediction tool that predicts the likelihood of future kidney stone episodes. The tool takes into account factors such as age, sex, body mass index, pregnancy history, and family history of stones.
Researchers at the Diabetes Research Institute have successfully transplanted islets into the eye of experimental recipients, achieving long-term immunosuppression-free survival. This approach also shows promise for inducing peripheral immune tolerance, allowing for reduced or eliminated anti-rejection therapy.
A study at Vanderbilt University Medical Center found that African-American patients with blood type B can receive blood type A2 kidneys with similar outcomes. This new option has improved access to transplants for minority patients, increasing the number of available organs and reducing disparities in wait times.
A recent study published in the Journal of the American College of Surgeons found that minority patients with blood type B can receive kidneys from donors with blood type A2 without compromising their health. The study showed comparable patient and graft survival rates for both groups, but higher costs for type B recipients who receive...
A new study identifies key factors involved in cell cycle arrest and illuminates a novel intracellular structure, paving the way for new therapeutic targets to treat kidney fibrosis. The research team found that blocking the formation of TASCCs reduced the severity of kidney fibrotic disease progression in preclinical models.
Scientists identified an enzyme that regulates kidney function and found that excessive suppression can trigger renal failure. This research has implications for the use of existing drugs like lithium and the development of new pharmaceuticals.
A recent study published in the Journal of the American Society of Nephrology found that frailty is associated with cognitive decline in adults undergoing kidney transplantation. Cognitive function improved after transplantation but declined in frail recipients over several years.
Researchers discovered that kidney-resident macrophages in mice undergo a developmental reprogramming after acute kidney injury, similar to those found in newborn mice. This reprogramming may aid in promoting healing and tissue regeneration, potentially leading to new therapeutic approaches for patients.
A streamlined process for low-risk kidney transplant candidates has been developed to maximize the chance of pre-emptive transplantation. Younger patients with few comorbidities and not on dialysis for over five years can expect a significantly longer life expectancy after transplantation.
Scientists at Sechenov University have discovered a new highly sensitive and quick method for diagnosing kidney cancer using antibodies to a retina protein. The method measures the immune response to arrestin-1, which is synthesized in cancerous cells of kidneys, and has been shown to detect benign growths at early stages.
A study found that whole-exome sequencing revealed a genetic diagnosis of kidney disease in 32.7% of pediatric kidney transplant recipients. This technique may help individualize pre- and post-transplant care for these young patients, guiding the development of more personalized treatment plans.
A team of researchers has discovered a previously unknown disease that causes children to suffer from epileptic seizures, loss of magnesium in urine, and reduced intelligence. The disease is linked to a mutation in the sodium-potassium pump's Alpha-1 form, affecting both kidneys and the brain.
A team of scientists has located the body's largest cell receptor, a mysterious structure that plays a crucial role in vitamin B12 absorption. The discovery, published in Nature Communications, sheds light on why people with specific genetic changes struggle to absorb the essential nutrient.
A new study found that genes cause about 1 in 10 cases of chronic kidney disease in adults, and identifying the responsible gene has a direct impact on treatment. DNA testing reclassified the cause of kidney disease in 1 out of 5 individuals with a genetic diagnosis.
A study reveals that nephrologists treat the most complex patients, with kidney disease patients having the highest number of comorbidities and medication needs. The findings highlight the need for better financial funding and awareness for kidney diseases in European healthcare systems.
A recent study on Australian diabetics aged under 50 reveals an alarming rise in end-stage kidney disease, underscoring the need for aggressive risk factor treatment. The research highlights the importance of early intervention to mitigate this trend and alleviate pressure on Australia's kidney dialysis services.
Chronic kidney disease (CKD) is characterized by progressive loss of kidney function, which can be attributed to faulty cellular energy sensing. Researchers have identified a link between decreased AMPK activity and CKD progression, highlighting a potential therapeutic target for treatment.
A national study suggests that kidneys from deceased donors with acute kidney injury have the same success rates as non-injured kidneys, and may be a valuable resource for patients in need of transplantation. The study found no significant differences in organ rejection rates or recipient outcomes between AKI and non-AKI kidneys.
Researchers identified microRNA-668 as a key player in protecting kidney cells from damage caused by acute kidney injury. By upregulating this microRNA, the protective pathway can prevent most of the damage and allow cells to function ideally until blood and oxygen are restored.
Researchers found that men with chronic kidney disease experience faster disease progression and higher death rates compared to women. The study analyzed over 4,000 participants and discovered a 17% lower risk of end-stage renal disease in women.
Researchers at Charité - Universitätsmedizin Berlin aim to develop new treatment strategies for chronic and acute kidney diseases through a €10.5 million funded Collaborative Research Center. The project focuses on identifying common pathways of kidney injury and developing tailored treatments.
Researchers discovered a new pathway to enhance kidney self-repair by reprogramming the body's metabolism. The 'lift and push' process involves shifting glucose from energy production to repair damaged cells, resulting in improved lifespan for injured animals.
Researchers from Kanazawa University investigated gut microbiota effects on kidney function and discovered that the gut microbiota produces D-serine, a substance protective for the kidney. Administering D-serine to normal mice mitigated kidney injury, suggesting its potential as a biomarker or medication for acute kidney injury.
An international study has discovered 35 kidney genes linked to chronic kidney disease risk, bringing a step closer to understanding, diagnosing, and preventing the disease. The study used next-generation RNA sequencing on one of the largest collections of human kidneys.
Scientists at Newcastle University have identified a gene editing method to stop kidney damage in patients with Joubert syndrome, a genetic condition causing brain and kidney issues. The 'exon-skipping' technique may lead to personalized therapies for inherited kidney diseases.
A recent study published in Clinical Kidney Journal found that marijuana use by live kidney donors had no measurable impact on the outcomes of kidney transplants. The study, which reviewed over 290 living donor medical records, also showed no long-term differences in kidney function between marijuana users and non-users.
Researchers discovered that lab-grown kidney cells can contain rogue brain and muscle cells, making them imperfect models for human kidneys. However, they found a way to prevent most of these off-target cells from forming, which could accelerate progress in developing better treatments for kidney disease.
Researchers found that SGLT2 inhibitors are associated with a two-fold increased risk of lower limb amputation and diabetic ketoacidosis compared to GLP1 receptor agonists. However, the use of these drugs was not linked to other serious adverse events.
A new method for treating and preventing acute kidney injury (AKI) has been developed using tiny, self-assembling forms of DNA origami nanostructures. These nanostructures were shown to protect the kidneys from harm as effectively as the leading drug therapy and alleviate symptoms of AKI.
Researchers have developed a mouse model that closely replicates human diabetic nephropathy, revealing a key role for immune and inflammatory responses in promoting kidney damage. This finding suggests targeting these pathways may be useful for preventing or slowing the development of diabetic nephropathy.
Researchers analyzed data from 28 papers involving over 1,300 participants and found no evidence linking high protein diets to kidney disease in healthy individuals or those at risk of kidney disease. A high-protein diet can actually increase kidney function, making it a safe and important tool for muscle health across the lifespan.
Researchers at Drexel University developed a wearable artificial kidney using MXene materials that can filter out urea from blood with high efficiency. The material has shown better ability to adsorb urea molecules compared to other known sorbents, paving the way for a more portable dialysis machine.
Researchers have successfully developed kidney tissue that exhibits the early stages of congenital kidney disease using iPS cells from a patient with a nephrin mutation. The study found that repairing the nephrin mutation can normalize abnormalities and may lead to the development of effective drugs for kidney disease.
Frailty in kidney failure patients is associated with lower likelihoods of being placed on the transplant waitlist and receiving a transplant. Frail participants had nearly twofold increased risk of dying while on the transplant waitlist and underwent transplantation at a 35% lower rate than nonfrail participants.
A study comparing transplant data from the US and France reveals that approximately 2,000 donated kidneys are discarded annually in the US, despite a shortage of organs. Adopting greater willingness to accept higher-risk donor groups could provide an additional 132,445 allograft life-years.
A recent study has found that nephrologists often lack confidence in managing various women's health issues, including menstrual disorders and menopause. The survey of 154 nephrologists revealed inconsistent documentation of obstetric history, highlighting the need for improved patient-centered care.
A new study has found that frequent home hemodialysis is associated with a lower mortality risk compared to traditional hemodialysis. The study analyzed data from over 1,700 patients and found that HHD patients were 23% less likely to die during follow-up than IHD patients.