Articles tagged with Kidney
A new study published in Mayo Clinic Proceedings found that renal infarction is associated with acute kidney injury in patients with cardiac amyloidosis. The study revealed a relatively high prevalence of renal infarction among these patients, suggesting it as a potential cause of acute kidney injury in this context.
A genomic collision may explain why many kidney transplants fail due to genetic incompatibility between donor and recipient. The study found that recipients with two copies of a deletion near the LIMS1 gene had a significantly higher risk of rejection when the donor kidney had at least one full-sized version of the same gene.
Children who receive kidney transplants have impaired quality of life with higher mental health difficulties and disrupted sleep patterns. Parents' reports often differ from children's self-reports, indicating more difficulties in emotional functioning and social domains.
A study found that children who developed de novo donor-specific antibodies (dnDSA) after kidney transplant had thicker carotid intima-media layers than those without these antibodies. Being African American was also associated with increased CIMT in transplant recipients.
Dr. Bradley Yoder receives the prestigious prize for his significant research on polycystic kidney disease, recognizing his work on primary cilium function and its role in cyst development. The award aims to stimulate research towards a treatment and cure for PKD.
A new study found that consuming a nutrient-rich plant-based diet may help protect against chronic kidney disease (CKD) development. Participants with the highest adherence to a healthy plant-based diet had a lower risk of developing CKD compared to those with low adherence.
Scientists at Joslin Diabetes Center discovered a group of 17 inflammatory proteins associated with diabetic kidney disease progression. These Kidney Risk Inflammatory Signature (KRIS) proteins, including TNF receptors, are indicative of systemic inflammation and may serve as drug targets to prevent and treat end-stage renal disease.
Kidney transplant patients face a higher risk of cardiovascular complications and mortality due to existing damage and immunosuppressive drug side effects. The current post-transplantation care is fragmented, leading to undertreatment of modifiable cardiovascular risk factors.
Researchers have discovered a potential new treatment for renal fibrosis by selectively activating AT1 receptors on T cells, which may help limit scar formation in the kidney. The study found that activating these receptors mitigates renal fibrogenesis by inhibiting Th1 differentiation and renal accumulation of pro-fibrotic macrophages.
The Kidney Health Atlas reveals that 14.5 million people will have end-stage kidney disease by 2030, yet only 5.4 million will receive treatment due to economic and social factors. The atlas highlights significant gaps in kidney care globally, particularly in low-income countries.
A large-scale genome-wide association study has identified 14 new variants associated with the development of kidney stones, including four linked to obesity and high blood uric acid levels. The findings may be useful for predicting individuals' risk of developing kidney stones and identifying new targets for prevention and treatment.
A study by UCSF researchers found that nearly one in seven kidney donors experience potentially adverse events related to their donation. Long-term systematic renal monitoring and routine checkups for living kidney donors are recommended to prevent renal failure and cardiovascular issues.
A case study reveals that taking high doses of vitamin D can lead to kidney damage and malfunction. Patients should be better informed about the risks of using excessive amounts of vitamin D, particularly in low-risk individuals.
A new global study, Global Kidney Health Atlas (GKHA), is released on April 12 at the World Congress of Nephrology, detailing country and region breakdowns of global kidney health. The study highlights disparities in treatment access due to social, economic, and political factors, resulting in over 2 million deaths annually worldwide.
A new study analyzed nearly 43,000 patients on a kidney transplant wait-list after implementation of the new system in 2014. The research found racial disparities in patient status on the list and sensitivity levels, which can affect transplantation likelihood.
Racial disparities in access to kidney transplants continue, with patients from underserved groups more likely to be listed as inactive and less likely to receive transplants than white patients. A new study analyzing data from 2014-2016 found significant inequities despite a system aimed at increasing access for vulnerable populations.
A multidisciplinary team from Johns Hopkins Medicine has completed the first living donor HIV-to-HIV kidney transplant in the US. Nina Martinez, a 35-year-old living with HIV, donated her kidney to an anonymous recipient after undergoing rigorous evaluation and testing.
A collaborative project between C-Path and Japan's PMDA aims to generate critical data for safety decisions in early-stage clinical trials. The study will compare biomarkers in healthy Japanese volunteers with similar Western subjects, informing regulatory submissions.
A synthetic peptide has been found to directly disrupt destructive inflammation in the kidneys, enabling better recovery and maintaining important functions. The peptide reduced immune cell movement, resolved inflammation, and improved kidney function without increasing blood pressure.
A recent study found that very few smartphone apps related to chronic kidney disease (CKD) are highly rated by both patients and physicians. The study suggests that patient opinions on app quality correlated poorly with physician ratings and consumer ratings from iOS and Android app stores.
A study of Swedish adults found a U-shaped relationship between kidney function and cancer incidence, with lower eGFR associated with higher cancer risk. The research suggests that individuals with mild to severe chronic kidney disease may be at increased risk for skin (non-melanoma) and urogenital cancers.
A machine learning approach using high-quality animal model data sheds new light on the biology of the liver and kidneys after toxin exposure, revealing nine distinct patterns of response to chemical exposure that may be broadly relevant to studies of human disease. The analysis highlights defense mechanisms and novel biomarkers, provi...
Researchers analyzed 385 patients with transplant glomerulopathy to identify distinct features and outcomes, developing a tool for clinicians to predict health outcomes. The study may help individualize treatments for patients at high risk of transplant failure.
A new study finds that occupational heat exposure is linked to a decline in kidney function and chronic kidney disease (CKD) in artisanal brick makers in Nicaragua. The researchers found 12.1% of the sample had stage 3-5 CKD, with risk factors including operating ovens, less education, older age, and inadequate water intake.
A large-scale study published in the Journal of Hepatology found that antiviral therapy significantly improves survival rates for kidney transplant recipients infected with hepatitis B or C. The study analyzed records of over 30,000 patients and confirmed that antiviral therapy should be systematically offered to these patients.
Researchers at Wake Forest Institute for Regenerative Medicine have made breakthroughs in treating chronic kidney disease with cell therapy. Amniotic fluid-derived stem cells injected into diseased kidneys showed improvement in kidney function and structural recovery after 10 weeks, reducing damage to capillary clusters.
Researchers at Children's National Hospital will examine genetic mutations causing nephrotic syndrome using Drosophila. The goal is to develop targeted treatments for pediatric patients with steroid-resistant nephrotic syndrome.
New research suggests that moderate water intake can reduce kidney cyst growth and fibrosis in people with polycystic kidney disease (PKD). Increased water consumption was also found to have secondary benefits, including reducing high blood pressure and cardiovascular risks associated with PKD.
A new study found that losing Medicare coverage before the three-year post-transplant mark significantly increases the risk of kidney failure and decreases medication adherence. This has significant policy implications, highlighting the need for healthcare safety nets and access to immunosuppressive medications.
A randomized controlled trial conducted across 18 countries found that steroid use during cardiopulmonary bypass surgery did not reduce the risk of acute kidney injury in patients at high risk of death. The study included 7286 patients and found no significant difference between those receiving steroids and those on placebo.
Researchers created a 3D vascularized proximal tubule model to study renal reabsorption outside the human body. The model exhibited functional epithelial and endothelial cell morphologies and transported glucose effectively, allowing for the testing of drugs and modeling of diseases.
Researchers at Utrecht University have successfully created mini kidneys from urine cells, which can be used to study certain kidney diseases. These mini kidneys can also be infected with viruses to test potential treatments for patients who undergo a transplant.
Researchers have developed a blood test that can predict kidney transplant rejection up to two months in advance. By monitoring seven immune genes, doctors may be able to intervene before damage occurs, improving patient outcomes and organ lifespan.
Patients who receive a kidney transplant are at increased risk of skin cancer, with the rate rising after stopping anti-rejection medications, according to a study. The study found that skin cancer rates fell during periods of transplant failure but remained higher than pre-transplant patients on dialysis.
Researchers found that cognitive behavioral therapy and the drug sertraline effectively reduce depression among people undergoing maintenance hemodialysis. The study, published in Annals of Internal Medicine, suggests that physicians should select the treatment available to patients, considering each comes with its own burdens.
A new study found that evidence-based care can improve patient outcomes for acute kidney injury, reducing hospital stays by several days. The intervention also led to improved recognition of AKI, medication optimization, and fluid assessment, resulting in better patient care.
A multinational collaboration study on familial primary distal renal tubular acidosis found that patients with adequate treatment had better growth and kidney function compared to those with inadequate treatment. The study, which included data from 340 patients across 29 countries, also highlighted the importance of controlling acid-ba...
A Brazilian project aims to assess how patients awaiting kidney transplants react to porcine blood, with the goal of reducing the country's transplant waiting list. The initiative uses gene-edited pigs and CRISPR-Cas9 technology to make organs compatible with human bodies.
Researchers at Wyss Institute develop method to enhance kidney organoid vascularization and maturation, enabling accurate modeling of kidney diseases and drug toxicity testing. This breakthrough paves the way for new building blocks in renal replacement therapies.
Researchers found blocked newborn kidneys can repair themselves after obstruction removal, shedding light on how kidney damage occurs and potentially leading to regeneration methods. They identified precursor cells playing critical roles in this process.
Researchers found that NSAID carprofen triggered low-grade inflammation in the heart and kidneys, amplifying cardiorenal syndrome. Biomarkers of kidney injury increased, indicating compromised glomerular structure integrity.
Researchers have successfully grown functional mouse kidneys inside rats from just a few donor stem cells, offering a promising solution to the global kidney shortage. The study, published in Nature Communications, used the blastocyst complementation method to generate human stem cell-derived organs.
Researchers used data from Olmsted County, Minnesota to develop an online prediction tool that predicts the likelihood of future kidney stone episodes. The tool takes into account factors such as age, sex, body mass index, pregnancy history, and family history of stones.
Researchers at the Diabetes Research Institute have successfully transplanted islets into the eye of experimental recipients, achieving long-term immunosuppression-free survival. This approach also shows promise for inducing peripheral immune tolerance, allowing for reduced or eliminated anti-rejection therapy.
A study at Vanderbilt University Medical Center found that African-American patients with blood type B can receive blood type A2 kidneys with similar outcomes. This new option has improved access to transplants for minority patients, increasing the number of available organs and reducing disparities in wait times.
A recent study published in the Journal of the American College of Surgeons found that minority patients with blood type B can receive kidneys from donors with blood type A2 without compromising their health. The study showed comparable patient and graft survival rates for both groups, but higher costs for type B recipients who receive...
A new study identifies key factors involved in cell cycle arrest and illuminates a novel intracellular structure, paving the way for new therapeutic targets to treat kidney fibrosis. The research team found that blocking the formation of TASCCs reduced the severity of kidney fibrotic disease progression in preclinical models.
Scientists identified an enzyme that regulates kidney function and found that excessive suppression can trigger renal failure. This research has implications for the use of existing drugs like lithium and the development of new pharmaceuticals.
A recent study published in the Journal of the American Society of Nephrology found that frailty is associated with cognitive decline in adults undergoing kidney transplantation. Cognitive function improved after transplantation but declined in frail recipients over several years.
Researchers discovered that kidney-resident macrophages in mice undergo a developmental reprogramming after acute kidney injury, similar to those found in newborn mice. This reprogramming may aid in promoting healing and tissue regeneration, potentially leading to new therapeutic approaches for patients.
A streamlined process for low-risk kidney transplant candidates has been developed to maximize the chance of pre-emptive transplantation. Younger patients with few comorbidities and not on dialysis for over five years can expect a significantly longer life expectancy after transplantation.
Scientists at Sechenov University have discovered a new highly sensitive and quick method for diagnosing kidney cancer using antibodies to a retina protein. The method measures the immune response to arrestin-1, which is synthesized in cancerous cells of kidneys, and has been shown to detect benign growths at early stages.
A study found that whole-exome sequencing revealed a genetic diagnosis of kidney disease in 32.7% of pediatric kidney transplant recipients. This technique may help individualize pre- and post-transplant care for these young patients, guiding the development of more personalized treatment plans.
A team of researchers has discovered a previously unknown disease that causes children to suffer from epileptic seizures, loss of magnesium in urine, and reduced intelligence. The disease is linked to a mutation in the sodium-potassium pump's Alpha-1 form, affecting both kidneys and the brain.
A team of scientists has located the body's largest cell receptor, a mysterious structure that plays a crucial role in vitamin B12 absorption. The discovery, published in Nature Communications, sheds light on why people with specific genetic changes struggle to absorb the essential nutrient.
A new study found that genes cause about 1 in 10 cases of chronic kidney disease in adults, and identifying the responsible gene has a direct impact on treatment. DNA testing reclassified the cause of kidney disease in 1 out of 5 individuals with a genetic diagnosis.
A study reveals that nephrologists treat the most complex patients, with kidney disease patients having the highest number of comorbidities and medication needs. The findings highlight the need for better financial funding and awareness for kidney diseases in European healthcare systems.
A recent study on Australian diabetics aged under 50 reveals an alarming rise in end-stage kidney disease, underscoring the need for aggressive risk factor treatment. The research highlights the importance of early intervention to mitigate this trend and alleviate pressure on Australia's kidney dialysis services.
Chronic kidney disease (CKD) is characterized by progressive loss of kidney function, which can be attributed to faulty cellular energy sensing. Researchers have identified a link between decreased AMPK activity and CKD progression, highlighting a potential therapeutic target for treatment.
A national study suggests that kidneys from deceased donors with acute kidney injury have the same success rates as non-injured kidneys, and may be a valuable resource for patients in need of transplantation. The study found no significant differences in organ rejection rates or recipient outcomes between AKI and non-AKI kidneys.