Articles tagged with Kidney
Research supported by the Accelerating Medicines Partnership has provided new insights into tissue damage in rheumatoid arthritis and lupus. Novel molecular signatures have been identified in kidney cells and specific white blood cells may reflect their active role in disease process.
The VITALE study found that high-dose vitamin D supplementation significantly reduces fracture risk in kidney transplant recipients, with a lower incidence of fractures in the high-dose group compared to the low-dose group. The treatment was well-tolerated with no increased risks of adverse effects.
A new biomarker, urinary DKK3, has been identified as a predictor of acute kidney injury (AKI) in patients undergoing cardiac surgery. High preoperative levels of DKK3 are associated with lower kidney function and increased risk of AKI.
A study found that one-fifth of US surgeons perform the less-recommended AV graft procedure too often, even when unnecessary. The research suggests that older, specialized surgeons are more likely to use this method.
Chronic kidney disease (CKD) is associated with increased cardiovascular risk due to high LDL-C levels. PCSK9 inhibitors like evolocumab and alirocumab have shown promise in reducing cardiovascular events, but more research is needed to prove their efficacy and safety in CKD patients.
A large international clinical trial found that dulaglutide reduced cardiovascular events by 12% and kidney disease by 15% in people with Type 2 diabetes. The study, REWIND, followed over 9,900 participants for five years.
A new study published by University of Pittsburgh researchers found that removing excess fluid too quickly from critically ill patients with failing kidneys increases the likelihood of death. For every 0.5 milliliter increase in fluid removed per kilogram of patient weight per hour, risk of death increases.
UC researchers present findings from the Belatacept Early Steroid Withdrawal Trial (BEST), showing that belatacept can safely and effectively treat kidney transplant patients. The study demonstrates reduced side effects and cardiovascular risk reduction compared to traditional immunosuppressive regimens.
Researchers developed a gel-based delivery system to improve tissue regeneration in kidney injuries. The study found that the system could significantly enhance cell proliferation and survival, leading to rapid functional recovery.
Researchers have discovered that inhibiting two key proteins, ATM and ATR, can reduce BK polyomavirus levels in infected cells. This finding may provide an opportunity to use existing cancer drugs to combat the virus without reducing immunosuppressing drugs, which are needed to prevent transplant rejection.
Researchers at Wake Forest Institute for Regenerative Medicine have successfully engineered vascularized functional renal tissues using a novel biomimetic scaffold. The study's findings suggest that this approach may be a more feasible and practical treatment strategy for patients with chronic kidney disease.
A recent study by Drexel University researchers found that patients who lost significant weight before a kidney transplant had an 18% higher risk of death after the procedure. The study analyzed data from over 94,000 transplant recipients and found that even planned weight loss could be dangerous if not closely monitored.
A USask-led research team is developing an artificial portable kidney that can be worn by patients with renal failure, reducing hospital visits and healthcare costs. The team aims to create a highly efficient dialysis membrane that mimics the human kidney's filtering properties.
Researchers developed a new testing method using single-cell RNA sequencing to analyze individual cells in diseased organs, revealing genetic glitches that may allow for more effective treatment. The study found promising results in lupus patients and could potentially improve biopsy accuracy for other diseases.
Researchers have discovered a way to predict which patients with systemic lupus erythematosus (SLE) are most likely to respond to therapy by analyzing tissue samples from their kidneys and skin. This breakthrough could lead to personalized treatment plans for SLE patients.
A genomic collision may explain why many kidney transplants fail due to genetic incompatibility between donor and recipient. The study found that recipients with two copies of a deletion near the LIMS1 gene had a significantly higher risk of rejection when the donor kidney had at least one full-sized version of the same gene.
A new study published in Mayo Clinic Proceedings found that renal infarction is associated with acute kidney injury in patients with cardiac amyloidosis. The study revealed a relatively high prevalence of renal infarction among these patients, suggesting it as a potential cause of acute kidney injury in this context.
Children who receive kidney transplants have impaired quality of life with higher mental health difficulties and disrupted sleep patterns. Parents' reports often differ from children's self-reports, indicating more difficulties in emotional functioning and social domains.
A study found that children who developed de novo donor-specific antibodies (dnDSA) after kidney transplant had thicker carotid intima-media layers than those without these antibodies. Being African American was also associated with increased CIMT in transplant recipients.
Dr. Bradley Yoder receives the prestigious prize for his significant research on polycystic kidney disease, recognizing his work on primary cilium function and its role in cyst development. The award aims to stimulate research towards a treatment and cure for PKD.
A new study found that consuming a nutrient-rich plant-based diet may help protect against chronic kidney disease (CKD) development. Participants with the highest adherence to a healthy plant-based diet had a lower risk of developing CKD compared to those with low adherence.
Scientists at Joslin Diabetes Center discovered a group of 17 inflammatory proteins associated with diabetic kidney disease progression. These Kidney Risk Inflammatory Signature (KRIS) proteins, including TNF receptors, are indicative of systemic inflammation and may serve as drug targets to prevent and treat end-stage renal disease.
Kidney transplant patients face a higher risk of cardiovascular complications and mortality due to existing damage and immunosuppressive drug side effects. The current post-transplantation care is fragmented, leading to undertreatment of modifiable cardiovascular risk factors.
Researchers have discovered a potential new treatment for renal fibrosis by selectively activating AT1 receptors on T cells, which may help limit scar formation in the kidney. The study found that activating these receptors mitigates renal fibrogenesis by inhibiting Th1 differentiation and renal accumulation of pro-fibrotic macrophages.
A large-scale genome-wide association study has identified 14 new variants associated with the development of kidney stones, including four linked to obesity and high blood uric acid levels. The findings may be useful for predicting individuals' risk of developing kidney stones and identifying new targets for prevention and treatment.
The Kidney Health Atlas reveals that 14.5 million people will have end-stage kidney disease by 2030, yet only 5.4 million will receive treatment due to economic and social factors. The atlas highlights significant gaps in kidney care globally, particularly in low-income countries.
A study by UCSF researchers found that nearly one in seven kidney donors experience potentially adverse events related to their donation. Long-term systematic renal monitoring and routine checkups for living kidney donors are recommended to prevent renal failure and cardiovascular issues.
A case study reveals that taking high doses of vitamin D can lead to kidney damage and malfunction. Patients should be better informed about the risks of using excessive amounts of vitamin D, particularly in low-risk individuals.
A new global study, Global Kidney Health Atlas (GKHA), is released on April 12 at the World Congress of Nephrology, detailing country and region breakdowns of global kidney health. The study highlights disparities in treatment access due to social, economic, and political factors, resulting in over 2 million deaths annually worldwide.
A new study analyzed nearly 43,000 patients on a kidney transplant wait-list after implementation of the new system in 2014. The research found racial disparities in patient status on the list and sensitivity levels, which can affect transplantation likelihood.
Racial disparities in access to kidney transplants continue, with patients from underserved groups more likely to be listed as inactive and less likely to receive transplants than white patients. A new study analyzing data from 2014-2016 found significant inequities despite a system aimed at increasing access for vulnerable populations.
A multidisciplinary team from Johns Hopkins Medicine has completed the first living donor HIV-to-HIV kidney transplant in the US. Nina Martinez, a 35-year-old living with HIV, donated her kidney to an anonymous recipient after undergoing rigorous evaluation and testing.
A collaborative project between C-Path and Japan's PMDA aims to generate critical data for safety decisions in early-stage clinical trials. The study will compare biomarkers in healthy Japanese volunteers with similar Western subjects, informing regulatory submissions.
A synthetic peptide has been found to directly disrupt destructive inflammation in the kidneys, enabling better recovery and maintaining important functions. The peptide reduced immune cell movement, resolved inflammation, and improved kidney function without increasing blood pressure.
A recent study found that very few smartphone apps related to chronic kidney disease (CKD) are highly rated by both patients and physicians. The study suggests that patient opinions on app quality correlated poorly with physician ratings and consumer ratings from iOS and Android app stores.
A study of Swedish adults found a U-shaped relationship between kidney function and cancer incidence, with lower eGFR associated with higher cancer risk. The research suggests that individuals with mild to severe chronic kidney disease may be at increased risk for skin (non-melanoma) and urogenital cancers.
A machine learning approach using high-quality animal model data sheds new light on the biology of the liver and kidneys after toxin exposure, revealing nine distinct patterns of response to chemical exposure that may be broadly relevant to studies of human disease. The analysis highlights defense mechanisms and novel biomarkers, provi...
Researchers analyzed 385 patients with transplant glomerulopathy to identify distinct features and outcomes, developing a tool for clinicians to predict health outcomes. The study may help individualize treatments for patients at high risk of transplant failure.
A new study finds that occupational heat exposure is linked to a decline in kidney function and chronic kidney disease (CKD) in artisanal brick makers in Nicaragua. The researchers found 12.1% of the sample had stage 3-5 CKD, with risk factors including operating ovens, less education, older age, and inadequate water intake.
A large-scale study published in the Journal of Hepatology found that antiviral therapy significantly improves survival rates for kidney transplant recipients infected with hepatitis B or C. The study analyzed records of over 30,000 patients and confirmed that antiviral therapy should be systematically offered to these patients.
Researchers at Wake Forest Institute for Regenerative Medicine have made breakthroughs in treating chronic kidney disease with cell therapy. Amniotic fluid-derived stem cells injected into diseased kidneys showed improvement in kidney function and structural recovery after 10 weeks, reducing damage to capillary clusters.
Researchers at Children's National Hospital will examine genetic mutations causing nephrotic syndrome using Drosophila. The goal is to develop targeted treatments for pediatric patients with steroid-resistant nephrotic syndrome.
New research suggests that moderate water intake can reduce kidney cyst growth and fibrosis in people with polycystic kidney disease (PKD). Increased water consumption was also found to have secondary benefits, including reducing high blood pressure and cardiovascular risks associated with PKD.
A new study found that losing Medicare coverage before the three-year post-transplant mark significantly increases the risk of kidney failure and decreases medication adherence. This has significant policy implications, highlighting the need for healthcare safety nets and access to immunosuppressive medications.
A randomized controlled trial conducted across 18 countries found that steroid use during cardiopulmonary bypass surgery did not reduce the risk of acute kidney injury in patients at high risk of death. The study included 7286 patients and found no significant difference between those receiving steroids and those on placebo.
Researchers created a 3D vascularized proximal tubule model to study renal reabsorption outside the human body. The model exhibited functional epithelial and endothelial cell morphologies and transported glucose effectively, allowing for the testing of drugs and modeling of diseases.
Researchers at Utrecht University have successfully created mini kidneys from urine cells, which can be used to study certain kidney diseases. These mini kidneys can also be infected with viruses to test potential treatments for patients who undergo a transplant.
Researchers have developed a blood test that can predict kidney transplant rejection up to two months in advance. By monitoring seven immune genes, doctors may be able to intervene before damage occurs, improving patient outcomes and organ lifespan.
Patients who receive a kidney transplant are at increased risk of skin cancer, with the rate rising after stopping anti-rejection medications, according to a study. The study found that skin cancer rates fell during periods of transplant failure but remained higher than pre-transplant patients on dialysis.
Researchers found that cognitive behavioral therapy and the drug sertraline effectively reduce depression among people undergoing maintenance hemodialysis. The study, published in Annals of Internal Medicine, suggests that physicians should select the treatment available to patients, considering each comes with its own burdens.
A new study found that evidence-based care can improve patient outcomes for acute kidney injury, reducing hospital stays by several days. The intervention also led to improved recognition of AKI, medication optimization, and fluid assessment, resulting in better patient care.
A multinational collaboration study on familial primary distal renal tubular acidosis found that patients with adequate treatment had better growth and kidney function compared to those with inadequate treatment. The study, which included data from 340 patients across 29 countries, also highlighted the importance of controlling acid-ba...
Researchers at Wyss Institute develop method to enhance kidney organoid vascularization and maturation, enabling accurate modeling of kidney diseases and drug toxicity testing. This breakthrough paves the way for new building blocks in renal replacement therapies.
A Brazilian project aims to assess how patients awaiting kidney transplants react to porcine blood, with the goal of reducing the country's transplant waiting list. The initiative uses gene-edited pigs and CRISPR-Cas9 technology to make organs compatible with human bodies.
Researchers found blocked newborn kidneys can repair themselves after obstruction removal, shedding light on how kidney damage occurs and potentially leading to regeneration methods. They identified precursor cells playing critical roles in this process.
Researchers found that NSAID carprofen triggered low-grade inflammation in the heart and kidneys, amplifying cardiorenal syndrome. Biomarkers of kidney injury increased, indicating compromised glomerular structure integrity.
Researchers have successfully grown functional mouse kidneys inside rats from just a few donor stem cells, offering a promising solution to the global kidney shortage. The study, published in Nature Communications, used the blastocyst complementation method to generate human stem cell-derived organs.
Researchers used data from Olmsted County, Minnesota to develop an online prediction tool that predicts the likelihood of future kidney stone episodes. The tool takes into account factors such as age, sex, body mass index, pregnancy history, and family history of stones.
Researchers at the Diabetes Research Institute have successfully transplanted islets into the eye of experimental recipients, achieving long-term immunosuppression-free survival. This approach also shows promise for inducing peripheral immune tolerance, allowing for reduced or eliminated anti-rejection therapy.
A study at Vanderbilt University Medical Center found that African-American patients with blood type B can receive blood type A2 kidneys with similar outcomes. This new option has improved access to transplants for minority patients, increasing the number of available organs and reducing disparities in wait times.